Traditional Chinese medicine composition for treating HPV infection and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating HPV infection and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The composition consists of ginseng, bighead atractylodes rhizome, poria cocos, liquorice, astragalus membranaceus, glossy privet fruit, polyporus umbellatus, lucid ganoderma, oldenlandia diffusa, sculellaria barbata, scutellaria baicalensis, isatis root, dandelion and lithospermum in specific parts by weight. The traditional Chinese medicine composition has the effects of supporting the healthy energy, clearing away heat and toxic materials, clearing damp and removing stasis, has the HPV negative conversion rate of more than 90% according to clinical verification, is suitable for cervical, perianal and skin type HPV infection, is safe and non-toxic, can be prepared into various dosage forms, and has extremely high clinical application value.

Description

A traditional Chinese medicine composition for treating HPV infection and its preparation method Technical Field (I)

[0002] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating human papillomavirus (HPV) infection, particularly cervical HPV infection, perianal HPV infection and cutaneous HPV infection, as well as its preparation and application. Background Technology (II)

[0004] HPV infection, especially persistent infection with high-risk HPV, is a significant contributing factor to cervical intraepithelial neoplasia, cervical cancer, and perianal and skin lesions. Current clinical treatment primarily relies on immune enhancement or physical resection of lesions, lacking direct and stable targeted therapies. Existing traditional Chinese medicine (TCM) formulas often focus on clearing heat and detoxifying, neglecting to strengthen the body's resistance and consolidating its foundation, resulting in unstable seroconversion rates and limited applicability. This invention provides a TCM composition that balances strengthening the body's resistance and eliminating pathogenic factors, is safe and highly effective, and has a wide range of applications. Summary of the Invention (III) Summary of the Invention

[0006] 1. Technical Solution

[0007] A traditional Chinese medicine composition for treating HPV infection, made from the following raw materials in parts by weight:

[0008] Ginseng 8g, Atractylodes macrocephala 15g, Poria cocos 15g, Glycyrrhiza uralensis 6g, Astragalus membranaceus 30g, Ligustrum lucidum 10g, Polyporus umbellatus 15g, Ganoderma lucidum 15g, Hedyotis diffusa 30g, Scutellaria barbata 15g, Scutellaria baicalensis 15g, Isatis indigotica 15g, Taraxacum mongolicum 15g, Lithospermum erythrorhizon 15g.

[0009] 2. Formulation Principles

[0010] This formula is based on the Four Gentlemen Decoction to invigorate the spleen, replenish qi, and support the body's resistance. It is combined with Astragalus membranaceus, Ligustrum lucidum, and Ganoderma lucidum to nourish the liver and kidneys and strengthen immunity. It is further supplemented with Polyporus umbellatus to promote diuresis and eliminate dampness. It is also combined with Hedyotis diffusa, Scutellaria barbata, Scutellaria baicalensis, Isatis indigotica, Taraxacum mongolicum, and Lithospermum erythrorhizon to clear heat, detoxify, disperse nodules, and resolve blood stasis. The whole formula strengthens the body's resistance, eliminates pathogens, and achieves HPV seroconversion.

[0011] 3. Beneficial effects

[0012] Clinically proven, this formula has an extremely high therapeutic effect on HPV infection:

[0013] 1. The HPV clearance rate can reach over 90%;

[0014] 2. Applicable to cervical HPV infection, effective regardless of whether there is intraepithelial lesion or whether surgery / conization treatment has been performed;

[0015] 3. It is applicable to both perianal and cutaneous HPV infections;

[0016] 4. Safe and without toxic side effects, suitable for long-term use;

[0017] 5. It can be prepared into various dosage forms such as decoction, granules, capsules, and oral liquid. Detailed Implementation Method (IV)

[0019] Example 1 (Decoction)

[0020] Weigh out the following ingredients: ginseng 8g, atractylodes macrocephala 15g, poria cocos 15g, licorice 6g, astragalus membranaceus 30g, privet fruit 10g, polyporus umbellatus 15g, ganoderma lucidum 15g, oldenlandia diffusa 30g, scutellaria barbata 15g, scutellaria baicalensis 15g, isatis indigotica 15g, dandelion 15g, and gromwell root 15g.

[0021] Soak in water for 30 minutes, then decoct as usual and concentrate to 400mL per dose. Take orally, one dose per day, divided into two administrations of 200mL each time, for 1-3 months as one course of treatment.

[0022] Example 2 (granules / capsules / oral liquid)

[0023] The composition can be extracted, concentrated, dried, and granulated using conventional pharmaceutical processes to produce granules, capsules, or oral liquids.

[0024] (v) Indications

[0025] It is used to treat cervical HPV infection, perianal HPV infection, and cutaneous HPV infection, including with or without intraepithelial lesions, and persistent infection after surgery.

Claims

1. A traditional Chinese medicine composition for treating HPV infection, characterized in that, It is made from the following ingredients in parts by weight: ginseng 8g, atractylodes macrocephala 15g, poria cocos 15g, licorice 6g, astragalus membranaceus 30g, privet fruit 10g, polyporus umbellatus 15g, ganoderma lucidum 15g, oldenlandia diffusa 30g, scutellaria barbata 15g, scutellaria baicalensis 15g, isatis indigotica 15g, dandelion 15g, and gromwell root 15g.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The HPV infection includes cervical HPV infection, perianal HPV infection, and cutaneous HPV infection.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is suitable for HPV infection with or without intraepithelial lesions, and persistent infection after cervical conization.

4. The traditional Chinese medicine composition according to claim 1, characterized in that, It can be prepared as a decoction, granules, capsules or oral liquid.

5. The use of the traditional Chinese medicine composition according to any one of claims 1 to 4 in the preparation of a drug for treating HPV infection.