Traditional Chinese medicine composition for treating leucopenia and anemia after chemotherapy and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating leucopenia and anemia after chemotherapy and a preparation method thereof, and relates to the field of traditional Chinese medicinal materials. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 30 parts of radix astragali seu hedysari, 5 to 15 parts of rhizoma polygonati, 5 to 15 parts of caulis spatholobi, 5 to 15 parts of fructus lycii, 5 to 15 parts of semen cuscutae, 5 to 15 parts of fructus ligustri lucidi, 5 to 15 parts of radix codonopsis, 5 to 15 parts of rhizoma atractylodis macrocephalae, 5 to 10 parts of radix aucklandiae, 5 to 15 parts of pericarpium citri reticulatae and 5 to 15 parts of medicated leaven. The marrow-generating decoction traditional Chinese medicine composition can effectively resist myelosuppression and regulate human immunity, so that the bone marrow hematopoiesis function is recovered, and leukocytes and erythrocytes are increased.

Description

Technical Field

[0001] The present invention relates to the field of Chinese medicinal materials, and in particular to a Chinese medicinal composition for treating post-chemotherapy leukopenia and anemia and a preparation method thereof. Background Art

[0002] Cancer patients will experience bone marrow suppression and a significant decrease in white blood cells and red blood cells after chemotherapy. Western medicine treatment methods are to increase white blood cells and red blood cells through blood transfusions, granulocyte stimulating factor, erythropoietin, etc.; however, such preparations cannot enhance the patient's hematopoietic function, the effect is short-lived, and has certain side effects.

[0003] In the field of traditional Chinese medicine, it is believed that leukocytopenia is related to qi deficiency. The clinical symptoms of leukocytopenia, such as fatigue, fear of cold, sweating, pale face, susceptibility to external pathogenic qi, etc., belong to the category of qi deficiency in traditional Chinese medicine. Red blood cells are related to the spleen and kidneys. The main function of red blood cells is to transport oxygen and carbon dioxide. The reduction of red blood cells may lead to symptoms such as anemia. Therefore, in traditional Chinese medicine theory, anemia is related to factors such as insufficient qi and blood, and weak spleen and kidney.

[0004] At present, in the field of traditional Chinese medicine, there are few Chinese medicine prescriptions used for rehabilitation treatment after chemotherapy and for increasing the number of red and white blood cells, and the treatment effect is not obvious. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for treating leukopenia and anemia after chemotherapy. The Shengsui decoction composition can effectively resist bone marrow suppression, regulate human immunity, thereby restoring bone marrow hematopoietic function and increasing white blood cells and red blood cells.

[0006] Another object of the present invention is to provide a method for preparing a Chinese medicine composition for treating leukopenia and anemia after chemotherapy, which adopts water extraction, concentration and other steps to prepare granules, thereby making full use of the effective ingredients of the raw materials.

[0007] The present invention solves the technical problem by adopting the following technical solutions.

[0008] On the one hand, an embodiment of the present invention provides a traditional Chinese medicine composition for treating leukopenia and anemia after chemotherapy, comprising the following raw materials by weight:

[0009] 15-30 parts of Astragalus, 5-15 parts of Polygonatum, 5-15 parts of Millettia Spatholobi, 5-15 parts of Lycium barbarum, 5-15 parts of Cuscuta australis, 5-15 parts of Ligustrum lucidum, 5-15 parts of Codonopsis pilosula, 5-15 parts of Atractylodes macrocephala, 5-10 parts of Costus root, 5-15 parts of Tangerine peel, and 5-15 parts of Shenqu.

[0010] In some embodiments of the present invention, the composition comprises the following raw materials in parts by weight:

[0011] 30 parts of Astragalus, 15 parts of Polygonatum, 15 parts of Millettia Spatholobi, 12 parts of Lycium barbarum, 12 parts of Cuscuta australis, 12 parts of Ligustrum lucidum, 15 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 6 parts of Aucklandia lappa, 10 parts of Citrus reticulata, and 10 parts of Shenqu.

