57 results about "Pathogenic factor" patented technology

The invention relates to a double-gene rare variation and disease relevance prediction model and an establishment method and application thereof, and belongs to the technical field of biological medicines.The establishment method of the double-gene rare variation and disease relevance prediction model comprises the following steps that S1, a sample library is screened; s2, performing quality control on whole exome sequencing data (WES); s3, performing phenotype screening; s4, performing grouping design; s5, carrying out PheWAS logistic regression analysis; s6, performing Firth logistic regression analysis and verification; and S7, carrying out double-gene feature analysis and double-gene pathogenicity relevance prediction. The method for analyzing the correlation between the rare double-gene variation and all disease phenotypes is designed for the first time, and a new method is provided for screening hereditary pathogenic factors of various diseases.

The application discloses a medicine for warming yang, promoting water excretion and detoxification, and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The medicine for warming yang, promoting water excretion and detoxification provided by the application takes prepared aconite, dried ginger and fried licorice as monarch drugs to stimulate the vital energy of the whole body and supplement yang qi of the heart, spleen and kidney; takes rhubarb and soapberry thorn as minister drugs to clear heat, detoxify and dredge the triple energizer; takes cassia twig and poria as auxiliary drugs to warm yang, promote the circulation of qi, reduce edema and promote water excretion; and takes taizishen as a minister drug to supplement qi, remove dampness and regulate qi movement. The whole prescription can supplement deficiency and eliminate excess, and has the functions of warming yang, detoxification and water excretion. The medicine can treat the root "deficiency of yang qi and invasion of pathogenic factors" of sepsis heart dysfunction, achieve the effect of treating the root and branch at the same time, reduce the inflammation level, cTnT and BNP level of a patient, and achieve the treatment of sepsis heart dysfunction.

This invention discloses a Tibetan medicine formula called Mabosongtang Lung-Nourishing Composition and its preparation method and application in modern formulations, more specifically relating to a preparation method and application of Mabosongtang Lung-Nourishing granules, oral liquid, and capsules. The composition is mainly prepared from the following medicinal materials: Tibetan Lithospermum erythrorhizon, Tibetan Rubia cordifolia, Lithospermum erythrorhizon, Bambusa textilis, Morinda officinalis, Lysimachia christinae, Hippophae rhamnoides, and Glycyrrhiza uralensis. The aqueous extract of this composition, with appropriate excipients, is prepared into granules, oral liquid, and capsules using modern pharmaceutical processes. The three formulations are effective, rationally formulated, advanced in dosage form, and stable in quality. They have the effects of calming the lungs, suppressing blood stasis, and clearing lung heat. They can be used for respiratory symptoms caused by the invasion of pathogenic factors into the lungs, and dysfunction of the lung's vital energy and ascending qi, such as cough, wheezing, shortness of breath, etc. (treatment of lung diseases with the above symptoms).

The present invention belongs to the field of traditional Chinese medicine technology, and specifically relates to a traditional Chinese medicine composition for preventing influenza, its preparation method, and application. The composition comprises the following raw materials in parts by weight: 6-30g of raw coix seed, 5-30g of kapok flower, 3-20g of patchouli, 3-15g of perilla leaf, 3-15g of siler, 3-15g of forsythia, 3-20g of astragalus, and 5-20g of ginger. The traditional Chinese medicine composition of the present application uses authentic Lingnan medicinal materials, is simple, convenient, inexpensive, and effective, and can treat both cold and warm effects, dispel pathogenic factors without damaging the body's health, strengthen the body's health without restraining pathogenic factors, and eliminate dampness without damaging yin. It dispels pathogenic factors and strengthens the body's health simultaneously, has a good effect on preventing influenza, can enhance the body's immunity, and has a good preventive and health-care effect.

