26 results about "Nausea sickness" patented technology

The invention discloses an anesthesia reviving room risk assessment system for postoperative nausea and vomiting prediction, relates to the technical field of postoperative nausea and vomiting prediction, and aims to perform multi-modal fusion on clinical features of a patient and brain function signals to realize basic probability calculation of postoperative nausea and vomiting risks, and introduce real-time dynamic physiological parameters as regulatory factors to realize postoperative nausea and vomiting risk prediction. And performing adaptive adjustment on the basic prediction result to generate a comprehensive risk probability value. The system can collect and process data in real time after a patient enters an anesthesia reviving room, and dynamic and personalized risk assessment is achieved. Compared with a traditional scoring method which only depends on static clinical features, the method has the advantages that tiny fluctuation of the postoperative physiological state of the patient can be captured, prediction precision and timeliness can be improved, clear decision support can be provided for nursing staff, and therefore preventive intervention measures are optimized, and the occurrence rate of complications is reduced.

A traditional Chinese medicine composition for alleviating gastrointestinal toxic side effects caused by chemotherapy, the traditional Chinese medicine composition for daily administration is prepared from the following weight ratio of traditional Chinese medicine formula: Taizishen 20-30g, Fuling 10-15g, Fried Baizhu 10-15g, Zhigancao 5-10g, Jiangbanxia 5-10g, Chenpi 5-15g. The formula can effectively alleviate the gastrointestinal toxic side effects caused by chemotherapy, such as nausea, vomiting, diarrhea, poor appetite, etc.

The invention relates to the technical field of ginger moxibustion, in particular to a portable temperature-controllable ginger moxibustion device for arresting vomiting of tumor patients, which comprises a shell, a tube is fixedly connected to the inner side wall of the shell, a pore plate is fixedly connected to the bottom of the tube, a temperature sensor is mounted on the inner side wall of the tube, and a cover is in threaded connection to the top of the shell. A cylinder is fixedly connected to the bottom of the cover body, and an electric heating rod is mounted at the bottom of the cylinder; the electric heating rod is used for simulating heating power of moxa in traditional ginger-separated moxibustion, controllable heating power is used for exciting drug efficacy of ginger of ginger slices on the pore plate, the synergistic effect mechanism that ginger penetrates through heating power and drug efficacy enters the acupoint is perfectly rescribed, the device is designed according to the core requirement of descending adverse-rising energy and arresting vomiting of tumor patients, the device can accurately act on related acupoints for arresting vomiting, and the effect is achieved. The symptoms of nausea and vomiting caused by chemoradiotherapy and the like are effectively relieved.

Disclosed are the use of methods for reducing one or more gastrointestinal side effects in a subject receiving glucagon-like peptide-1 (GLP-1) receptor agonist (RA) therapy. The methods include administering to a subject receiving GLP-1 RA therapy an amount of homotaurine-like gastrointestinal distress-relieving (HTL-GIDR) composition effective to reduce gastrointestinal side effects of GLP-1 RA therapy, e.g., nausea, vomiting, and constipation. Generally, the HTL-GIDR composition can be homotaurine or a homotaurine analog such as acamprosate calcium and valiltramiprosate (ALZ-801), or a combination thereof. Furthermore, the HTL-GIDR composition may facilitate tolerance during the GLP-1 RA dose escalation phases and enable administration of higher GLP-1 RA doses, thereby enhancing therapeutic outcomes in conditions including diabetes, obesity, and neurodegenerative diseases.

The invention discloses a traditional Chinese medicine composition for treating a warm disease clinically belonging to the same disease of defensive qi and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 5-35 parts of bupleurum chinense, 9-50 parts of scutellaria baicalensis, 9-50 parts of artemisia apiacea, 5-35 parts of radix paeoniae rubra, 5-35 parts of moutan bark and 4-26 parts of folia perillae acutae. According to the traditional Chinese medicine composition, the effects of all the medicines are utilized to generate a synergistic effect, and the effects of relieving fever, eliminating evil and detoxifying are achieved together. The traditional Chinese medicine composition is used for treating fever or hyperpyrexia, slight aversion to wind-cold, headache, sweating, thirst, cough and pharyngalgia caused by cold, viral cold and upper respiratory tract infection febrile disease defensive qi, and can be accompanied by nausea, vomiting, neck stiffness, rash appearance, red eye swelling and pain and the like, so that the febrile disease is effectively treated.

