Flavored lung-heat-clearing traditional Chinese medicine compound and preparation method thereof

Abstract

The invention discloses a modified lung heat clearing decoction traditional Chinese medicine compound and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, the compound comprises the following components by mass: 6 g of raw ephedra, 10 g of almond, 30 g of gypsum, 6 g of raw licorice, 10 g of platycodon grandiflorum, 10 g of burdock, 10 g of scutellaria baicalensis, 15 g of polygonum cuspidatum, 10 g of schizonepeta, 10 g of notopterygium root, and 10 g of stiff silkworm. According to the traditional Chinese medicine composition, exterior syndrome relieving medicines are added to export pathogenic factors, meanwhile, medicines for ventilating the lung, depressing qi, relieving sore-throat and inducing resuscitation are added to quickly relieve main symptoms and recover lung functions, and medicines with the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, promoting diuresis and dredging collaterals are selected to more comprehensively inhibit viruses and relieve pathological damage of organisms; and a co-decoction granule technology is adopted, so that the drug effect is stable, and the'unification 'and the optimal drug effect of a complex prescription are guaranteed.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a modified Qingfei Yin (lung-clearing decoction) traditional Chinese medicine compound and its preparation method. Background Technology

[0002] 1. Current Climate and Pathogenic Characteristics (Natural Environment): Modern influenza is often not caused by a single pathogenic factor (warmth), but frequently involves external pathogens such as wind, cold, and dampness. Especially during seasonal transitions, patients often initially contract wind, cold, and dampness, but due to their constitution or the characteristics of the virus, these pathogens quickly penetrate deeper and transform into heat, manifesting as a complex state of "external cold and internal heat" or "external obstruction and internal stagnation." The original prescription lacks medications to expel pathogens on the surface. If the surface qi is blocked, the pathogens have no way to escape and are completely stagnant internally. Even with heavy use of heat-clearing herbs, the effect is diminished, and it may even lead to a deeper heat. Therefore, it is necessary to add exterior-releasing herbs to provide an outlet for the pathogens.

[0003] 2. Patient's Constitution and Pathological Characteristics (Human Environment): Modern people experience high levels of stress and have complex diets, resulting in a constitution that is often characterized by a mixture of deficiency and excess. After influenza infection, the lung's function of dispersing and descending qi is severely disrupted, commonly manifesting as severe cough, sore throat, and body aches. The original formula is weak in dispersing and descending lung qi and relieving sore throat and pain. Ephedra can only disperse lung qi, lacking the coordination of herbs that descend lung qi, making it difficult to harmonize qi. Therefore, it is insufficiently targeted at severe cough and sore throat. Thus, it is necessary to enhance the dispersing and descending of lung qi, and the relieving of sore throat and opening of the orifices, in order to quickly alleviate the main symptoms and restore lung function.

[0004] 3. Viral Pathogenic Characteristics and Modern Pharmacology (Viral Environment): Modern influenza viruses are highly virulent and easily cause strong inflammatory responses (referred to as "toxic heat" or "blood stasis heat" in Traditional Chinese Medicine), leading to high fever, pain, and even pneumonia. The original formula, *Hedyotis diffusa*, has a strong effect in clearing heat and detoxifying, but it is relatively weak in "removing blood stasis and unblocking the meridians." Its effect can be further enhanced for deep inflammation and pain caused by viruses. Therefore, it is necessary to select drugs that combine the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and clearing dampness and unblocking the meridians, in order to more comprehensively inhibit the virus and reduce pathological damage to the body.