The invention provides a meridian warming and activating traditional Chinese medicine compound for treating facial paralysis and a preparation method thereof, and belongs to the field of traditional Chinese medicine treatment of facial paralysis. The meridian-warming and collateral-dredging traditional Chinese medicine compound follows the compatibility theory of monarch, minister, assistant and guide in traditional Chinese medicine, is rigorous in composition, and has the effects of warming and dredging meridians, dispelling wind, reducing phlegm, reinforcing qi and nourishing blood aiming at the pathogenesis of facial paralysis, such as wind-cold attacking collaterals, unsmooth qi and blood and deficiency of vital qi, so as to achieve the effects of harmonizing yin and yang and strengthening body resistance to eliminate pathogenic factors. The traditional Chinese medicine composition has a good curative effect on Bell facial paralysis caused by wind-cold invasion and meridian blockage, and the symptoms of sudden oblique mouth and eyes, facial numbness, incomplete eye closure, frontal line disappearance and the like. Contrast experiments prove that the total treatment effective rate of the meridian-warming and collateral-dredging pill is obviously higher than that of mecobalamine tablets and prednisolone acetate tablets, and the meridian-warming and collateral-dredging pill has more obvious effects on relieving the severity of facial paralysis and improving the score of facial paralysis. Therefore, the meridian-warming and collateral-dredging pill shows a good clinical curative effect in the aspect of treating the wind-cold arthralgia type bellar paralysis, and is expected to provide a better choice for clinical treatment of the wind-cold arthralgia type bellar paralysis.

The invention provides a traditional Chinese medicine composition and application thereof in preparation of an anti-breast cancer medicine, and relates to the technical field of biological medicine and traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 60 parts of radix acanthopanacis semticosi, 30 to 60 parts of fructus ligustri lucidi, 30 to 60 parts of rhizoma bolbostemmae, 30 to 60 parts of caulis spatholobi, 30 to 60 parts of resina liquidamberis, 30 to 60 parts of tabasheer, 30 to 60 parts of gynura procumbens, 30 to 60 parts of aspongopus, 30 to 60 parts of pecteilis sumadai, 30 to 60 parts of thlaspi arvense, 30 to 60 parts of herba dendrobii and 10 to 30 parts of fructus ziziphi jujubae. The traditional Chinese medicine composition has the effects of strengthening the body resistance to eliminate pathogenic factors, detoxifying, removing stasis, activating blood, reducing phlegm, tonifying qi and nourishing yin. On the in-vitro level, the traditional Chinese medicine composition can remarkably inhibit proliferation, migration and invasion of BT549 and 4T1 cells at different concentrations. On the in-vivo level, the traditional Chinese medicine composition can significantly inhibit the growth speed, volume and quality of tumors, and shows an excellent tumor inhibition effect. And the anti-tumor effect of the compound can be improved after the compound is combined with adriamycin. The traditional Chinese medicine composition is expected to be further popularized and applied as an anti-breast cancer medicine.

The invention discloses a traditional Chinese medicine composition for treating tumors. The invention belongs to the medical field of traditional Chinese medicine for treating tumors. The medicine consists of 21 traditional Chinese medicines such as artemisia anomala, pseudo-ginseng, pseudobulbus cremastrae seu pleiones, rhizoma paridis, dried alum, sal ammoniac and ground beeltle, and comprises plant medicines, mineral medicines and animal medicines. According to the theory that tumor formation is mostly caused by qi and blood stasis, phlegm-damp toxin and stagnation and accumulation and is essentially blood death, stubborn phlegm and rotten water, the traditional Chinese medicine composition is prepared by adopting the method of regulating qi, promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, eliminating phlegm, dredging collaterals, clearing away heat and toxic materials, relieving pain, removing rotten water and inducing diuresis as well as strengthening body resistance to eliminate pathogenic factors according to the principle of syndrome differentiation and treatment of traditional Chinese medicine. The method is an empirical method gradually formed by continuous exploration in the practice process. The medicine has a treatment effect on tumors; the traditional Chinese medicine composition also has the effect of relieving and easing pain caused by tumors.