[0012] In some embodiments of the present invention, the composition comprises the following raw materials by weight:

[0013] 15 parts of Astragalus, 5 parts of Polygonatum, 5 parts of Millettia Spatholobi, 5 parts of Lycium barbarum, 5 parts of Cuscuta australis, 5 parts of Ligustrum lucidum, 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 10 parts of Aucklandia lappa, 5 parts of Citrus reticulata, and 5 parts of Shenqu.

[0014] In some embodiments of the present invention, the above-mentioned polygonatum is steamed polygonatum.

[0015] In some embodiments of the present invention, the above-mentioned dodder is salt dodder.

[0016] In some embodiments of the present invention, the above-mentioned Ligustrum lucidum is Ligustrum lucidum.

[0017] On the other hand, an embodiment of the present invention provides a method for preparing a Chinese medicine composition for treating leukopenia and anemia after chemotherapy, comprising the following steps:

[0018] S1, mixing the raw materials, adding water to soak; adding water to boil for the first time for 1.5 hours, collecting the first decoction; adding water to boil for the second time for 1 hour, collecting the second decoction;

[0019] S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract;

[0020] S3, dried extract, crushed into powder;

[0021] S4, adding auxiliary materials to the powder of step S3, granulating and drying.

[0022] In some embodiments of the present invention, the relative density of the extract at 60° C. is 1.20-1.35.

[0023] In some embodiments of the present invention, the auxiliary materials are sucrose and 80% ethanol solution by volume.

[0024] In some embodiments of the present invention, the mass volume ratio of the powder to the ethanol solution is 1g:0.30ml-1g:0.35ml.

[0025] In some embodiments of the present invention, the mass ratio of the powder to the sucrose is 1:1.0-1:1.1.

[0026] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0027] The Shengsui decoction composition provided by the present invention has astragalus, polygonatum and millettia as main drugs, which have the effects of invigorating qi and nourishing blood, tonifying kidney and strengthening spleen, wolfberry, dodder seed, glossy privet fruit, codonopsis and atractylodes as subordinate drugs, which have the effects of nourishing liver and kidney, promoting blood circulation and replenishing blood, and enhancing body immunity, and costus root, tangerine peel and Shenqu as adjuvant drugs, which have the effects of promoting digestion and relieving indigestion. The raw materials cooperate with each other and are used for asthenia caused by qi and blood deficiency and spleen and kidney deficiency, symptoms of shortness of breath and fatigue, loss of appetite, sore waist and weak legs, spontaneous sweating, palpitations, pale red or dark tongue, thin fur, leukopenia and anemia after radiotherapy and chemotherapy. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0029] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other. The present invention will be described in detail below with reference to specific embodiments.

[0030] The embodiment of the present invention provides a traditional Chinese medicine composition for treating leukopenia and anemia after chemotherapy, which comprises the following raw materials in parts by weight:

[0031] 15-30 parts of Astragalus, 5-15 parts of Polygonatum, 5-15 parts of Millettia Spatholobi, 5-15 parts of Lycium barbarum, 5-15 parts of Cuscuta australis, 5-15 parts of Ligustrum lucidum, 5-15 parts of Codonopsis pilosula, 5-15 parts of Atractylodes macrocephala, 5-10 parts of Costus root, 5-15 parts of Tangerine peel, and 5-15 parts of Shenqu.

[0032] Preferably, the composition comprises the following raw materials by weight:

[0033] 30 parts of Astragalus, 15 parts of Polygonatum, 15 parts of Millettia Spatholobi, 12 parts of Lycium barbarum, 12 parts of Cuscuta australis, 12 parts of Ligustrum lucidum, 15 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 6 parts of Aucklandia lappa, 10 parts of Citrus reticulata, and 10 parts of Shenqu.

[0034] Preferably, the composition comprises the following raw materials by weight:

[0035] 15 parts of Astragalus, 5 parts of Polygonatum, 5 parts of Millettia Spatholobi, 5 parts of Lycium barbarum, 5 parts of Cuscuta australis, 5 parts of Ligustrum lucidum, 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 10 parts of Aucklandia lappa, 5 parts of Citrus reticulata, and 5 parts of Shenqu.

