A traditional Chinese medicine compound composition for treating hypertension-induced dizziness and its preparation method

Abstract

The present invention relates to the technical field of traditional Chinese medicine for treating hypertension vertigo, and particularly relates to a traditional Chinese medicine compound composition for treating hypertension vertigo and a preparation method thereof. Calculated by mass parts, the raw materials of the traditional Chinese medicine compound composition for treating hypertension vertigo include: calcined magnetite 30 - 120 parts, eucommia ulmoides 15 - 60 parts, gastrodia elata 20 - 180 parts, apocynum venetum leaves 15 - 120 parts, cyathula officinalis 10 - 40 parts, pinellia ternata processed with rhizoma zingiberis recens 8 - 30 parts, stir-fried atractylodes macrocephala 15 - 120 parts, alisma orientale 10 - 120 parts, pueraria lobata 30 - 120 parts, corn stigma 10 - 60 parts, and stevia rebaudiana 10 - 40 parts. The traditional Chinese medicine compound composition of the present invention has a good antihypertensive effect on patients with hypertension vertigo, can significantly improve the clinical symptoms of patients with hypertension vertigo such as dizziness and heaviness in the head, dizziness and blurred vision, dimmed vision, tinnitus and bitter taste in the mouth, nausea and vomiting, limb numbness, restlessness and difficulty in falling asleep, etc. The curative effect on treating hypertension vertigo (syndrome of wind-phlegm disturbing upward) is definite, and the medication is safe and reliable.

Description

Technical Field

[0001] The invention relates to the technical field of treating hypertension and vertigo with traditional Chinese medicine, and in particular to a traditional Chinese medicine compound composition for treating hypertension and vertigo and a preparation method thereof. Background Art

[0002] Vertigo is an abnormal sense of orientation of the human body to spatial relationships. It often occurs suddenly with severe symptoms, such as dizziness, visual rotation, nausea, and vomiting. Vertigo is common in patients with hypertension, who are a high-risk group for vertigo. Increased blood pressure can induce or be accompanied by vertigo, and vertigo can also induce increased blood pressure. The two can be mutually causal, forming a vicious circle. When hypertension causes vertigo, if the symptoms of vertigo are not actively improved, the antihypertensive effect will be greatly affected. At the same time, for the increase in blood pressure involved in the symptoms of vertigo, if antihypertensive drugs are excessively used without actively improving the symptoms of vertigo, it is easy to cause hypotension after the vertigo gradually improves. However, most of the existing clinical antihypertensive drugs only target the reduction of blood pressure values, and have no obvious improvement effect on the symptoms of vertigo. There is no ideal drug in the existing clinic that can simultaneously reduce blood pressure and improve vertigo symptoms. Summary of the invention

[0003] Based on the above content, the present invention provides a Chinese medicine compound composition for treating hypertensive vertigo and a preparation method thereof. The Chinese medicine compound composition for treating hypertensive vertigo of the present invention solves the clinical prevention and treatment difficulty of the balance between the vertigo symptoms of hypertensive vertigo and the blood pressure level, has a therapeutic effect on hypertensive vertigo, and has the effects of resolving phlegm and calming wind, calming the liver and suppressing yang.

[0004] To achieve the above object, the present invention provides the following solutions:

[0005] One of the technical solutions of the present invention is a Chinese medicine compound composition for treating hypertension and vertigo. The raw materials include, by weight: 30-120 parts of calcined magnetite, 15-60 parts of eucommia bark, 20-180 parts of gastrodia elata, 15-120 parts of apocynum venetum leaves, 10-40 parts of cyathula officinalis, 8-30 parts of pinellia ternata, 15-120 parts of stir-fried atractylodes macrocephala, 10-120 parts of orientalis, 30-120 parts of kudzu root, 10-60 parts of corn silk, and 10-40 parts of stevia.