The application discloses a traditional Chinese medicine composition with the effect of treating infantile recurrent respiratory tract infection and a preparation method thereof. Through a large amount of clinical practice, the application selects radix pseudostellariae, fried atractylodes, fried rhizoma atractylodis, agastache, levisticus, lonicera, radix scrophulariae, carbonized wheat bran, calcined osseous, ephedra root as raw materials, and is prepared into an oral or external dosage form according to weight ratio. The application has the effects of transporting the spleen, preventing the invasion of pathogenic factors, and consolidating the surface and stopping sweating, and is used for infantile recurrent respiratory tract infection with the syndrome of the spleen failing to transport and the lung and defensive system failing to consolidate. The application is verified by clinical tests, has remarkable curative effect, no toxic side effect, and good safety. Animal experiment researches show that the traditional Chinese medicine composition can effectively relieve the chronic inflammation level of model mice, improve the airway epithelial barrier damage, improve the body's ability to resist pathogenic factors, and reduce the risk of infection. The application can fill the market blank of treating infantile recurrent respiratory tract infection diseases based on the theory of 'four seasons with the spleen being strong and not being invaded by pathogenic factors' and 'the spleen being strong is not about tonifying but about transportation', and has great development prospect.

The application belongs to the technical field of veterinary drugs, and specifically discloses a traditional Chinese medicine composition for preventing and treating diarrhea of calves, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: Bupleurum 5-10 parts, Paeonia 1-5 parts, Fructus Aurantii 1-5 parts, Alisma 1-5 parts, Atractylodes 5-10 parts, Astragalus 5-10 parts, Scutellaria 1-5 parts, Saposhnikovia 1-5 parts, Poria 1-5 parts, Pericarpium Citri Reticulatae 1-5 parts, Gardenia 1-5 parts, and Glycyrrhiza 1-5 parts. The traditional Chinese medicine composition provided by the application can be taken by the calf as soon as diarrhea occurs, helps the calf to supplement qi and consolidate the exterior, support the healthy qi and eliminate the pathogenic factors, and improve the immunity, and then, while the feeding quality is ensured, the traditional Chinese medicine composition has the effects of increasing the weight of the calf, improving anemia of the calf, improving the liver and kidney functions of the calf, and regulating and enhancing the immunity.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating sepsis and a traditional Chinese medicine preparation and application thereof. The traditional Chinese medicine composition consists of the following components in parts by weight: 15-40 parts of honeysuckle stem, 10-25 parts of coix seed, 5-20 parts of rheum officinale, 5-20 parts of patrinia, 5-25 parts of radix aconiti lateralis preparata, 5-20 parts of cassia twig, 3-17 parts of bighead atractylodes rhizome, 2-10 parts of coptis chinensis and 3-10 parts of honey-fried licorice root. The traditional Chinese medicine composition is based on the core pathogenesis that sepsis is externally infected with heat toxin, is internally impressed with damp heat, obstructs veins and is damaged in yang qi, adopts the methods of clearing away heat and toxic materials, promoting diuresis and expelling pus, warming yang and dredging collaterals and strengthening the body resistance to eliminate pathogenic factors, is used for resisting sepsis through multi-mechanism synergy, and is particularly suitable for patients with sepsis with the syndromes of exuberance of heat toxin, damp heat and obstruction of stasis and deficiency of yang qi. The traditional Chinese medicine composition combines cold and warm effects, combines purgation and tonification effects, and has the characteristics of high safety and small side effects.

A compound anti-tumor traditional Chinese medicine composition, and a preparation method therefor and the use thereof. The compound anti-tumor traditional Chinese medicine composition comprises the following components in parts by weight: 300-600 parts of astragali radix, 80-120 parts of red ginseng, 4-10 parts of blister beetle and 1-4 parts of bufonis venenum. The combination of these components has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, softening hardness to remove stasis, and strengthening body resistance to eliminate pathogenic factors.

