41 results about "Pathogenic factor" patented technology

The application discloses a medicine for warming yang, promoting water excretion and detoxification, and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The medicine for warming yang, promoting water excretion and detoxification provided by the application takes prepared aconite, dried ginger and fried licorice as monarch drugs to stimulate the vital energy of the whole body and supplement yang qi of the heart, spleen and kidney; takes rhubarb and soapberry thorn as minister drugs to clear heat, detoxify and dredge the triple energizer; takes cassia twig and poria as auxiliary drugs to warm yang, promote the circulation of qi, reduce edema and promote water excretion; and takes taizishen as a minister drug to supplement qi, remove dampness and regulate qi movement. The whole prescription can supplement deficiency and eliminate excess, and has the functions of warming yang, detoxification and water excretion. The medicine can treat the root "deficiency of yang qi and invasion of pathogenic factors" of sepsis heart dysfunction, achieve the effect of treating the root and branch at the same time, reduce the inflammation level, cTnT and BNP level of a patient, and achieve the treatment of sepsis heart dysfunction.

This invention discloses a Tibetan medicine formula called Mabosongtang Lung-Nourishing Composition and its preparation method and application in modern formulations, more specifically relating to a preparation method and application of Mabosongtang Lung-Nourishing granules, oral liquid, and capsules. The composition is mainly prepared from the following medicinal materials: Tibetan Lithospermum erythrorhizon, Tibetan Rubia cordifolia, Lithospermum erythrorhizon, Bambusa textilis, Morinda officinalis, Lysimachia christinae, Hippophae rhamnoides, and Glycyrrhiza uralensis. The aqueous extract of this composition, with appropriate excipients, is prepared into granules, oral liquid, and capsules using modern pharmaceutical processes. The three formulations are effective, rationally formulated, advanced in dosage form, and stable in quality. They have the effects of calming the lungs, suppressing blood stasis, and clearing lung heat. They can be used for respiratory symptoms caused by the invasion of pathogenic factors into the lungs, and dysfunction of the lung's vital energy and ascending qi, such as cough, wheezing, shortness of breath, etc. (treatment of lung diseases with the above symptoms).

The invention provides a traditional Chinese medicine composition and application thereof in preparation of an anti-breast cancer medicine, and relates to the technical field of biological medicine and traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 60 parts of radix acanthopanacis semticosi, 30 to 60 parts of fructus ligustri lucidi, 30 to 60 parts of rhizoma bolbostemmae, 30 to 60 parts of caulis spatholobi, 30 to 60 parts of resina liquidamberis, 30 to 60 parts of tabasheer, 30 to 60 parts of gynura procumbens, 30 to 60 parts of aspongopus, 30 to 60 parts of pecteilis sumadai, 30 to 60 parts of thlaspi arvense, 30 to 60 parts of herba dendrobii and 10 to 30 parts of fructus ziziphi jujubae. The traditional Chinese medicine composition has the effects of strengthening the body resistance to eliminate pathogenic factors, detoxifying, removing stasis, activating blood, reducing phlegm, tonifying qi and nourishing yin. On the in-vitro level, the traditional Chinese medicine composition can remarkably inhibit proliferation, migration and invasion of BT549 and 4T1 cells at different concentrations. On the in-vivo level, the traditional Chinese medicine composition can significantly inhibit the growth speed, volume and quality of tumors, and shows an excellent tumor inhibition effect. And the anti-tumor effect of the compound can be improved after the compound is combined with adriamycin. The traditional Chinese medicine composition is expected to be further popularized and applied as an anti-breast cancer medicine.

The invention discloses a traditional Chinese medicine composition for treating tumors. The invention belongs to the medical field of traditional Chinese medicine for treating tumors. The medicine consists of 21 traditional Chinese medicines such as artemisia anomala, pseudo-ginseng, pseudobulbus cremastrae seu pleiones, rhizoma paridis, dried alum, sal ammoniac and ground beeltle, and comprises plant medicines, mineral medicines and animal medicines. According to the theory that tumor formation is mostly caused by qi and blood stasis, phlegm-damp toxin and stagnation and accumulation and is essentially blood death, stubborn phlegm and rotten water, the traditional Chinese medicine composition is prepared by adopting the method of regulating qi, promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, eliminating phlegm, dredging collaterals, clearing away heat and toxic materials, relieving pain, removing rotten water and inducing diuresis as well as strengthening body resistance to eliminate pathogenic factors according to the principle of syndrome differentiation and treatment of traditional Chinese medicine. The method is an empirical method gradually formed by continuous exploration in the practice process. The medicine has a treatment effect on tumors; the traditional Chinese medicine composition also has the effect of relieving and easing pain caused by tumors.