The invention relates to the technical field of biological medicine, in particular to a medicine solution composition, a preparation method thereof, a nasal spray and application. The medicine solution composition comprises a medicine active component, an osmotic pressure regulator, a pH regulator and water. The active pharmaceutical ingredient comprises ondansetron or a pharmaceutically acceptable salt of ondansetron. The medicine solution composition provided by the invention can be quickly absorbed into blood through nasal mucosa, reaches a peak within 5-10 minutes after being administered through nasal spray administration, is expected to take effect quickly, can help a patient to deal with nausea and vomiting caused by cytotoxic chemotherapy and radiotherapy in time and be used for preventing postoperative nausea and vomiting (PONV), and is good in stability.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with an antiemetic effect and a preparation method thereof. The traditional Chinese medicine composition contains perilla leaf, Coptis chinensis, Amomum villosum, Saussurea lappa, Pinellia ternata, ginger, Chinese yam and honey. The traditional Chinese medicine composition has a good relieving and treating effect on pregnancy vomiting through pharmacological experiments and clinical use verification. The clinical treatment rate of pregnancy vomiting reaches 92.86%, and the traditional Chinese medicine composition can effectively relieve the clinical symptoms of patients, such as nausea and vomiting, dizziness, anorexia, food entering the stomach and then vomiting, and the like. The preparation process is simple, the traditional Chinese medicine composition can be further produced, and has a wide market prospect.

This invention provides a method for treating postoperative nausea and vomiting using buccal acupuncture combined with a triple antiemetic regimen. The method employs a combined intervention of buccal acupuncture and a triple antiemetic regimen. The triple regimen consists of a 5-HT3 receptor antagonist, a glucocorticoid, and a dopamine receptor antagonist, administered intravenously in two separate doses. The buccal acupuncture uses CA-2 (upper jiao), CA-3 (middle jiao), and CA-4 (lower jiao) as core acupoints, with auxiliary and reinforcing acupoints added based on the surgical site and high-risk groups. A standardized procedure of pecking stimulation is applied, along with a corresponding postoperative remedial antiemetic medication regimen. This invention organically combines multi-target drug blockade with buccal acupuncture's visceral regulation, synergistically enhancing the antiemetic effect, reducing the incidence of nausea and vomiting, and decreasing the need for remedial medication. The regimen is highly standardized, widely adaptable, and can meet the postoperative nausea and vomiting control needs of various surgeries and high-risk groups. It exhibits good safety, strong repeatability, and high clinical application value.

The present disclosure relates generally to methods of treating, preventing, or reducing nausea, vomiting, or a combination thereof, hyperemesis gravidarum (HG), nausea gravidarum and vomiting (NVP), or sequelae thereof in a human subject in need thereof, the methods comprise administering to the human subject a therapeutically effective amount of an antibody that specifically binds to a human glial cell line derived neurotrophic factor family receptor alpha-like (GFRAL).

This invention belongs to the field of traditional Chinese medicine technology, and relates to a topical Chinese medicine composition, topical drug, topical patch, acupoint patch, and preparation method and application for treating nausea and vomiting caused by chemotherapy for intracranial tumors. The Chinese medicine composition consists of the following raw materials in parts by weight: 1-2 parts of Ligusticum chuanxiong, 1-2 parts of Gastrodia elata, 2-4 parts of Uncaria rhynchophylla, 1-2 parts of Citrus aurantium, 1-2 parts of Sinapis alba, 1-2 parts of Clematis chinensis, 0.5-1 part of Melia toosendan, 0.5-1 part of Panax ginseng, 1-2 parts of Pinellia ternata, 1-2 parts of Albizia julibrissin bark, 0.5-1 part of Lentinus edodes, and 1-2 parts of Astragalus membranaceus. This Chinese medicine composition has the effects of relieving nausea and vomiting, soothing the liver and strengthening the spleen, detoxifying and eliminating turbidity, calming the liver and extinguishing wind, and calming the mind and soothing the nerves. It not only effectively controls the nausea and vomiting symptoms caused by chemotherapy for intracranial tumors, but also harmonizes the body's Qi and organ functions. The Chinese medicine composition has a simple formula, widely available ingredients, and a simple preparation method; it is for topical application, convenient for clinical use, and has low adverse reactions.

