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Refined seal oil and application thereof to preparation of medicament for treating non-alcoholic fatty liver

A non-alcoholic seal oil technology, which is applied in drug combinations, pharmaceutical formulas, and medical raw materials derived from mammals, etc., can solve the problems of large doses of seal oil and expensive drugs, and achieve economic burden reduction, wide selection, and reduced Effect of Total Cholesterol and Triglycerides

Inactive Publication Date: 2012-10-31
ZHEJIANG KIMNUOKANG BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The Chinese invention patent application with the application number "01135517.4" authorized and published on April 12, 2006 discloses the use of seal oil as a drug for the treatment of fatty liver, but the dose required for the seal oil is too large for patients. expensive

Method used

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  • Refined seal oil and application thereof to preparation of medicament for treating non-alcoholic fatty liver
  • Refined seal oil and application thereof to preparation of medicament for treating non-alcoholic fatty liver
  • Refined seal oil and application thereof to preparation of medicament for treating non-alcoholic fatty liver

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Experimental program
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Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of refining fur seal oil

[0023] Equipment: EA250 / KD200 single-stage short-range molecular distillation extraction equipment manufactured by German UIC company is adopted.

[0024] I. The preparation process is as follows:

[0025] 1. Mince 100kg of fur seal animal fat;

[0026] 2. Wash the chopped fur seal animal fat with warm water at a temperature of 40°C;

[0027] 3. Wash the chopped seal animal fat and put it into the oil-water separator for centrifugation to obtain separated water and fat raw materials;

[0028] 4. Filtrating the water separated in step 3 to obtain water and the fat material missed by centrifugation, adding the fat material missed by centrifugation to the fat material;

[0029] 5. Turn on the molecular still, and when the vacuum of the system reaches 0.001mbar, set the temperature of the main heater to 310°C, set the temperature of the feed heater to 200°C, and degas the fat raw material;

[0030] 6. When the tem...

Embodiment 2

[0116] Embodiment 2: the preparation of refining fur seal oil

[0117] Equipment: EA250 / KD200 single-stage short-range molecular distillation extraction equipment manufactured by German UIC company is adopted.

[0118] The preparation process is as follows:

[0119] 1. Mince 100kg of fur seal animal fat;

[0120] 2. Wash the chopped fur seal animal fat with warm water at a temperature of 45°C;

[0121] 3. Wash the chopped seal animal fat and put it into the oil-water separator for centrifugation to obtain separated water and fat raw materials;

[0122] 4. Filtrating the water separated in step 3 to obtain water and the fat material missed by centrifugation, adding the fat material missed by centrifugation to the fat material;

[0123] 5. Turn on the molecular still, and when the vacuum of the system reaches 0.003mbar, set the temperature of the main heater to 320°C, set the temperature of the feed heater to 220°C, and degas the fat raw material;

[0124] 6. When the temper...

Embodiment 3

[0129] Embodiment 3: the preparation of refining fur seal oil

[0130] Equipment: EA250 / KD200 single-stage short-range molecular distillation extraction equipment manufactured by German UIC company is adopted.

[0131] The preparation process is as follows:

[0132] 8. Mince 100kg of fur seal animal fat;

[0133] 9. Wash the chopped fur seal animal fat with warm water at a temperature of 45°C;

[0134] 10. After cleaning the chopped seal animal fat, put it into an oil-water separator for centrifugation to obtain separated water and fat raw materials;

[0135] 11. Filter the water separated in step 3 to obtain water and the fat raw material missed by centrifugation, and add the fat raw material missed by centrifugation to the fat raw material;

[0136] 12. Turn on the molecular still, when the vacuum of the system reaches 0.002mbar, set the temperature of the main heater to 315°C, set the temperature of the feed heater to 210°C, and degas the fat raw material;

[0137] 13. ...

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Abstract

The invention discloses refined seal oil, which is characterized in that: an omega-3 polyunsaturated fatty acid in the refined seal oil consists of the following components in percentage by weight: 4.64-5.03 percent of eicosapentaenoic acid (EPA) C20H30O2, 3.86-4.18 percent of docosapentaenoic acid (DPA) C22H34O2 and 9.5-10.29 percent of docosahexenoic acid (DHA) C22H32O2. The invention further discloses an application of the refined seal oil to preparation of a medicament for treating non-alcoholic fatty liver. The refined seal oil disclosed by the invention can be used for treating non-alcoholic fatty liver, and can also be used for effectively reducing total cholesterol and triglyceride in blood serum.

Description

technical field [0001] The invention relates to a refined seal oil and its application in the preparation of medicine for treating non-alcoholic fatty liver. The invention also relates to the application of the refined seal oil in the preparation of medicines for reducing total cholesterol or triglyceride in serum. Background technique [0002] Harp seal oil, commonly known as seal oil, is an oil extracted and processed from the fat layer of mammalian fur seals in deep sea alpine (-50°C) waters. Seals feed on precious cod, salmon, etc., and their bodies are rich in thick fat layers. Seal oil is rich in omega-3 polyunsaturated fatty acids (EPA, DPA, DHA). In addition, the natural ecological environment of the Arctic is clean and pollution-free. Seal oil becomes an important source of nature's most ideal omega-3 unsaturated fatty acids. Its functions of protecting the liver and regulating blood lipids have been reported in some literatures, which has attracted great attentio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/12A61P1/16A61K35/35
Inventor 侯国新茹玲玲
Owner ZHEJIANG KIMNUOKANG BIO PHARMA
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