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Bear gall powder for preventing or treating liver diseases and liver fibrosis as well as improving liver function and application

A technology of bear bile powder and bear bile is applied in the functions of food ingredients, medical preparations containing active ingredients, applications, etc., and can solve the problems of extremely fishy smell, unstable nature, and easy corruption.

Inactive Publication Date: 2018-10-12
齐光伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] CN1311002A (00102073.0, Shi Lixia) discloses a refined bear bile powder and its preparation method, which belongs to the field of pharmacy. Common bear bile powder is easy to absorb moisture and agglomerate, has a sticky tooth feeling, extremely fishy smell, extremely bitter taste, many impurities, and slow absorption. The property is unstable and easy to be corrupted, and the content of active ingredients is low, which limits the application range of bear bile powder. Oral application often adds flavoring agents to reduce the stench

Method used

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  • Bear gall powder for preventing or treating liver diseases and liver fibrosis as well as improving liver function and application
  • Bear gall powder for preventing or treating liver diseases and liver fibrosis as well as improving liver function and application
  • Bear gall powder for preventing or treating liver diseases and liver fibrosis as well as improving liver function and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Example 1: Preparation of bear bile powder

[0100] (1) filter the bear bile collected by the tubeless drainage method to obtain a filtrate, add 0.75 times the amount of water to dilute to obtain the bear bile liquid, stand at a temperature of 2 to 6 ° C for 12 hours, and then carry out subsequent operations;

[0101] (2) in the mode of bubbling, in step (1) gained bear bile liquid, fill nitrogen 27min, then fill carbon dioxide 18min;

[0102] (3) Pour the bear bile liquid processed by the above operation into the material tray (the depth of the liquid layer is 1.5-2.5 cm), immediately place it in a freeze dryer pre-frozen to -50 ° C, and freeze for 3.5 hours; The temperature was raised to -22°C at a rate of 0.3°C and held for 1 hour; then increased to -3°C at a rate of 0.3°C per minute and held for 2.5 hours; then increased to 10°C at a rate of 0.3°C per minute and held for 4.5 hours; then The temperature was raised to 32°C at a rate of 0.3°C per minute, and the temp...

Embodiment 2

[0110] Example 2: Preparation of bear bile powder

[0111] (1) filter the bear bile collected by the tubeless drainage method to obtain a filtrate, add 0.5 times the amount of water to dilute to obtain the bear bile, and leave it to stand at a temperature of 2 to 6 ° C for 12 hours, and then carry out follow-up operations;

[0112] (2) in the mode of bubbling, in step (1) gained bear bile liquid, fill nitrogen 30min, then fill carbon dioxide 15min;

[0113] (3) Pour the bear bile liquid treated by the above operation into the material tray (the depth of the liquid layer is 1.5-2.5 cm), immediately place it in a freeze dryer pre-frozen to -55 ° C, and freeze for 3 hours; The temperature was raised to -23°C at a rate of 0.3°C and held for 1.5 hours; then, the temperature was raised to -2°C at a rate of 0.25°C per minute and held for 2 hours; then the temperature was raised to 12°C at a rate of 0.25°C per minute and held for 5 hours; then The temperature was raised to 30°C at ...

Embodiment 3

[0121] Example 3: Preparation of bear bile powder

[0122] (1) filter the bear bile collected by the tubeless drainage method to obtain the filtrate, add 1 times the amount of water to dilute to obtain the bear bile, stand at a temperature of 2~6 ℃ for 12 hours, and then carry out the follow-up operation;

[0123] (2) in the mode of bubbling, in step (1) gained bear bile liquid, fill nitrogen 25min, then fill carbon dioxide 20min;

[0124] (3) Pour the bear bile liquid treated by the above operation into the material tray (the depth of the liquid layer is 1.5-2.5 cm), immediately place it in a freeze dryer pre-frozen to -45 ° C, and freeze for 4 hours; The temperature was raised to -20°C at a rate of 0.35°C and held for 1.2 hours; then the temperature was raised to -2°C at a rate of 0.35°C per minute and held for 3 hours; then the temperature was raised to 15°C at a rate of 0.34°C per minute and held for 4 hours; then The temperature was raised to 35°C at a rate of 0.35°C p...

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Abstract

The invention discloses bear gall powder for preventing or treating liver diseases and liver fibrosis as well as improving the liver function and application. The bear gall powder can be used for adjusting the blood fat, reducing the total cholesterol, preventing the cardiovascular and cerebrovascular diseases and preventing the atherosclerosis, and can also be used for treating or preventing theliver diseases and the liver fibrosis as well as improving the liver function. The invention relates to a production method of ball gall powder and ball gall powder prepared by the production method.In the process for preparing the bear gall powder, materials are crystallized, then the materials are frozen and dried, thus obtaining the icy-crystal bear gall powder, or the bear gall powder can benamed as icy-crystal bear gall powder. The bear gall powder named as Semper bear gall powder contains no auxiliary material and chemical additive. The icy-crystal bear gall powder not only can effectively adjust the blood fat and reduce the total cholesterol, but also can be effectively used for preventing the cardiovascular and cerebrovascular diseases and preventing the atherosclerosis, and moreparticularly, the bear gall powder can be effectively used for preventing and treating the liver disease and the liver fibrosis as well as improving the liver function.

Description

technical field [0001] The invention belongs to the technical field of medical and health products, relates to a bear bile powder prepared by a specific process, and also relates to a preparation method of the bear bile powder. The present invention makes the material ice crystallized and then freeze-dried in the preparation process of the bear bile powder, and the prepared bear bile powder exhibits excellent technical effects, especially in terms of physical and chemical properties. In particular, in the present invention, when preparing the bear bile powder, it is diluted with a small amount of water in advance, filled with two gases, and then deep-frozen, so that the active ingredients contained in the bear bile are in a state of ice crystals, and then sublimed, so that the obtained freeze-drying is carried out. In the present invention, the bear bile powder may be referred to as ice crystal bear bile powder, or may be referred to as ice crystal bear bile powder, or may be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/19A61P1/16A61P9/10A61P3/06A61P9/00A23L33/00
CPCA61K35/413A23L33/00A23V2002/00A61K9/19A61P1/16A61P3/06A61P9/00A61P9/10A23V2200/326A23V2200/3262A23V2300/10A23V2300/20A23V2250/11A23V2250/124A23V2200/32A23V2200/30A23V2200/304A23V2200/314A23V2200/308
Inventor 齐光伟
Owner 齐光伟
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