[0036] Astragalus has the effects of invigorating qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting body fluid and nourishing blood, etc. It is often used to treat symptoms such as qi deficiency and fatigue, poor appetite and loose stools, and sinking of qi in the middle, which can improve the overall function of the body and enhance the body's resistance to diseases. It can enhance the body's ability to consolidate and control, prevent excessive loss of sweat, maintain the normal physiological functions of the human body, and has a good therapeutic effect on symptoms such as spontaneous sweating due to exterior deficiency, weakness of the limbs, and lack of energy. It also has the effect of enhancing the transportation and transformation of the spleen and stomach, can promote the transportation and transformation of water and moisture, can promote diuresis and remove water and moisture, and has a significant effect on symptoms such as edema and oliguria caused by qi deficiency. Astragalus can invigorate qi and absorb blood, and promote blood circulation, so it can be used to treat blood in the stool and metrorrhagia caused by qi deficiency and failure to absorb, and can also be used to regulate symptoms such as pain, numbness, and hemiplegia caused by qi deficiency and blood stasis.

[0037] Polygonatum sibiricum is the rhizome of Polygonatum sibiricum, Polygonatum yunnanensis and Polygonatum multiflorum of the Liliaceae family. In the embodiment of the present invention, steamed Polygonatum sibiricum is used. Steamed Polygonatum sibiricum is to put Polygonatum sibiricum in a steamer and steam it over high heat for more than 3 hours to ensure that Polygonatum sibiricum is steamed thoroughly. After steaming, take out Polygonatum sibiricum and put it in the sun for one day to ensure that it is thoroughly dried. Then repeat the process of steaming and drying for a total of nine times, the so-called "nine steaming and nine drying". Steamed Polygonatum sibiricum has the effects of replenishing qi and nourishing yin, strengthening the spleen and moistening the lungs, replenishing the kidney and astringing essence, moistening the lungs and relieving cough. It can be used to improve physical fatigue caused by deficiency of both qi and yin, mental depression, loss of appetite caused by weak spleen and stomach, abdominal distension, loose stools, soreness of waist and knees caused by deficiency of kidney essence, dizziness and tinnitus and other discomfort symptoms.

[0038] Millettia reticulata has the effects of promoting blood circulation, replenishing blood, regulating menstruation and relieving pain, relaxing muscles and activating collaterals, etc. It can promote blood circulation, increase the number of red blood cells in the blood, and enhance hematopoietic function. It has a good effect on symptoms such as sallow complexion, dizziness and palpitations caused by blood deficiency. At the same time, it also has a significant effect on relieving women's menstrual disorders, dysmenorrhea and other problems. It can reconcile qi and blood, soothe uterine smooth muscles, and relieve menstrual discomfort.

[0039] Lycium barbarum is mild in nature, sweet in taste, and belongs to the liver and kidney meridians. It has the effects of delaying aging, enhancing immunity, clearing the liver and improving eyesight, lowering blood pressure, and nourishing qi and blood. It is rich in antioxidants such as Lycium barbarum polysaccharides, β-carotene, vitamin E, flavonoids, etc., which can fight free radical peroxidation and reduce free radical peroxidation damage, thus helping to delay aging. It contains carotene, vitamins and calcium and can be used for blurred vision and night blindness caused by liver blood deficiency and kidney yin deficiency. Lycium barbarum can reduce the toxic side effects of cyclophosphamide in anti-tumor treatment, promote the recovery of hematopoietic function, increase the number of white blood cells in peripheral blood, and have a protective effect on the body.

[0040] Cuscuta is sweet in taste, warm in nature, and enters the liver, kidney, and spleen meridians. In an embodiment of the present invention, the salt dodder used is prepared by soaking raw dodder in salt water, allowing the dodder to fully absorb salt water, and then frying it. Salt dodder has the effects of nourishing the kidney and replenishing essence, nourishing the liver and improving eyesight, removing rheumatism, regulating endocrine, etc., and is often used to treat symptoms caused by kidney deficiency, such as soreness of the waist and knees, impotence and spermatorrhea, frequent urination, etc. It also contains rich flavonoids and vitamin A, which helps to protect liver function, and has a positive effect on relieving visual fatigue and preventing eye diseases. An appropriate amount of salt dodder intake helps to improve vision and prevent night blindness. The polysaccharides and steroid compounds contained can inhibit the production of inflammatory factors in the body, and are suitable for the adjuvant treatment of patients with rheumatoid arthritis. The polysaccharide components in dodder can significantly improve the body's immune function, enhance the immune regulation ability of leukocytes, thereby improving the body's ability to resist diseases.

