120 results about "Liver function tests" patented technology

A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed.

The present invention relates to a diagnostic agent for liver function, comprising a compound labelled with 13C at least at one specific position selected from the group consisting of the following (a) to (f): (a) galactose, glucose or xylose labelled with 13C at least at one specific position or a starch composed of glucose units labelled with 13C at least at one specific position; (b) a polar amino acid, heterocyclic amino acid, isoleucine or valine labelled with 13C at least at one specific position; (c) a carboxylic acid constituting the glycolytic pathway or the citric acid cycle, labelled with 13C at least at one specific position; (d) a fatty acid labelled with 13C at least at one specific position; (e) a glyceride labelled with 13C at least at one specific position; and (f) glycerol labelled with 13C at least at one specific position. According to the present invention, a diagnostic agent for liver function which imposes less physical burden on a subject, can give accurate test result immediately, and can be used safely without side effects is provided. The diagnostic agent of the invention is useful for evaluating the liver function of a subject at the time when the test is carried out.

The invention provides a combining reagent for preparing a bioartificial liver stent. The reagent comprises perfusate 1, perfusate 2, perfusate 3, perfusate 4, eluent 1 and eluent 2, wherein the perfusate is alkalescent hypotonic solution or pure water; the perfusate 2 is a group of ionic detergent aqueous solutions with gradient concentration; the perfusate 3 is aqueous electrolyte solution; theperfusate 4 is anticoagulant factor aqueous solution; the eluent 1 is distilled water; and the eluent 2 is non-ionic detergent aqueous solution. The invention also provides a method for preparing an implantable bioartificial liver by using the combining reagent, and the implantable bioartificial liver prepared by using the method. The bioartificial liver stent prepared by using the combining reagent is decellularized completely; and the structure of an extracellular matrix is kept complete. The bioartificial liver can accommodate a large number of cells and provide adequate blood supply, so that the survival time of a rate with an acute hepatic failure is prolonged obviously; and a liver function is improved obviously. Therefore, the bioartificial liver has an extremely good clinical application prospect.

The invention relates to a traditional Chinese medicine preparation for treating chronic hepatitis b, which comprises the following raw medicines: angelica sinensis, oldenlandia diffusa, astragali, houttuynia, radix bupleuri, tropaeolum, baical skullcap, forsythia, isatis, self-heal, honeysuckle, magnolia vine fruit, tuckahoe, white atractylodes rhizome, prepared fleece-flower root, glossy privet fruit, yerbadetajo, root of red rooted salvia, white peony root, oriental wormwood, natural indigo, barbat skullcap, phellodendron bark, rhizoma cyperi, liquorice and cortex dictamni radicis. The traditional Chinese medicine preparation has the efficacies of soothing the liver, regulating the flow of qi, relieving the depressed liver, promoting blood circulation, removing blood stasis, invigorating qi, restoring qi, strengthening the body resistance, consolidating the constitution, and tonifying the liver and kidney. The traditional Chinese medicine preparation has the following beneficial effects of: 1, clearing away heat and toxic material, promoting urination and elimination of toxicant, removing heat from the liver, gall and liver, promoting blood circulation, removing blood stasis, strengthening the spleen and removing dampness by diuresis; 2, protecting liver, reducing enzyme, removing toxin, restoring the liver function to normal, and thoroughly removing virus; and 3, nourishing after birth, enhancing the body immunologic function, and promoting hepatocyte proliferation. All medicines have synergistic effects to restore the body immunologic function to normal and achieve the purposes of removing virus and promoting recovery.

A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

The present invention is directed to a composition for use in liver function improvement, blood alcohol level reduction and in-vivo antioxidant activity enhancement, comprising Lactobacillus brevis HY7401, Lactobacillus fermentum CS332, Lactobacillus acidophilus CSG, Bifidobacterium longum HY8001, an Alder tree extract, a Selfheal extract, a milk thistle extract, a green bean-rice bran fermentation extract, a turnip extract, a tomato extract, a broccoli extract, a pineapple extract, a colostrum powder, betaine, vitamin B1, B2, B3, B6, B9, B12, C, and E. The composition can improve declined liver functions and shows excellent hepatoprotective and hepatocurative activity against alcohol on excessive or habitual drinking with the ability to reduce blood alcohol levels. Its superior enhancement of in-vivo antioxidant activity also contributes to the use of the composition in the prevention of liver diseases and the improvement of liver functions. Also disclosed are fermented dairy foods, beverages, and health foods, containing the composition as an effective component.