The invention discloses anti-vomiting hydrolyzed whey protein and a preparation method thereof, and belongs to the technical field of food processing. The product provided by the invention reduces the digestion burden of protein and relieves the symptom of vomiting. According to the method disclosed by the invention, protein sequences are mutually crosslinked by virtue of a treatment mode of first fibration, second polymerization and final hydrolysis, and a hydrolyzed polypeptide sequence is changed, so that the abundance of the polypeptide SLAMAASDISLA in a hydrolysate is improved. The polypeptide has the characteristics of being easy to recognize by intestinal peptidase and relatively high in PepT1 affinity, the bioavailability of protein is improved, and the deamination proportion of unutilized amino acid is reduced, so that substances generating nitrogen-containing toxoid are reduced, the stimulation of toxin accumulation on gastrointestinal mucosa is relieved, and the symptoms of nausea, vomiting and the like of a user are avoided.

The invention provides a spleen-tonifying and detoxifying traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises a formula A and a formula B. The traditional Chinese medicine composition has a comprehensive conditioning effect and can relieve chemotherapy side effects, improve intestinal flora distribution, promote intestinal health, enhance the chemotherapy effect and improve the disease control rate. Wherein the formula A focuses on tonifying spleen and regulating qi, and improving nausea, vomiting and other symptoms at the initial stage of chemotherapy, and the formula B is added with medicines for clearing away heat and toxic materials and promoting blood circulation to remove blood stasis on the basis, is suitable for patients with myelosuppression with cancer toxicity residue, and strengthens the effects of clearing away heat and toxic materials and removing stasis; the composition has a multi-target action mechanism, and through the combined action of multiple ways, the treatment effect is enhanced, and the side effect is reduced.

This invention relates to the field of chemical pharmaceutical technology, specifically to the application of sesquiterpenoid compounds in relieving nausea and vomiting. The sesquiterpenoid compounds of this invention are cypressin and its analogues, racemates, stereoisomers, tautomers, isotope-labeled compounds, solvates, polymorphs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof, having the following structures, wherein R1-R8 are as described in the claims and specification. These sesquiterpenoid compounds can reduce kaolin ingestion in pica rats and significantly alleviate nausea and vomiting symptoms induced by chemotherapeutic drugs such as cisplatin during tumor treatment. They can also relieve vomiting caused by gastrointestinal damage, inflammatory diseases, anorexia, etc. They can be used to prepare drugs for relieving / treating nausea and vomiting or to prepare foods that help protect the gastric mucosa.

The present invention belongs to the field of polypeptide pharmaceuticals, and provides a dual agonist polypeptide compound and the pharmaceutical use thereof. An amino acid sequence of a GIP-R and GLP-1R dual agonist polypeptide compound is: Y1-X1-EGTFTSDYSI-X2-LDKI-X3-Q-Bn-X4-X5-VQWLI-X6-GGPSSG-X7-PPPS, and the C-terminal amino acid is amidated. The GIP-R and GLP-1R dual agonist polypeptide compound has a more significant dual agonistic effect on human glucose-dependent insulinotropic polypeptide (GIP) and human glucagon-like peptide-1 (GLP-1) receptors. The compound not only has the effects of lowering blood sugar and reducing weight, but also has a longer half-life and a higher bioavailability. The compound can avoid adverse reactions such as nausea and vomiting caused by the long-term use of existing drugs, and thus can be used as an effective raw material for the preparation of a drug for treating or preventing diabetes or an anti-obesity drug.

This invention belongs to the field of medical auxiliary device technology and discloses a chemotherapy support device for oncology. It includes a seat body, a respiratory status detection device, and a controller. The seat body is connected to armrests, a Neiguan acupoint massage component, a Zusanli acupoint massage component, an abdominal heat therapy component, a headrest, and a speaker. The Neiguan acupoint massage component includes a base, a motor, a fixed gear ring, a sun gear, planetary gears, and massage balls. The Zusanli acupoint massage component includes an air pump and an airbag. The abdominal heat therapy component includes a strap, a medicine storage box, a heat therapy bag, and an electric heating wire. The respiratory status detection device includes a pressure sensor. This invention utilizes the Neiguan acupoint massage component to stimulate and massage the Neiguan acupoint, the Zusanli acupoint massage component to compress the Zusanli acupoint, and the abdominal heat therapy component to provide heat therapy to the abdomen, effectively relieving symptoms such as nausea and vomiting, numbness in the hands and feet, and abdominal cold pain after chemotherapy.