[0041] Fructus Ligustri Lucidi nature and flavor: sweet, bitter, cool, enter the liver and kidney meridians. In the embodiment of the present invention, Fructus Ligustri Lucidi wine is used, and its preparation method is: pick clean Fructus Ligustri Lucidi, mix it with rice wine, put it into a container and seal it tightly, then put it into a pot with water, steam it until the wine is absorbed, take it out and dry it. Fructus Ligustri Lucidi wine has the effects of nourishing the liver and kidney, improving eyesight, blackening hair, nourishing yin, relieving fatigue, etc., and can be used to treat dizziness, tinnitus, sore waist and weak knees caused by liver and kidney yin deficiency, and relieve blurred vision, fatigue, etc.

[0042] Codonopsis, nature and flavor: sweet, neutral. It belongs to the spleen and lung meridians. It has the effects of tonifying the middle and replenishing qi, strengthening the spleen and lungs, nourishing blood and promoting body fluid, and calming the nerves. It can replenish the qi needed by the human body and has a significant improvement on symptoms such as fatigue, shortness of breath, and loss of appetite caused by qi deficiency. It promotes the transportation and transformation function of the spleen and stomach, enhances the digestive function of the spleen and stomach, and improves symptoms such as loss of appetite, abdominal distension, and diarrhea. At the same time, it also helps to improve the ability to absorb nutrients, and can enhance the function of the lungs to spread and descend, and improve symptoms of lung discomfort such as cough and asthma. It promotes blood production and circulation, and improves symptoms such as pale complexion and dizziness. At the same time, Codonopsis also has the effect of promoting body fluid and quenching thirst, and has a certain effect on symptoms such as thirst and dry throat. It regulates the nervous system and relieves mental symptoms such as anxiety and insomnia. For modern people who are under great pressure and nervous, taking Codonopsis properly can soothe nerves and improve sleep quality.

[0043] Atractylodes macrocephala tastes sweet and bitter, is warm in nature, and enters the spleen and stomach meridians. It has the effects of strengthening the spleen and stomach, replenishing qi, removing dampness and resolving phlegm, and consolidating the exterior and stopping sweating. It can enhance the spleen and stomach functions, promote digestion and absorption, and improve symptoms such as loss of appetite and indigestion caused by spleen and stomach weakness. It can also replenish qi and improve symptoms such as physical fatigue and weakness, and pale complexion. Atractylodes macrocephala has the effect of removing dampness and resolving phlegm, which can help eliminate moisture and phlegm in the body and relieve the discomfort caused by moisture and phlegm. Atractylodes macrocephala also has a good therapeutic effect on symptoms such as jaundice, frequent urination, and edema caused by damp heat. Atractylodes macrocephala can regulate the secretion of sweat in the body, reduce excessive sweating, and has a significant alleviating effect on symptoms such as spontaneous sweating and night sweats.

[0044] Costus root is the dried root of the Asteraceae plant Costus root, which has the effects of promoting qi and relieving pain, regulating the middle and removing stagnation, strengthening the spleen and digesting food. Costus root can dredge the meridians, harmonize qi and blood, and has significant effects on symptoms such as abdominal distension and pain caused by spleen and stomach qi stagnation. Costus root can strengthen the spleen and stomach, enhance the spleen and stomach function, and promote digestion. It has a good effect on symptoms such as chest tightness and abdominal distension, poor appetite and loose stools caused by dampness and turbidity in the middle, and has an improvement effect on symptoms such as indigestion and loss of appetite.

