27 results about "Alcoholic liver damage" patented technology

The invention relates to a plant composition as well as a preparation method and application thereof, and belongs to the technical field of health food. The plant composition is prepared from the following components in parts by mass: 5 to 30 parts of fructus gardeniae, 5 to 30 parts of fructus rubi and 5 to 30 parts of fructus lycii. The plant composition can effectively relieve liver oxidative stress and inflammation conditions, relieve and / or improve alcoholic liver injury, protect liver cells from oxidative injury, assist a body in resisting oxygen free radical invasion and maintain the health state of the body, does not affect the blood sugar level, and has the advantages of being reasonable in compatibility, good in quality, safe and effective.

This invention discloses a compound peptide nutrient with fat-reducing effects, belonging to the field of health food technology. Specifically, it relates to a VQPIPY peptide or a product containing VQPIPY peptide in the preparation of lipid-lowering drugs or health products, or in the preparation of drugs for treating and / or alleviating alcoholic liver damage. This invention also provides a meal replacement powder containing VQPIPY peptide, shown as a compound of whey powder, milk powder, oats, spinach powder, allulose, and camel milk peptide in a specific ratio. Through the synergistic effect of its components, this product achieves multiple effects such as providing satiety, inhibiting blood sugar, and lowering blood lipids. It is characterized by balanced nutrition, safety, effectiveness, and good taste, and can be used for weight management and daily health maintenance.

The invention belongs to the field of medicines, and relates to a traditional Chinese medicine composition for dispelling the effects of alcohol and relieving alcoholic liver injury and application thereof. The pharmaceutical composition is prepared from the following raw materials: curcuma zedoary, fructus amomi, rhizoma alismatis, rhizoma atractylodis macrocephalae and radix angelicae.

The invention discloses a medicinal and edible composite particle capable of relieving liver injury and a preparation method and application thereof.The particle is a puerarin-loaded phosphorylated hollow zein-chitosan oligosaccharide particle and has an efficient delivery structure with the exterior hydrophilic and the interior hydrophobic, the bioavailability is improved while the puerarin drug loading capacity is increased, and the bioavailability is improved. The circulation time in the body is prolonged, and the medicinal effect is enhanced. Meanwhile, the chitosan oligosaccharide in the components of the composite particle has a liver protection effect and can be cooperated with the anti-oxidation and anti-alcohol characteristics of puerarin, so that multi-target protection in alcoholic liver injury is realized, and the composite particle can be used for expanding and developing treatment medicines or health-care foods with anti-alcohol and liver-protecting effects and has remarkable economic and social values.

This invention relates to a composition for improving alcoholic liver damage, belonging to the field of health product technology. This application provides the use of rhodioloside and lactose-N-trisaccharide in the prevention and / or inhibition of alcoholic liver disease. This application also provides a composition of human lactose oligosaccharides and rhodioloside. The compositions described in this application can prevent the occurrence of alcoholic liver disease or inhibit its further deterioration. This application provides a green, safe, and healthy composition, offering an ideal composition for protecting human health.

This invention discloses the application of American ginseng glycoprotein extract in the preparation of drugs for treating alcoholic liver disease, belonging to the field of biomedical technology. This invention verifies that TD can significantly reduce serum ALT, AST, and TG levels in ALD mice, effectively reducing liver damage and lipid accumulation; inhibit NLRP3 protein expression and its downstream targets, effectively alleviating liver inflammation and pyroptosis; and improve intestinal flora imbalance in ALD mice. American ginseng glycoprotein extract has multi-target protective effects against alcoholic liver disease, reducing alcohol-induced liver tissue inflammation and oxidative stress damage. It has a mild composition and high safety profile, and can synergistically exert effects in liver protection, anti-inflammation, and antioxidation, making it suitable for adjunctive intervention and long-term management of alcoholic liver disease, providing a natural, mild, and effective protective pathway for alcoholic liver damage.

The invention relates to a novel application of ergothioneine, in particular to an application of ergothioneine in preparation of a product for preventing or improving alcoholic liver injury. The invention finds that the ergothioneine has a very remarkable effect in the aspect of preventing or improving the alcoholic liver injury, and the ergothioneine particularly has the effects of preventing or relieving liver pathological injury, regulating alcohol metabolism, regulating lipid metabolism, improving liver oxidative stress injury and improving the liver inflammation state. The ergothioneine is used for preparing products with related effects and has an application prospect.