The invention relates to pharmaceutical compositions comprising at least one fibrate and at least one bile acid, and to methods for the treatment of hyperlipidaemia or elevated liver function tests in a patient by administering at least one fibrate and at least one bile acid to the patient.

The invention discloses a pharmaceutical composition for treating liver diseases, which is prepared by the following active ingredients according to the mixture ratio by weight: liquoric root: white paeony root is equal to 1: 1.1-1: 1.9. In addition, the invention further discloses a preparation method, a use and a quality detection method of the pharmaceutical composition. Clinical observation proves that the pharmaceutical composition can effectively reduce aminotransferase, stop liver area pain and effectively restore liver functions, so that the pharmaceutical composition can be used for treating acute and chronic viral hepatitis and early cirrhosis, and also has better efficacy for patients with advanced schistosomiasis. The medicament with the formula has no toxicity or side effects and can meet the period treatment demand of the patients with the acute and chronic viral hepatitis.

Disclosed is a functional food composition, which is effective in relieving alcohol-induced hangover symptoms and improving liver function. The composition includes 6–18% by dry weight of Polygonati Rhizoma, 10–40% by dry weight of Astragalus membranaceus Bge., 5–15% by dry weight of Artemisiae Scopariae Herba, 10–30% by dry weight of White Hoelen, 5–25% by dry weight of Atractylodes rhizome white, 4–12% by dry weight of Rehmanniae Radix, 2–10% by dry weight of Mentha arvensis, 2–10% by dry weight of Curcuma longa, and 2–10% by dry weight of Puerariae Radix, based on the total dry weight of the composition. The composition, including herbal components known to have no side effects, is effective in relieving hangover symptoms and improving liver function by removing or neutralizing factors responsible for hangover symptoms, such as alcohol absorbed in the body or acetaldehyde, the oxidation product of alcohol.

A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

The invention relates to a drug for treating fatty liver, in particular to a traditional Chinese compound for treating fatty liver, which is made by adopting plants and herbal medicine as raw materials. The traditional Chinese compound for treating fatty liver is characterized in that: the raw materials made into effective components are included as follows according to the parts by weight: 15 to 25g of Radix Bupleuri, 10 to 20g of Radix Paeoniae Alba, 15 to 25g of Radix Angelicae Sinensis, 5 to 15g of Radix Curcumae, 5 to 15g of Semen Cassiae, 10 to 20g of Rhizoma Atractylodis Macrocephalae, 15 to 25g of Radix cynanchi wilfordii, 5 to 15g of Rhizoma Cyperi, 15 to 25g of Radix Salviae Miltiorrhizae, 20 to 30g of Rhizoma Alismatis, 5 to 15g of Fructus Citri Sarcodactylis, 50 to 70g of Fructus Crataegi and 2 to 5g of Radix Glycyrrhizae. The traditional Chinese compound for treating fatty liver is compounded to benefit mutually, and has the effects of harmonizing Shaoyang, soothing the liver and harmonizing the stomach, regulating and promoting blood circulation for removing blood stasis, eliminating blood stasis and promoting qi flow, activating blood circulation to dissipate blood stasis, and relieving pain, soothing the liver and invigorating the function of the spleen, removing food stagnation and removing blood stasis. Due to the drug effect interaction, the blood lipid level is effectively reduced, liver functions are improved, liver injury is repaired, and liver fibrosis is alleviated, thereby achieving the purposes of eliminating pathogenic factors without damaging vital energy and strengthening vital energy without pathogenic factors left.

The invention relates to pharmaceutical compositions comprising at least one fibrate and at least one bile acid, and to methods for the treatment of hyperlipidaemia or elevated liver function tests in a patient by administering at least one fibrate and at least one bile acid to the patient.

The invention discloses bear gall powder for preventing or treating liver diseases and liver fibrosis as well as improving the liver function and application. The bear gall powder can be used for adjusting the blood fat, reducing the total cholesterol, preventing the cardiovascular and cerebrovascular diseases and preventing the atherosclerosis, and can also be used for treating or preventing theliver diseases and the liver fibrosis as well as improving the liver function. The invention relates to a production method of ball gall powder and ball gall powder prepared by the production method.In the process for preparing the bear gall powder, materials are crystallized, then the materials are frozen and dried, thus obtaining the icy-crystal bear gall powder, or the bear gall powder can benamed as icy-crystal bear gall powder. The bear gall powder named as Semper bear gall powder contains no auxiliary material and chemical additive. The icy-crystal bear gall powder not only can effectively adjust the blood fat and reduce the total cholesterol, but also can be effectively used for preventing the cardiovascular and cerebrovascular diseases and preventing the atherosclerosis, and moreparticularly, the bear gall powder can be effectively used for preventing and treating the liver disease and the liver fibrosis as well as improving the liver function.