[0006] The second technical solution of the present invention is a method for preparing the above-mentioned Chinese medicine compound composition for treating hypertension and vertigo, comprising the following steps:

[0007] According to the mass proportion, calcined magnetite is boiled with water to obtain filtrate 1;

[0008] Add water to the raw materials except the calcined magnetite and boil them to obtain filtrate 2;

[0009] The filtrate 1 and the filtrate 2 are combined and filtered, concentrated, precipitated with alcohol to remove the precipitate, and concentrated in sequence to obtain an extract.

[0010] The third technical solution of the present invention is a medicine for treating hypertension and vertigo, the raw materials of which include the above-mentioned Chinese medicine compound composition for treating hypertension and vertigo.

[0011] The present invention discloses the following technical effects:

[0012] The invention provides a Chinese medicine compound composition for treating hypertension and vertigo, which has good curative effect of lowering blood pressure and improving dizziness symptoms in patients with hypertension and vertigo, and can significantly improve clinical symptoms of dizziness, heaviness of the head, vertigo, blurred vision, tinnitus, bitter taste in the mouth, nausea and vomiting, limb numbness, restlessness and insomnia in patients with hypertension and vertigo, has a definite curative effect in treating hypertension and vertigo (wind-phlegm disturbance syndrome), has little toxic and side effects when taken for a long time, and is safe and reliable. DETAILED DESCRIPTION

[0013] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0014] It should be understood that the terms described in the present invention are only for describing a particular embodiment and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0015] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0016] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present invention description and examples are exemplary only.

[0017] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0018] The first aspect of the present invention provides a Chinese medicine compound composition for treating hypertension and vertigo. The raw materials include, by weight, 30 to 120 parts of calcined magnetite, 15 to 60 parts of eucommia bark, 20 to 180 parts of gastrodia elata, 15 to 120 parts of apocynum venetum leaves, 10 to 40 parts of cyathula capitata, 8 to 30 parts of pinellia ternata, 15 to 120 parts of stir-fried atractylodes macrocephala, 10 to 120 parts of orientalis, 30 to 120 parts of kudzu root, 10 to 60 parts of corn silk, and 10 to 40 parts of stevia.

[0019] In a preferred embodiment of the present invention, the raw materials include, by mass: 30 parts of calcined magnetite, 15 parts of Eucommia ulmoides, 20 parts of Gastrodia elata, 15 parts of Apocynum venetum leaves, 10 parts of Cyathula capitata, 8 parts of Pinellia ternata, 15 parts of stir-fried Atractylodes macrocephala, 10 parts of Alisma orientalis, 30 parts of Pueraria root, 10 parts of Corn silk, and 10 parts of Stevia rebaudiana.

[0020] In a preferred embodiment of the present invention, the raw materials include, by mass: 30 parts of calcined magnetite, 20 parts of Eucommia ulmoides, 120 parts of Gastrodia elata, 60 parts of Apocynum venetum leaves, 30 parts of Cyathula capitata, 15 parts of Pinellia ternata, 60 parts of stir-fried Atractylodes macrocephala, 60 parts of Orientalis alisma, 60 parts of Pueraria root, 30 parts of Corn silk, and 20 parts of Stevia rebaudiana.

[0021] In a preferred embodiment of the present invention, the raw materials include, by mass: 120 parts of calcined magnetite, 60 parts of Eucommia ulmoides, 180 parts of Gastrodia elata, 120 parts of Apocynum venetum leaves, 40 parts of Cyathula capitata, 30 parts of Pinellia ternata, 120 parts of stir-fried Atractylodes macrocephala, 120 parts of Alisma orientalis, 120 parts of Pueraria lobata, 60 parts of Corn silk, and 40 parts of Stevia rebaudiana.

[0022] The multi-target and multi-pharmacodynamic synergistic advantages of traditional Chinese medicine have obvious advantages in the treatment of hypertensive vertigo. It can synergistically act and synergistically improve the symptoms of high blood pressure and vertigo. The clinical manifestations of hypertensive vertigo are related to diseases such as "vertigo and headache" in traditional Chinese medicine. Based on relevant knowledge of traditional Chinese medicine, the inventor of the present invention innovatively proposed the "phlegm-excess and wind-induced" pathogenesis theory system of hypertensive vertigo, and believed that the main location of the disease is in the liver and spleen, "the disease originates from liver depression and spleen deficiency, and is caused by internal accumulation of phlegm and dampness, liver fire and dampness and heat, and yin injury and yang hyperactivity. The disease is caused by liver wind causing phlegm turbidity to rush up and disturb the clear orifices." Guided by this pathogenesis theory, the prescription is prescribed and the treatment of hypertensive vertigo with calming wind and resolving phlegm is proposed, and a traditional Chinese medicine compound is condensed according to clinical experience, which can effectively lower blood pressure and relieve vertigo symptoms, with good clinical efficacy.

