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Pharmaceutical composition for treating cancers, pharmaceutical preparation as well as applications and production methods thereof

A technology of pharmaceutical preparations and compositions, which is applied in the field of pharmaceutical preparations for the treatment of cancer, can solve the problems of large dosage, unclear active ingredients and their mechanism of action, etc., and achieve the effects of fast curative effect, improvement of side effects, and obvious anti-tumor effect

Active Publication Date: 2011-10-26
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The technical problem to be solved by the present invention is to overcome the defects of large dosage, active ingredients and unclear mechanism of action in the existing traditional Chinese medicine preparations for treating cancer, and to provide a pharmaceutical composition for treating cancer with rapid curative effect, safety and quality control and its preparation method

Method used

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  • Pharmaceutical composition for treating cancers, pharmaceutical preparation as well as applications and production methods thereof
  • Pharmaceutical composition for treating cancers, pharmaceutical preparation as well as applications and production methods thereof
  • Pharmaceutical composition for treating cancers, pharmaceutical preparation as well as applications and production methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1: Preparation of A1 lyophilization

[0055] Take 100 mg of ginsenoside Rb1, 50 mg of ginsenoside Rg1, 100 mg of ginsenoside Re, 40 mg of astragaloside IV, 20 mg of versiflavone glucoside, 75 mg of syringin, and 5.25 mg of cantharidin, and add them to 5 ml of glycerin. After heating and dissolving in a water bath, add 5 ml of Span and mix well, then add 40g mannitol, add water for injection to dissolve and make up to 200ml, adjust the pH value to 3 with dilute hydrochloric acid, filter, fill in 5ml vials, 2ml each, freeze-dried, capped, 100 finished products were prepared, and each active ingredient was about 3.90 mg.

Embodiment 2

[0056] Example 2: Preparation of A2 lyophilization

[0057] Take 100 mg of ginsenoside Rb1, 50 mg of ginsenoside Rg1, 100 mg of ginsenoside Re, 40 mg of astragaloside IV, 20 mg of Verisoflavone glucoside, 75 mg of syringin, 6.3 mg of cantharidin, and 70 mg of norcantharidin, added to 20 ml of propylene glycol, and water bath. After heating and dissolving, add 20ml of Tween 80 and mix well, then add 120g of dextrin, add water for injection to dissolve and dissolve to 200ml, adjust the pH value to 3 with dilute hydrochloric acid, filter, and fill in 5ml vials, 2ml per bottle , freeze-drying, and capping to obtain 100 finished products, each of which is about 4.61 mg of active ingredient.

Embodiment 3

[0058] Example 3: Preparation of lyophilized A3

[0059] Take 90 mg of ginsenoside Rb1, 45 mg of ginsenoside Rg1, 110 mg of ginsenoside Re, 48 mg of astragaloside IV, 18 mg of Verisoflavone glucoside, 67.5 mg of syringin, and 5.8 mg of cantharidin, and add them to 10 ml of glycerin. After heating and dissolving in a water bath, add Mix 10ml of Tween 80, then add 60g of lactose, add water for injection to dissolve and make up to 200ml, adjust the pH to 4 with dilute hydrochloric acid, filter, fill in 5ml vials, 2ml per bottle, freeze-dried, capped , to obtain 100 finished products, each active ingredient is about 3.84mg.

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Abstract

The invention relates to a pharmaceutical composition for treating cancers, a pharmaceutical preparation as well as applications and production methods thereof. The pharmaceutical composition and the pharmaceutical preparation respectively contain a ginseng monomer component, an Astragalus root monomer component, a manyprickle acanthopanax monomer component and a blister beetle monomer component as well as optionally blister beetle monomer derivatives which are added as required. Preferably, the pharmaceutical composition and the pharmaceutical preparation contain 200 to 300 parts by weight of ginseng saponin monomer, 48 to 72 parts by weight of Astragalus root monomer, 60 to 90 parts by weight of manyprickle acanthopanax monomer and 4.2 to 6.3 parts by weight of blister beetle monomer. The pharmaceutical preparation is prepared by the conventional preparation process from the Chinese medicine extracts mentioned above and optionally blister beetle monomer derivatives in addition with adjuvant materials. The pharmaceutical composition and the pharmaceutical preparation thereof, provided by the invention, are used for treating various cancers, such as primary liver cancer, lung cancer, rectal cancer, malignant lymphoma and gynecological malignant tumors, show unexpected curative effects, and can achieve both cancer therapy and immunity enhancement and at the same time reduce the toxicity.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations for treating cancer, in particular to a pharmaceutical composition, pharmaceutical preparation, application and preparation method for treating cancer. Background technique [0002] In recent years, the incidence of lung cancer, primary liver cancer, colorectal cancer, and gynecological malignant tumors has increased year by year, and has become the most common malignant tumor that seriously endangers human health, bringing many changes to our society, economy, and life. . [0003] There are many cancer treatment products on the market, including chemical medicines and Chinese patent medicines. Chemical drugs have obvious therapeutic effects, but they also have many side effects, ranging from nausea and vomiting to severe cases resulting in bone marrow transplantation, leukopenia, blood diseases, and life-threatening. The Chinese patent medicine adjusts the functions of the h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P35/00A61K35/64
Inventor 窦啟玲杨青波汤琼黄成武
Owner GUIZHOU YIBAI PHARMA CO LTD
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