Hepatic cirrhosis is considered a severe health problem in Mexico, since it is the third mortality cause in working-age people and there is no 100% effective treatment. Cirrhosis is characterized by an exacerbated increase of collagen in liver parenchyma, replacing the hepatocytes and thus provoking liver failure. This is one of the reasons why we have used a gene therapy through specific delivery to cirrhotic livers of the gene of human urokinase plasminogen activator (huPA), which activates mechanisms that induce the degradation of excess cellular matrix and stimulate hepatocyte proliferation, obtaining thus a fast re-establishment of the liver function. In the instant invention, the modified human uPA gene was inserted in the adenoviral vector (pAd-DeltahuPA), because it is not secreted and does not provoke hypercoagulation or spontaneous internal bleedings. Moreover, data from the bio-distribution essay with an adenoviral vector with reporter gene beta-gal have shown liver specificity as the target organ of the vector. Using ELISA, huPa protein was detected in liver homogenates (4500 pg / ml) in animals treated with pAd-DeltahuPA and was also intracellularly detected through immunochemistry in liver cuts (80% positive cells). huPa induced a dramatic fibrosis reduction (85%) on day 10 of vector administration, compared to control cirrhotic rats and 55% hepatocyte proliferation increase. Liver function tests (ALT, AST, alkaline phosphatase and bilirubin) dropped to nearly normal levels and hepatocyte proliferation was observed. Because of the two beneficial event cascades, gene therapy with modified huPA can be developed as a definite potential treatment for patients with liver cirrhosis.

The invention discloses a composition for improving the liver function and reducing the damage to liver. The composition comprises schisandra chinensis compound powder, vitamin B group, glycine, clam meat extract, zinc glucondined, artichoke and cordyceps sinensis, wherein the preset weight percentage of the schisandra chinensis compound powder to the vitamin B group, the glycine and the clam meat extract to the zinc glucondined, the artichoke and the cordyceps sinensis is (29-55):(26-52):(19-45). The composition disclosed by the invention can be used for promoting fat metabolism of liver cell, preventing fatty liver and liver cirrhosis, repairing the liver cell, helping the liver detoxify and reducing the damage to the liver.

The invention provides a traditional Chinese medicine composition for treating anglerfish liver and gall syndromes, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises, by weight, 5-15 parts of radix isatidis, 6-16 parts of felwort, 6-15 parts of uncaria rhynchophylla, 5-15 parts of astragalus membranaceus, 4-15 parts of angelica sinensis, 6-16 parts of capillary artemisia, 8-16 parts of liquorice and 4-15 parts of atractylodes macrocephala koidz. The traditional Chinese medicine composition for treating the anglerfish liver and gall syndromes is reasonable in compatibility, through the complementary effect of traditional Chinese medicine, the functions of detoxication, liver injury prevention, bleeding stop, blood stasis removal, regeneration of the liver cells and restoration of the liver function can be achieved, stress reactions are effectively reduced, the anglerfish liver and gall syndromes can be well prevented and treated, and the treatment effective rate reaches up to 98%. The traditional Chinese medicine composition is environmentally friendly, free of pollution and any toxic action, and suitable for being widely used and popularized.

The invention relates to the technical field of wine making, in particular to liver protection baijiu and a preparation method thereof. The liver protection baijiu is made by joint fermentation of grain and Chinese herbal medicines including Flos Calendulae, beet, Fructus Lycii, Flos Puerariae, Radix Puerariae, parsley and the like. By Flos Calendulae with efficacies of alcoholism alleviating, liver tonifying and reducing of liver total lipids, cholesterol and triglyceride, beet with an efficacy of liver function improving, Fructus Lycii with efficacies of vital essence replenishing, eyesightimproving and liver and kidney nourishing, Flos Puerariae with efficacies of alcohol effect dispelling, spleen activating and bleeding stopping, Radix Puerariae with efficacies of muscle pathogenic factor dispelling, fever alleviating, saliva secretion promoting and thirst quenching, and parsley with efficacies of liver calming, blood pressure reducing, tranquilizing, nerve calming and the like, harms caused by alcohol to the liver are reduced while the content of nutrients in the baijiu is increased. Finally, the liver protection baijiu with efficacies of dilating blood vessel, reducing bloodpressure and clearing lipids in blood is obtained and is further capable of improving immunity, tranquilizing mind and soothing nerves.