[0023] The Chinese medicine compound composition for treating hypertension and vertigo of the present invention aims at the basic pathogenesis of hypertension and vertigo caused by internal phlegm and dampness, liver fire and damp heat, yin injury and hyperactivity of yang, and liver wind causing phlegm turbidity to rush against the clear orifices, and establishes the treatment principle and method of resolving phlegm and calming wind, calming the liver and suppressing yang. In the prescription, the calcined magnetite has the property of heavy quality and sedimentation, which can calm energy and calm energy if it is heavy, has cold nature and clears heat, clears and purges the fire of the heart and liver, and suppresses the hyperactivity of the liver yang, enters the heart meridian and can calm the nerves, has salty taste and enters the kidney, and also has the function of benefiting the kidney, can protect the true yin, and suppress the floating yang; the pinellia is warm in nature and pungent in taste, can enter the spleen and stomach meridians, can dry spleen dampness, resolve phlegm and dampness, and reduce adverse qi; the two are cold and warm, and are used together, and are aimed at the core pathogenesis of wind and phlegm, and are the main medicines. Eucommia ulmoides moisturizes the liver, replenishes liver deficiency, and benefits the kidney essence; Gastrodia elata is called "wind-fixing grass" in the Compendium of Materia Medica, which can calm wind and stop spasms, calm liver yang, dispel wind and dredge collaterals; Alisma orientalis promotes diuresis, drains dampness, and relieves heat, and the Compendium of Materia Medica says that it "drains dampness and heat, and removes phlegm and fluid"; the three can nourish the liver and kidney, calm the liver and calm wind, promote diuresis and drain dampness, and help the main medicine, and are collectively the minister medicine. The leaves of Lophatherum venetum are bitter and cool in nature, and are specifically used in the liver meridian. They have the functions of calming liver yang, clearing liver heat, and promoting diuresis and draining dampness; stir-fried Atractylodes macrocephala can not only replenish qi to strengthen the spleen, but also dry dampness and promote urination; corn silk is sweet and light, and has the function of draining water and draining dampness; Stevia is sweet, harmonizes various medicines, improves the taste of medicines, and can lower blood pressure; Sichuan Cyathula promotes blood circulation and dredges menstruation, and can also lead blood downward; they are collectively the adjuvant medicine. Pueraria root, with a light body, floats and slightly descends, can lead the medicine upward into the head, and enters the spleen to relieve dryness, and is the guiding medicine. The combination of these medicines can resolve phlegm and calm wind, calm the liver and suppress yang, so that liver yang is leveled, liver wind is calmed, phlegm and dampness are discharged, yin and yang are harmonized, and symptoms are eliminated.

[0024] In a preferred embodiment of the present invention, the dosage form is ointment, oral solution, granules, capsules, tablets or pills.

[0025] The second aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine compound composition for treating hypertension and vertigo, comprising the following steps:

[0026] According to the mass proportion, calcined magnetite is boiled with water to obtain filtrate 1;

[0027] Add water to the raw materials except the calcined magnetite and boil them to obtain filtrate 2;

[0028] The filtrate 1 and the filtrate 2 are combined and filtered, concentrated, precipitated with alcohol to remove the precipitate, and concentrated in sequence to obtain an extract.