The application discloses a traditional Chinese medicine composition with the effect of treating infantile recurrent respiratory tract infection and a preparation method thereof. Through a large amount of clinical practice, the application selects radix pseudostellariae, fried atractylodes, fried rhizoma atractylodis, agastache, levisticus, lonicera, radix scrophulariae, carbonized wheat bran, calcined osseous, ephedra root as raw materials, and is prepared into an oral or external dosage form according to weight ratio. The application has the effects of transporting the spleen, preventing the invasion of pathogenic factors, and consolidating the surface and stopping sweating, and is used for infantile recurrent respiratory tract infection with the syndrome of the spleen failing to transport and the lung and defensive system failing to consolidate. The application is verified by clinical tests, has remarkable curative effect, no toxic side effect, and good safety. Animal experiment researches show that the traditional Chinese medicine composition can effectively relieve the chronic inflammation level of model mice, improve the airway epithelial barrier damage, improve the body's ability to resist pathogenic factors, and reduce the risk of infection. The application can fill the market blank of treating infantile recurrent respiratory tract infection diseases based on the theory of 'four seasons with the spleen being strong and not being invaded by pathogenic factors' and 'the spleen being strong is not about tonifying but about transportation', and has great development prospect.

The application belongs to the technical field of veterinary drugs, and specifically discloses a traditional Chinese medicine composition for preventing and treating diarrhea of calves, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: Bupleurum 5-10 parts, Paeonia 1-5 parts, Fructus Aurantii 1-5 parts, Alisma 1-5 parts, Atractylodes 5-10 parts, Astragalus 5-10 parts, Scutellaria 1-5 parts, Saposhnikovia 1-5 parts, Poria 1-5 parts, Pericarpium Citri Reticulatae 1-5 parts, Gardenia 1-5 parts, and Glycyrrhiza 1-5 parts. The traditional Chinese medicine composition provided by the application can be taken by the calf as soon as diarrhea occurs, helps the calf to supplement qi and consolidate the exterior, support the healthy qi and eliminate the pathogenic factors, and improve the immunity, and then, while the feeding quality is ensured, the traditional Chinese medicine composition has the effects of increasing the weight of the calf, improving anemia of the calf, improving the liver and kidney functions of the calf, and regulating and enhancing the immunity.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating sepsis and a traditional Chinese medicine preparation and application thereof. The traditional Chinese medicine composition consists of the following components in parts by weight: 15-40 parts of honeysuckle stem, 10-25 parts of coix seed, 5-20 parts of rheum officinale, 5-20 parts of patrinia, 5-25 parts of radix aconiti lateralis preparata, 5-20 parts of cassia twig, 3-17 parts of bighead atractylodes rhizome, 2-10 parts of coptis chinensis and 3-10 parts of honey-fried licorice root. The traditional Chinese medicine composition is based on the core pathogenesis that sepsis is externally infected with heat toxin, is internally impressed with damp heat, obstructs veins and is damaged in yang qi, adopts the methods of clearing away heat and toxic materials, promoting diuresis and expelling pus, warming yang and dredging collaterals and strengthening the body resistance to eliminate pathogenic factors, is used for resisting sepsis through multi-mechanism synergy, and is particularly suitable for patients with sepsis with the syndromes of exuberance of heat toxin, damp heat and obstruction of stasis and deficiency of yang qi. The traditional Chinese medicine composition combines cold and warm effects, combines purgation and tonification effects, and has the characteristics of high safety and small side effects.