[0045] Tangerine peel tastes bitter and pungent, is warm in nature, and enters the spleen and lung meridians. It has the effects of promoting digestion, resolving phlegm and relieving cough, promoting qi and relieving pain, strengthening the spleen and stomach, and anti-inflammatory and antibacterial, which can effectively relieve symptoms such as indigestion and abdominal distension. It can also stimulate the smooth muscles of the gastrointestinal tract, promote the secretion of digestive juices, and enhance gastrointestinal motility, thereby improving gastrointestinal discomfort such as loss of appetite, nausea, and vomiting. Tangerine peel has the effect of drying dampness and resolving phlegm, and can relieve symptoms such as cough and sputum. Its drying dampness effect can remove moisture from the body and reduce sputum formation; while its phlegm-resolving effect can promote the discharge of phlegm, thereby relieving symptoms such as cough and sputum. Tangerine peel can soothe the liver and regulate qi, promote qi and relieve pain, and help relieve pain caused by qi stagnation. It can be used to treat symptoms such as chest and flank distension and pain, stomach distension and pain, and gastrointestinal qi stagnation. Tangerine peel helps to strengthen the spleen and stomach function and improve symptoms such as loss of appetite and diarrhea caused by spleen and stomach weakness. It can also promote the absorption and utilization of nutrients and help maintain good health. Tangerine peel contains a variety of anti-inflammatory and antibacterial ingredients, which can effectively inhibit the growth of a variety of pathogens. This helps prevent and treat a variety of infectious diseases and improve immunity.

[0046] Shenqu tastes sweet and pungent, is warm in nature, and enters the spleen and stomach meridians. It has the effects of strengthening the spleen and appetizing, digesting food and eliminating accumulation, dispelling cold, removing dampness and removing phlegm, etc. Shenqu can promote the secretion of digestive juices and enhance gastrointestinal motility, thereby improving symptoms such as loss of appetite and indigestion. It can also regulate the function of the spleen and stomach, and relieve problems such as abdominal distension and diarrhea caused by spleen and stomach weakness. Shenqu has a good effect on relieving symptoms such as food stagnation and abdominal distension. It can promote food digestion and reduce the residence time of food in the gastrointestinal tract, thereby avoiding the discomfort caused by food accumulation and fermentation. Shenqu tastes pungent and has a certain effect of dispelling cold. It can be used to treat symptoms such as colds, headaches, and body pains, especially for patients with colds accompanied by food stagnation. Shenqu can warm the stomach and resolve phlegm, expel water and eliminate stagnation, and remove dampness and resolve phlegm. Shenqu also has a certain effect on relieving symptoms such as phlegm cough and edema of the limbs.

[0047] The preparation method of the above composition comprises the following steps:

[0048] S1, mixing the raw materials, adding water to soak; after the first decoction for 1.5 hours, collecting the first decoction; adding water again for the second decoction for 1 hour, collecting the second decoction;

[0049] S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract;

[0050] S3, dried extract, crushed into powder;

[0051] S4, adding auxiliary materials to the powder of step S3, granulating and drying.

[0052] Preferably, the relative density of the extract at 60° C. is 1.20-1.35.

[0053] Preferably, the auxiliary materials are sucrose and 80% by volume ethanol solution.

[0054] Preferably, the mass volume ratio of the powder to the ethanol solution is 1g:0.30ml-1g:0.35ml.

[0055] Preferably, the mass ratio of the powder to the sucrose is 1:1.0-1:1.1.

[0056] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0057] Example 1

[0058] Prepare the raw materials according to the following ratio:

[0059] 30 parts of astragalus, 15 parts of steamed polygonatum, 15 parts of millettia reticulata, 12 parts of wolfberry, 12 parts of salt dodder seeds, 12 parts of wine privet fruit, 15 parts of codonopsis pilosula, 10 parts of atractylodes, 6 parts of costusroot, 10 parts of tangerine peel, and 10 parts of Shenqu.

[0060] The composition of this example was prepared as follows:

[0061] S1, mix the raw materials, add 8 times the volume of water and soak for 0.5h; decoct for 1.5h, collect the first decoction; then add 6 times the volume of water and decoct for a second time for 1h, collect the second decoction;

[0062] S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract with a relative density of 1.25;

[0063] S3, dried extract, crushed into powder;

[0064] S4, add sucrose (mass ratio, dry paste powder: sucrose = 1:1) to the powder of step S3, stir for 10 minutes, then add 80% ethanol solution by volume, wherein the mass volume ratio of dry paste powder to ethanol solution is 1g:0.3ml, stir evenly, granulate and dry.