A Limosilactobacillus fermentum strain capable of alleviating a hangover and the use thereof. The strain is at least one strain of Limosilactobacillus fermentum ibiome020, Limosilactobacillus fermentum ibiome021 and Limosilactobacillus fermentum ibiome022 respectively deposited with deposit numbers of CCTCC NO: M 2024188, CCTCC NO: M 2024222 and CCTCC NO: M 2024189. The Limosilactobacillus fermentum is a natural bacterium derived from the intestine of a healthy human and has high safety; can alleviate chronic / acute alcoholism, alcoholic intestinal damage or alcoholic liver damage; can accelerate the metabolism of ethanol and / or acetaldehyde, and delay the onset of intoxication; can shorten the sobering-up time; can reduce the mortality caused by drinking alcohol; can reduce the liver index; can lower the level of AST and / or ALT in serum; can alleviate discomfort caused by ethanol and / or acetaldehyde, and mitigate symptoms such as dizziness, headache, nausea and vomiting, and hangover after drinking alcohol; can ameliorate oxidative stress caused by alcohol, and increase the level of GSH in the liver; and also has excellent resistance to gastrointestinal fluid and bile salt, and can adapt to the complex environment within the body.

A method for extracting 3,5-O-dicaffeoylquinic acid from Huangshan Gongju and its application in drugs for protecting against alcoholic liver damage. The 3,5-O-dicaffeoylquinic acid has the following structural formula:The present disclosure selects the medicinal and edible homology plant, Huangshan Gongju, as the research object. This plant is abundant in resources and the raw materials are easy to obtain. Specifically, the present disclosure uses 70% ethanol to extract Huangshan Gongju, uses the method of bioactivity-guided isolation, and uses a FLA-2025-10-120A preparative liquid chromatograph to isolate a phenolic compound from the active site of Gongju that resists alcoholic liver damage. The compound separation method is simple, quick, and easy to operate.

The invention discloses saposhnicovia divaricata polysaccharide as well as a preparation method and application thereof, and belongs to the field of natural polymers. The method has the advantages that the average relative molecular weight is measured through GPC, monosaccharide composition is analyzed through GC-MS, it is found that the average relative molecular weight of the saposhnicovia divaricata polysaccharide RSP-1 is 111125 Da, the protein content of the saposhnicovia divaricata polysaccharide RSP-1 is 1.29%, the saposhnicovia divaricata polysaccharide RSP-1 does not contain uronic acid and is neutral polysaccharide, and it is found that trace beta-pyranose exists. Meanwhile, the saposhnicovia divaricata polysaccharide RSP-1 disclosed by the invention can be used for remarkably relieving liver fat infiltration, reducing the number of ballooning and necrotic cells and relieving alcoholic liver injury.

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating alcoholic hepatitis. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 15 to 20 parts of radix puerariae, 15 to 20 parts of rhizoma phragmitis, 15 to 20 parts of rhizoma imperatae, 10 to 15 parts of dried herba dendrobii, 6 to 10 parts of fructus citri sarcodactylis, 10 to 15 parts of herba pogostemonis, 15 to 20 parts of herba lophatheri, 6 to 10 parts of herb tea and 10 to 15 parts of pericarpium citri reticulatae. The research finds that the aqueous extract of the traditional Chinese medicine composition can remarkably improve alcoholic liver injury tissue edema and inflammatory cell infiltration, improve the alcohol metabolism capability of a body, relieve inflammatory response and reduce the oxidative stress level of liver tissue, so that the purposes of treating alcoholic hepatitis and protecting the liver are achieved.

The invention discloses an application of Aradiclat lactobacillus plantarum GXUN74705 in improvement of alcoholic liver injury, and belongs to the technical field of microorganisms. The invention proves that the application of the Aradicatrat lactobacillus plantarum GXUN74705 in treating the alcoholic liver injury, the strain can effectively improve the liver injury caused by alcohol, and the pathological process of the alcoholic liver injury is comprehensively relieved by regulating liver function indexes, correcting blood lipid metabolism disorder, relieving oxidative stress and inhibiting inflammatory response. In addition, the strain can also reduce liver lipid accumulation, repair a liver cell structure, and further improve liver health by adjusting an intestinal flora structure and intestinal bile acid metabolism. The strain has remarkable effects in the aspects of reducing blood fat, reducing cholesterol, resisting oxidation and the like, or has important clinical application and market value when being applied to foods, food additives, health care products, medicines or feeds as functional probiotics.