This invention belongs to the technical field of skin disease treatment products, specifically relating to a topical hot compress for treating scleroderma and its preparation method. The topical hot compress for treating scleroderma is made from the following raw materials in parts by weight: 20-40 parts of Artemisia argyi, 20-40 parts of Cinnamomum cassia, 10-20 parts of Sparganium stoloniferum, 10-20 parts of Curcuma zedoaria, 10-20 parts of Loranthus parasiticus, 15-30 parts of Gynostemma pentaphyllum, 10-20 parts of Spirodela polyrhiza, 15-30 parts of Spirodela polyrhiza, 15-30 parts of Ephedra sinica, 20-40 parts of Clematis chinensis, 5-15 parts of Eupolyphaga sinensis, 15-25 parts of Eriocaulon buergerianum, 5-15 parts of Carthamus tinctorius, 3-6 parts of Dracaena cochinchinensis, 3-6 parts of processed Strychnos nux-vomica, 20-40 parts of Vaccaria segetalis, 20-40 parts of Astragalus membranaceus, 10-20 parts of Magnolia officinalis, 10-20 parts of Aconitum carmichaelii, and 22-40 parts of rice wine. This invention is a topical medication that eliminates the need for oral administration, treating the disease externally and guiding the pathogenic factors to a cure. It avoids the inconvenience of bitter medications and effectively relieves symptoms and promotes the cure of localized scleroderma.

The application discloses a hot compress plaster for promoting blood circulation and removing blood stasis and a preparation method thereof, and belongs to the technical field of external preparations of traditional Chinese medicines. The hot compress plaster is prepared from Prunella vulgaris, Gastrodia elata, Cyperus rotundus and other Chinese medicines and beeswax. The preparation method comprises the steps of raw material screening and pretreatment, medicine powder preparation, base preparation, mixing and forming, cooling and shaping and packaging and storage. The application is based on the pathogenesis of Qi stagnation and blood stasis and phlegm and blood stasis intermingling, follows the principles of promoting blood circulation, removing phlegm and resolving stasis, strengthening healthy energy and eliminating pathogenic factors, and can effectively improve the blood circulation of the body and dissipate tumor nodules in combination with the warm action of hot compress. The hot compress plaster is flexible in proportioning and can be personalized, is simple in preparation, safe in use, small in side effect, suitable for the auxiliary treatment of tumor nodules, and has high clinical application value and popularization prospect.

The invention discloses a modified lung heat clearing decoction traditional Chinese medicine compound and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, the compound comprises the following components by mass: 6 g of raw ephedra, 10 g of almond, 30 g of gypsum, 6 g of raw licorice, 10 g of platycodon grandiflorum, 10 g of burdock, 10 g of scutellaria baicalensis, 15 g of polygonum cuspidatum, 10 g of schizonepeta, 10 g of notopterygium root, and 10 g of stiff silkworm. According to the traditional Chinese medicine composition, exterior syndrome relieving medicines are added to export pathogenic factors, meanwhile, medicines for ventilating the lung, depressing qi, relieving sore-throat and inducing resuscitation are added to quickly relieve main symptoms and recover lung functions, and medicines with the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, promoting diuresis and dredging collaterals are selected to more comprehensively inhibit viruses and relieve pathological damage of organisms; and a co-decoction granule technology is adopted, so that the drug effect is stable, and the'unification 'and the optimal drug effect of a complex prescription are guaranteed.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition, a preparation method and application thereof. Specifically, based on the theory of traditional Chinese veterinary medicine of'strengthening the body resistance and eliminating pathogenic factors, and treating the root and branch', aiming at the pathogenesis of 'deficiency in the root and excess in the branch' of low immunity in animals, eight kinds of medicinal materials are scientifically screened to form a traditional Chinese medicine compound with the effects of tonifying qi and nourishing blood, invigorating the spleen and kidney, dredging collaterals and eliminating dampness, and clearing heat and detoxifying. Through the verification of a cyclophosphamide-induced low immunity mouse model, the traditional Chinese medicine composition can significantly improve the mental state of the mice, restore the body weight and thymus / spleen index, repair the pathological damage of the spleen tissue, and adjust the inflammatory factor level in the serum and spleen tissue. In addition, in a Marek's disease virus infection model, the traditional Chinese medicine composition combined with the Marek's disease virus vaccine can significantly reduce the viral load in the peripheral blood, liver and spleen, and reduce the liver enlargement, hemorrhage and microscopic structure damage, showing a good immune synergistic effect.

