39 results about "Alcoholic liver damage" patented technology

The invention relates to a plant composition as well as a preparation method and application thereof, and belongs to the technical field of health food. The plant composition is prepared from the following components in parts by mass: 5 to 30 parts of fructus gardeniae, 5 to 30 parts of fructus rubi and 5 to 30 parts of fructus lycii. The plant composition can effectively relieve liver oxidative stress and inflammation conditions, relieve and / or improve alcoholic liver injury, protect liver cells from oxidative injury, assist a body in resisting oxygen free radical invasion and maintain the health state of the body, does not affect the blood sugar level, and has the advantages of being reasonable in compatibility, good in quality, safe and effective.

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating alcoholic liver injury, a preparation and application thereof, the optimal medicine ratio is determined, the traditional Chinese medicine composition is dendrobium officinale liver protection soup, and the active ingredient raw materials of the traditional Chinese medicine composition comprise the following raw materials in parts by weight: 5-15 parts of dendrobium officinale, 6-10 parts of turmeric, 10-20 parts of radix puerariae, 6-12 parts of medicated leaven and 2-6 parts of amomum cardamomum. The dendrobium huoshanense liver protection decoction can remarkably reduce the levels of ALT, AST and TG in mouse serum, reduce the content of MDA in the liver and the levels of IL-1beta, IL-6 and TNF-alpha, improve the SOD level, relieve fat deposition in the mouse liver, relieve pathological damage to the mouse liver and relieve the oxidative stress level and the inflammatory factor level, and has a good protection effect on the liver with alcoholic liver damage.

The invention provides construction of gene engineering lactic acid bacteria with high expression of IL22 and a protective effect of the gene engineering lactic acid bacteria on alcoholic liver injury. The gene engineering lactic acid bacteria are lactobacillus reuteri DSM17938-IL22. The invention further provides a preparation method of the gene engineering lactic acid bacteria. The lactobacillus reuteri is obtained by electrically transforming a recombinant plasmid pSET4s-himar1-cat-IL22 into a competent cell of a probiotic lactobacillus reuteri DSM17938, and the lactobacillus reuteri is preserved in the China Center for Type Culture Collection in March 2023. The IL22 and the lactobacillus reuteri can effectively improve intestinal epithelium injury and relieve liver inflammation, the lactobacillus reuteri can further induce generation of the IL22, and the combination of the IL22 and the lactobacillus reuteri can obviously improve intestinal microbiota. Therefore, the lactobacillus reuteri can give full play to the synergistic effect of the lactobacillus reuteri and the lactobacillus reuteri, and a better intestinal liver axis immunoregulation effect is achieved.

A use of Hemerocallis citrina Baroni or an extract thereof as an active ingredient in preparing a composition for dispelling effects of an alcohol. In addition, the composition can also be used for auxiliary protection against alcoholic liver damage.

The present invention belongs to the field of food biotechnology and discloses an oyster high F value oligopeptide for protecting against alcoholic liver damage, as well as its preparation method and application. The present invention obtains four high F value oligopeptides for protecting against alcoholic liver damage from Pacific oyster meat through two-step enzymatic hydrolysis, including at least one of the peptides with amino acid sequences shown in SEQ.ID.NO.1~4. The docking energies of the four high F value oligopeptides with the ALDH receptor are ‑7.1 kcal / mol, ‑6.5 kcal / mol, ‑8.0 kcal / mol and ‑7.2 kcal / mol, respectively. The above peptides have a high ALDH activation rate. The oyster-derived high F value oligopeptides for protecting against alcoholic liver damage of the present invention can be used for the research and development of functional foods and have broad market prospects.