[0005] 4. Technical Advantages of Co-Decoction Granules: Utilizing co-decoction granule technology ensures stable efficacy, guaranteeing the "unity" and optimal efficacy of complex formulas; stable quality ensures reliable treatment, providing consistent support for acute disease treatment. Convenient to use, it can be prepared and taken immediately, is easy to carry, improves compliance, enables early intervention, and cuts off disease progression. Component retention ensures the effective implementation of key treatment methods. Summary of the Invention

[0006] The present invention aims to provide a modified Qingfei Decoction, a traditional Chinese medicine compound, and its preparation method, in order to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A modified lung-clearing decoction, characterized in that: the compound components, by weight, include 6g of raw ephedra, 10g of apricot kernel, 30g of raw gypsum, 6g of raw licorice, 10g of platycodon, 10g of burdock fruit, 10g of scutellaria, 15g of polygonum cuspidatum, 10g of schizonepeta, 10g of notopterygium root, and 10g of silkworm.

[0009] A method for preparing a modified Qingfei Yin (lung-clearing decoction) traditional Chinese medicine compound, characterized by the following preparation steps:

[0010] S1. First decoct raw ephedra, then add other medicinal ingredients except raw gypsum;

[0011] S2. Add gypsum later, filter, heat the filtrate to 50°C and concentrate, then set aside.

[0012] S3. Add an appropriate amount of dextrin, granulate, dry, and sizing.

[0013] Furthermore, the relative density of the concentrated filtrate is 1.08~1.12 g / cm³.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] 1. The optimized core framework of the prescription is a modified version of Ma Xing Shi Gan Tang, which incorporates the classic formula "Ma Xing Shi Gan Tang" as its basic framework. Raw ephedra promotes lung function, apricot kernel descends lung qi, raw gypsum clears heat, and raw licorice harmonizes and relieves cough, establishing a synergistic mechanism of "promoting, descending, and clearing." This allows lung qi to be dispersed and descended smoothly, thus relieving asthma and cough more quickly and restoring the normal physiological function of the lungs—a fundamental treatment strategy.

[0016] 2. The optimized formula for relieving exterior symptoms and expelling pathogens includes Schizonepeta and Notopterygium, aiming to open the skin and pores and induce sweating to relieve exterior symptoms. This achieves "dual relief of both exterior and interior," because Schizonepeta and Notopterygium can dispel pathogens on the surface, open the closed pores, and provide a channel for the internal heat toxins to be released outward. This can effectively prevent the pathogens from further penetrating inward, resulting in more thorough fever reduction and a shorter course of illness;

[0017] 3. To soothe the throat and relieve cough, the optimized formula includes Platycodon grandiflorus, Arctium lappa, and Bombyx batryticatus. Platycodon grandiflorus clears the lungs and soothes the throat, acting as a "boat and oar" to guide the medicine upwards; Arctium lappa dispels wind, soothes the throat, and detoxifies; Bombyx batryticatus dispels wind, resolves phlegm, and disperses nodules. The three work synergistically to target the throat, a vital passageway, and powerfully target the core symptoms of the respiratory tract. These three herbs can directly relieve sore throat and hoarseness, dispel wind and resolve phlegm, reduce the severity of cough, and significantly improve patient comfort.

[0018] 4. The optimized formula for clearing heat and detoxifying includes Polygonum cuspidatum, which enhances its heat-clearing and detoxifying effects. Modern pharmacology has also confirmed its good antiviral properties. It has a broader antiviral spectrum and also possesses the effect of "activating blood circulation and unblocking collaterals." The addition of Polygonum cuspidatum not only clears heat toxins but also improves blood stasis caused by excessive heat and toxins (corresponding to microcirculatory disorders and inflammatory responses in modern medicine), thus being more beneficial in relieving systemic muscle soreness and preventing heat toxins from damaging the collaterals and entering the bloodstream. Attached Figure Description

[0019] Figure 1 A diagram illustrating the preparation steps of a modified Qingfei Yin (lung-clearing decoction) traditional Chinese medicine formula and its preparation method; Detailed Implementation

[0020] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments:

[0021] like Figure 1 As shown, the present invention provides a modified Qingfei Yin (lung-clearing decoction) traditional Chinese medicine compound and its preparation method, the components of which include: 6g of raw ephedra, 10g of apricot kernel, 30g of raw gypsum, 6g of raw licorice, 10g of platycodon, 10g of burdock fruit, 10g of scutellaria, 15g of polygonum cuspidatum, 10g of schizonepeta, 10g of notopterygium root, and 10g of silkworm.