The invention provides a probe combination and a kit for detecting knee osteoarthritis and application of the probe combination and the kit, belongs to the technical field of biological medicine detection, and can solve the technical problems of low speed, relatively low detection flux, high detection cost and the like of the existing knee osteoarthritis risk or pathogenesis factor detection means. The probe combination comprises 112 probe sequences for detecting 56 target genes, the nucleotide sequences of the 112 probe sequences are respectively shown as SEQ ID NO.1-SEQ ID NO.112, and each target gene corresponds to at least two probe sequences; wherein the 56 target genes comprise 20 bone metabolism and cartilage formation related genes, 19 inflammatory response related genes, 8 extracellular matrix related genes and 9 drug metabolism and curative effect related genes. The method has the characteristics of high throughput, rapidness, accuracy and the like. The method can be applied to genetic risk assessment of knee osteoarthritis and the like.

This invention relates to a traditional Chinese medicine composition for treating primary liver cancer. The composition is made from the following raw materials in parts by weight: 25-30 parts of *Codonopsis pilosula*, 10-15 parts of *Cremastra appendiculata*, 15-20 parts of *Scutellaria barbata*, 20-25 parts of *Curcuma zedoaria*, 10-15 parts of *Polygonum cuspidatum*, and 5-10 parts of *Citrus reticulata*. This invention also provides applications of the traditional Chinese medicine composition. The "Liver-Clearing Formula" of this invention uses a combination of various traditional Chinese herbs, focusing on "damp-heat, phlegm, qi stagnation, and blood stasis." The six herbs are combined to both attack and tonify, supporting the body's resistance and eliminating pathogenic factors, aiming to achieve the goal of strengthening the body's resistance and reducing pathogenic factors, thus achieving the effects of clearing heat and dampness, promoting qi circulation, resolving phlegm, and breaking up blood stasis. This helps improve the patient's quality of life and prognosis. At the same time, the use of this traditional Chinese medicine is expected to reduce the toxicity and enhance the efficacy of Western medicine, reducing adverse reactions and achieving the best therapeutic effect.

The invention discloses Yao-strengthening ointment for improving immune disorder of an HIV infected person. The Yao-strengthening ointment is mainly prepared from the following raw materials: astragalus membranaceus, poria cocos, rhizoma cimicifugae, radix achyranthis bidentatae, roasted ephedra, prepared radix aconiti carmichaeli, asarum, roasted liquorice, philippine flemingia root, giantleaf ardisia rhizome, caulis sinomenii, tripterygium wilfordii and gynostemma pentaphylla. The preparation method of the Zhuang Yao ointment comprises the steps of medicinal material treatment, medicinal material extraction and ointment preparation. The whole formula is mainly used for strengthening the body resistance (tonifying qi and warming yang) and eliminating evil (dehumidifying, activating blood and detoxifying), through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine aims at core qi deficiency and yang deficiency of immune disorder of HIV infected people and also eliminates pathological products such as dampness, stasis and heat toxin, meanwhile, honey-fried licorice root is used for regulating the medicine property, CD4 cells of the HIV infected people can be improved, immune disorder can be improved to a certain extent, and immune reconstitution is promoted.

The invention provides a construction method and application of a high-precision controllable rat molar wear model, and belongs to the technical field of oral medicine animal models. According to the method, after the rat is fed with hard food, anesthesia is performed, the oral cavity is opened, and the rat incisor is stimulated by selecting or not selecting any one or more modes of acid erosion and thermocycling stimulation, so that the high-precision controllable rat molar wear model is obtained. The invention develops an acid etching-hard food-cold and hot cycle three-factor time sequence controllable modeling system by simulating the diversity reasons of clinical wear, controlling the types of pathogenic factors and the model construction time to accurately control the severity degree of wear and simulating the progressive process of human functional occlusion wear. A wear model is established in the SD rat molar. The wear form of the model is a composite horseshoe-shaped wear pit which is highly matched with the morphology and biology of human pathological wear. As an experiment is carried out on the living medullary teeth, the pathological manifestation is consistent with the pathological manifestation of clinical progressive wear.

