230 results about "Leukopenia" patented technology

A method for treating chemo therapy or radiation therapy side effects in a mammal undergoing chemotherapy and/or radiation therapy, the method comprising a step of administering to the mammal a therapeutically effective amount of a RAR antagonist or RAR inverse agonist which binds to receptors of the RARα, RARβ and RARγ subtypes is disclosed. Such side effects include chemoradiotherapy-induced alopecia, chemoradiotherapy-induced thrombocytopenia, chemoradiotherapy-induced leucopenia and chemoradiotherapy-induced neutropenia.

The invention relates to a sanguisorba root general saponin extract, method for preparation and use thereof, characterized in that, a sanguisorba root general saponin extract is provided which contains sanguisorba root general saponin, the percentage by weight is 10-90%, it can be utilized in the preparation of medicinal preparation for treating or preventing human leucocytopenia. The beneficial effects of the invention are, the preparation can be made into multiple doses including oral, tablet and capsule, and it is adapted for leucocytopenia of unknown reasons.

The invention relates to the application of recombinant Ganoderma lucidum immunoregulatory protein rLZ-8 in the preparation of medicine for treating leukopenia caused by chemotherapeutic drugs. The invention establishes a leukopenia disease model in rats caused by cyclophosphamide, and uses the recombinant Ganoderma lucidum immunoregulatory protein to conduct treatment experiments. The experimental results prove that the recombinant Ganoderma lucidum immunomodulatory protein has a very significant effect on increasing white blood cells.

The present invention provides an anticancer auxiliary medicine using 20(S)-protopanaxadiol as effective component and its application. Said medicine possesses the action of raising therapeutic effect of anticancer medicine, reducing toxicity of anticancer medicine, preventing and curing leukopenia due to radiotherapy and chemotherapy and raising immunity of human body, and can be used for auxiliary therapy of carcinoma.

The invention relates to a Chinese medicinal decoction for treating leucocytopenia caused by chemotherapy for cancer, and also to the process for preparation, wherein the constituents include (by weigh ratio) root of American ginseng 20g, hairy deerhorn 30g, ganoderma lucidum 20g, astragalus root 30g, fruit of barbary wolf berry 20g, Chinese caterpillar fungus 20g, dry human placenta 20g, aniseed 10g, prepared aconite root 20g, notoginseng 10g, euphoria longan steud 20g, white atractylodes rhizome 10g, Ficus carica 20g, dried rehmannia root 20g, psoralea fruit 10g, aloe 10g, turtle shell 10g, ophiopogon root 10g, ligustrum japonicum 20g, Siberian solomonseal rhizome 10g, broomrape 10g, mongloian snakegourd 10g, root of herbaceous peony 10g, coix seed 10g, cornus officinalis 10g, rhubarb horsetails 5g, cape jasmine 5g, schisandra fruit 10g, licorice root 10g, lily bulb 5g.

The invention relates to a freeze-drying composition of a posaconazole prodrug and a preparation method and application of the freeze-drying composition of the posaconazole prodrug. The freeze-drying composition has the advantages that the freeze-drying composition is high in water solubility, and safety of the freeze-drying composition is guaranteed due to the fact that cyclodextrins auxiliary materials need not to be added during the preparation of the freeze-drying composition; the freeze-drying composition is suitable for being used for treating various amphotericin-intolerant or refractory adult invasive fungal infections; the freeze-drying composition is used as a preventive drug for high-risk patients, the freeze-drying composition is applicable to patients above 13 years old and with impaired immunity and especially applicable to patients who have graft versus host disease (GVHD) after hematopoietic stem cell transplant, patients with leukemia and patients with long-term leukopenia due to chemotherapy; compared with control drugs such as fluconazole and itraconazole, the freeze-drying composition can effectively prevent invasive aspergillosis and can lower the mortality related to the invasive fungal infections.

The invention relates to a drug for treating leukopenia caused by concurrent chemoradiotherapy of malignant tumor and a preparation method thereof. The traditional drug for treating leukopenia caused by concurrent chemoradiotherapy of malignant tumor has incomplete absorption, low bioavailability and slow curative effect. The drug comprises seven types of traditional Chinese medicines, such as radix polygonum multiflorum preparata, glossy privet fruit, mulberry, yerbadetajo herb, white paeony root, raidx astragali and rhizoma cibotii. In the invention, the yerbadetajo herb is monarch drug, the glossy privet fruit and the mulberry have the effect of strengthening the nourishing of the liver and kidney of the monarch drug, and are ministerial drugs in the formula, and the raidx astragali is adjuvant drug and is matched with the monarch drug and the ministerial drugs to enhance the treating effect; the radix polygonum multiflorum preparata, the white paeony root and the rhizoma cibotii are used for assisting the monarch drug and the ministerial drugs to strengthen the treatment of syndrome of the deficiency of yin and blood. The whole formula has the effects of nourishing the liver and the kidney and benefiting vital energy and blood, are used for treating the symptoms such as leukopenia, mental fatigue and acratia, fatigue and weakness of waist and knee, dizziness and tinnitus, palpitation, shortness of breath, agrypnia, dryness of the throat, bad food intake and little eating and the like.

