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81results about How to "Lower LDL" patented technology

Application of dendrobium officinale and extract thereof to improvement of diabetes and metabolic syndrome in combination with probiotics

The invention relates to the technical field of biology, in particular to dendrobium officinale and a dendrobium officinale extract combined probiotics for regulating blood sugar and blood fat, and improving diabetes and metabolic syndrome and alleviating occurrence of related complications so as to maintain metabolic stability of organisms. The dendrobium officinale has the effects of regulatingand controlling blood sugar, enhancing body immunity and the like; the probiotics is an active microorganism beneficial to a host, can regulate intestinal flora balance, and can generate an exact health effect so as to improve the micro-ecological balance of the host and play a beneficial role. According to the invention, the dendrobium officinale exerts the effects of reducing blood sugar and blood fat, prebiotics can promote the growth of probiotics and regulate glucose uptake and improve the gastrointestinal irritation caused by taking the probiotics alone, so that the probiotics and dendrobium officinale can better play the role in reducing blood sugar, complications are reduced, and a pharmaceutical composition for preventing or treating diabetes mellitus and metabolic syndromes can be prepared by the probiotics and dendrobium officinale. Therefore, the product provides a new application for improving diabetes and metabolic syndrome related diseases.
Owner:NANJING UNIV

PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) resistant monoclonal antibody

The invention relates to the technical field of antibody engineering and in particular discloses a PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) resistant monoclonal antibody. The monoclonal antibody disclosed by the invention comprises an amino acid sequence coding an antibody variable region and a CDR region. The invention further discloses an acquiring method and application of the monoclonal antibody. The method comprises the following steps: screening a PCSK9 resistant monoclonal antibody from a phage antibody library, performing affinity maturation through a method for constructing the phage antibody library by virtue of strand displacement, performing mutant library-construction screening on light-chain CDR1, 2 and 3 regions of the monoclonal antibody obtained by preliminaryscreening, selecting a monoclonal antibody with high affinity, performing mutant library-construction screening on heavy-chain CDR1, 2 and 3 regions of the monoclonal antibody, and finally screeningthe PCSK9 resistant monoclonal antibody with high affinity. The PCSK9 resistant monoclonal antibody obtained in the invention has excellent affinity to PCSK9, is capable of inhibiting binding betweenthe PCSK9 and ligands thereof, and can be used for treating dyslipidemia, cardiovascular and cerebrovascular diseases and thrombosis-obstructive diseases.
Owner:BEIJING DONGFANG BIOTECH

Application of probiotics combined with Phyllanthus emblica extract to improvement of diabetes and metabolic syndrome

The invention relates to the technical field of biology, in particular to application of probiotics, which is combined with a phyllanthus emblica xtract in regulating blood sugar and blood fat, improving diabetes and metabolic syndrome, slowing down occurrence of related complications and further maintaining metabolic stability of organisms. The probiotics is an active microorganism beneficial toa host, can regulate intestinal flora balance, and can generate an exact health effect so as to improve the micro-ecological balance of the host and play a beneficial role; the phyllanthus emblica hasthe effects of regulating blood sugar, enhancing body immunity and the like. The phyllanthus emblica is found to play a role in reducing blood sugar and blood fat; the phyllanthus emblica component can provide a good environment for the growth of probiotics; meanwhile, the probiotics are promoted to regulate glucose uptake, and the gastrointestinal tract stimulation effect generated by taking theprobiotics alone is improved, so that the probiotics and the phyllanthus emblica can better play a role in reducing blood sugar, complications are reduced, and the material can be prepared into a pharmaceutical composition for preventing or treating diabetes and metabolic syndrome. Therefore, the invention provides a new application for improving diabetes and metabolic syndrome related diseases.
Owner:NANJING UNIV

Lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia

Provided are lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia. Lucid ganoderma and strigose hydrangea juvenile leaves serve as a culture medium, the culture medium is inoculated with Chinese caterpillar fungus strains after being sterilized, culture is carried out till mycelia grow on the whole culture medium, and then the culture medium where the mycelia grow is crushed to obtain the mycelia. By means of the mycelia, lucid ganoderma, strigose hydrangea juvenile leaves and cordyceps militaris are combined through the biotechnology to form a special combination, namely, the lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia, the formed product is special and novel, nutrition is enriched better, and the functions and the healthcare effect are more remarkable. The lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia are a novel and special healthcare product. The production and preparation process of the final product, namely, the lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia has the advantages of being short in culture period, simple, high and stable in product production efficiency and the like. In addition, the formed product is wide in application range, and can serve as a raw material for preparing medicine, healthcare products and special food additives. Very good market prospects are achieved, and the generated economic benefits are very remarkable.
Owner:黄秀英

Application of probiotics combined with dendrobium officinale, Phyllanthus emblica and extracts in improvement of diabetes and metabolic syndrome

The invention relates to the technical field of biology, in particular to probiotics, which is combined with dendrobium officinale, phyllanthus emblica and the extracts to regulate blood sugar and blood fat, improve diabetes mellitus and metabolic syndrome, slow down occurrence of related complications and further maintain metabolic stability of organisms. The probiotics is an active microorganismbeneficial to a host, can regulate intestinal flora balance, and can generate an exact health effect so as to improve the micro-ecological balance of the host and play a beneficial role; the phyllanthus emblica has the effects of regulating blood sugar, enhancing body immunity and the like. The dendrobium officinale and phyllanthus emblica are found to play a role in reducing blood sugar and blood fat; the dendrobium officinale and phyllanthus emblica components can provide a good environment for the growth of probiotics; meanwhile, the probiotics are promoted to regulate glucose uptake, andthe gastrointestinal tract stimulation effect generated by taking the probiotics alone is improved, so that the probiotics and the phyllanthus emblica can better play a role in reducing blood sugar, complications are reduced, and the material can be prepared into a pharmaceutical composition for preventing or treating diabetes and metabolic syndrome. Therefore, the invention provides a new application for improving diabetes mellitus and metabolic syndrome related diseases.
Owner:NANJING UNIV
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