This invention belongs to the technical field of skin disease treatment products, specifically relating to a topical hot compress for treating scleroderma and its preparation method. The topical hot compress for treating scleroderma is made from the following raw materials in parts by weight: 20-40 parts of Artemisia argyi, 20-40 parts of Cinnamomum cassia, 10-20 parts of Sparganium stoloniferum, 10-20 parts of Curcuma zedoaria, 10-20 parts of Loranthus parasiticus, 15-30 parts of Gynostemma pentaphyllum, 10-20 parts of Spirodela polyrhiza, 15-30 parts of Spirodela polyrhiza, 15-30 parts of Ephedra sinica, 20-40 parts of Clematis chinensis, 5-15 parts of Eupolyphaga sinensis, 15-25 parts of Eriocaulon buergerianum, 5-15 parts of Carthamus tinctorius, 3-6 parts of Dracaena cochinchinensis, 3-6 parts of processed Strychnos nux-vomica, 20-40 parts of Vaccaria segetalis, 20-40 parts of Astragalus membranaceus, 10-20 parts of Magnolia officinalis, 10-20 parts of Aconitum carmichaelii, and 22-40 parts of rice wine. This invention is a topical medication that eliminates the need for oral administration, treating the disease externally and guiding the pathogenic factors to a cure. It avoids the inconvenience of bitter medications and effectively relieves symptoms and promotes the cure of localized scleroderma.

The invention discloses a traditional Chinese medicine composition for treating hyperuricemia. The traditional Chinese medicine composition comprises the following components in parts by mass: 5-7 parts of lalang grass rhizome, 4-6 parts of lophatherum gracile and 0.5-2 parts of Chinese dates. The lalang grass rhizome is a monarch drug, has the effects of reducing fever, causing diuresis, dredging the bladder waterway and inducing damp-heat and turbid evil to be removed from urination, conforms to the method of cleaning the government, and is a core drug for removing turbid and acid. The lophatherum gracile is used as a ministerial drug, has the effects of dredging small intestines, enhancing the effects of distinguishing and secreting turbidity, enhancing the effect of excreting damp turbidity and relieving polydipsia and insomnia caused by damp-heat disturbing heart, and forms the effect of treating both upper and lower jiao together with the monarch drug, so that the turbid stasis does not hide in the body. The Chinese dates are used as assistant and guide medicines, have the functions of tonifying spleen and consolidating foundation and harmonizing the medicines, and reflect the nursing idea of'warm medicines are used for harmonizing the medicines for patients with phlegm and fluid retention ', so that pathogenic factors are attacked without hurting healthy qi. The whole formula has the effects of eliminating evil without hurting the body resistance and strengthening the body resistance without helping evil through the ingenious balance of the three medicine properties and flavor tropism to realize the curative effects of eliminating evil without hurting the body resistance and strengthening the body resistance without helping evil. Experiments prove that the blood uric acid level of a treatment group is lower than that of a same-period control group (Plt; 0.01) of the substrate.

The application discloses a hot compress plaster for promoting blood circulation and removing blood stasis and a preparation method thereof, and belongs to the technical field of external preparations of traditional Chinese medicines. The hot compress plaster is prepared from Prunella vulgaris, Gastrodia elata, Cyperus rotundus and other Chinese medicines and beeswax. The preparation method comprises the steps of raw material screening and pretreatment, medicine powder preparation, base preparation, mixing and forming, cooling and shaping and packaging and storage. The application is based on the pathogenesis of Qi stagnation and blood stasis and phlegm and blood stasis intermingling, follows the principles of promoting blood circulation, removing phlegm and resolving stasis, strengthening healthy energy and eliminating pathogenic factors, and can effectively improve the blood circulation of the body and dissipate tumor nodules in combination with the warm action of hot compress. The hot compress plaster is flexible in proportioning and can be personalized, is simple in preparation, safe in use, small in side effect, suitable for the auxiliary treatment of tumor nodules, and has high clinical application value and popularization prospect.

