290results about How to "Lower total cholesterol" patented technology

The invention relates to the field of microorganisms and discloses lactobacillus plantarum with a weight reducing function and application thereof. The lactobacillus plantarum 1701 strain is separatedfrom a yogurt powder sample collected from rural areas of Shigatse in the Tibet Autonomous Region. The strain is preserved in the China General Microbiological Culture Collection Center on October 23, 2019, and the microorganism has the preservation number of CGMCC NO.18728. The lactobacillus plantarum 1701 has excellent tolerance and adhesion, can remarkably reduce the weight of a rat, reduce fat accumulation in a body, reduce the viscera ratio and body fat ratio, reduce the leptin level and reduce blood lipid and can be used in medicines, health-protecting products and health foods for preventing and treating obesity. Furthermore, the strain still has a weight reducing function after inactivation, thus having rich product mode, wide application range, high product stability and long preservation period.

The invention provides Chinese herbal medicine additive for improving meat quality of java tilapia, containing by weight of: 22-30% of spatholobus stem, 30-40% of black bean, 10-15% of glycyrrhiza, 5-10% of honeysuckle, 5-10% of radix isatidis and 10-15% of hawthorn. The advantages of the invention comprise: (1) having good phagostimulant effect, (2) substantially reducing fat content and cholesterol level in muscles of java tilapia, substantially increasing flavor substance content of inosinic acid in muscles, improving muscles quality of java tilapia, (3), adding and using conveniently, and directly adding in commercial feedstuff, wherein the components can generates synergistic effect with other additive components in commercial feedstuff, and raise weighting rate and disease resistance of java tilapia, and (4) having stabile raw material resource, low price, simple production process and easy for industrialization production.

The invention discloses medicinal steamed bread for treating diabetes. Every 100 grams of steamed bread contain 3-10 percent by weight of medicament which is prepared from the following raw materials in parts by weight: 10-6 parts of Chinese yam, 10-5 parts of gorgon euryale seed, 10-3 parts of fragrant solomonseal rhizome, 8-3 parts of common anemarrhena, 8-3 parts of Mongolian snakegourd root, 8-3 parts of sophora flower, 8-2 parts of sealwort, 8-2 parts of corn stigma, 6-2 parts of dwarf lilyturf root, 6-2 parts of asparagus, 6-2 parts of propolis, 6-1 parts of curcumin and 6-1 parts of mulberry leaf. The medicinal steamed bread can be used for relieving, improving, preventing and treating diabetes type I and diabetes type II, so that the aims of relieving, improving, preventing and treating with medicinal foods are achieved.

The invention provides a production technology of a blood lipid reducing lotus leaf tea, pertaining to the tea processing technical field. Fresh lotus leaves are cut into squares with a side length of 4cm, laid open on a conveyer belt of a 6CW-10E type tea microwave de-enzyming and drying device for being treated with de-enzyming of the lotus leaves, laid for cooling for 20min, put into a 6CR-30 type tea roller for rolling for 20-40min based on a principle of 'light-heavy-light', then the lotus leaves are laid open on the conveyer belt evenly for drying and cooling, crushed through 40 meshes and packaged into tea bags. The production process of the lotus tea provided by the invention adopts microwave technology for de-enzyming and drying the lotus leaves, which greatly shortens the production time of the lotus leaf tea, improves the production efficiency and enhances preservation of flavone substances in the lotus leaves. Water soluble lotus leaf flavone contained in the tea soup of the lotus leaf tea is not less than 0.23mg / g, thereby being capable of reducing serum triglyceride and total cholesterol remarkably and having auxiliary function for reducing blood lipid.

The invention discloses a method for extracting boxthorn seed oil by supercritical CO2. The method comprises the following steps: a, drying and grinding boxthorn seeds and loading in extraction kettle; b, injecting the supercritical CO2 into the extraction kettle, and extracting under the temperature of 40-50 degrees centigrade, pressure of 30-40Mpa and CO2 flow rate of 8-18L / min for 2.5-4 hours; c, inducing the CO2 fluid solved with boxthorn seed oil into a separation kettle, separating out the boxthorn seed oil by adjusting temperature and pressure, compressing the CO2 gas and inducing into the extraction kettle for circulation. The invention has a simple process and convenient operation, avoids the organic solvent residue, shortens the extraction time, increases the boxthorn seed oil extraction efficiency, especially increases the contents of alpha-linolenic acid and gamma-linolenic acid in the boxthorn seed oil greatly.

