44 results about "Absolute number" patented technology

A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell Spotter® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies CTC's. The absolute number of CTC's detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. The mean time to survival of patients depended upon a threshold number of 5 CTC's per 7.5 ml of blood. Detection of CTC's in metastatic cancer represents a novel prognostic factor in patients with metastatic cancers, suggests a biological role for the presence of tumor cells in the blood, and indicates that the detection of CTC's could be considered an appropriate surrogate marker for prospective therapeutic clinical trials.

The present invention relates to pharmaceutical kits and methods to treat lung inflammation and redox imbalance in human cystic fibrosis patients using pharmaceutical compositions containing N-acetylcysteine (NAC), pharmaceutically acceptable salts of N-acetylcysteine, or N-acetylcysteine derivatives. In phase I studies, treatment with oral NAC at a dose of from about 1800 mg/day to about 3000 mg/day for a period of 4 weeks produced significant positive effects, namely, it decreased absolute numbers of white blood cells and neutrophils in the sputum and produced concomitant decreases in sputum neutrophil elastase specific activity and sputum interleukin-8 levels, suggesting an amelioration of lung inflammation in the patients. These effects were associated with an increased total GSH level in whole blood as well increased staining for reduced GSH in blood neutrophils, both of which reflect an amelioration of the redox imbalance in the patients. In ongoing phase II studies, oral NAC at a dose of about 2700 mg/day administered in double-blind manner for 12 weeks showed excellent safety and significantly decreased white blood cells in sputum as compared to placebo.

The invention relates to the medicines for gynecopathy, in particular to gel for adjusting microecology in vaginas of women, solving the problem that the traditional gynecological lotion kills probiotics while killing pathogens, thus causing vaginal flora imbalance and low immunity and further causing repeated vaginitis. The gel comprises the following components according to mass concentration: 0.5-2% of Carbomer, 0.1-1% of soy peptide, 0.001-0.01% of isoflavone, 0.5-3.5% of carotene and 0.3-3% of tea tree oil. The gel achieves the aim of suppressing pathogens by promoting lactobacillus proliferation. At present, the products in the market aim to kill the bacteria but finally disturb normal flora balance. The gel increases the absolute number of the lactobacillus, a predominant bacterium, simultaneously reduces the pathogens, maintains the balance of microecology in vaginas and improves vaginal cleanliness and the immunity of the vagina mucosa, thus achieving the aims of preventing gynecological vagina inflammation and reducing the reoccurrence rate of gynecological vaginitis. Besides, the formula of the gel is pure vegetable protein, thus being safer than other bacteriostats and bactericides.

Control beads are disclosed that allow for improved quantitation of analytes in multiplexed bead assays. The control beads have a range of concentrations of calibration moieties that provide for the preparation of a titration curve. The titration curve can be used to quantify the concentration of the analytes. The titration curve can be used to correlate the signal obtained from a bead with the concentration (or absolute number of molecules) of the analyte bound to the bead.

The invention discloses a method and a device for pushing information to a mobile terminal, which can determine positions in which a user is possible to take interest according to contact information saved by the user, and recommend the positions to the user according to a certain order. According to the technical scheme of the invention, contact information saved in different apps in the mobile terminal of the user is collected and summarized for analysis; relation between various apps is taken into consideration, so that the potential function of the information is exerted to the maximum degree, and the information resource utilization ratio is increased. Particularly, the positions can be sorted according to the absolute number of occurrence times of each position or the contact frequency of the contact and the user, and pushed information from a region which the user wants most is placed at the top of the sequence, so that the user is free from searching by oneself, blindness during user choosing is reduced, time is saved for the user, convenience is brought to the user to acquire pushed information from other regions, and the user experience is improved.

The invention belongs to the technical field of high polymer materials and in particular relates to a method for preparing a high-performance thermoplastic polyurethane elastomer. According to the method, a novel idea is adopted, the defect that the molecular weight of a polyurethane elastomer is controlled by a single R value is avoided, although preparation of certain molecular weights of thermoplastic polyurethane elastomers sealed by different groups can be stilled affected by factors such as equipment metering precision and moisture at an early stage, the molecular weights can be remarkably increased when being compared with those of early-stage products after two times of polymerization at a later stage, and the viscosity and the mechanical properties can be remarkably improved; themethod is simple in production process and high in operability, and the absolute number-average molecular weight of the prepared thermoplastic polyurethane elastomer is 80.000 g/mol or greater (GPC (Gel Permeation Chromatography), light scattering methods).