The invention discloses a three-dimensional artificial intelligence model for pneumonia pathogenesis discrimination based on a CT image, and relates to the technical field of medical imaging, and the three-dimensional artificial intelligence model comprises the following steps: carrying out patient identity information anonymization processing; performing three-dimensional resampling processing on the image of the CT image; the U-Net model is preprocessed; and pneumonia pathogenesis identification and disease course staging are completed. According to the method, a model capable of accurately distinguishing two different pathogens of the mycoplasma pneumonia and the psittaci pneumonia and a model capable of distinguishing the morning course, the noon course and the evening course of the mycoplasma pneumonia and the psittaci pneumonia are established, a set of complete and feasible solution is provided for AI-assisted accurate pneumonia diagnosis and treatment, unified and accurate cutting of focuses of various different special diagnoses is achieved, and the accuracy of diagnosis and treatment is improved. Compared with the prior art, manual intervention is reduced, a whole process scheme from original DICOM to precise focus cutting is completed, clinical feasibility is improved, fine but key differences are captured, and a pneumonia pathogenesis identification model with high precision is screened early.

The invention relates to the technical field of animal model construction, and particularly provides a gavage agent for constructing a metabolism-related fatty liver disease animal model as well as a preparation method and application of the gavage agent. The gavage agent comprises cholesterol, sodium cholate, Tween 80 and corn oil according to a specific ratio, a quantitative gavage administration mode is adopted, and the technical problems that an existing MAFLD animal model is long in modeling period, high in cost and large in individual difference, and a single pathogenic factor cannot be accurately researched are solved. The gavage agent is used for building a rat model and can efficiently and stably induce an MAFLD animal model with typical liver fatty degeneration and lipid disorder characteristics within 8 weeks, the modeling period is shortened by more than 4 weeks compared with that of a traditional high-fat feed method, the individual difference of the model is remarkably reduced through accurate dosage control, and the method is suitable for large-scale popularization and application. And meanwhile, the single-day modeling cost is controlled at a relatively low level.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating diseases caused by external pathogenic factors and sequelae thereof. In the present application, the traditional Chinese medicine composition is derived from a folk traditional Chinese medicine inheritance compound Nanteng Zhitong prescription, and is prepared from raw materials including Shishengteng, Wacaocen, Ganjiang and Wangguacen. The present application first finds that the traditional Chinese medicine composition has obvious effective therapeutic effect on diseases caused by external pathogenic factors and sequelae thereof. Meanwhile, the traditional Chinese medicine composition has diverse action targets, is not prone to drug resistance, has no or less adverse reactions, and has broad development and popularization prospect.

The application discloses a rice rice blast occurrence and prevalence prediction method, a prediction device and electronic equipment. The prediction method comprises the following steps: acquiring data of pathogenic factors and actual occurrence indexes of rice blast in different regions for at least five years; screening an influence factor of the actual occurrence indexes of rice blast through a stepdisc process according to the data of the pathogenic factors and the actual occurrence indexes of rice blast for at least five years; establishing a discriminant function through a discrim process according to data of the influence factor; and inputting data of the influence factor of the current year into the discriminant function to obtain a predicted occurrence index of rice blast in the current year. The prediction device comprises an acquisition module, an influence factor screening module, a discriminant function establishing module and a prediction module. The electronic equipment comprises a memory and a processor. The application improves the accuracy of the prediction of the occurrence and prevalence of rice blast, and can effectively guide comprehensive disease control in a timely manner.

The invention provides a livestock and poultry state evaluation method and system based on a multi-modal sensor and artificial intelligence, and relates to the technical field of livestock and poultry health monitoring, and the method comprises the steps: firstly obtaining the physiological metabolism, activity track and field microenvironment data of a livestock and poultry individual, and constructing a multi-modal time sequence diagram; then, a space-time diagram neural network is combined with a group normal behavior atlas database to identify an individual abnormal mode and generate an abnormal mode vector; then, calculating the importance of each node in the time sequence diagram based on a historical epidemic disease case database and a gradient boosting tree to extract key index data; then, state evolution is carried out in combination with the key indexes and time sequence information in the abnormal mode vector, and a dynamic state sequence is generated; finally, a random forest model is adopted to carry out feature learning on the sequence, a state evaluation report is generated, abnormal individuals can be accurately locked, key pathogenic factors can be efficiently recognized, and then the accuracy and timeliness of livestock and poultry epidemic disease early warning are improved.