The invention relates to a method for screening compounds having activity of protecting liver function of zebra fishes. The method includes: enabling carbaryl and a to-be-detected compound to jointly act on a zebra fish, or using carbaryl to act on the zebra fish to cause liver damage and then using the to-be-detected compound to treat the zebra fish after being damaged; utilizing liver area index change as an indicator to detect the liver function, and analyzing whether the to-be-detected compound has the activity of protecting or improving the liver function or not. For the first time, carbaryl is utilized to build a zebra fish liver function damage model, and the zebra fish liver function damage model has the advantages of simplicity and quickness in building, stability, reliability and high repeatability, so that building cost of the liver function damage model is lowered, and reliability of experimental study results is improved.

The invention provides a noninvasive multiparameter measuring device for the liver function and a detecting method. The noninvasive multiparameter measuring device is provided with two paths of same measuring units; finger-clip type sensors transmit lights with three types of wavelengths and are connected with a simulation front-end unit which is connected with a single chip microcomputer; a display device is connected with an IO interface of the single chip microcomputer; a power supply supplies power to a system, the single chip microcomputer is connected with the upper computer, and operation software is stored and operated in the upper computer. The detection method comprises the following steps: utilizing a mathematical relation between the characteristics of biological tissues for absorbing lights with different wavelengths to establish an equation group, converting component change in the biological tissues into a coefficient of linear regressive equation to be solved, and obtaining parameters such as 15-minute retention rate of ICG pigment, blood-oxygen saturation degree and pulse heart rate and the like for noninvasive detection. The noninvasive multiparameter measuring device and the detecting method provided by the invention have the advantages that the measured pulse rate is 30bpm-300bpm, and the accuracy can reach + / 2bpm; the blood-oxygen saturation degree is 70%-100%, and the accuracy is + / -2digit; and the ICG pigment accuracy is + / -5%, the accuracy and the stability are high, and reliable device and method can be provided for evaluation on the liver reserve functions and surgical risks.

Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof:wherein R is ═CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.

The invention discloses a preparation method of a Chinese wolfberry tablet for liver protection. The method comprises the following steps: (1) masterbatch granulation of the anti-liver tablet; (2) preparation of a coating masterbatch; (3) mixing; (4) tabletting; and (5) coating. The method employs Chinese wolfberry as a main raw material, which is added with some auxiliary materials to prepare a health food with auxiliary protection function on chemical liver injury; the tablet can effectively prevent and treat fatty liver; after administration, fatty liver patients recover from a severe condition to a moderate condition, or from a moderate condition to a mild condition; therefore, the Chinese wolfberry tablet for liver protection has obvious benefits for improving liver function of the human body and shows broad market prospect.

The invention discloses a test card for the liver function and a preparation method thereof. The test card comprises an upper shell, a lower shell, a sample adding hole formed in the upper shell, an alanine transaminase detecting unit, a total bilirubin detecting unit and a glutamic oxalacetic transaminase detecting unit, wherein the alanine transaminase detecting unit, the total bilirubin detecting unit and the glutamic oxalacetic transaminase detecting unit are disposed between the upper shell and the lower shell. The alanine transaminase detecting unit, a total bilirubin detecting unit anda glutamic oxalacetic transaminase detecting unit comprise a bottom plate disposed at the upper end of the lower shell, lower shell detecting holes formed in the lower shell, bottom plate detecting holes formed in the bottom plate, a diffusion film disposed at the lower end of the upper shell and connected to the bottom plate, a whole blood separation layer disposed under the diffusion film and areaction layer disposed between the whole blood separation layer and the bottom plate detecting holes. The test card is matched with a dry biochemical analyzer for use, the operation is simple, the content of alanine transaminase, total bilirubin and glutamic oxalacetic transaminase can be detected rapidly and simultaneously without the need of a professional, and the detecting results are well matched with hospital detecting results.

The invention provides a medical composition. The medical composition comprises n-Butylidenephthalide (Type Z) illustrated by formula (I) and used for effective dose treatment, type E or the mixture of type E and type Z, or medically acceptable salt or ester and a medically acceptable carrier. The medical composition in the invention can be used for treating liver injuries such as liver fibrosis, liver cirrhosis and liver abscess, and / or improving liver functions.