The invention provides a pharmaceutical composition for treating thrombocytopenia, which comprises gen-seng, epimeddium, radix astragali, angelica sinensis, radix rehmanniae preparata, spatholobus stems, hairyvein agrimony, and tangerine peel. The pharmaceutical composition of the invention can be prepared into clinically-acceptable dosage forms by adding routine auxiliary materials according to routine technology. The pharmaceutical composition of the invention has significant effect on treating thrombocytopenia and leucopenia, promoting proliferation of bone marrow hematopoietic stem cells, repairing damage and injury of bone marrow hematopoietic tissue caused by radiation, preventing marrow inhibition caused by radiotherapy and chemotherapy, or improving symptoms and increasing life quality of tumor patients, and has no side effect.

The invention provides oligomerization mannuronic acid and application of medicinal salts of oligomerization mannuronic acid in leucopenia prevention medicine. In in-vitro cell experiments, oligomerization mannuronic acid can obviously promote forming of colony-forming unit-granulocyte macrophage (CFU-GM), simultaneously can promote marrow stroma cells to breed and secrete CFU-GM and promote splenic lymphocytes to secrete interleukin-3. In vivo experiments further indicates that oligomerization mannuronic acid can obviously restrain reduction of white blood cells in mice caused by cyclophosphamide, increase the number marrow nucleated cell of the mice and promote forming of CFU-GM. Experiment results indicate that oligomerization mannuronic acid can be developed to be a clinical medicine capable of effectively preventing leucopenia.

The disclosure provides methods for treating, controlling or mitigating leukopenia (e.g. neutropenia) and/or thrombocytopenia, for example in the context of cancer chemotherapy, comprising administration of a monoacetyl-diacyl-glycerol compound, as well as compositions useful therefor.

The invention provides total ziyuglycoside extract and a preparation method and application thereof. The total ziyuglycoside extract has total saponins content up to 98.50%. Compared with existing methods, the preparation method has the advantage that content of total ziyuglycoside in the total ziyuglycoside extract is significantly increased, with activity of rising white blood cells being significantly improved. The preparation method is simple to operate, high in efficiency and low in production cost, and industrial production of the total ziyuglycoside is benefited. The rising white blood cells in the total ziyuglycoside extract prepared by the invention are high in activity, and a new pharmaceutical for the clinical treatment of leukopenia is provided.

The invention belongs to the fileds of chemistry and pharmacy, in particular to caffeic acid p-nitrophenyl ethyl ester of which the structural formula is as shown in formula I. The caffeic acid p-nitrophenyl ethyl ester has the effect of increasing leukocytes, can obviously increase the number of the peripheral blood leukocytes of mice with immunosuppression caused by cyclophosphamide, can be used for preparing medicaments for increasing the white blood cells, plays an important role in treating leukopenia after radiochemotherapy on malignant tumors and possibly has a good curative effect on the leukopenia caused by other pathogenic factors. The invention also provides a preparation method of the caffeic acid p-nitrophenyl ethyl ester, which comprises the following steps: heating caffeic acid and thionyl chloride in a polar organic solvent to carry out a refluxing reaction so as to generate caffeic acid acyl chloride, adding p-nitrophenyl ethanol, continuing to heat to carry out the refluxing reaction so as to generate the caffeic acid p-nitrophenyl ethyl ester, and finally separating and purifying by column chromatography to obtain pure caffeic acid p-nitrophenyl ethyl ester. Themethod has the advantages of high yield and low cost, is convenient to operate and the like.

The present invention provides methods for dosing patients with naphthalimides, including amonafide, amonafide salts, and analogs thereof based on N-acetyl transferase genotyping. The invention also provides methods for dosing the amount of granulocyte colony stimulating factor (GCSF) used in combination with naphthalimide to prevent or modulate leukocytopenia.

The invention requests to protect a traditional Chinese medicine composition prepared from the following medicinal raw materials in parts by weight: 5-20 parts of astragalus root, 1-5 parts of ginseng, 1-5 parts of magnolia vine fruit and 0.5-10 parts of ophiopogon root. The invention also provides a preparation method and application of the composition, and the composition can effectively treat chronic fatigue syndrome and leukopenia.

The invention discloses a medicine for treating post-chemotherapy leucopenia and a preparation method thereof. The medicine consists of the following raw materials in part by weight: 2 to 20 parts of ginseng, 5 to 50 parts of astragalus, 5 to 50 parts of gensing, 5 to 50 parts of largehead atractylodes rhizome, 5 to 30 parts of epimedium, 5 to 20 parts of malaytea scurfpea fruit, 5 to 30 parts ofChinese angelica, 5 to 50 parts of suberect spatholobus stem, 5 to 50 parts of medlar, 5 to 30 parts of dwarf lilyturf tuber, 3 to 25 parts of bupleurum, 3 to 35 parts of largetrifoliolious bugbane rhizome and 1 to 15 parts of pangolin scales. According to the preparation method, the Chinese medicinal composition is prepared according to a method for the conventional preparation of Chinese medicines, wherein the conventional preparation comprises a water decoction, an oral liquid, granules, capsules or powder and the like. According to the medicine, a prescription for treating post-chemotherapy leucopenia is created on the basis of clinical experiences of multiple years, and a curative effect is obvious.