This invention discloses a compound peptide nutrient with fat-reducing effects, belonging to the field of health food technology. Specifically, it relates to a VQPIPY peptide or a product containing VQPIPY peptide in the preparation of lipid-lowering drugs or health products, or in the preparation of drugs for treating and / or alleviating alcoholic liver damage. This invention also provides a meal replacement powder containing VQPIPY peptide, shown as a compound of whey powder, milk powder, oats, spinach powder, allulose, and camel milk peptide in a specific ratio. Through the synergistic effect of its components, this product achieves multiple effects such as providing satiety, inhibiting blood sugar, and lowering blood lipids. It is characterized by balanced nutrition, safety, effectiveness, and good taste, and can be used for weight management and daily health maintenance.

The invention belongs to the field of medicines, and relates to a traditional Chinese medicine composition for dispelling the effects of alcohol and relieving alcoholic liver injury and application thereof. The pharmaceutical composition is prepared from the following raw materials: curcuma zedoary, fructus amomi, rhizoma alismatis, rhizoma atractylodis macrocephalae and radix angelicae.

The invention discloses a medicinal and edible composite particle capable of relieving liver injury and a preparation method and application thereof.The particle is a puerarin-loaded phosphorylated hollow zein-chitosan oligosaccharide particle and has an efficient delivery structure with the exterior hydrophilic and the interior hydrophobic, the bioavailability is improved while the puerarin drug loading capacity is increased, and the bioavailability is improved. The circulation time in the body is prolonged, and the medicinal effect is enhanced. Meanwhile, the chitosan oligosaccharide in the components of the composite particle has a liver protection effect and can be cooperated with the anti-oxidation and anti-alcohol characteristics of puerarin, so that multi-target protection in alcoholic liver injury is realized, and the composite particle can be used for expanding and developing treatment medicines or health-care foods with anti-alcohol and liver-protecting effects and has remarkable economic and social values.

The invention belongs to the technical field of pharmacotherapeutics, and particularly relates to application of cryptochlorogenic acid in preparation of a medicine for preventing and treating alcoholic liver injury. The cryptochlorogenic acid has a structural formula as shown in a formula A: # imgabs0 # experiments show that the cryptochlorogenic acid can reduce liver tissue lipid metabolism disorder and reduce cell inflammation in a dose-dependent manner, reduce the levels of ALT, AST, TG, TG and LPS in animal serum, remarkably improve alcohol-induced deletion of intestinal tight junction protein, reduce intestinal leakage, and improve the bioavailability of the liver tissue. Therefore, the compound has a certain capability of treating or preventing the alcoholic liver injury, and has the potential of being developed into a medicine for treating or preventing the alcoholic liver injury.

This invention relates to a composition for improving alcoholic liver damage, belonging to the field of health product technology. This application provides the use of rhodioloside and lactose-N-trisaccharide in the prevention and / or inhibition of alcoholic liver disease. This application also provides a composition of human lactose oligosaccharides and rhodioloside. The compositions described in this application can prevent the occurrence of alcoholic liver disease or inhibit its further deterioration. This application provides a green, safe, and healthy composition, offering an ideal composition for protecting human health.

This invention discloses the application of American ginseng glycoprotein extract in the preparation of drugs for treating alcoholic liver disease, belonging to the field of biomedical technology. This invention verifies that TD can significantly reduce serum ALT, AST, and TG levels in ALD mice, effectively reducing liver damage and lipid accumulation; inhibit NLRP3 protein expression and its downstream targets, effectively alleviating liver inflammation and pyroptosis; and improve intestinal flora imbalance in ALD mice. American ginseng glycoprotein extract has multi-target protective effects against alcoholic liver disease, reducing alcohol-induced liver tissue inflammation and oxidative stress damage. It has a mild composition and high safety profile, and can synergistically exert effects in liver protection, anti-inflammation, and antioxidation, making it suitable for adjunctive intervention and long-term management of alcoholic liver disease, providing a natural, mild, and effective protective pathway for alcoholic liver damage.

The invention relates to a novel application of ergothioneine, in particular to an application of ergothioneine in preparation of a product for preventing or improving alcoholic liver injury. The invention finds that the ergothioneine has a very remarkable effect in the aspect of preventing or improving the alcoholic liver injury, and the ergothioneine particularly has the effects of preventing or relieving liver pathological injury, regulating alcohol metabolism, regulating lipid metabolism, improving liver oxidative stress injury and improving the liver inflammation state. The ergothioneine is used for preparing products with related effects and has an application prospect.