[0029] In a preferred embodiment of the present invention, the preparation method of the above-mentioned Chinese medicine compound composition for treating hypertension and vertigo comprises the following steps: weighing calcined magnetite by weight, adding water to decoct twice, combining the decoctions to obtain filtrate 1; weighing Eucommia ulmoides, Gastrodia elata, Apocynum venetum leaf, Cyathula officinalis, Pinellia ternata, stir-fried Atractylodes macrocephala, Rhizoma Alismatis, Radix Puerariae, Stigma corneum, Stevia rebaudiana, and decoction pieces by weight, adding water to decoct twice, combining the decoctions to obtain filtrate 2; combining filtrate 1 and filtrate 2, filtering the decoctions, concentrating the filtrate, subjecting the concentrated filtrate to alcohol precipitation treatment, filtering off the precipitate, recovering the filtrate after filtering off the precipitate and concentrating at 80°C to a relative density of 1.30 to 1.36, and obtaining an extract. The obtained extract can be prepared into an ointment, oral liquid, granule, capsule, tablet or pill dosage form as required.

[0030] In a further preferred embodiment of the present invention, the decocting time of the filtrate 1 is 2.0 hours each time, and the decocting time of the filtrate 2 is 1.0 hour each time; and the alcohol precipitation treatment uses ethanol with a volume concentration of 85%.

[0031] The third aspect of the present invention provides a medicine for treating hypertension and vertigo, the raw materials of which include the above-mentioned Chinese medicine compound composition for treating hypertension and vertigo

[0032] The present invention will be further described below by way of examples.

[0033] Example 1

[0034] A Chinese medicinal compound composition for treating hypertension and vertigo, the raw materials of which are 30g of calcined magnetite, 15g of eucommia bark, 20g of gastrodia elata, 15g of apocynum venetum leaf, 10g of cyathula officinalis, 8g of pinellia ternata, 15g of stir-fried atractylodes macrocephala, 10g of oriental arisaema, 30g of kudzu root, 10g of corn silk and 10g of stevia.

[0035] The preparation method of the water decoction of the above-mentioned Chinese medicine compound composition for treating hypertension and vertigo is as follows:

[0036] The calcined magnetite is placed in a casserole for decoction, 500 ml of water is added, the mixture is boiled over high heat, and the mixture is decocted over low heat for 30 min with the lid open; the remaining medicinal materials are added, the volume of water is increased to 500 ml, the mixture is boiled over high heat, and the mixture is decocted over low heat for 20 min with the lid open, and the decoction is filtered; the volume of water is increased to 500 ml, the mixture is boiled over high heat, and the mixture is decocted over low heat for 20 min with the lid open, and the decoction is filtered; the two decoctions are combined to obtain a water decoction of a Chinese medicine compound composition for treating hypertension and vertigo.

[0037] Example 2

[0038] A Chinese medicinal compound composition for treating hypertension and vertigo, the raw materials of which are 30g of calcined magnetite, 20g of Eucommia ulmoides, 120g of Gastrodia elata, 60g of Apocynum venetum leaf, 30g of Cyathula officinalis, 15g of Pinellia ternata, 60g of stir-fried Atractylodes macrocephala, 60g of Rhizoma Alismatis, 60g of Radix Puerariae, 30g of Corn Silk and 20g of Stevia rebaudiana.

[0039] The preparation method comprises the following steps:

[0040] Weigh the calcined magnetite according to the above weight, add water and boil it twice (the amount of water added for each decoction is 500 ml, and each decoction is first boiled over high heat and then boiled over low heat for 30 minutes), combine the decoctions obtained from the two times to obtain filtrate 1.

[0041] Weigh eucommia ulmoides, gastrodia elata, apocynum venetum leaves, cyathula officinalis, pinellia ternata, stir-fried atractylodes macrocephala, orientalis rhizome, kudzu root, corn silk, and stevia by weight, add water and decoct twice (the amount of water added for each decoction is 500 ml, and each decoction is first boiled over high heat and then decocted over low heat for 30 minutes), combine the decoctions obtained twice to obtain filtrate 2.