[0022] The preparation steps are as follows:

[0023] First decoct raw ephedra, then add other medicinal ingredients except for raw gypsum, followed by raw gypsum, filter, and concentrate the filtrate to a relative density of 1.08~1.12 (50℃) for later use; add an appropriate amount of dextrin, granulate, dry, and granulate.

[0024] The prepared modified Qingfei Decoction has the effects of clearing the lungs and resolving phlegm, detoxifying and expelling pathogens. In the formula, raw ephedra and raw gypsum are the chief herbs, which promote lung function, relieve asthma, release the exterior and expel pathogens, and at the same time clear lung heat to generate fluids; apricot kernel promotes lung qi and relieves asthma and cough; platycodon opens the lungs and promotes qi, promotes lung function and resolves phlegm; burdock seed dispels wind and heat, detoxifies and soothes the throat; scutellaria clears heat and dries dampness; polygonum cuspidatum resolves phlegm and stops cough, clears heat and promotes diuresis; schizonepeta releases the exterior and dispels wind; notopterygium releases the exterior and dispels cold; silkworm dispels wind, resolves phlegm and relieves pain, all of which are the assistant herbs; raw licorice invigorates qi and harmonizes the middle jiao, and regulates cold and heat, and promotes the downward movement of qi, serving as the adjuvant herbs.

[0025] Clinical trial example:

[0026] The optimized prescription is currently undergoing a randomized controlled clinical trial, and the preliminary analysis results are as follows:

[0027] Patients were divided into a traditional Chinese medicine (TCM) group (using Jiawei Qingfei Yin granules combined with conventional Western medicine treatment) and a control group (using conventional Western medicine treatment) based on whether they took Jiawei Qingfei Yin. The TCM symptom scoring scale was used to assess patients' symptoms such as fever, cough, and sore throat on the day of consultation and on days 3 and 7 after treatment. The degree of improvement in TCM symptom scores before and after treatment was compared between different groups using paired rank-sum tests. The differences in the degree of improvement in overall symptoms, major symptoms, and minor symptoms between the TCM group and the control group were compared using Wilcoxon tests. A total of 66 influenza patients were included so far. Preliminary analysis suggests that the combination of Jiawei Qingfei Yin and conventional Western medicine treatment can better improve the clinical symptoms of influenza patients.

[0028] Case 1: Mr. Liu, male, 75 years old, Han nationality, visited on January 7, 2024. Height: 1.76m, weight: 86kg, BMI: 27.76kg / m². 2 On January 7, 2024, the patient suddenly developed a fever without any obvious cause, with a maximum temperature of 39°C, accompanied by cough and sputum production, with alternating yellow and white sticky sputum, sore throat, muscle aches, thirst, and a red tongue with a thick, greasy yellow coating. Physical examination revealed a temperature of 39°C, slightly enlarged tonsils, and mild pharyngeal congestion. Past medical history: history of hypertension and coronary heart disease, which were controlled with regular medication. Blood tests and influenza virus testing confirmed a positive result for influenza A. Treatment: Traditional Chinese medicine: 3 doses of Jiawei Qingfei Yin granules, twice daily; Antiviral: Oseltamivir 75 mg, twice daily, orally.

[0029] Follow-up three days later: 24 hours after taking the medication, the patient's temperature dropped to 37.7℃; 48 hours after taking the medication, the temperature dropped to 37.0℃; and the temperature returned to normal on the third day. Cough and sputum production were reduced, with only a small amount of white sputum remaining; sore throat and muscle aches disappeared.

[0030] Follow-up seven days later: The patient's body temperature returned to normal, all symptoms disappeared, and there was no discomfort.