The invention belongs to the technical field of medical instruments, and particularly relates to an auxiliary device suitable for paranasal sinus negative pressure replacement and a using method.The auxiliary device comprises two clamping handles and a controller, an elastic bent strip is arranged between the two clamping handles, and the two ends of the elastic bent strip are fixedly connected with the inner walls of the two clamping handles correspondingly; the inner side wall of the tail end of the clamping handle is fixedly connected with a first induction piece, the tail end of the clamping handle is fixedly connected with an expansion air bag, and the clamping handle is of a cavity structure. An air pump is further included, the output end of the air pump is fixedly communicated with a catheter, the outer end of the catheter is fixedly communicated with a three-way pipe, and the other two ends of the three-way pipe are communicated with the two clamping handle cavities respectively. Compared with a traditional method, the requirement for the body position of a patient is not very strict, the matching degree of the patient is greatly increased, the possibility that medicine flows into the throat and the lower respiratory tract is limited through the expansion air bag of the rear nostril, the reaction degree of nausea and vomiting of the patient is greatly reduced, and complications are also reduced.

This invention discloses a dual-activator polypeptide compound and its pharmaceutical uses, belonging to the field of polypeptide pharmaceuticals. The amino acid sequence of the GIP-R and GLP-1R dual-activator polypeptide compound is: Y-Z-EGTFTSDYSI-X2-LDKI-A-Q-B n -X4-X5-VQWLI-X6-GGPSSG-A-PPPS, with the C-terminal amino acid being amidated. The GIP-R and GLP-1R dual-agonist polypeptide compounds of this invention exhibit more significant dual-agonist activity against human glucose-dependent insulinotropic peptide (GIP) and human glucagon-like peptide-1 (GLP-1) receptors. They not only possess hypoglycemic and weight-loss effects but also have a longer half-life and higher bioavailability, avoiding adverse reactions such as nausea and vomiting caused by long-term use of existing drugs. They can be used as effective raw materials for preparing drugs for treating or preventing diabetes or weight-loss drugs.

The invention relates to the technical field of medicines and foods, relates to a composition for relieving nausea and vomiting, and particularly relates to a composition which is prepared by taking ginseng and ginger as main raw materials through mixing, mixed heating or mixed heating pulping and application of the composition in preparation of medicines for relieving / treating nausea and vomiting. In the composition, the mass ratio of the ginseng to the ginger is (1: 10)-(1: 60), and the mass ratio of the mixed raw materials of the ginseng and the ginger to the water is (1: 10)-(1: 40). The composition comprises total ginsenoside and total gingerol, the content of the total ginsenoside is 15-55%, the content of the total gingerol is 2.5-9%, and the content of rare ginsenoside accounts for more than 60% of the content of the total ginsenoside. The composition is prepared by the following steps: mixing radix ginseng and fresh ginger, adding water for soaking, and mixing and pulping at 60-100 DEG C for 30-75 minutes to obtain the composition. The composition can obviously relieve nausea and vomiting and can be used for treating nausea and vomiting caused by various reasons.

A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

Use of sesquiterpenoids having the structures of formula (I) and formula (П) in relieving nausea and vomiting. The sesquiterpenoids having the structures of formula (I) and formula (П) are cedrol and analogs, racemates, stereoisomers, tautomers, isotopically labeled compounds, solvates, polymorphs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof, wherein R 1 to R 8 are as described in the claims and the description. The compounds having the structures of formula (I) and formula (П) can reduce kaolin intake in pica rats, significantly alleviate the symptoms of nausea and vomiting induced by chemotherapeutic drugs such as cisplatin when used in tumor treatment, and can also relieve vomiting caused by gastrointestinal injury, inflammatory diseases, anorexia, etc. In addition, the compounds having the structures of formula (I) and formula (П) can also be used in the preparation of drugs for relieving / treating nausea and vomiting or in the preparation of foods for assisting in protecting the gastric mucosa.