A Limosilactobacillus fermentum strain capable of alleviating a hangover and the use thereof. The strain is at least one strain of Limosilactobacillus fermentum ibiome020, Limosilactobacillus fermentum ibiome021 and Limosilactobacillus fermentum ibiome022 respectively deposited with deposit numbers of CCTCC NO: M 2024188, CCTCC NO: M 2024222 and CCTCC NO: M 2024189. The Limosilactobacillus fermentum is a natural bacterium derived from the intestine of a healthy human and has high safety; can alleviate chronic / acute alcoholism, alcoholic intestinal damage or alcoholic liver damage; can accelerate the metabolism of ethanol and / or acetaldehyde, and delay the onset of intoxication; can shorten the sobering-up time; can reduce the mortality caused by drinking alcohol; can reduce the liver index; can lower the level of AST and / or ALT in serum; can alleviate discomfort caused by ethanol and / or acetaldehyde, and mitigate symptoms such as dizziness, headache, nausea and vomiting, and hangover after drinking alcohol; can ameliorate oxidative stress caused by alcohol, and increase the level of GSH in the liver; and also has excellent resistance to gastrointestinal fluid and bile salt, and can adapt to the complex environment within the body.

The invention discloses a charcoal medicine with an effect of treating alcoholic liver injury, belongs to the technical field of medicines, relates to the charcoal medicine with the effect of treating the alcoholic liver injury, and in particular relates to a novel application of charcoal of achyranthes bidentata in preparation of a medicine for treating the alcoholic liver injury. Animal pharmacological experiments show that the charred achyranthes bidentata has a definite protection effect on alcoholic liver injury, and has the effects of relieving liver pathological injury, resisting inflammation and resisting oxidation.

A method for extracting 3,5-O-dicaffeoylquinic acid from Huangshan Gongju and its application in drugs for protecting against alcoholic liver damage. The 3,5-O-dicaffeoylquinic acid has the following structural formula:The present disclosure selects the medicinal and edible homology plant, Huangshan Gongju, as the research object. This plant is abundant in resources and the raw materials are easy to obtain. Specifically, the present disclosure uses 70% ethanol to extract Huangshan Gongju, uses the method of bioactivity-guided isolation, and uses a FLA-2025-10-120A preparative liquid chromatograph to isolate a phenolic compound from the active site of Gongju that resists alcoholic liver damage. The compound separation method is simple, quick, and easy to operate.

The invention discloses saposhnicovia divaricata polysaccharide as well as a preparation method and application thereof, and belongs to the field of natural polymers. The method has the advantages that the average relative molecular weight is measured through GPC, monosaccharide composition is analyzed through GC-MS, it is found that the average relative molecular weight of the saposhnicovia divaricata polysaccharide RSP-1 is 111125 Da, the protein content of the saposhnicovia divaricata polysaccharide RSP-1 is 1.29%, the saposhnicovia divaricata polysaccharide RSP-1 does not contain uronic acid and is neutral polysaccharide, and it is found that trace beta-pyranose exists. Meanwhile, the saposhnicovia divaricata polysaccharide RSP-1 disclosed by the invention can be used for remarkably relieving liver fat infiltration, reducing the number of ballooning and necrotic cells and relieving alcoholic liver injury.

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating alcoholic hepatitis. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 15 to 20 parts of radix puerariae, 15 to 20 parts of rhizoma phragmitis, 15 to 20 parts of rhizoma imperatae, 10 to 15 parts of dried herba dendrobii, 6 to 10 parts of fructus citri sarcodactylis, 10 to 15 parts of herba pogostemonis, 15 to 20 parts of herba lophatheri, 6 to 10 parts of herb tea and 10 to 15 parts of pericarpium citri reticulatae. The research finds that the aqueous extract of the traditional Chinese medicine composition can remarkably improve alcoholic liver injury tissue edema and inflammatory cell infiltration, improve the alcohol metabolism capability of a body, relieve inflammatory response and reduce the oxidative stress level of liver tissue, so that the purposes of treating alcoholic hepatitis and protecting the liver are achieved.