The invention discloses a traditional Chinese medicine composition for treating bone diseases and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared by taking black monkshood, raw semen strychni, datura stramonium, dragon's blood and sappan wood as monarch drugs and taking ground beeltle, centipede, scorpio, Jin snake, zaocys dhumnade, black ant, teasel, rhizoma cibotii, native copper, rhizoma drynariae, radix achyranthis bidentatae, radix salviae miltiorrhizae, raw radix aconiti and the like as ministerial drugs; according to etiology and pathogenesis of bone diseases including cervical spondylosis, scapulohumeral periarthritis, rheumatic arthritis, hyperosteogeny and the like, medicines are reasonably combined, according to the etiology and pathogenesis, warm dredging and attacking evil are taken as main medicines, worm medicines are used for searching collaterals and eliminating evil are taken as essential medicines, the liver and kidney are tonified, the muscles and bones are strengthened, and the evil is prevented from hurting the body resistance; the traditional Chinese medicine can achieve the effects of warming channels and expelling cold, dispelling wind and eliminating dampness, activating meridians to stop pain, searching collaterals and eliminating evil, tonifying the liver and the kidney and the like, can effectively treat various orthopedic diseases, can treat symptoms by attacking evil and dredging collaterals, can treat root causes by tonifying the liver and the kidney, and achieves the purpose of treating both symptoms and root causes.

The present invention relates to the technical field of traditional Chinese medicine, and discloses a moisturizing and rejuvenating cream and an application thereof in the prevention and treatment of hand-foot syndrome caused by donafenib tosylate. The moisturizing and rejuvenating cream comprises the following components in parts by mass: 40g of Xinjiang lithospermum erythrorhizon, 40g of angelica sinensis, 40g of gallnut, 20g of sanguisorba officinalis, 20g of Kochia scoparia, 15g of angelica dahurica, 15g of bletilla striata, 20g of phellodendron amurense, 20g of scutellaria baicalensis, 15g of mint, 15g of honeysuckle, 20g of myrrh vinegar, 20g of smilax glabra, 20g of Cnidium monnieri, 30g of Semen Ziziphi Spinosae, and 24g of matrix have the effects of clearing away heat and detoxifying, moistening dryness and promoting tissue regeneration, astringing and relieving itching, and promoting blood circulation and relieving pain. It clears heat without damaging yin, moistens dryness and eliminates pathogenic factors, and has the effect of treating both the symptoms and the root causes. It can effectively prevent and treat HFS related to donafenib tosylate, and has a good effect in improving the quality of life of patients and improving treatment compliance to ensure the smooth implementation of targeted treatment. It is also affordable and easy to use, has good clinical application prospects, and has promotion significance.

The invention discloses a modified lung heat clearing decoction traditional Chinese medicine compound and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, the compound comprises the following components by mass: 6 g of raw ephedra, 10 g of almond, 30 g of gypsum, 6 g of raw licorice, 10 g of platycodon grandiflorum, 10 g of burdock, 10 g of scutellaria baicalensis, 15 g of polygonum cuspidatum, 10 g of schizonepeta, 10 g of notopterygium root, and 10 g of stiff silkworm. According to the traditional Chinese medicine composition, exterior syndrome relieving medicines are added to export pathogenic factors, meanwhile, medicines for ventilating the lung, depressing qi, relieving sore-throat and inducing resuscitation are added to quickly relieve main symptoms and recover lung functions, and medicines with the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, promoting diuresis and dredging collaterals are selected to more comprehensively inhibit viruses and relieve pathological damage of organisms; and a co-decoction granule technology is adopted, so that the drug effect is stable, and the'unification 'and the optimal drug effect of a complex prescription are guaranteed.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition, a preparation method and application thereof. Specifically, based on the theory of traditional Chinese veterinary medicine of'strengthening the body resistance and eliminating pathogenic factors, and treating the root and branch', aiming at the pathogenesis of 'deficiency in the root and excess in the branch' of low immunity in animals, eight kinds of medicinal materials are scientifically screened to form a traditional Chinese medicine compound with the effects of tonifying qi and nourishing blood, invigorating the spleen and kidney, dredging collaterals and eliminating dampness, and clearing heat and detoxifying. Through the verification of a cyclophosphamide-induced low immunity mouse model, the traditional Chinese medicine composition can significantly improve the mental state of the mice, restore the body weight and thymus / spleen index, repair the pathological damage of the spleen tissue, and adjust the inflammatory factor level in the serum and spleen tissue. In addition, in a Marek's disease virus infection model, the traditional Chinese medicine composition combined with the Marek's disease virus vaccine can significantly reduce the viral load in the peripheral blood, liver and spleen, and reduce the liver enlargement, hemorrhage and microscopic structure damage, showing a good immune synergistic effect.