[0042] After combining filtrate 1 and filtrate 2, the filtrate was filtered and concentrated at a concentration temperature of 60°C (50-70°C) to a relative density of 1.10 (1.05-1.15) mg / cm 3 , a concentrated solution was obtained, and the concentrated solution was subjected to alcohol precipitation treatment (specifically: an ethanol-water solution with a volume concentration of 85% was added to the concentrated solution, and the volume ratio of ethanol-water solution to concentrated solution was 5:1, and the solution was stirred and dissolved at 60°C for 120 minutes), and then the precipitate was filtered off, and the obtained filtrate was recovered and concentrated at 80°C to a relative density of 1.33 (1.30-1.36) mg / cm 3 , obtain extract.

[0043] Example 3

[0044] A Chinese medicinal compound composition for treating hypertension and vertigo, the raw materials of which are 120g of calcined magnetite, 60g of Eucommia ulmoides, 180g of Gastrodia elata, 120g of Apocynum venetum leaf, 40g of Cyathula officinalis, 30g of Pinellia ternata, 120g of stir-fried Atractylodes macrocephala, 120g of Orientalis alisma, 120g of Pueraria root, 60g of Corn silk, and 40g of Stevia rebaudiana.

[0045] The preparation method is the same as Example 1.

[0046] Effect Example 1

[0047] (1) A total of 80 patients with hypertension and vertigo (wind-phlegm disturbance syndrome) who met the inclusion criteria and visited the Department of Cardiology at Jiangsu Hospital of Integrated Traditional Chinese and Western Medicine between February 2022 and December 2023 were selected as the research subjects and randomly divided into a Chinese medicine group (n=40) and a control group (n=40) by the coin-tossing method.

[0048] (2) Treatment methods

[0049] Control group: given lercanidipine hydrochloride tablets (Recordati SPA, Italy, national medicine standard H20160258), 10 mg / d-1 , taken all at once; or Olmesartan Medoxomil Tablets (Shenzhen Xinlitai Pharmaceutical Co., Ltd., National Medicine Standard No. H20193216), 20 mg / d -1 , take it all at once; or use the two drugs together according to blood pressure conditions.

[0050] The Chinese medicine group was given the Chinese medicine compound water decoction of Example 1, decocted in water to 100 ml, 1 dose per day (the dosage of the raw materials recorded in Example 1 is 1 dose), taken twice a day, morning and evening.

[0051] The course of treatment for both groups was 2 weeks.

[0052] (3) Observation indicators and methods

[0053] ① Blood pressure

[0054] Blood pressure in the clinic: The patient rests for at least 15 minutes at rest, and uses an electronic blood pressure monitor to measure the blood pressure of both upper arms three times. The average of the three blood pressure readings is taken, and the blood pressure on the higher side of both sides is recorded. Blood pressure monitoring at home: The patient measures blood pressure at home every day according to the blood pressure monitoring record sheet provided. Before measurement, the patient rests for at least 15 minutes at rest, and uses an electronic blood pressure monitor to measure the blood pressure on the higher arm, and records it in the blood pressure monitoring record sheet issued. The patient brings it back for the follow-up visit, and the physician records the value.

[0055] ② TCM syndrome efficacy standard

[0056] It was formulated in reference to the "Guiding Principles for Clinical Research of New Chinese Medicines" and adopts the integration method. The main symptoms are scored 0, 2, 4, and 6 according to their absence, mild, moderate, and severe conditions, respectively. The secondary symptoms are scored 0, 1, 2, and 3 according to their absence, mild, moderate, and severe conditions, respectively. Tongue and pulse conditions are not scored.

[0057] Efficacy index = (total score before treatment - total score after treatment) ÷ total score before treatment.

[0058] The efficacy was determined according to the following criteria: markedly effective: symptoms improved significantly, with the symptom score reduced by ≥70% compared with before treatment; effective: symptoms improved, with the symptom score reduced by ≥30% and <70% compared with before treatment; ineffective: symptoms did not improve, with the symptom score reduced by <30% compared with before treatment.

[0059] ④Safety indicators

[0060] Blood routine test, liver and kidney function: performed before the start of treatment and in the second week after treatment as safety assessment indicators.

[0061] Results and Analysis

[0062] SPSS21 statistical software was used to analyze the collected data, and the measurement data were expressed as mean ± standard deviation. The paired sample t test was used for intra-group comparison, and the independent sample t test was used for inter-group comparison. The count data were expressed as rate and composition ratio, and the chi-square test was used. 2 P < 0.05 was considered statistically significant.

