The invention discloses a traditional Chinese medicine composition for treating tumors. The composition is prepared from Chinese blister beetles, dry frogs, venenum bufonis, centipede, scorpio, apiary, asarum sagittarioides, realgar, asarum, calomel, borneol, Mercurous chloride and mercuric chloride, semen persicae, paris polyphylla, bletilla, Thunberg Fritillary Bulb, kelp, seaweed, oyster, radixscrophulariae, dandelion, tortoise plastron, turtle shells, Houttuynia cordata, moutan bark, fructus forsythia, honeysuckle, root of rehmannia, root of common peony, feverfew, Sculellaria barbata, Chinese lobelia, concha meretricis seu cyclinae, bryozoatum, radix ranunculi ternate, lucid ganoderma, wikstroemia indica, selaginella doederleinii hieron, akebia quinata DC, Fallopia japonica and sanguisorba officinalis. The invention further discloses a preparation method and application of the traditional Chinese medicine composition for treating tumors. The traditional Chinese medicine composition is scientific and reasonable in ratio, synergic cooperation of all the raw materials is enhanced, the composition has the good effects of resisting cancers, relieving internal heat or fever, strengthening body resistance, eliminating evil, balancing yin and yang, improving the body immunity and disease resistance, various tumors can be effectively treated, the application range is wide, the safety is high, and the toxic and side effects are low.