The present invention is preparation process and application of instant Pu'er tea granule. The preparation process includes the following steps: setting mature Pu'er tea and / or raw Pu'er tea in a extracting and concentrating tank, adding beta-cyclodextrin in 0.1-10 % weight of the tea, leaching circularly with hot water at over 90 deg.c and in 10 times weight of the tea for 1-6 hr to obtain extracted solution; concentrating the extracted solution to obtain extractum of 1.1-1.4 g / ml density; adding maltodextrin in 1-10 times weight of the extractum, pelletizing and 40-100 mesh sieving to obtain instant Pu'er tea granule. The instant Pu'er tea granule may be served directly after being mixed with boiled water, or further prepared into instant health Pu'er tea beverage through mixing with levo-carnitine and / or its derivative, xylitol, oligofructose and / or other bifid factor matter in certain weight proportion. The instant Pu'er tea granule has certain health functions.

A medical composition is composed of the active components of alismatic rhizome, that is, the alisol A24-acetate and alisol B23-acetate in weight ratio of 1: (0.05-20). It can be used for treating hyperlipemia, fatty liver, atherosclerosis and coronary heart disease.

Disclosed herein are extended cheese products, pre-filled cheese extender packages having dry blends used in the process of making extended cheese products, as well as methods of making extended cheese products.

The invention relates to a healthcare product, in particular to a tea bag for preventing and treating hypertension, hyperlipidemia and hyperglycemia and a processing method. The tea bag comprises the following components in parts by weight: 20-40 parts of oolong tea, 8-15 parts of mulberry leaves, 8-15 parts of roots of kudzu vine, 8-15 parts of lotus leaves, 8-15 parts of lalang grass rhizome, 5-12 parts of reed rhizome, 5-12 parts of hawthorn, 5-12 parts of white chrysanthemum, 3-10 parts of fried cassia seeds, 3-6 parts of purple perilla, 3-5 parts of watermelon peel, 3-5 parts of orange peel and 1-5 parts of corn stigma. The tea bag has the effects of reducing blood fat, blood sugar and cholesterol and treating stagnation of liver qi, liver-stomach disharmony and the like, and has treatment effects on diseases such as heart and blood vessels, arteriosclerosis, hypertension, hyperlipidemia and hyperglycemia; the raw materials have natural antioxidant functions and comprise various precious trace elements, various vitamins and bioflavonoid substances, so that human body cells can be activated, metabolism of human bodies can be promoted, human body function balance can be regulated, human body health can be maintained, and many magic effects of nourishing stomachs and protecting livers, reducing fat and reducing blood pressure, preventing and treating cancer, and the like can be achieved.

The invention relates to the field of microorganisms, and discloses lactobacillus fermentum with a weight reducing function and an application of the lactobacillus fermentum. The lactobacillus fermentum is named as WHH3906, is separated from butter collected in Tibet Autonomous Region in China, is preserved in China General Microbiological Culture Collection Center on March 13, 2020, has a preservation number of CGMCC NO.19472, and is classified and named as lactobacillus fermentum. The lactobacillus fermentum strain can effectively reduce serum leptin level to recover leptin sensitivity of anorganism, effectively prevent and treat obesity, relieve non-alcoholic fatty liver and relieve chronic inflammation. After being compounded with lactobacillus plantarum 1701, the lactobacillus fermentum can synergistically relieve chronic inflammation.

The invention discloses an omega-3 unsaturated fatty acid-enriched seasoning sauce. The omega-3 unsaturated fatty acid-enriched seasoning sauce is composed of, by weight part, 1-25 parts of flaxseed meal, 1-10 parts of salad oil, 1-85 parts of sauce, 0.5-5 parts of emulsifier, appropriate amount of water, 1-5 parts of moringa seed oil and / or 1-8 parts of fruit and vegetable enzyme powder. The omega-3 unsaturated fatty acid-enriched seasoning sauce introduces high-activity components such as omega-3 unsaturated fatty acid into the sauce to improve the flavor and taste of conventional sauce, add nutritive value and healthcare efficacy; omega-9 monounsaturated fatty acid contained in the moringa seed oil can reduce the content of total cholesterol and bad cholesterol in blood; the fruit and vegetable enzyme powder can decompose proteins, carbonhydrate and fat in the sauce to promote digestion and absorption of nutrients, to add multiple vitamins inside the seasoning sauce and meanwhile to improve the originally rich taste and high salt content of the sauce, thereby making up for the deficiencies of traditional sauced foods.