The invention relates to a compositive therapeutic instrument for fatty liver, comprising a principle machine and a treatment head with two functions. The circuit of the principle machine comprises an input, a single chip microcomputer system, an output, an air pump, a pipeline, a stander and a power supply. The treatment head with two functions is provided with a modulation intermediate frequency electrode, an infrared electric heating device, a temperature transmitter and a negative pressure positioning osculum. The compositive therapeutic instrument for fatty liver uses two physical agents to provide activation energy for body pathological cells; when the modulation intermediate frequency is alternately exerted in an electrode pair, the infrared electric heating device radiates far infrared, and the shrink and diastole movement of the patient abdomen acts with infrared warming effect so that the blood flow volume of the liver is observably increased, liver cells are supplied with enough blood oxygen and various nutrients, the metabolism of the liver cells is increased, the excretion of the body fat accumulated in the liver is quickened, and the goal of liver function treatment and recovery is obtained. The invention has the advantages of double clinical effect, simple structure and no any side effect; and the invention is especially used for the fatty liver complication patients and the patients who can not choose aerobic exercise to treat fatty liver.

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine for treating fatty liver, which is prepared from the following active pharmaceutical ingredients in parts by weight: 15-25 of salvia miltiorrhiza, 25-35 of sargassum, 20-30 of radix bupleuri, 15-25 of semen cassiae, 10-15 of polygonum cuspidatum and 20-30 of rhizoma alismatis. The traditional Chinese medicine has the efficacies of lowering lipid level, recovering the liver function and retracting the liver.

A method of determining the liver function of a patient, comprises the steps of (i) processing a series of blood samples which have passed through the liver of the patient and which have been collected at timed intervals after introducing an effective amount of a coloured or fluorescent bile acid derivative intravenously into the patient; and (ii) accessing the colour or fluorescence of bile acid derivative in each sample by: (a) processing the blood sample to obtain blood plasma containing the bile acid derivative, (b) measuring the colour or fluorescence of the bile acid derivative in the blood plasma, and (c) fitting the measurements obtained in step (b) to a plasma elimination curve and comparing the plasma elimination curve with plasma elimination curves obtained from individuals having known liver function, to arrive at a determination of liver function for the patient.

The invention discloses an integrated citrine clam fruit and vegetable ferment powder, prepared from, by weight, 50-70 parts of fruit and vegetable ferment, 3-10 parts of curcumin, 3-10 parts of fine citrine clam powder, 3-10 parts of kudzuvine root powder, 3-10 parts of calcium lactate powder, and 0.5-2 parts of taurine. The invention also discloses the technology of preparing the integrated citrine clam fruit and vegetable ferment powder. The invention applies technology of ferment hydrolysis and freeze drying and makes fine citrine clam powder, taurine, kudzuvine root, turmeric, calcium lactate and fruit and vegetable ferment perfectly combine with each other and play the function of synergy, not only ensuring product activity and effects, but also adding no chemical additive, thus it is safe and free from toxic and side effect; the product in the invention forms protection, effectively promotes components of liver function, accelerates alcohol catabolism, and facilitates blood circulation, which is a healthcare product in functions of lever protection, lever promotion, fatigue resistance, and reinforcement of body's metabolism.

The invention provides nutritional health dried sweet potatoes and a preparation method thereof, belonging to the technical field of food processing. The dried sweet potatoes comprise the following raw materials: sweet potatoes, walnuts, cape jasmine, lucid ganoderma, astragalus membranaceus and red ginseng. The dried sweet potatoes have medicinal functions of promoting brain activation, benefiting the brain, developing intelligence, promoting sleep, beautifying and moistening skin, delaying brain aging function, replenishing inhibitory neurotransmitter of a human body, well reducing blood pressure, promoting improvement and protection of kidney function, inhibiting fatty liver, activating liver function, improving the immunity of the human body, resisting radiation, inhibiting tumors and the like; meanwhile, by adopting a unique preparation process, the original nutrition and specific flavor of the sweet potatoes can be kept, the energy resources can be saved, the waste can be reduced, the processing time can be shortened, and the efficiency can be improved.

The invention belongs to the technical field of research and development of medicine products, and relates to a biotechnological product formulation capable of playing a protection role in immunological liver injury. The method comprises the following steps of: shelling oysters; cleaning oyster meat; removing impurities; draining; beating; carrying out enzymolysis; extracting effective components, and further purifying to prepare the gel formulation; bottling; and sealing for use when needed. The product disclosed by the invention plays the protection role in the liver and a conditioning role in a liver function and is favorable to the industrialized production.