The present invention relates to the use of fermented lactobacillus grx08 in the preparation of food, functional food and medicine with the effect of alleviating alcoholic liver damage and related symptoms thereof, and the preservation number of the fermented lactobacillus grx08 is CGMCC No: 7695. The fermented lactobacillus grx08 has the effect of reducing alcohol dehydrogenase and alleviating and restoring the balance of ethanol metabolism. The fermented lactobacillus grx08 has the effect of reducing alanine aminotransferase, reducing liver lipid accumulation, reducing liver lipid peroxidation products, and alleviating liver damage. Animal experiments have shown that fermented lactobacillus grx08 (CGMCC No: 7695) can restore the metabolic balance of rat alcohol dehydrogenase, reduce the level of alanine aminotransferase, reduce lipid accumulation and lipid peroxides in the liver, and alleviate liver damage. In addition, fermented lactobacillus grx08 can also alleviate kidney damage, enhance the tight connectivity of rat intestines, reduce inflammatory factors in the body, and alleviate the increase in blood sugar caused by acute alcohol intervention.

The invention discloses an astaxanthin carrier with liver targeting and intestinal slow release effects for improving acute alcoholic liver injury and a preparation method of the astaxanthin carrier, and belongs to the field of food science and biological medicine. The astaxanthin in the astaxanthin carrier is loaded by sea cucumber peptide (SCP) and proanthocyanidins (PCs) and encapsulated in hyaluronic acid and the sea cucumber peptide carrier, so that liver enrichment of stable and high-expression astaxanthin is realized, and the effect of improving acute alcoholic liver injury is realized in animal experiments. Therefore, the problems that the astaxanthin is poor in stability and low in availability when being directly applied to living bodies are effectively solved. The carrier has high loading capacity, intestinal slow release and liver targeting capacity, can effectively relieve symptoms of the acute alcoholic liver injury by repairing liver tissue injury, reduces oxidative stress and expression level of inflammatory factors, and lays a foundation for relieving and treating the acute alcoholic liver injury by accurately delivering AXT.

The invention discloses an application of Aradiclat lactobacillus plantarum GXUN74705 in improvement of alcoholic liver injury, and belongs to the technical field of microorganisms. The invention proves that the application of the Aradicatrat lactobacillus plantarum GXUN74705 in treating the alcoholic liver injury, the strain can effectively improve the liver injury caused by alcohol, and the pathological process of the alcoholic liver injury is comprehensively relieved by regulating liver function indexes, correcting blood lipid metabolism disorder, relieving oxidative stress and inhibiting inflammatory response. In addition, the strain can also reduce liver lipid accumulation, repair a liver cell structure, and further improve liver health by adjusting an intestinal flora structure and intestinal bile acid metabolism. The strain has remarkable effects in the aspects of reducing blood fat, reducing cholesterol, resisting oxidation and the like, or has important clinical application and market value when being applied to foods, food additives, health care products, medicines or feeds as functional probiotics.

The invention belongs to the technical field of food source nutrient nano-delivery, and discloses a preparation method of a protein and astaxanthin nano-composite based on low-frequency acoustic resonance, galactose is used for modifying protein through a low-temperature Maillard reaction, high acceleration and acoustic flow are generated by using low-frequency acoustic resonance equipment, and the nano-composite is prepared. According to the present invention, the astaxanthin is uniformly entrapped in the protein-galactose composite carrier to form the stable nanometer suspending agent, the method has advantages of green environmental protection, significant treatment effect and the like, the water solubility, the targeting property and the bioavailability of the astaxanthin can be effectively improved, the astaxanthin can be accurately delivered to the liver, and the alcoholic liver injury repair can be rapidly promoted.