The invention belongs to the technical field of food processing, and discloses a fungus fiber diet solid beverage as well as a making method and application thereof. According to the formula, the solid beverage relatively balanced in nutrient structure is designed according to big data of nutriology, three big nutrients in a normal balanced diet are maintained, wherein carbohydrates account for 60% of gross calorific power, protein accounts for 25% of the gross calorific power, fat accounts for 15% of the gross calorific power, and besides, mineral elements and vitamins are complemented according to the normal balanced diet; and specific raw materials of the solid beverage comprise cane sugar, crystallization levulose, funguses, straw mushrooms, shiitake mushrooms, soy protein isolate, redbeans, soybeans, brown rice, oat, chenopodium quinoa, mulberry leaves, amaranthus hypochondriacus leaves, walnuts, apricot kernels, olive oil powder, tea-seed oil powder, psyllium husk powder, konjac, resistant dextrin, fructo-oligosaccharide, complex mineral elements and composite vitamins. The product namely the solid beverage has the functions and effects of assisting in reducing weight, reducing blood lipid, reducing blood sugar, reducing blood pressure, promoting lead discharge, dispelling acne, regulating intestinal flora, promoting digestion, easing constipation and the like.

The invention provides a water-based beverage containing phytosterol and oryzanol and a preparation method thereof. The water-based beverage contains the phytosterol, the oryzanol and at least one emulsifying agent, wherein the weight ratio of the phytosterol, the oryzanol to the emulsifying agent is 1: 0.1-10: 0.01-5; and the emulsifying agent is selected from one or more of sucrose fatty acid ester, octyl and decyl glycerate and polyglyceryl fatty acid ester. The water-based beverage maximizes the fat reducing effects of the phytosterol and the oryzanol by using the synergy of the phytosterol and the oryzanol, and can obviously reduce the total cholesterol level of the human body and reduce the risk of human cardiovascular diseases. In the water-based beverage containing the phytosteroland the oryzanol and the preparation method thereof, the phytosterol and the oryzanol are successfully dispersed into the water-based beverage, and the formed oil phase droplets containing the phytosterol and the oryzanol are less than 2 microns.

The invention relates to a disease preventing and curing medicinal mouth-muffle and a medicinal composite. The disease preventing and curing medicinal mouth-muffle (1) comprises a mouth-muffle body (2), one surface of the mouth-muffle body (2) is provided with an insert pocket (3), and a powder bag (4) which packages the medicinal composite is placed in the insert pocket (3). The medicinal composite comprises the following Chinese herbs by weight: 2.2 percent of chrysanthemum and muskiness, 4.2 percent of cinnamon, good ginger, long pepper, radix aconite, frankincense, myrrh and clove, 5.0 percent of vermilion, 6.4 percent of asarum, eaglewood, croton, resina draconis, early plum flowers and rhizoma ligustici wallichii and 7.6 percent of tooth soap, arsenic sulphide and brain sand. The disease preventing and curing medicinal mouth-muffle internally carries the medicinal composite which plays a role during the mouth-muffle wearing process, thereby having disease prevention and cure and being simple and direct and also effective in treatment.

The present invention provides an excellent medicinal composition for lowering blood lipid level. The medicinal composition containing an HMG-CoA reductase inhibitor and bile acids.

Compounds of formula (I): wherein: X represents oxygen or sulphur or a group CH2 or R1, R2, R3, R4, R5 and R6 are as defined in the description, A represents an alkylene chain as defined in the description, B represents alkyl or alkenyl substituted by a group  or R9, or B represents a group  or R9, D represents a benzene, pyridine, pyrazine, pyrimidine or pyridazine nucleus. Medicaments

The invention relates to high-fiber corn flake healthy food and a production method thereof, belonging to the food processing technology. The method comprises the following steps of: screening corn seeds to remove inedible impurities; rinsing, drying and crushing to obtain pure corn meal; adding a proper amount of high-quality corn dietary fiber, flavor endowing agent and the like, and adjusting the components; and preparing the corn flake healthy food with abnormal metabolism regulation functions such as shaping, resisting constipation and the like by the technology integrating separation and recombination, quick cropping and forming. The product is crispy, has good flavor, is suitable for all consumer groups, and can be taken as leisure food as well as snack or staple food. In the production process, the raw materials are completely used, the production of pollution, waste slag, waste gas and harmful substances is avoided, and the food is safe to eat because no chemical reagent is used.

The invention discloses a method for preventing or treating conjunctivitis and herpes zoster palpebral dermatitis, bear gall powder used by the method, and a preparation method of the bear gall powder. The bear gall powder can be used for regulating blood lipid, lowering total cholesterol, preventing cardiovascular and cerebrovascular diseases and preventing atherosclerosis. Materials are subjected to ice crystallization during the preparation of the bear gall powder, and then freeze drying is performed to obtain the freeze-dried bear gall powder which can be called ice-crystalized bear gall powder. The Senbao ice-crystalized bear gall powder does not contain any auxiliary materials and chemical additives, can effectively regulate the blood lipid and lower the total cholesterol, can be effectively used for preventing cardiovascular and cerebrovascular diseases and atherosclerosis and preventing and treating solid tumor and blood system tumor, and can be particularly effectively used for preventing or treating the conjunctivitis and herpes zoster palpebral dermatitis.