A disposable, self-contained electro-stimulation device configured with paired cutaneous electrodes for placement over specific acupuncture and neurostimulation points (such P6) on a patient's wrist, delivering controlled electrical pulses to reduce or prevent nausea and vomiting following surgery or anesthesia. Its advanced circuitry trades boost-converter efficiency for total system energy conservation, optimized for the low-duty-cycle pulse output used in neuromodulation rather than continuous high-power operation. Its single-IC, digitally controlled pulse engine performs both biphasic stimulation and contact verification, optimizing it for compact, battery-powered wearable medical devices. It also uses a miniature Hall-effect magnetic-field sensor positioned over a planar helical trace that carries the stimulation current, producing a proportional magnetic field detectable by the Hall sensor for the non-invasive current detection and skin-contact verification.

[Problem] To provide an iron supplement free from bad taste (metallic taste), which is a drawback of iron agents, and free from side effects such as nausea, vomiting, and constipation, and that has excellent storage stability (oxidation resistance). [Solution] The present invention provides an iron supplement containing a magnesium hydroxide-based solid solution represented by formula (1): (Mg)1-x-y(Fe2+)x(M2+)y(OH)2-nz(An-)z. (In the formula, M2+ represents at least one selected from Zn, Mn, Cu, and Co, An- represents at least one of organic acid ion moieties, x, y and z are in the respective ranges: 0 < x < 0.3, preferably 0.01 ≤ x ≤ 0.2, 0 ≤ y < 0.2, preferably 0 ≤ y ≤ 0.1, and 0 ≤ z < 0.1, preferably 0.001 ≤ z ≤ 0.005, and n represents zero or an integer in the range of 0-4.)

The utility model discloses a vomiting-stopping bracelet, which is provided with a diffusing part capable of diffusing vomiting-stopping smell, the vomiting-stopping bracelet comprises a plurality of beads and a string, each bead is provided with a through hole for the string to pass through, and each bead comprises a base body and a magnetic bead embedded on the base body. According to the utility model, the traditional Chinese medicine with the effect of stopping vomiting is combined with the magnetic beads capable of massaging the Neiguan point through the structural arrangement of the bracelet, and the symptoms of nausea and vomiting of a patient are relieved through the combined action.

Use of a compound of formula (I) or its stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, co-crystal or a composition thereof, in the manufacture of a medicament for preventing postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting.

The invention relates to the technical field of markers. The invention provides a marker for judging postoperative nausea and vomiting with clinical significance and application of the marker. The marker is GDF-15. According to the method, a more accurate CIPONV prediction tool can be provided for a specific high-risk group by analyzing the preoperative and postoperative GDF-15 concentrations and the difference of the preoperative and postoperative GDF-15 concentrations of the patient, so that personalized management and treatment of the high-risk patient are realized, and the postoperative recovery process of the patient is finally improved. The development of the method is based on collection and analysis of the GDF-15 concentration data of the surgical patient, and aims to provide a more comprehensive and more accurate prediction model for postoperative management so as to promote postoperative recovery of the patient, reduce the CIPONV incidence rate and improve the overall medical experience of the patient.

The invention relates to a traditional Chinese medicine composition for treating fatigue anxiety, nausea and vomiting in a perioperative period and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components: ginseng, Chinese dates, ginger juice, phyllanthus emblica and maltodextrin. Preferably, the traditional Chinese medicine composition is prepared from the following components in parts by mass: 20 to 40 parts of radix ginseng, 20 to 40 parts of fructus ziziphi jujubae, 10 to 25 parts of ginger juice, 10 to 30 parts of fructus phyllanthi and 20 to 30 parts of maltodextrin. Further preferably, the traditional Chinese medicine composition is prepared from the following components in parts by mass: 30 parts of ginseng, 25 parts of Chinese dates, 15 parts of ginger juice, 20 parts of phyllanthus emblica and 25 parts of maltodextrin. The traditional Chinese medicine composition can be used for preparing a traditional Chinese medicine preparation for treating fatigue anxiety and / or nausea and vomiting in the perioperative period, such as a preoperative traditional Chinese medicine clear beverage, has the effects of tonifying qi and nourishing yin, promoting the production of body fluid to quench thirst, harmonizing the stomach and arresting vomiting, and can improve thirst, hunger, fatigue and anxiety caused by fasting in the perioperative period and relieve postoperative fatigue when being used in the perioperative period. The occurrence rate of postoperative nausea and vomiting is reduced.