A method for determining absolute number densities of particles in a solution is disclosed based on a light scattering method. A light scattering photometer is calibrated to produce the Rayleigh ratio at each angle measured with respect to light scattered per unit incident intensity, per unit volume illuminated within the field of view of each detector per steradian subtended by said detector. In order that the numbers calculated be accurate, the illuminated particles should be effectively monodisperse. From the excess Rayleigh ratios measured at a plurality of angles with respect to the incident light beam illuminating said sample particles, an effective size is calculated which, in turn, is used to calculate the differential scattered intensity at each angle. The number of particles per unit volume element is then determined from the measured excess Rayleigh ratio divided by the corresponding differential scattered intensity.

The invention relates to a peripheral blood lymphocyte subpopulation cell concentration detection kit and a detection method thereof, and belongs to the technical field of cell detection and screening. According to the technical scheme, the peripheral blood lymphocyte subpopulation cell concentration detection kit comprises an antibody kit and a stimulation liquid kit which is coordinately used with the antibody kit and is characterized in that a six-hole reagent tank is stored in the antibody kit, reagent tubes ranging from number A to number F and representing six antibody solutions are correspondingly arranged in the six-hole reagent tank according to the numbers of the six-hole reagent tank, and a standby reagent bottle is further stored in the antibody kit; after the detection of peripheral blood lymphocyte subpopulation cell concentration and the detection of CD4+T cell subpopulation cell concentration are carried out, samples are placed on a flow cytometer to analyze flow cytological maps, relative percentage is acquired and analyzed by MultiSET software or CellQuest software, and the cell absolute number of various subpopulations is calculated. The peripheral blood lymphocyte subpopulation cell concentration detection kit has the advantages that the technical problem that cell detection is large in errors and complicated in steps is solved, and the detection kit is capable of providing various antibodies and reagents, capable of simultaneously testing a plurality of samples during clinical application, simple in test steps, good in quality control and high in cell detection precision.

The present specification discloses methods of characterizing a population of particles using a particle analyzer. Particles may be characterized by size, absolute number, whether the particle is non-proteinaceous or proteinaceous, whether a proteinaceous particle has or lacks a certain physical property, or any combination thereof.

The invention discloses a stem-cell-like memorability T cell in-vitro inducer and a method. The inventor finds through experiments that a CD8 initial T cell can be rapidly induced, differentiated and amplified into TSCM cells in vitro if a histamine H1 receptor antagonist is additionally added into a T cell induction medium, the ratio of the TSCM cells to the CD8 cell can be remarkably increased, and the absolute number of the TSCM cells can be remarkably increased. Properties and functions of the induced, differentiated and amplified TSCM cell are maintained. The security of the histamine H1 receptor antagonist to human bodies is already tested through clinical practice, and a long research and development cycle of a new drug can be avoided. Meanwhile, as a developed medicine, the histamine H1 receptor antagonist has the advantages of low cost and good security, the TSCM cells induced, differentiated and amplified with the histamine H1 receptor antagonist can be re-transfused without special treatment, a powerful practice basis can be provided for tumor cell treatment, and significant development values and popularization meanings can be achieved.

The CellTracks® System provides a system to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies CTC's. The absolute number of CTC's detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. Pre-clinical studies of circulating tumor cells (CTC's) have been limited by the inability to repetitively monitor CTC's in animal models. The present invention provides a method to enumerate CTC's in blood samples obtained from living mice, using a protocol similar to an in vitro diagnostic system for quantifying CTC's in patients. Accordingly, this technology can be adapted for serial monitoring of CTC's in mouse xenograft tumor models of human breast cancer.

The invention discloses a laser induced plasma parameter characterization method based on self-absorption quantification of a spectral line. The self-absorption degree of the spectral line is quantified by measuring the line width of the element spectral line so as to obtain plasma parameters such as electron temperature, element content ratio and particle absolute number density. Because the calculation process of the method has no need of using spectral line intensity, adverse influences caused by the self-absorption effect during traditional calculation of the plasma parameters based on thespectral line intensity are avoided, and the spectral efficiency of a detector does not need to be corrected so as to effectively prolong the calibration period of LIBS (Laser-Induced Breakdown Spectroscopy) detection equipment and directly and accurately characterize the plasma parameters.