The invention relates to a small interfering ribonucleic acid, a pharmaceutical composition and application thereof. The siRNA contains a positive-sense strand and an antisense strand, wherein the positive-sense strand contains a nucleotide sequence shown as SEQ ID NO.2, and the antisense strand contains a nucleotide sequence shown as SEQ ID NO.3. Moreover, phosphate and / or ribosyl in a phosphate-sugar framework of the siRNA refers to phosphate and ribosyl with or without a modified group. The invention provides brand new efficient siRNA and the pharmaceutical composition thereof, and dyslipidemia can be effectively prevented and / or treated.

The invention relates to a traditional Chinese medicine for reducing the blood fat, and a preparation method thereof. The traditional Chinese medicine comprises: a dry extract paste of extracts obtained through carrying out water decoction extraction or ethanol reflux extraction on mixed Rhizoma Alismatis, haw, Gynostemma pentaphylla, Radix Puerariae and Lycium Chinense; and Panax Notoginseng powder. The preparation method comprises the following steps: taking and mixing the Rhizoma Alismatis, the haw, the Gynostemma pentaphylla, the Radix Puerariae and the Lycium Chinense, extracting through decocting with water or refluxing with ethanol to obtain an extract solution, and concentrating the extract solution to obtain the dry extract paste; selecting Panax Notoginseng, drying, carrying out radiant quantity disinfection, and crushing to 80 mesh fine powder; and adding the water or ethanol extraction dry extract paste and the Panax Notoginseng powder to a mixer together, and mixing to obtain the traditional Chinese medicinal powder for reducing the blood fat of the invention. The obtained medicinal powder can be filled to capsules or added with other routine medicinal carriers or excipients to prepare usual oral medicinal forms. Hyperlipidemia belongs to the 'turbid phlegm' category of the traditional Chinese medicine, so the traditional Chinese medicine screens the composition according to dampness removing, turbidity transforming, stasis scattering and vein relaxing principles, can nourish blood in the liver and the kidney, and also can prevent extremeness disadvantages of the haw and the Gynostemma pentaphylla, thereby the new traditional Chinese medicine with a substantial curative effect is provided for treating the hyperlipidemia.

The invention discloses a cellulite-reducing and slimming cream and a preparation method thereof, comprising the following components and contents (parts by weight): cellulite-reducing active blend: 9.721-60.703, emulsifier: 8-17.5, oil: 15.101-37.909, Thickener: 0.11‑0.54, humectant: 13.5‑57.5, chelating agent: 0.1‑0.7, pH neutralizer: 0.5‑4, fragrance: 0.82‑4.08, preservative: 0.4‑2.25, deionized water: 40‑ 80. The anti-cellulite active blend comprises peppermint leaf extract, geranium geranium extract, golden chamomile extract, flavescens root extract, purslane extract, aloe barbadensis leaf extract, brazilian cocoa Fruit extract, coix seed extract, licorice extract, salvia miltiorrhiza extract, Sichuan Codonopsis pilosula extract, Osmanthus seaweed extract, oolong tea extract, astragalus root extract, chuanxiong root extract combination. Melt oil and emulsifier, add water, humectant and thickener to the mixture and emulsify, then add chelating agent, pH neutralizer, essence and preservative. It has a good fat-reducing and slimming effect.

The invention relates to the technical field of antibody engineering and specifically discloses an anti-PCSK9 monoclonal antibody. The invention comprises an amino acid sequence coding an antibody variable region and a CDR region as well as an acquisition method and an application of the monoclonal antibody. The monoclonal antibody disclosed by the invention is prepared by the following steps: screening out anti-PCSK9 monoclonal antibodies from a phage library; performing affinity maturation by a method of establishing phage library through strand displacement; screening the mutant libraries of light-chain CDR1, 2, and 3 regions of the monoclonal antibody obtained by primary screening, and selecting the monoclonal antibodies with relatively high affinity; and screening the mutant libraries of heavy-chain CDR1, 2, and 3 to finally obtain the anti-PCSK9 monoclonal antibody with high affinity. In the invention, the obtained PCSK9 antibody has good affinity on PCSK9 and can inhibit combination of the PCSK9 with ligand thereof and can be used for treating dyslipidemia, cardiovascular and cerebrovascular diseases and thrombosis-obstructive diseases.