This invention relates to the field of preservation films, specifically to a nanocomposite film for apple storage and preservation and its preparation method, comprising a base film and a coating liquid. This invention combines a cellulose nanocrystal base film with an evaporation-induced self-assembled layered ordered structure with a superhydrophobic cellulose ester coating. A cyclodextrin-laccase cascade system is integrated in the base film to specifically capture and enzymatically degrade the pathogenic factors of tiger skin disease. A micro-nano rough structure is constructed in the coating to encapsulate humidity-triggered microencapsulated degradation enzymes. Compared with existing technologies, this invention simultaneously achieves multiple effects on a single film: passive regulation of the respiratory microenvironment, active removal of stored pathogens, surface anti-condensation, and accelerated degradation on demand after disposal. It leaves no harmful residues throughout its entire life cycle and has broad application prospects in the cold chain logistics and green packaging of fresh agricultural products.

The application belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating Klebsiella pneumoniae pneumonia and a preparation method thereof. The traditional Chinese medicine composition is prepared from eight raw medicinal materials of Zhejiang fritillary bulb, white mulberry bark, Chinese plume-pod seed, dandelion, platycodon root, lily, apricot kernel and poria cocos. The composition has the effects of promoting lung and clearing heat, relieving cough and reducing sputum, and strengthening body resistance and eliminating pathogenic factors. Pharmacodynamic experiments show that the composition has a significant therapeutic effect on Klebsiella pneumoniae pneumonia.

The present application relates to the technical field of pharmaceutical compositions, and discloses a traditional Chinese medicine composition for preventing and alleviating radiation-induced lung injury, which comprises, by mass fraction, 10-12 parts of radix astragali, 9-12 parts of north radix notoginseng, 9-12 parts of rhodiolae, 5-8 parts of mulberry bark, 5-8 parts of cortex lycii, 5-8 parts of salvia miltiorrhiza, 5-8 parts of raw licorice, 5-8 parts of euphorbiae fischerianae semen, 3-5 parts of honeyed loquat leaf, 3-4 parts of jujube, 3-4 parts of radix stephaniae tetrandrae, 3-4 parts of radix scophulariae, and 3-4 parts of radix scophulariae. The composition is based on tonifying qi and nourishing yin, and aims at clearing heat and toxic material, resolving phlegm and removing blood stasis, and is characterized by supporting healthy qi and eliminating pathogenic factors, moistening dryness and dredging collaterals, and is suitable for qi and yin deficiency, heat and toxic material damaging the lung, and phlegm and blood stasis blocking collaterals, and is a good formula for protecting the lung, resisting radiation, and repairing lung injury.

The present application relates to the field of medical systems. The present application discloses a kind of intelligent management system and its management method for intelligent medical treatment, it includes individual gene, environmental exposure and life habit data acquisition module acquisition;Disease association network construction module constructs network containing three kinds of risk factor nodes and association according to this;Data processing module processes node and calculates disease type and risk probability;Risk partition module partitions output risk sub-network according to factor type;Risk assessment module generates evaluation results and intervention suggestions according to sub-network. Each module is connected in turn.The present application captures pathogenic factors comprehensively through gene, environmental, life habit data acquisition;Structured association network can be constructed to visually display factor relationship;Ensure that result is scientific through data cleaning and other processing;Sub-network is divided to realize hierarchical management and factor collaborative capture;Dynamic module real-time monitoring feedback;Static and dynamic cooperation form time-space continuous evaluation to adapt to multiple needs.