The application provides application of Gao Yao-4 medicine powder in preparation of a medicine for treating or preventing acute alcoholic liver, and belongs to the field of medicine. It is found for the first time that the drugs in the Gao Yao-4 medicine powder have a combined effect, can effectively reduce the content of AST, ALT and TBIL in serum and liver tissue after a large amount of drinking, effectively reduce the content of TC, TG, MDA, TNF-alpha, IL-1beta and IL-6 in liver tissue after a large amount of drinking, improve the content of SOD, reduce the apoptosis rate of liver tissue cells, improve the expression amount of Bc1-2 protein, and reduce the expression amount of Bax, caspase3 and C-caspase3 protein, and has a repairing and protecting effect on alcoholic liver cell damage. It is shown that the Gao Yao-4 medicine powder can be used for treating / preventing acute alcoholic liver damage, and does not have side effects, and has high safety.

This invention provides a traditional Chinese medicine composition with hepatoprotective and alcohol-relieving effects, made from the following raw materials in parts by weight: 1-5 parts rose petals, 1-5 parts chrysanthemum, 1-5 parts Japanese raisin tree fruit, 1-5 parts paper mulberry fruit, and 1-5 parts kudzu root. The traditional Chinese medicine composition of this invention can be prepared into decoctions, granules, powders, capsules, tablets, mixtures, or oral liquids using conventional pharmaceutical methods. The formulation of the traditional Chinese medicine composition of this invention is based on traditional Chinese medicine theory combined with modern medical research findings, and has hepatoprotective and alcohol-relieving effects. Experimental studies have shown that this composition has good preventive and therapeutic effects on alcoholic liver damage and cirrhosis.

The invention relates to the technical field of spica prunellae polysaccharide extraction, and discloses a spica prunellae polysaccharide and an extraction method and application thereof, the method comprises the following steps: (1) crushing spica prunellae clusters, sieving, and degreasing with an organic solvent; (2) mixing the degreased prunella vulgaris powder with water, stirring at 20-28 DEG C, and repeating for 2-4 times to obtain first medicinal material residues; (3) stirring the first medicinal material residues in hot water at 75-85 DEG C, repeating for 1-3 times, and stirring the obtained second medicinal material residues with acidified water; and (4) extracting the third medicinal material residue by using an ammonium oxalate solution, repeatedly extracting for 1-3 times, and decoloring and deproteinizing the collected extracting solution. According to the method, cold water, hot water and acidified water are sequentially adopted for pre-treatment of selfheal, then an ammonium oxalate solution is utilized for polysaccharide extraction, the selfheal polysaccharide is obtained, the purity and the yield of the selfheal polysaccharide are high, and the selfheal polysaccharide is identified as pectic polysaccharide; the prunella vulgaris pectic polysaccharide has good prevention and treatment effects on alcoholic liver injury.

The invention relates to the field of food, in particular to milk tea, a preparation method thereof and application of the milk tea in prevention of alcoholic liver injury or hangover alleviating. The milk tea is prepared from the following components in parts by volume: 35.6 to 40.6 parts of black tea extract, 60.9 to 64.9 parts of raw milk and 1.0 to 1.2 parts of fructus momordicae concentrated juice, wherein a preparation method of the black tea extract comprises the following steps: crushing black tea, adding ultrapure water according to a solid-liquid ratio of 1: (25-30), extracting at 90-100 DEG C, and centrifuging to obtain primary extraction supernatant and precipitate; adding an ethanol aqueous solution into the precipitate according to a solid-liquid ratio of 1: (25-30), carrying out secondary extraction at 90-100 DEG C, and centrifuging to obtain a secondary extraction supernatant; combining the supernate, and concentrating to obtain the black tea extract. The milk tea provided by the invention can prevent liver injury caused by AALI by promoting alcohol metabolism, relieving oxidative stress injury and relieving liver inflammation.