The application discloses a traditional Chinese medicine composition for treating renal clear cell carcinoma and a preparation method and application thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition provided by the application comprises ginseng, astragalus, atractylodes, poria cocos, herba impatiens, oldenlandia, zedoary, dogwood fruit, ligustrum lucidum and prunella vulgaris. The traditional Chinese medicine composition provided by the application is scientific and reasonable in combination, can support healthy qi and eliminate pathogenic factors, clear heat and resolve toxins, activate blood and resolve stasis, and soften and resolve hard masses. The clinical experimental results show that the traditional Chinese medicine composition provided by the application can effectively treat renal clear cell carcinoma, and the treatment efficiency is better than that of the targeted drug sorafenib; and the medicine is safe, has no obvious toxic and side effects, and performs well in improving patient's traditional Chinese medicine syndromes, improving the quality of life and reducing the level of tumor markers. The application provides a new idea and method for treating renal clear cell carcinoma, and has significant clinical significance and important popularization value.

The invention provides a probe combination and a kit for detecting knee osteoarthritis and application of the probe combination and the kit, belongs to the technical field of biological medicine detection, and can solve the technical problems of low speed, relatively low detection flux, high detection cost and the like of the existing knee osteoarthritis risk or pathogenesis factor detection means. The probe combination comprises 112 probe sequences for detecting 56 target genes, the nucleotide sequences of the 112 probe sequences are respectively shown as SEQ ID NO.1-SEQ ID NO.112, and each target gene corresponds to at least two probe sequences; wherein the 56 target genes comprise 20 bone metabolism and cartilage formation related genes, 19 inflammatory response related genes, 8 extracellular matrix related genes and 9 drug metabolism and curative effect related genes. The method has the characteristics of high throughput, rapidness, accuracy and the like. The method can be applied to genetic risk assessment of knee osteoarthritis and the like.

This invention relates to a traditional Chinese medicine composition for treating primary liver cancer. The composition is made from the following raw materials in parts by weight: 25-30 parts of *Codonopsis pilosula*, 10-15 parts of *Cremastra appendiculata*, 15-20 parts of *Scutellaria barbata*, 20-25 parts of *Curcuma zedoaria*, 10-15 parts of *Polygonum cuspidatum*, and 5-10 parts of *Citrus reticulata*. This invention also provides applications of the traditional Chinese medicine composition. The "Liver-Clearing Formula" of this invention uses a combination of various traditional Chinese herbs, focusing on "damp-heat, phlegm, qi stagnation, and blood stasis." The six herbs are combined to both attack and tonify, supporting the body's resistance and eliminating pathogenic factors, aiming to achieve the goal of strengthening the body's resistance and reducing pathogenic factors, thus achieving the effects of clearing heat and dampness, promoting qi circulation, resolving phlegm, and breaking up blood stasis. This helps improve the patient's quality of life and prognosis. At the same time, the use of this traditional Chinese medicine is expected to reduce the toxicity and enhance the efficacy of Western medicine, reducing adverse reactions and achieving the best therapeutic effect.

The present application discloses a Chinese medicine composition, a Chinese medicine acupoint patch and a preparation method thereof, wherein the Chinese medicine composition is composed of the following raw materials in parts by weight: 10-30 parts by weight of Astragalus, 10-15 parts by weight of Citron, 5-10 parts by weight of Curcuma, 10-15 parts by weight of Curculigo, 5-10 parts by weight of Epimedium, 5-10 parts by weight of Clematidis, 5-10 parts by weight of Ephedra, and 3-10 parts by weight of Menthol. The above-mentioned Chinese medicine acupoint patch is used for both tonifying and purging, with Astragalus, Curculigo, and Epimedium replenishing, while Curcuma, Citron, Clematidis, and Ephedra dredging, taking into account strengthening the body and dispelling pathogenic factors, and Menthol harmonizing cold and heat, preventing dryness and protecting yin; through the reasonable compatibility of monarch, minister, assistant, and envoy, the combination of external treatment and internal adjustment is achieved, reflecting the flexible thinking of "internal and external treatment" of traditional Chinese medicine, and therefore having the effect of improving cancer-related fatigue in patients with lung cancer.