The invention relates to the technical field of immunocyte targeting therapy, in particular to an optimized kit system and application for separating and purifying memory immune cells (TCM) or CD8T+ cells from human peripheral blood or peripheral blood mononuclear cells, a TCM induction and amplification kit and a kit for product quality control and identification. In clinical application, TCM cells were cultured with many reagents, inconsistent standards, as that culture process has the advantages of large workload, long culture time, tedious process, instability, high contamination risk anddifficult control of cell quality standards, it is difficult for many technicians to culture TCM cell with uniform quality in a short period of time, and it is urgent to develop a simple and formattedkit. Meanwhile, the invention further optimizes the inducer composition TCM-III, the raw material is saved and the production cost is reduced; TCM-II-coated culture plate increased the proliferationof TCM cells by 2-3 times, the apoptotic index decreased, and the activity is increased by 10%-20%, the absolute number of effective cells increased by 2-3 times; before TCR gene transfection, TCM-II-coated culture plate can improve the transfection efficiency. The invention improves the process, which has important significance for clinically improving the curative effect of tumor treatment, removing residual lesions, and preventing the recurrence and metastasis of tumor.

A method for compressing a string of characters, initially defined by an original ordered sequence of characters each represented by an absolute number uniquely representing each character, according to an absolute coding table, comprising the steps of: - parsing said original sequence into at least one first type sub-sequence comprising contiguous characters, each of the contiguous characters of the first type sub-sequence being selected based on a matching character in a relative coding table (20), and, into at least one second type sub-sequence comprising remaining contiguous characters, - coding each first type sub-sequence using said relative coding table (20), - representing each character from each second type sub-sequence by its absolute representing number from said absolute coding table. A corresponding method for decompressing a compressed sequence.

The invention relates to an angle-measuring device for a rotationally driven linear actuator, in particular for a clutch actuator, which has at least the following components: - a rotor element whichhas an axis of rotation and rotates concentrically with a rotor of a rotatory drive for an axially movable linear actuator element; - a first measurement magnet arrangement which is fixed relative tothe rotor element and has a polarization, the polarization being oriented in such a way that the magnetic field lines can change with a rotation of the rotor element so as to enable the angle to be precisely determined from at least one measurement position; - at one of the measuring positions, a 360-degree sensor for measuring angular positions based on the measurement magnet arrangement; at oneof the measurement positions, a revolution-counting sensor for counting an absolute number of revolutions carried out based on the measurement magnet arrangement. The angle-measuring device proposed here ensures fail-safe reading out of the absolute travel position of, for example, a master piston of a hydrostatic clutch actuator and has low space requirements.

A flow cytometry method and kit is provided for quantifying an absolute number of mature sperm cells in a semen sample, the method comprising (a) determining a total particle number (T); (b) determining a number of DNA comprising particles (D); (c) determining a number of cells which are not mature sperm cells (B) and; (d) determining a background signal (A); wherein steps (a) to (d) are not effected in a single aliquot of the semen sample, and whereas the number of mature sperm cells in the semen sample is equal to [(T×D)/100]−(A+B), thereby quantifying the absolute number of mature sperm cells in the semen sample.

Disclosed is a method and apparatus for determining stone cells within a sample of wood pulp or paper. According to the instant invention a portion of the sample is irradiated with light at a predetermined wavelength or within a predetermined range of wavelengths. The incident light causes those areas of the sample that are occupied by stone cells to fluoresce strongly relative to the background matrix of wood pulp or paper. The strongly fluorescing stone cells are registered digitally using a detector, or are observed visually by an operator viewing the sample through an ocular device. The absolute number of stone cells per unit area or a stone cell size-distribution-plot is obtained using one of automated or manual image analysis.

An absolute position-measuring device includes a first subassembly having a measuring standard on which at least one code track is disposed, and a scanning unit with which, by scanning the at least one code track in a measuring direction, position signals are able to be produced, from which an absolute digital position value is able to be generated. The position-measuring device includes a second subassembly having at least one peripheral unit adapted to perform an additional or auxiliary function of the position-measuring device. The first subassembly and the second subassembly are connected to each other by a plurality of electric lines for the transmission of electrical signals. The first subassembly exclusively includes components which are suitable for use in a radiation area of a machine.

The invention discloses an electronic identity system for a power storage battery of an electric vehicle. The electronic identity system is installed on a battery pack of a pure electric vehicle or a hybrid vehicle with a storage battery as one of the power sources and cannot be disassembled. The electronic identity system not only endows the power storage battery with a unique battery electronic identity, but also stores the actual remaining power, geographical location, used The vehicle identity information of the electric vehicle and the absolute number of kilometers driven of the electric vehicle used. All the data stored above are continuously uploaded to the file server or cloud server through the peripheral sub-terminal. The present invention collects and provides necessary basic parameters for the quantified management of the traction storage battery, so that the fair and reasonable exchange and use of the traction storage battery of the electric vehicle becomes a feasible solution.