The present invention relates to the field of food, and in particular to a milk tea and its preparation method and its application in preventing alcoholic liver damage or sobering up. The milk tea, by volume, comprises 35.6-40.6 parts of black tea extract, 60.9-64.9 parts of raw cow's milk and 1.0-1.2 parts of monk fruit concentrate; wherein, the preparation method of the black tea extract comprises the following steps: crushing the black tea, adding ultrapure water according to a material-liquid ratio of 1:25-30, extracting at 90-100°C, centrifuging to obtain a primary extraction supernatant and a precipitate; adding ethanol aqueous solution to the precipitate according to a material-liquid ratio of 1:25-30, extracting twice at 90-100°C, centrifuging to obtain a secondary extraction supernatant; combining the supernatants, concentrating to obtain the black tea extract. The milk tea of ​​the present invention prevents liver damage caused by AALI by promoting alcohol metabolism, reducing oxidative stress damage and alleviating liver inflammation.

The invention provides application of setuzumab in preparation of a medicine for treating non-alcoholic liver injury, and belongs to the technical field of biological medicine. Results show that the setutuzumab can significantly reduce ALT level and AST level in serum of a mouse with non-alcoholic liver injury, so that the setutuzumab can effectively prevent and / or treat the non-alcoholic liver injury. Space exploration experiment results show that the exploration distance of the quadrant where the platform of the non-alcoholic liver injury model mouse treated by the cetuzumab is located, the exploration time of the quadrant where the platform is located and the crossing frequency are obviously larger than those of a control group, so that the cetuzumab effectively improves the spatial memory ability and the positioning cruising ability of the non-alcoholic liver injury model mouse; therefore, the effect of treating the cognitive impairment caused by the non-alcoholic liver injury is achieved. Open field and tail suspension experiment results show that the cetuzumab can improve depression and anxiety behaviors of non-alcoholic liver injury model mice, and has the effect of treating depression caused by non-alcoholic liver injury.

This invention discloses a traditional Chinese medicine compound composition and a probiotic-fermented traditional Chinese medicine compound composition for alleviating alcoholic liver damage. The raw materials include Terminalia chebula, Phragmites communis, Morus alba, Polygonatum sibiricum, Hovenia dulcis, Hippophae rhamnoides, Fennel, Mung bean, Glycyrrhiza uralensis, Lycium barbarum, and Jujube. The fermented probiotics are Lactobacillus rhamnosus and Bifidobacterium adolescentis. The traditional Chinese medicine compound and its probiotic fermentation product of this invention can improve hepatocyte vitality, reduce alcohol-induced hepatocyte damage, regulate hepatic lipid metabolism disorders, and achieve the effect of detoxifying and protecting the liver by reducing alcohol-induced oxidative stress in the liver.

The invention provides a traditional Chinese medicine health-care product for assisting in preventing alcoholic liver injury, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 parts of dandelion, 4 parts of radix puerariae, 2 parts of radix paeoniae rubra, 2 parts of honeysuckle, 2 parts of chrysanthemum, 3 parts of poria cocos, 3 parts of coix seeds, 3 parts of fingered citron, 2 parts of pericarpium citri reticulatae, 2 parts of pericarpium citri reticulatae viride, 3 parts of rhizoma atractylodis macrocephalae, 2 parts of hawthorn, 3 parts of liquorice, 3 parts of fructus perillae, 3 parts of salvia miltiorrhiza, 2 parts of radix paeoniae alba, 2 parts of angelica sinensis, 2 parts of rehmannia, 2 parts of fructus lycii, 3 parts of astragalus membranaceus and 4 parts of hovenia dulcis thunb. The traditional Chinese medicine composition has the effects of clearing heat, resolving dampness, soothing the liver, regulating qi, strengthening the spleen and the stomach, reducing phlegm, promoting blood circulation to remove blood stasis, nourishing yin, tonifying qi, relieving alcoholism, preventing alcoholic liver injury in an auxiliary manner and promoting the body to recover a normal and healthy state.

The maca extract has the effects of protecting alcoholic liver injury and relaxing the bowels. The maca extract is a maca water extract or a maca alcohol extract or a maca powder solution.