The invention discloses refined seal oil, which is characterized in that: an omega-3 polyunsaturated fatty acid in the refined seal oil consists of the following components in percentage by weight: 4.64-5.03 percent of eicosapentaenoic acid (EPA) C20H30O2, 3.86-4.18 percent of docosapentaenoic acid (DPA) C22H34O2 and 9.5-10.29 percent of docosahexenoic acid (DHA) C22H32O2. The invention further discloses an application of the refined seal oil to preparation of a medicament for treating non-alcoholic fatty liver. The refined seal oil disclosed by the invention can be used for treating non-alcoholic fatty liver, and can also be used for effectively reducing total cholesterol and triglyceride in blood serum.

The invention discloses a method for preventing or treating solid tumors and blood system tumors and bear gall powder used in the same. The bear gall powder can be used for adjusting blood fat, reducing total cholesterol, preventing cardiovascular and cerebrovascular diseases, preventing atherosclerosis and treating or preventing the solid tumors and the blood system tumors. The invention discloses a preparation method of the bear gall powder and the bear gall powder obtained through the method. In a bear gall powder preparation process, a material is subjected to ice crystallization and thenfreeze drying, and the obtained freeze dried bear gall powder can be called ice crystal-state bear gall powder or ice crystal bear gall powder; especially, the bear gall powder which can be called senbao bear gall powder does not contain any auxiliaries or chemical additives; more especially, the invention finds that the ice crystal-state bear gall powder can not only more effectively adjust the blood fat and reduce the total cholesterol, but also more effectively be used for preventing the cardiovascular and cerebrovascular diseases, preventing atherosclerosis and the like, and more especially, the ice crystal-state bear gall powder can effectively be used for preventing and treating the solid tumors and blood system tumors.

The invention discloses a lactobacillus probiotic strain. The preservation number of the strain is CGMCC NO. 12422, and the preservation date is May, 6th, 2016. The 16S rRNA sequence of the strain is shown as SEQ ID NO: 2. The invention also discloses an application of the strain in preparing a lipid-lowering drug, food and a healthcare product. The strain is harmless to animals and has effects of regulating and lowering blood fat.

The invention provides lactobacillus plantarum with a function of reducing blood lipids and application of the lactobacillus plantarum, and belongs to the technical field of new bacterial strains of lactobacillus and application of the new bacterial strains. According to the lactobacillus plantarum nbk-MA2, the preservation number is CGMCC NO.16872. Bacterial powder and inactivated bacterial powder of the lactobacillus plantarum nbk-MA2 can reduce the content of triglyceride, total cholesterol, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, high-density lipoprotein and low-density lipoprotein in a body, recovering to the normal level is achieved, and the effect of reducing blood lipids is achieved; in addition, the lactobacillus plantarum nbk-MA2 has good acid and bile salt tolerance, and enough quantity of living bacteria can reach the intestinal tract and play a probiotic role.

A mixed substance for treating hypertension, constipation, detoxification, boost immune system produced by extracting arctium lappa L., carrot, and whole radish with water one or two hours at temperature 70° C. 100° C. under agitating, separated the extracts and solid by-products, vacuum condensed the extracts, then at low temperature lyophilized condensed extracts to powder, encapsulated powder or pressed powder to tablet. Patient taking a daily dosage of this vegetable medicine have shown greatly improved healthy condition.

The invention relates to a pravastatin transdermal administration preparation and a preparation method thereof. In the invention, pravastatin or a pharmaceutically acceptable salt of the pravastatin serves as a medicament active ingredient, and the medicament active ingredient is a filling closed transdermal preparation which consists of a protective layer, an adhesive layer, a controlled-release membrane layer, a medicament reservoir and a backing layer; the medicament reservoir comprises 1 to 20 percent of pravastatin, and the balance of reservoir substrate; the adhesive layer comprises 0 to 10 percent of pravastatin, and the balance of pressure-sensitive adhesive; the reservoir substrate comprises 5 to 50 percent of transdermal enhancer, while the adhesive layer comprises 0 to 20 percent of transdermal enhancer; and the medicament release area of the preparation is 1 to 100 cm<2>. The pravastatin transdermal administration preparation is convenient to use and carry; the first pass effect of a liver and a gastrointestinal tract is avoided; and an in-vivo experiment of an animal proves that the preparation has no irritation or sensitization to skin. The pravastatin transdermal administration preparation can keep stable and persistent blood concentration, the continuous medicament releasing time is 1 to 7 days, so that the preparation provides the more convenient and safer treatment method for a patient.