64 results about "Obstructive diseases" patented technology

The tiotropium bromide inhalant is prepared through spray drying the mixture solution of tiotropium bromide and amino acid to form superfine powder, mixing with re-crystallized lactose, and capsulizing or preparing other proper preparation form. It is administrated with special device so that the dry medicine powder enters to the lung via respiratory tract to treat chronic obstructive diseases. The present invention has simple preparation process without organic solvent and preservative used, and the prepared powdered preparation has good flowability, accurate dosage, high effective part depositing amount and no irritation to mucous membrane. The preparation process of the present invention may be also used for preparing Salbutamol, salmeterol and other inhalant.

A method for treating or inhibiting artery obstructive disease, such as restenosis after angioplasty and stenting procedures and stenosis after coronary artery bypass surgery, in a subject by administering to the subject a therapeutically effective amount of dasatinib or a derivative thereof Also provided are drug-eluting medical devices, including stents, having a therapeutically effective amount of dasatinib.

The present invention provides methods to protect a subject from a respiratory disorder involving an airway obstructive disease such as asthma or chronic obstructive pulmonary disease. Provided are methods to protect a subject from an airway obstructive disease using gene therapy. Methods are provided for supplying FoxA2 function to cells of the lung and airway, such as smooth muscle and epithelial cells, by FoxA2 gene therapy. The FoxA2 gene, a modified FoxA2 gene, or a part of the gene may be introduced into the cell in a vector such that the gene remains extrachromosomal or may be integrated into the subjects chromosomal DNA for expression. These methods provide for administering to a subject in need of such treatment a therapeutically effective amount of a FoxA2 gene, or pharmaceutically acceptable composition thereof, for overexpressing the FoxA2 gene. Such methods of expressing the administered FoxA2 gene in the lungs and airway provide for: (1) preventing or alleving bronchial hyperresponsiveness; (2) preventing or alleving of an airway obstructive disease, e.g., bronchial hyperreactivity, airway hyperresponsiveness, asthma or chronic obstructive pulmonary disorder (“COPD”); (3) reducing the airway resistance response to inhaled natural or synthetic bronchoconstrictors or allergens or to exercise; and (4) enhancing responsiveness (relaxation) of airway tissues to β-agonists.

The invention relates to traditional Chinese medicine particles for treating the syndrome of insufficiency of lung and kidney qi caused by chronic obstructive disease of lung, which can effectively solve the problem of treatment medication for the syndrome of insufficiency of lung and kidney qi caused by chronic obstructive disease of lung. The traditional Chinese medicine particles are prepared from 6-12g of ginseng, 15-30g of radix astragali, 9-15g of cornel, 9-15g of wolfberry fruit, 6-12g of magnolia vine fruit, 6-12g of epimedium, 9-15g of thunberg fritillary bulb, 9-15g of red peony root, 9-15g of earthworm, 9-15g of perilla fruit, 15-30g of Japanese ardisia and 9-15g of dried orange peel. The traditional Chinese medicine particles have abundant raw materials and a scientific and advanced preparation method, have the efficacies of supplementing qi, benefiting lung and kidney, resolving phlegm and promoting blood circulation, and are innovations in the traditional Chinese medicine.

The present invention discloses a Chinese medicine for effectively curing and preventing chronic obstructive disease of lung with obvious therapeutic effect. It is made up by using (by weight portion) 1-30 portions of astragalus root, 1-20 portions of pilose asiabell root, 1-15 portions of bile-processed arisaema root and 1-15 portions of silkworm through a certain preparation process.

The invention discloses an image fusion method for detecting peripheral vascular obstructive diseases. The method comprises: in a first part, using a near-infrared II-region fluorescent blood vessel imaging technology and a laser speckle blood flow imaging technology for obtaining two heterologous images; in a second part, using an image fusion method for carrying out operation on the two images output in the last step; wherein the third part is used for positioning a concerned blood vessel in the living blood vessel information image, calculating indexes for reflecting the health condition ofthe blood vessel, mainly the blood vessel diameter stenosis rate and the blood flow velocity, and finally detecting whether the blood vessel is blocked or not according to the indexes. The advantageinformation and complementary information of the static blood vessel image and the dynamic blood flow image are organically combined, the part and the condition of vascular occlusion lesion can be well displayed, and other reasons causing limb swelling or pain, such as hematoma, vein compression and the like, can be found out. The development condition of the disease of the patient can be effectively evaluated, and corresponding treatment is provided for clinic.

The invention provides an application of licorice flavonoids in preparing antitussives for treating acute and chronic cough caused by a plurality of reasons. The related acute and chronic cough comprises cough symptoms caused by various diseases such as acute and chronic tracheitis, asthma, chronic obstructive disease of lung, idiopathic pulmonary fibrosis, tuberculosis, bacterial pneumonia, bronchiectasis and the like. The licorice flavonoids extracted from liquorice proves to have very strong effect in preventing cough according to pharmacological tests; drug potency thereof is similar to the drug potency of codein in narcotic antitussive; the function mechanism analyses indicate that the licorice flavonoids plays the role of preventing cough through the non-narcotic nerve centre. In addition, the licorice flavonoids extracted from natural plants can also be prepared into health food. The invention solves the problem that the non-narcotic potent antitussives are badly needed, provides a non-narcotic potent antitussives which has fine social and economical benefits.