The invention discloses Yao-strengthening ointment for improving immune disorder of an HIV infected person. The Yao-strengthening ointment is mainly prepared from the following raw materials: astragalus membranaceus, poria cocos, rhizoma cimicifugae, radix achyranthis bidentatae, roasted ephedra, prepared radix aconiti carmichaeli, asarum, roasted liquorice, philippine flemingia root, giantleaf ardisia rhizome, caulis sinomenii, tripterygium wilfordii and gynostemma pentaphylla. The preparation method of the Zhuang Yao ointment comprises the steps of medicinal material treatment, medicinal material extraction and ointment preparation. The whole formula is mainly used for strengthening the body resistance (tonifying qi and warming yang) and eliminating evil (dehumidifying, activating blood and detoxifying), through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine aims at core qi deficiency and yang deficiency of immune disorder of HIV infected people and also eliminates pathological products such as dampness, stasis and heat toxin, meanwhile, honey-fried licorice root is used for regulating the medicine property, CD4 cells of the HIV infected people can be improved, immune disorder can be improved to a certain extent, and immune reconstitution is promoted.

The invention belongs to but not limited to the technical field of biological control of plant diseases, and discloses bacillus velezensis BV1 and application thereof in enhancing the resistance of wheat to basal stem rot. The bacillus velezensis BV1 provided by the invention can inhibit the growth of fusarium pseudograminearum, and the inhibition rate is 66.67%. The BV1 can enable hyphae of the fusarium pseudograminearum to expand, deform and generate apoptosis. According to the invention, the mechanism of inducing the apoptosis of the fusarium pseudograminearum by the BV1 is analyzed. Meanwhile, the main pathogenic factor RPL22 in the fusarium pseudograminearum is found. A foundation is laid for developing RPL22 gene silencing biological agents to reduce toxins generated by the fusarium pseudograminearum, so that the wheat yield and the food safety are guaranteed.

The invention provides a construction method and application of a high-precision controllable rat molar wear model, and belongs to the technical field of oral medicine animal models. According to the method, after the rat is fed with hard food, anesthesia is performed, the oral cavity is opened, and the rat incisor is stimulated by selecting or not selecting any one or more modes of acid erosion and thermocycling stimulation, so that the high-precision controllable rat molar wear model is obtained. The invention develops an acid etching-hard food-cold and hot cycle three-factor time sequence controllable modeling system by simulating the diversity reasons of clinical wear, controlling the types of pathogenic factors and the model construction time to accurately control the severity degree of wear and simulating the progressive process of human functional occlusion wear. A wear model is established in the SD rat molar. The wear form of the model is a composite horseshoe-shaped wear pit which is highly matched with the morphology and biology of human pathological wear. As an experiment is carried out on the living medullary teeth, the pathological manifestation is consistent with the pathological manifestation of clinical progressive wear.

The invention provides a traditional Chinese medicine composition for treating warm disease damp-heat syndrome and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared aiming at the warm disease damp-heat syndrome caused by influenza A virus H1N1, the traditional Chinese medicine composition is prepared from artemisia apiacea, scutellaria baicalensis, pericarpium citri reticulatae, rhizoma pinellinae praeparata, fructus aurantii, caulis bambusae in taeniam, talc, folium isatidis, isatis root, poria cocos and liquorice for compatibility, and the artemisia apiacea and the scutellaria baicalensis in the formula are aromatic, bitter and cold, have the effects of clearing away yang-deficiency damp-heat and expelling evil and serve as monarch drugs; the bamboo shavings, the fructus aurantii, the pericarpium citri reticulatae and the pinellia ternate are used as ministerial drugs for clearing heat, eliminating dampness and eliminating phlegm; poria cocos, folium isatidis and radix isatidis are used as assistants to clear heat, promote diuresis and induce dampness from urination. The traditional Chinese medicine composition mainly clears heat and eliminates dampness, realizes individualized treatment on the pathogenesis of damp-heat accumulation and difficulty in resolving in warm disease damp-heat syndromes, realizes integral regulation through multiple targets, eliminates evil without hurting the body resistance, and has obvious clinical treatment effect.