[0065] Example 2

[0066] Prepare the raw materials according to the following ratio:

[0067] 15 parts of Astragalus, 5 parts of steamed Polygonatum, 5 parts of Millettia reticulata, 5 parts of Lycium barbarum, 5 parts of Salt Cuscuta chinensis, 5 parts of Ligustrum lucidum, 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 10 parts of Aucklandia lappa, 5 parts of Tangerine peel, and 5 parts of Shenqu.

[0068] The composition of this example was prepared as follows:

[0069] S1, mix all the raw materials, add 8 times the volume of water and soak for 0.5h; after boiling for 1.5h, collect the first decoction; then add 6 times the volume of water and boil for the second time for 1h, collect the second decoction;

[0070] S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract with a relative density of 1.31;

[0071] S3, dried extract, crushed into powder;

[0072] S4, add sucrose (mass ratio, dry paste powder: sucrose = 1:1.1) to the powder of step S3, stir for 10 minutes, then add 80% ethanol solution by volume, wherein the mass volume ratio of dry paste powder to ethanol solution is 1g:0.35ml, stir evenly, granulate and dry.

[0073] Example 3

[0074] Prepare the raw materials according to the following ratio:

[0075] 20 parts of Astragalus, 10 parts of steamed Polygonatum, 10 parts of Millettia Spatholobi, 10 parts of Lycium barbarum, 10 parts of Salt Cuscuta Sinensis, 15 parts of Ligustrum lucidum, 5 parts of Codonopsis pilosula, 15 parts of Atractylodes macrocephala, 8 parts of costus root, 15 parts of dried tangerine peel, and 15 parts of Shenqu.

[0076] The composition of this example was prepared as follows:

[0077] S1, mix all the raw materials, add 8 times the volume of water and soak for 0.5h; after boiling for 1.5h, collect the first decoction; then add 6 times the volume of water and boil for the second time for 1h, collect the second decoction;

[0078] S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract with a relative density of 1.23;

[0079] S3, dried extract, crushed into powder;

[0080] S4, add sucrose (mass ratio, dry paste powder: sucrose = 1:1) to the powder of step S3, stir for 10 minutes, then add 80% ethanol solution by volume, wherein the mass volume ratio of the dry paste powder to the ethanol solution is 1:0.3, stir evenly, granulate and dry.

[0081] Example 4

[0082] Prepare the raw materials according to the following ratio:

[0083] 30 parts of Astragalus, 15 parts of steamed Polygonatum, 5 parts of Millettia Spatholobi, 15 parts of Lycium barbarum, 10 parts of Salt Cuscuta Seed, 10 parts of Ligustrum lucidum, 15 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 5 parts of costus root, 15 parts of dried tangerine peel, and 15 parts of Shenqu.

[0084] The composition of this example was prepared as follows:

[0085] S1, mix all the raw materials, add 10 times the volume of water and soak for 0.5h; after boiling for 2h, collect the first decoction; then add 6 times the volume of water and boil for the second time for 1.5h, collect the second decoction;

[0086] S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract with a relative density of 1.35;

[0087] S3, dried extract, crushed into powder;

[0088] S4, add sucrose (mass ratio, dry paste powder: sucrose = 1:1.1) to the powder of step S3, stir for 5 minutes, then add ethanol solution with a volume fraction of 80%, wherein the mass volume ratio of dry paste powder to ethanol solution is 1g:0.35ml, stir evenly, granulate and dry.

[0089] Example 5

[0090] Prepare the raw materials according to the following ratio:

[0091] 15 parts of Astragalus, 5 parts of steamed Polygonatum, 5 parts of Millettia reticulata, 5 parts of Lycium barbarum, 5 parts of Salt Cuscuta chinensis, 5 parts of Ligustrum lucidum, 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 10 parts of Aucklandia lappa, 5 parts of Tangerine peel, and 5 parts of Shenqu.