[0063] (1) The Chinese medicine compound composition of the present invention can significantly reduce the systolic and diastolic blood pressure of patients with hypertension and vertigo

[0064] The systolic and diastolic blood pressures of the patients in the Chinese medicine group and the control group were significantly lowered after treatment than before treatment, and the differences were statistically significant (P < 0.01); there was no statistically significant difference between the systolic and diastolic blood pressures of the Chinese medicine group and the control group (P > 0.05). The results show that the Chinese medicine compound composition of the present invention has a good antihypertensive effect on the systolic and diastolic blood pressures of patients with hypertension and vertigo (Table 1).

[0065] Table 1 Comparison of blood pressure between the two groups before and after treatment (mmHg)

[0066]

[0067] Note: Intra-group comparison **P<0.01

[0068] (2) The efficacy of the Chinese medicine compound composition of the present invention on TCM syndromes is significantly better than that of Western medicine alone

[0069] The total effective rate of TCM syndrome in the TCM group was significantly better than that in the control group, and the difference was statistically significant. The results are shown in Table 2:

[0070] Table 2 Comparison of TCM syndrome efficacy between the two groups before and after treatment

[0071] Group Number of cases Significant effect efficient invalid Total effective rate / % Chinese Medicine Group 40 22 14 4 <![CDATA[90.00 # ]]> Control group 40 4 12 24 40.00

[0072] Note: 2 Test, χ 2 =9.72, # P<0.05

[0073] (3) The Chinese medicine compound composition of the present invention can significantly reduce the single syndrome score of the main symptoms of traditional Chinese medicine

[0074] After treatment, the TCM syndrome scores of dizziness, headache, irritability, headache, red face, bitter mouth, and heaviness in limbs in the TCM group were significantly reduced (P < 0.05 or P < 0.01), while the TCM syndrome scores of dizziness, headache, irritability, headache, and heaviness in limbs in the control group were reduced, and the scores of red face, bitter mouth, and loose stools did not change significantly. After treatment, the main symptom scores of the two groups were compared, and the main symptom scores of the TCM group were lower than those of the control group (P < 0.01). The results are shown in Table 3.

[0075] Table 3 Comparison of single syndrome scores of TCM main symptoms between the two groups before and after treatment

[0076]

[0077]

[0078] Note: Intra-group comparison * P<0.05, ** P<0.01, comparison between groups # P<0.05, ## P<0.01

[0079] (4) Conclusion

[0080] The Chinese medicine compound composition of the present invention has a good antihypertensive effect on patients with hypertension and vertigo, and can significantly improve clinical symptoms such as dizziness, headache, irritability, dizziness, red face, bitter taste in the mouth, heaviness of limbs, etc. in patients with hypertension and vertigo, and the efficacy is significantly better than that of simple Western medicine treatment.

[0081] Effect Example 2

[0082] Patient Cai, female, 42 years old, dizziness and nausea for 2 days. History of hypertension for more than 1 year, blood pressure is usually around 140-160 / 92-100mmHg, and no antihypertensive drugs are taken. 2 days ago, I felt dizzy, visual rotation, accompanied by nausea and vomiting, unsteady walking, heavy limbs, fatigue, upset and bitter mouth, no limb numbness, activity disorder, no tinnitus, poor sleep at night, sticky and uncomfortable stool, red tongue, fat tongue, tooth marks on the edge, thick and greasy fur, and stringy pulse. Blood pressure was measured at 158 / 104mmHg. No obvious abnormalities were found in the head CT. After taking the Chinese medicine compound water decoction of the embodiment of the present invention 1 for 3 days, the symptoms of dizziness, nausea, and unsteady walking were significantly relieved, and the blood pressure dropped to 142 / 92mmHg. After taking the Chinese medicine compound water decoction of the embodiment of the present invention 1 for 2 weeks, all symptoms disappeared, blood pressure returned to normal (126 / 84mmHg), and the fur turned white and slightly greasy.