The invention relates to a lacrimal passage conduction device and a matching lacrimal passage prospecting apparatus to cure lacrimal passage block. A current tubular conduction device has the disadvantages that the operation is complicated when putting the conduction device in the lacrimal passage and it needs to probe the lacrimal passage through first and then introduce in the conduction device through a down-lead. The invention discloses a lacrimal passage conduction device and a matching lacrimal passage prospecting stick, which can solve the above problem. The lacrimal passage conduction device comprises at least one conduction part composed of at least one bendable solid strip, at least one connecting part connected with the conduction part to connect the probing end of the lacrimal passage prospecting stick and at least one detaining part connected with the other end of the conduction part to prevent the entire conduction device from sliding into the lacrimal passage. The matching lacrimal passage prospecting stick is provided with a fixing device at the position with a certain distance from the probing end of the prospecting stick to relatively fix the prospecting stick and the lacrimal passage conduction device. With the matching lacrimal passage prospecting apparatus, the lacrimal passage probing and the installation of the lacrimal passage conduction device can be done at the same time.

The invention discloses a traditional Chinese medicine preparation for preventing and treating thrombus. The traditional Chinese medicine preparation is characterized by comprising leech, earthworm, safflowers, salvia miltiorrhiza, panax notoginseng, radix isatidis, honeysuckle and dandelion; the leech, the earthworm, the safflowers, the salvia miltiorrhiza, the panax notoginseng, the radix isatidis, the honeysuckle and the dandelion are ground to obtain fine powder, and then the fine powder and honey are mixed with each other to obtain honeyed pills. The traditional Chinese medicine preparation has the advantages that traditional Chinese medicine varieties for preventing and treating the thrombus can be increased, the traditional Chinese medicine preparation is low in production cost, high in cure rate, suitable for preventing and treating venous thrombus, arterial thrombus and microcirculation thrombus diseases and also suitable for treating thrombus obstructive diseases with inflammation, and can become effective fast, and good thrombus preventing and treating effects can be realized.

An agent for the prevention and/or treatment of urine collection disorders associated with lower urinary tract obstructive disease, characterized by containing an indoline derivative represented by the following general formula (I):

wherein R; R¹; and R² are defined in the specification. The derivative and salt are usable as an agent for the prevention and/or treatment of urine collection disorders associated with lower urinary tract obstructive disease. Silodosin is the preferred indoline derivative.

The invention relates to a compound solid preparation for treating asthma, which consists of ambroxol hydrochloride and azithromycin which serve as active ingredients and auxiliary materials, wherein the ratio of the ambroxol hydrochloride to the azithromycin is 2:1-10:1, the weight ratio of the active ingredients to the auxiliary materials is 1:5-100, and preferably the medicament content of each single dose is 7.5:2 to 30:12 mg. The oral solid preparation containing the ambroxol hydrochloride and the azithromycin which serve as the active ingredients has the characteristics of stability in storage, convenience for carrying, capability of reducing production cost, and suitability for large-scale production. The oral solid preparation has the obvious synergistic effect on the relief of symptoms such as dyspnea and the like caused by airway obstructive diseases such as bronchial asthma, chronic bronchitis, emphysema and the like.

A compound represented by general formula (I), or a stereoisomer, a hydrate, a metabolite, a solvate, a pharmaceutically acceptable salt, a cocrystal, or a prodrug thereof, the preparation method thereof, and use thereof in the manufacture of a medicament for treatment of an airway obstructive disease,

wherein the substituents are defined as in the specification.

The invention discloses a traditional Chinese medicinal powder for treating obstructive disease and embolic disease of lung and a preparation method thereof. The traditional Chinese medicinal powder is prepared from 12 traditional Chinese medicinal materials such as nux vomica, dragon's blood, frankincense, myrrh, typhonium giganteum, ephedra, radix sileris, coptis root, baikal skullcap root, safflower, catechu and the like, and the sum of contents of the components is 100%. The traditional Chinese medicinal powder for treating obstructive disease and embolic disease of lung can be prepared by the steps of: removing impurities from weighed 12 traditional Chinese medicinal materials, cleaning and drying in the sun, mixing and pulverizing all the traditional Chinese medicinal materials by atraditional Chinese medicine pulverizer, mixing uniformly, and grinding the pulverized mixture into fine powder. The invention solves the problems of long treatment cycle, big side effect and high recurrence rate of the traditional Chinese medicine in the prior art, and high expense and big risk of surgical treatment, and the method disclosed by the invention has a simple preparation process and obvious effect.