[0031] Case 2: Ms. Cao, female, 19 years old, Han nationality, visited the clinic on January 11, 2024. Height: 1.65m, weight: 50kg, BMI: 18.37kg / m². 2 On January 11, 2024, the patient suddenly developed a fever without any obvious cause, with a maximum temperature of 39.5℃, accompanied by cough, expectoration of yellow, sticky sputum, sore throat, muscle aches, thirst, and a red tongue with a yellow, greasy coating. Physical examination revealed a temperature of 39.5℃, enlarged tonsils, and pharyngeal congestion. The patient had no prior medical history. Blood tests and influenza virus testing confirmed a positive result for influenza A. Treatment: Traditional Chinese medicine: 3 doses of Jiawei Qingfei Yin granules, twice daily; Antiviral: Oseltamivir 75 mg, twice daily, orally.

[0032] Follow-up three days later: 24 hours after taking the medication, the patient's temperature dropped to 36.5℃; 48 hours after taking the medication, the temperature dropped to 36.3℃; and the temperature returned to normal on the third day. The cough lessened, there was no phlegm, and the sore throat and muscle aches disappeared.

[0033] Follow-up seven days later: The patient's body temperature returned to normal. All symptoms disappeared, and there was no discomfort.

[0034] Case 3: Mr. Jiang, male, 46 years old, Han nationality, visited the clinic on January 11, 2024. Height: 1.75m, weight: 72kg, BMI: 23.51kg / m². 2 On January 9, 2024, the patient suddenly developed a fever without any obvious cause, with a maximum temperature of 38.5℃, accompanied by cough, expectoration of yellow, sticky sputum, sore throat (worse when swallowing), muscle aches, persistent pain, significant fatigue, thirst, red tongue with a yellow, greasy coating, and a temperature of 38.5℃ upon examination. Enlarged tonsils and pharyngeal congestion were also observed. The patient had no prior medical history. Blood tests for influenza A confirmed a positive result. Treatment: Traditional Chinese medicine: Qingfei Yin granules, 3 doses, twice daily; Antiviral: Oseltamivir 75 mg, twice daily, orally.

[0035] Follow-up three days later: 24 hours after taking the medication, the patient's temperature was 38.6℃; 48 hours after taking the medication, the temperature dropped to 36.1℃; and the temperature returned to normal on the third day. The cough lessened, the sputum became less and whiter, and the sore throat and muscle aches were relieved, but fatigue persisted.

[0036] Follow-up seven days later: The patient's body temperature returned to normal, all symptoms disappeared, and there was no discomfort.

[0037] The above descriptions are merely embodiments of the present invention, and common knowledge such as specific technical solutions and / or characteristics are not described in detail here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the technical solutions of the present invention, and these should also be considered within the scope of protection of the present invention. These modifications and improvements will not affect the effectiveness of the implementation of the present invention or the practicality of the patent. The scope of protection claimed in this application should be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. A modified lung-clearing decoction, characterized in that: The compound ingredients, by weight, include 6g of raw ephedra, 10g of apricot kernel, 30g of raw gypsum, 6g of raw licorice, 10g of platycodon, 10g of burdock fruit, 10g of scutellaria, 15g of polygonum cuspidatum, 10g of schizonepeta, 10g of notopterygium root, and 10g of silkworm pupae.

2. A method for preparing a modified Qingfei Yin (lung-clearing decoction) traditional Chinese medicine compound, characterized in that: The preparation steps are as follows: S1. First decoct raw ephedra, then add other medicinal ingredients except raw gypsum; S2. Add gypsum later, filter, heat the filtrate to 50°C and concentrate, then set aside. S3. Add an appropriate amount of dextrin, granulate, dry, and sizing.

3. The preparation method of the modified Qingfei Decoction traditional Chinese medicine compound according to claim 2, characterized in that: The relative density of the concentrated filtrate is 1.08~1.12.

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