[0092] The composition of this example was prepared as follows:

[0093] S1, mix all the raw materials, add 8 times the volume of water and soak for 0.5h; after boiling for 1.5h, collect the first decoction; then add 6 times the volume of water and boil for the second time for 1h, collect the second decoction;

[0094] S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract with a relative density of 1.35;

[0095] S3, dried extract, crushed into powder;

[0096] S4, add sucrose (mass ratio, dry paste powder: sucrose = 1:1.1) to the powder of step S3, stir for 10 minutes, then add 80% ethanol solution by volume, wherein the mass volume ratio of dry paste powder to ethanol solution is 1g:0.35ml, stir evenly, granulate and dry.

[0097] Experimental example

[0098] The drug of Example 1 was sent to a third-party testing agency for component testing, and the results are shown in Table 1.

[0099] Table 1

[0100] Analytical methods standard result Thin layer identification Astragalus Astragalus Thin layer chromatography Codonopsis pilosula Codonopsis pilosula Thin layer chromatography Millettia spatholobi Millettia spatholobi Thin layer chromatography Cuscuta salsa Cuscuta salsa granularity Should not exceed 15% 8％ Moisture Should not exceed 8.0% 3.5％ Solubility Should comply with regulations Comply with regulations

[0101] Typical Cases

[0102] Case 1: Cancer patient, the patient complained of dizziness, sweating, hair loss, normal appetite, normal bowel movements, normal sleep at night; yellow complexion, soft abdomen without tenderness, no swelling in both lower limbs, pale red tongue, thin white fur, soft pulse; diagnosed as Qi and blood deficiency and spleen and stomach weakness caused by cancer. Treatment: replenishing Qi and nourishing blood, strengthening spleen and stomach, light diet, avoid spicy stimulation. Take 5 doses of the composition of Example 1 and then return for follow-up.

[0103] Case 2: After chemotherapy, the patient complained of fatigue, normal appetite, bitter mouth, normal bowel movements, normal urination, and normal sleep at night. Examination: yellow complexion, soft abdomen without tenderness, no swelling of both lower limbs. Pale red tongue, thin white fur, thin pulse. TCM diagnosis: cancer, asthenia, deficiency of qi and blood, insufficiency of spleen and kidney; treatment: replenishing qi and nourishing blood, strengthening spleen and stomach, light diet, avoiding spicy stimulation. Take 7 doses of the composition of Example 1, Shengsui Decoction with additions and subtractions, and then return for follow-up.

[0104] Case 3: The patient was admitted to the hospital because of "breast cancer was discovered more than 7 years ago, and recurred more than 20 days after 4 cycles of chemotherapy". After chemotherapy, the patient complained of shortness of breath, hair loss, abdominal distension, poor appetite, normal bowel movements, normal urination, and normal sleep at night. Examination: pale complexion, pale complexion, soft abdomen without tenderness, no swelling of both lower limbs. Pale tongue, white and greasy coating, thin pulse. TCM diagnosis: cancer-related asthenia, deficiency of both qi and blood, and deficiency of spleen and kidney; treatment principle: replenishing qi and nourishing blood, tonifying kidney and strengthening spleen, prescription: 7 doses of Shengsui Decoction of Example 1, decocted in water, 1 dose per day, doctor's advice: 1. Follow up after taking the medicine. 2. Eat a light diet and avoid spicy stimulation.

[0105] Case 4: The patient did not complain of special discomfort, normal appetite, normal bowel movements, normal urination, and normal sleep at night. Examination: sallow complexion, soft abdomen without tenderness, no swelling of both lower limbs. Tender red tongue, thin white fur, weak pulse. TCM diagnosis: cancer, deficiency of both qi and blood, weak spleen and stomach, treatment principle: replenishing qi, nourishing blood, and strengthening spleen and stomach, prescription: Example 1 Shengsui Decoction plus or minus 15 doses, decocted in water, 1 dose per day. Dosage: 2 times a day. Doctor's advice: 1. Follow-up after taking the medicine. 2. Eat a light diet and avoid spicy stimulation.