The invention belongs to the technical field of food source nutrient nano-delivery, and discloses a preparation method of a protein and astaxanthin nano-composite based on low-frequency acoustic resonance, galactose is used for modifying protein through a low-temperature Maillard reaction, high acceleration and acoustic flow are generated by using low-frequency acoustic resonance equipment, and the nano-composite is prepared. According to the present invention, the astaxanthin is uniformly entrapped in the protein-galactose composite carrier to form the stable nanometer suspending agent, the method has advantages of green environmental protection, significant treatment effect and the like, the water solubility, the targeting property and the bioavailability of the astaxanthin can be effectively improved, the astaxanthin can be accurately delivered to the liver, and the alcoholic liver injury repair can be rapidly promoted.

The application provides application of Gao Yao-4 medicine powder in preparation of a medicine for treating or preventing acute alcoholic liver, and belongs to the field of medicine. It is found for the first time that the drugs in the Gao Yao-4 medicine powder have a combined effect, can effectively reduce the content of AST, ALT and TBIL in serum and liver tissue after a large amount of drinking, effectively reduce the content of TC, TG, MDA, TNF-alpha, IL-1beta and IL-6 in liver tissue after a large amount of drinking, improve the content of SOD, reduce the apoptosis rate of liver tissue cells, improve the expression amount of Bc1-2 protein, and reduce the expression amount of Bax, caspase3 and C-caspase3 protein, and has a repairing and protecting effect on alcoholic liver cell damage. It is shown that the Gao Yao-4 medicine powder can be used for treating / preventing acute alcoholic liver damage, and does not have side effects, and has high safety.

This invention provides a traditional Chinese medicine composition with hepatoprotective and alcohol-relieving effects, made from the following raw materials in parts by weight: 1-5 parts rose petals, 1-5 parts chrysanthemum, 1-5 parts Japanese raisin tree fruit, 1-5 parts paper mulberry fruit, and 1-5 parts kudzu root. The traditional Chinese medicine composition of this invention can be prepared into decoctions, granules, powders, capsules, tablets, mixtures, or oral liquids using conventional pharmaceutical methods. The formulation of the traditional Chinese medicine composition of this invention is based on traditional Chinese medicine theory combined with modern medical research findings, and has hepatoprotective and alcohol-relieving effects. Experimental studies have shown that this composition has good preventive and therapeutic effects on alcoholic liver damage and cirrhosis.

The present invention relates to the field of food, and in particular to a milk tea and its preparation method and its application in preventing alcoholic liver damage or sobering up. The milk tea, by volume, comprises 35.6-40.6 parts of black tea extract, 60.9-64.9 parts of raw cow's milk and 1.0-1.2 parts of monk fruit concentrate; wherein, the preparation method of the black tea extract comprises the following steps: crushing the black tea, adding ultrapure water according to a material-liquid ratio of 1:25-30, extracting at 90-100°C, centrifuging to obtain a primary extraction supernatant and a precipitate; adding ethanol aqueous solution to the precipitate according to a material-liquid ratio of 1:25-30, extracting twice at 90-100°C, centrifuging to obtain a secondary extraction supernatant; combining the supernatants, concentrating to obtain the black tea extract. The milk tea of ​​the present invention prevents liver damage caused by AALI by promoting alcohol metabolism, reducing oxidative stress damage and alleviating liver inflammation.

The invention provides application of setuzumab in preparation of a medicine for treating non-alcoholic liver injury, and belongs to the technical field of biological medicine. Results show that the setutuzumab can significantly reduce ALT level and AST level in serum of a mouse with non-alcoholic liver injury, so that the setutuzumab can effectively prevent and / or treat the non-alcoholic liver injury. Space exploration experiment results show that the exploration distance of the quadrant where the platform of the non-alcoholic liver injury model mouse treated by the cetuzumab is located, the exploration time of the quadrant where the platform is located and the crossing frequency are obviously larger than those of a control group, so that the cetuzumab effectively improves the spatial memory ability and the positioning cruising ability of the non-alcoholic liver injury model mouse; therefore, the effect of treating the cognitive impairment caused by the non-alcoholic liver injury is achieved. Open field and tail suspension experiment results show that the cetuzumab can improve depression and anxiety behaviors of non-alcoholic liver injury model mice, and has the effect of treating depression caused by non-alcoholic liver injury.