This invention relates to a traditional Chinese medicine composition for treating chronic cervicitis complicated with HPV infection. The composition is made from the following raw materials in parts by weight: 26-34 parts raw Astragalus membranaceus, 26-34 parts Smilax glabra, 11-19 parts Toona sinensis root bark, and 26-34 parts raw Coix lacryma-jobi. This invention also provides the uses of the traditional Chinese medicine composition. In this invention, raw Astragalus membranaceus is the principal ingredient, tonifying Qi and strengthening the body's resistance; Smilax glabra and Toona sinensis root bark clear heat and dry dampness; and raw Coix lacryma-jobi dispels dampness and promotes tissue regeneration, serving as assistant ingredients; the entire formula works synergistically to strengthen the body's resistance, eliminate pathogenic factors, and promote tissue regeneration.

The invention provides an additive for promoting intestinal mucosa repair of laying hens as well as preparation and application thereof. The additive is a fermentation supernatant of Lactobacillus salivarius 8-2, and the preservation number of the strain is CGMCC (China General Microbiological Culture Collection Center) NO.30612. The invention further discloses a preparation method of the feed additive. The preparation of the fermentation supernatant only needs a biochemical incubator and a centrifugal machine, and the operation difficulty is low. By adding the additive with proper concentration into the conventional chick feed, the aims of relieving intestinal mucosa injury, improving the activity of intestinal stem cells and promoting intestinal mucosa repair can be fulfilled. The additive disclosed by the invention has the characteristics of safety, greenness, no toxicity, harmlessness and no residue, and can effectively relieve the problem of intestinal injury caused by pathogenic factors in chick breeding. The preparation cost is low, the cost is reduced to 0.001 yuan / chicken / day, and the feed is suitable for large-scale popularization and application. The method is an important way for realizing antibiotic-free culture, and has a wide market application prospect.

This invention discloses a pathogenic factor of sugarcane smut and its application. This invention discovers... SsPHACA Application in regulating sexual mating, SDS tolerance, and pathogenicity of *Ustilago maydis*. This invention utilizes the principle of homologous recombination, employing a PEG-mediated protoplast transformation method to... SsPHACA Knockout and replacement were performed, resulting in knockout mutants and replacement strains. The results showed... SsPHACA Knockout resulted in a reduced ability of *Ustilago canescens* to form dimycelia through sexual mating, increased susceptibility to SDS, and decreased pathogenicity, indicating... SsPHACA This gene plays a crucial role in regulating the sexual mating, SDS tolerance, and pathogenicity of *Ustilago maydis*. This invention provides a novel target gene for the development of effective fungicides.

The invention discloses a children Maxingshigan mixture, which relates to the technical field of traditional Chinese medicine pharmacy, and has the technical key points that the children Maxingshigan mixture is prepared into an oral liquid dosage form by mixing ephedra, bitter apricot kernel, gypsum, liquorice, folium isatidis, houttuynia cordata, trichosanthes peel and scutellaria baicalensis according to a specific weight ratio and adding auxiliary materials. The preparation method comprises the following steps: pretreating the raw materials, decocting and extracting twice, merging filtrate, refrigerating and finely filtering, concentrating in vacuum, preparing liquid to a constant volume, filtering and filling at a terminal, sterilizing and the like. The mixture disclosed by the invention has the effects of diffusing lung, depressing qi, clearing heat and eliminating phlegm, is mainly used for treating heat cough and asthma syndromes caused by exogenous evil entering the interior and transforming heat in children, and is particularly suitable for patients with acute bronchitis with the syndromes. The dosage form is convenient for children to take, stable in quality and exact in curative effect.

The invention relates to a Chinese-Western compound preparation for treating skin ulcer, and belongs to the technical field of Chinese-Western compound preparations. The Chinese and western compound preparation is prepared from a Danhuang anti-inflammatory preparation and a temperature-sensitive hydroxybutyl chitosan wound-protecting dressing, wherein the Danhuang anti-inflammatory preparation is prepared from astragalus membranaceus, salvia miltiorrhiza, honeysuckle, golden cypress, spina gleditsiae, angelica sinensis and rheum officinale. The Danhuang anti-inflammatory preparation provided by the invention has better effects of activating blood, detoxifying, strengthening body resistance and detoxifying, is clinically used for treating various skin ulcers, and has a better treatment effect.