[0106] Case 5: The patient complained of fatigue, bitter taste in the mouth, no abdominal distension and pain, poor appetite, dry stool, normal urination, and normal sleep at night. Examination: sallow complexion, soft abdomen without tenderness, no swelling of both lower limbs. Pale red tongue, yellow and greasy fur, thin pulse. TCM diagnosis: cancer, deficiency of both qi and blood, weak spleen and stomach, treatment principle: replenishing qi and nourishing blood, strengthening spleen and stomach, prescription: Example 1 Shengsui Decoction plus or minus, 10 doses, administration: 1 pack each time, 2 times a day. Doctor's advice: 1. Follow-up visit after taking the medicine. 2. Light diet, avoid spicy stimulation.

[0107] In summary, the composition provided by the embodiment of the present invention, with astragalus, polygonatum, millettia as the main medicine, has the effects of invigorating qi and nourishing blood, tonifying the kidney and strengthening the spleen, wolfberry, dodder seed, glossy privet fruit, codonopsis, atractylodes as the ministerial medicine, has the effects of nourishing the liver and kidney, tonifying the spleen, replenishing qi and blood, and enhancing the body's immunity, and costus root, tangerine peel, Shenqu as adjuvant, has the effects of promoting digestion and relieving indigestion. Each raw material cooperates with each other, and is used for deficiency of qi and blood, asthenia caused by deficiency of spleen and kidney, symptoms of shortness of breath and fatigue, loss of appetite, sore waist and weak legs, spontaneous sweating, palpitations, pale red or dark tongue, thin fur, leukopenia and anemia after radiotherapy and chemotherapy.

[0108] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating leukopenia and anemia after chemotherapy, characterized in that: The following raw materials are included by weight: 15-30 parts of Astragalus, 5-15 parts of Polygonatum, 5-15 parts of Millettia Spatholobi, 5-15 parts of Lycium barbarum, 5-15 parts of Cuscuta australis, 5-15 parts of Ligustrum lucidum, 5-15 parts of Codonopsis pilosula, 5-15 parts of Atractylodes macrocephala, 5-10 parts of Costus root, 5-15 parts of Tangerine peel, and 5-15 parts of Shenqu.

2. The Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 1, characterized in that: The following raw materials are included by weight: 30 parts of Astragalus, 15 parts of Polygonatum, 15 parts of Millettia Spatholobi, 12 parts of Lycium barbarum, 12 parts of Cuscuta australis, 12 parts of Ligustrum lucidum, 15 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 6 parts of Aucklandia lappa, 10 parts of Citrus reticulata, and 10 parts of Shenqu.

3. The Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 1, characterized in that: The following raw materials are included by weight: 15 parts of Astragalus, 5 parts of Polygonatum, 5 parts of Millettia Spatholobi, 5 parts of Lycium barbarum, 5 parts of Cuscuta australis, 5 parts of Ligustrum lucidum, 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 10 parts of Aucklandia lappa, 5 parts of Citrus reticulata, and 5 parts of Shenqu.

4. The Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 1, characterized in that: The polygonatum sibiricum is steamed polygonatum sibiricum.

5. The Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 1, characterized in that: The dodder seed is salt dodder seed.

6. The Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 1, characterized in that: The fructus Ligustri Lucidi described is fructus Ligustri Lucidi.

7. A method for preparing a Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1, mixing the raw materials and soaking them in water; After the first decoction of 1.5 hours, the first decoction was collected; water was added again for the second decoction of 1 hour, and the second decoction was collected; S2, combining the first decoction and the second decoction, filtering, and concentrating the filtrate to obtain an extract; S3, dried extract, crushed into powder; S4, adding auxiliary materials to the powder of step S3, granulating and drying.

8. The method for preparing the Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 7, characterized in that: The relative density of the extract at 60° C. is 1.20-1.

35.

9. The method for preparing the Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 7, characterized in that: The auxiliary materials are sucrose and ethanol solution with a volume fraction of 80%.

10. The method for preparing the Chinese medicine composition for treating leukopenia and anemia after chemotherapy according to claim 9, characterized in that: The mass volume ratio of the powder to the ethanol solution is 1:0.30-1:0.35.