The invention discloses a three-dimensional artificial intelligence model for pneumonia pathogenesis discrimination based on a CT image, and relates to the technical field of medical imaging, and the three-dimensional artificial intelligence model comprises the following steps: carrying out patient identity information anonymization processing; performing three-dimensional resampling processing on the image of the CT image; the U-Net model is preprocessed; and pneumonia pathogenesis identification and disease course staging are completed. According to the method, a model capable of accurately distinguishing two different pathogens of the mycoplasma pneumonia and the psittaci pneumonia and a model capable of distinguishing the morning course, the noon course and the evening course of the mycoplasma pneumonia and the psittaci pneumonia are established, a set of complete and feasible solution is provided for AI-assisted accurate pneumonia diagnosis and treatment, unified and accurate cutting of focuses of various different special diagnoses is achieved, and the accuracy of diagnosis and treatment is improved. Compared with the prior art, manual intervention is reduced, a whole process scheme from original DICOM to precise focus cutting is completed, clinical feasibility is improved, fine but key differences are captured, and a pneumonia pathogenesis identification model with high precision is screened early.

The invention relates to the technical field of animal model construction, and particularly provides a gavage agent for constructing a metabolism-related fatty liver disease animal model as well as a preparation method and application of the gavage agent. The gavage agent comprises cholesterol, sodium cholate, Tween 80 and corn oil according to a specific ratio, a quantitative gavage administration mode is adopted, and the technical problems that an existing MAFLD animal model is long in modeling period, high in cost and large in individual difference, and a single pathogenic factor cannot be accurately researched are solved. The gavage agent is used for building a rat model and can efficiently and stably induce an MAFLD animal model with typical liver fatty degeneration and lipid disorder characteristics within 8 weeks, the modeling period is shortened by more than 4 weeks compared with that of a traditional high-fat feed method, the individual difference of the model is remarkably reduced through accurate dosage control, and the method is suitable for large-scale popularization and application. And meanwhile, the single-day modeling cost is controlled at a relatively low level.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating diseases caused by external pathogenic factors and sequelae thereof. In the present application, the traditional Chinese medicine composition is derived from a folk traditional Chinese medicine inheritance compound Nanteng Zhitong prescription, and is prepared from raw materials including Shishengteng, Wacaocen, Ganjiang and Wangguacen. The present application first finds that the traditional Chinese medicine composition has obvious effective therapeutic effect on diseases caused by external pathogenic factors and sequelae thereof. Meanwhile, the traditional Chinese medicine composition has diverse action targets, is not prone to drug resistance, has no or less adverse reactions, and has broad development and popularization prospect.

The application discloses a rice rice blast occurrence and prevalence prediction method, a prediction device and electronic equipment. The prediction method comprises the following steps: acquiring data of pathogenic factors and actual occurrence indexes of rice blast in different regions for at least five years; screening an influence factor of the actual occurrence indexes of rice blast through a stepdisc process according to the data of the pathogenic factors and the actual occurrence indexes of rice blast for at least five years; establishing a discriminant function through a discrim process according to data of the influence factor; and inputting data of the influence factor of the current year into the discriminant function to obtain a predicted occurrence index of rice blast in the current year. The prediction device comprises an acquisition module, an influence factor screening module, a discriminant function establishing module and a prediction module. The electronic equipment comprises a memory and a processor. The application improves the accuracy of the prediction of the occurrence and prevalence of rice blast, and can effectively guide comprehensive disease control in a timely manner.