The invention provides a compound capsule containing ginseng saponin Rb1, ginseng saponin Re, radix notoginseng saponin R1, tryptophan, threonine, leucine, valine, methionine, isoleucine, phenylalanine and lysine hydrochloride, wherein the compound capsule can also contain arginine hydrochloride and/or histidine hydrochloride. The preparation method of the capsule comprises the step of preparing various amino acids and saponin into coating micro-pills respectively. The capsule has stable quality, convenient transportation, storage and use and good absorbing effect. An advanced micro-pill coating preparation technique is adopted, the amino acids, the pseudo-ginseng saponin and the ginseng saponin are respectively prepared into the coating micro-pills with various colors, the quality is more stable by respective packaging, and the absorption of an organism is further promoted, thereby retaining the high potency of the capsule. The capsule has definite curative effect and wide adaptive disease, and clinical observation shows that the capsule can effectively enhance the immunity of the organism, can quicken the healing of wounds and has a very good curative effect on various leukopenia and gastrointestinal tract malabsorption diseases.

Adenosine receptor agonists, particularly an agonist which binds to the A3 adenosine receptor, are used for induction of production or secretion of G-CSF within the body, prevention or treatment of toxic side effects of a drug or prevention or treatment of leukopenia, particularly drug-induced leukopenias; and inhibition of abnormal cell growth and proliferation.

The invention provides a traditional Chinese medicine composition having the effects of tonifying kidney, replenishing essence, tonifying qi, nourishing blood and consolidating basis, and a preparation method and application thereof. The traditional Chinese medicine composition provided by the invention is prepared from polygonum multiflorum, sealwort, prepared rehmannia root, gorgon fruit, human placenta, black sesame, astragalus membranaceus, poria cocos, Chinese yam, American ginseng, asparagus fern, radix ophiopogonis, pearl, lamber, dragon bone, cacumen biotae and black soybean. The traditional Chinese medicine composition provided by the invention is reasonable in formula, scientific in preparation method and free from toxic and side effects; all drugs in the whole formula are matched rigorously and important for each other; clearing and digesting drugs are added in great tonic drugs, so that the traditional Chinese medicine composition is tonic but not greasy; all drugs are matched for use and complementary for each other, and used for adjusting yin and yang; the traditional Chinese medicine composition provided by the invention has the effects of tonifying kidney, replenishing essence, tonifying qi, nourishing blood, consolidating basis, adjusting viscera and the like and has good curative effects to insomnia, amnesia, dizziness, tinnitus, fatigued spirit, lacking in strength, anorexia and the like; the traditional Chinese medicine composition provided by the invention can also be used for treating leukopenia and hyperlipidemia after radiotherapy and chemotherapy; in addition, the traditional Chinese medicine composition provided by the invention has the effects of improving immunity of the organism and learning and memory ability.

The invention discloses a Chinese medicinal composition for raising leucocytes, which is mainly prepared from the following raw material medicaments in part by weight: 6 to 60 parts of astragalus, 6 to 60 parts of Siberian solomonseal rhizome, 6 to 60 parts of Mongolian snakegourd root and 3 to 30 parts of epimedium herb. The invention also discloses a method for preparing the Chinese medicinal composition and application thereof in preparation of a medicament for treating leucopenia, improving immune function of an organism, promoting proliferation of marrow hematopoietic stem/progenitor cells, protecting hemopoietic microenvironment, repairing the damage and harm to marrow hematopoietic tissues by radioactive rays, preventing and controlling marrow suppression of chemoradiotherapy, promoting colony formation of granulocytes and monocytes, improving Chinese medicinal symptoms and living quality of patients with cancer, or promoting the recovery of patients with Qi-Yin deficiency.

The invention discloses a broad-spectrum antineoplastic agent, relating to a micro-emulsified injection with Sodium Demethylcantharidate , which is suitable for the curing of patients with a plurality of tumors such as primary liver cancer, lung cancer, esophagus cancer, nasopharyngeal cancer, malignant lymphoma, bladder cancer, gynecologic malignant tumor and leukopenia, hepatitis, liver cirrhosis and hepatitis b virus, the invention also discloses the preparation method of the medicine, which is characterized in having good curing effect and low adverse reaction.

The invention discloses a freeze dried stephanine hydrochloride injection for treating leukopenia caused by radiotheraphy and chemotherapy, which comprises the following medicaments (by weight ratio): stephanine hydrochloride 1-10 parts, freeze-drying excipient 10-400 parts. The invention also discloses the process for preparing the freeze dried injection. The freeze-drying excipient can be mannitol, glucose, trehalose, sucrose or lactose.