[0083] Effect Example 3

[0084] Patient Zhang, male, 46 years old, dizziness more than 1 month. Hypertension history more than 10 years, usually take " felodipine 5mg qd ", blood pressure control in normal range. Nearly 1 month without obvious inducement blood pressure rise, SBP reaches 160 / 110mmHg, dizziness, head swelling, numbness of both hands, facial hot feeling, tinnitus, poor sleep, dark red tongue, edge has tooth marks, white greasy fur, stringy pulse. Take the extract of the embodiment of the present invention 2 Chinese medicine compound compositions, twice a day, each 20ml. After 7 days, blood pressure dropped to 126 / 80mmHg, and the discomfort symptoms such as dizziness were obviously alleviated.

[0085] Effect Example 4

[0086] Patient Qin, 66 years old, had recurrent dizziness for more than 3 years. He had a history of hypertension for more than 20 years. In the past 3 years, he had dizziness and unstable walking every summer rainy season and winter. During the attack, his blood pressure rose, up to 180 / 110 mmHg. He was obese and usually had loose stools. His tongue was pale and fat, with teeth marks on the edges, white and greasy fur, and a stringy pulse. He took the decoction of the Chinese medicine compound composition of Example 3 of the present invention for 3 months, 1 dose per day (the amount of raw materials recorded in Example 3 is 1 dose), divided into two doses, 1 dose every other day, and he had no dizziness for nearly 1 year and his blood pressure was stable.

[0087] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A Chinese medicinal compound composition for treating hypertension and vertigo, characterized in that: The drug is prepared from the following raw materials in parts by weight: 30-120 parts of calcined magnetite, 15-60 parts of eucommia bark, 20-180 parts of gastrodia elata, 15-120 parts of apocynum venetum leaves, 10-40 parts of cyathulae, 8-30 parts of pinellia tuber, 15-120 parts of stir-fried atractylodes macrocephala, 10-120 parts of oriental rhizome, 30-120 parts of kudzu root, 10-60 parts of corn silk and 10-40 parts of stevia.

2. The Chinese medicinal compound composition for treating hypertension and vertigo according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 30 parts of calcined magnetite, 15 parts of eucommia bark, 20 parts of gastrodia elata, 15 parts of apocynum venetum leaves, 10 parts of cyathulae, 8 parts of pinellia tuber, 15 parts of stir-fried atractylodes macrocephala, 10 parts of oriental water chestnuts, 30 parts of kudzu root, 10 parts of corn silk and 10 parts of stevia.

3. The Chinese medicinal compound composition for treating hypertension and vertigo according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 30 parts of calcined magnetite, 20 parts of eucommia bark, 120 parts of gastrodia elata, 60 parts of apocynum venetum leaves, 30 parts of cyathula officinalis, 15 parts of pinellia ternata, 60 parts of stir-fried atractylodes macrocephala, 60 parts of orientalis, 60 parts of kudzu root, 30 parts of corn silk and 20 parts of stevia.

4. The Chinese medicinal compound composition for treating hypertension and vertigo according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 120 parts of calcined magnetite, 60 parts of eucommia bark, 180 parts of gastrodia elata, 120 parts of apocynum venetum leaves, 40 parts of cyathulae, 30 parts of pinellia tuber, 120 parts of stir-fried atractylodes macrocephala, 120 parts of orientalis, 120 parts of kudzu root, 60 parts of corn silk and 40 parts of stevia.

5. The Chinese medicinal compound composition for treating hypertension and vertigo according to claim 1, characterized in that: The dosage form is ointment, oral solution, granules, capsules, tablets or pills.

6. A method for preparing the Chinese medicinal compound composition for treating hypertension and vertigo according to any one of claims 1 to 5, characterized in that: The following steps are involved: According to the mass proportion, calcined magnetite is boiled with water to obtain filtrate 1; Add water to the raw materials except the calcined magnetite and boil them to obtain filtrate 2; The filtrate 1 and the filtrate 2 are combined and filtered, concentrated, precipitated with alcohol to remove the precipitate, and concentrated in sequence to obtain an extract.

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