This invention discloses a traditional Chinese medicine compound composition and a probiotic-fermented traditional Chinese medicine compound composition for alleviating alcoholic liver damage. The raw materials include Terminalia chebula, Phragmites communis, Morus alba, Polygonatum sibiricum, Hovenia dulcis, Hippophae rhamnoides, Fennel, Mung bean, Glycyrrhiza uralensis, Lycium barbarum, and Jujube. The fermented probiotics are Lactobacillus rhamnosus and Bifidobacterium adolescentis. The traditional Chinese medicine compound and its probiotic fermentation product of this invention can improve hepatocyte vitality, reduce alcohol-induced hepatocyte damage, regulate hepatic lipid metabolism disorders, and achieve the effect of detoxifying and protecting the liver by reducing alcohol-induced oxidative stress in the liver.

The invention provides a traditional Chinese medicine health-care product for assisting in preventing alcoholic liver injury, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 parts of dandelion, 4 parts of radix puerariae, 2 parts of radix paeoniae rubra, 2 parts of honeysuckle, 2 parts of chrysanthemum, 3 parts of poria cocos, 3 parts of coix seeds, 3 parts of fingered citron, 2 parts of pericarpium citri reticulatae, 2 parts of pericarpium citri reticulatae viride, 3 parts of rhizoma atractylodis macrocephalae, 2 parts of hawthorn, 3 parts of liquorice, 3 parts of fructus perillae, 3 parts of salvia miltiorrhiza, 2 parts of radix paeoniae alba, 2 parts of angelica sinensis, 2 parts of rehmannia, 2 parts of fructus lycii, 3 parts of astragalus membranaceus and 4 parts of hovenia dulcis thunb. The traditional Chinese medicine composition has the effects of clearing heat, resolving dampness, soothing the liver, regulating qi, strengthening the spleen and the stomach, reducing phlegm, promoting blood circulation to remove blood stasis, nourishing yin, tonifying qi, relieving alcoholism, preventing alcoholic liver injury in an auxiliary manner and promoting the body to recover a normal and healthy state.

The maca extract has the effects of protecting alcoholic liver injury and relaxing the bowels. The maca extract is a maca water extract or a maca alcohol extract or a maca powder solution.

The embodiment of the invention discloses silybum marianum peptide as well as a preparation method and application thereof, and belongs to the technical field of bioactive peptides. The silybum marianum peptide comprises a peptide chain 1, a peptide chain 2 and a peptide chain 3, the peptide chain 1 comprises an amino acid sequence as shown in SEQ ID NO: 1, the peptide chain 2 comprises an amino acid sequence as shown in SEQ ID NO: 2, and the peptide chain 3 comprises an amino acid sequence as shown in SEQ ID NO: 3. The silybum marianum peptide disclosed by the invention has a remarkable effect of improving or relieving the non-alcoholic liver injury, can effectively regulate lipid metabolism and relieve oxidative stress and inflammatory response, and provides a new effective means for treating the non-alcoholic liver injury. The silybum marianum peptide disclosed by the invention is derived from natural silybum marianum, is high in safety and small in side effect, can be applied to multiple fields of medicines, health foods and the like, and has good social benefits and economic benefits. The preparation method is simple, low in cost and suitable for large-scale industrial production, and has a wide market application prospect.

The present invention relates to the field of biomedicine and specifically discloses a composition containing clausenamide and its use in preparing a medicament for treating liver damage. The clausenamide-containing composition comprises clausenamide and an active compound; the active compound is selected from ergolactone and / or isosaxifragine. Studies have shown that the composition has an effect on resisting alcoholic liver damage and, in addition, an effect on resisting hepatitis B virus. Therefore, using the composition of the present invention as an active ingredient in preparing a medicament for treating liver damage and a medicament for resisting hepatitis B virus has important application value.

The invention provides a theaflavin composition for treating alcoholic liver injury as well as a preparation method and application thereof, and relates to the technical field of medicines. The theaflavin composition comprises theaflavin, a radix puerariae extract, a hovenia dulcis thunb extract, a coreopsis tinctoria extract, a kelp extract, a licorice extract and an antioxidant. Wherein the theaflavin, the senecio cineraria extract and the antioxidant can reduce oxidative stress, the radix puerariae extract, the liquorice extract and the hovenia dulcis thunb extract have an anti-inflammatory effect, the radix puerariae extract and the hovenia dulcis thunb extract promote alcohol metabolism, and the kelp extract and the liquorice extract have an effect of promoting liver cell regeneration. All the components of the theaflavin composition can effectively relieve alcoholic liver injury through multi-target and multi-path synergistic effects, and the theaflavin composition has remarkable liver protection and anti-inflammatory effects.

The invention belongs to the technical field of protein, and relates to an anti-digestion peptide capable of relieving alcoholic liver injury and a preparation method and application thereof, and the amino acid sequence of the peptide is PIPFPR. The anti-digestion peptide can resist degradation of gastrointestinal tract digestive enzymes and be absorbed by intestinal epithelial cells, and can relieve liver cell injury by resisting cell viability decline, scavenging free radicals and resisting oxidative stress induced by ethanol. The invention also provides a preparation method and application of the absorption peptide for resisting digestion and relieving alcoholic liver injury.

This invention discloses the application of a traditional Chinese medicine composition in the preparation of drugs, foods, or health products for the prevention and / or treatment of Alzheimer's disease and / or neuroinflammation and / or cognitive impairment. The traditional Chinese medicine composition includes Hovenia dulcis, mung bean, sea buckthorn or fresh sea buckthorn, tangerine peel, mulberry or fresh mulberry, turmeric, and hawthorn. It exhibits good preventive and therapeutic effects on Alzheimer's disease, improves neuroinflammation, and alleviates cognitive impairment. It can effectively avoid the toxic effects of acetaldehyde on the human body, achieve the prevention of drunkenness and rapid sobering up. It has good improvement effects on alcoholic liver damage, alcoholic gastric damage, alcoholic kidney damage, alcoholic brain damage, alcoholic cardiomyopathy, and alcohol-induced cognitive impairment. It also has the effects of protecting the cardiovascular and cerebrovascular systems, strengthening the spleen and stomach, and protecting the liver. It has the advantages of having a small number of medicinal ingredients, low cost, convenient administration, no obvious toxic side effects, and convenient daily carrying. It is suitable for timely administration by people who want to sober up and for preventive health care by the general population. Its market prospects are even broader.

The invention provides a probiotic compound preparation with double effects of short-term hangover alleviating and long-term liver protection. The silybum marianum and hovenia dulcis thunb compound is fermented through the bifidobacterium animalis subsp. Animalis HX-BA21, and the concentration of the anti-inflammatory protein P75, the dihydromyricetin and the silybin which serve as core functional components is remarkably increased; and further compounding with corn oligopeptide, glutathione yeast and turmeric to construct a multi-channel synergistic system of anti-inflammation, metabolism acceleration, oxidation resistance, hepatocyte repair and lipid metabolism regulation. On one hand, alcohol metabolism is accelerated, the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) is improved, and rapid alcohol effect dispelling is achieved; on the other hand, the antioxidant capacity is enhanced (SOD and GSH-Px are remarkably improved, and MDA is reduced), intestinal tract-derived inflammation signals are synergistically inhibited (IL-6 and TNF-alpha are reduced), hepatocytes are synergistically repaired, and lipid metabolism is regulated (TC and TG of the liver and ALT and AST of serum are reduced) through P75 protein, so that long-term protection and hepatocyte repair of alcoholic liver injury are realized while the acute drunkenness symptom is relieved. The method has the advantages of high efficiency, safety and multi-target intervention, and is obviously superior to a single component or a simple physical mixture.

The application belongs to the technical field of proteins, and relates to an anti-digestion peptide capable of relieving alcoholic liver injury, a preparation method and application of the anti-digestion peptide, and the amino acid sequence of the anti-digestion peptide is PIPFPR. The anti-digestion peptide can resist the degradation of gastrointestinal digestive enzymes and be absorbed by intestinal epithelial cells, can resist the decrease of cell viability, eliminate free radicals, resist ethanol-induced oxidative stress, and relieve liver cell injury. The application further provides a preparation method and application of the anti-digestion peptide capable of relieving alcoholic liver injury.