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43 results about "Feline calicivirus infection" patented technology
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Jump to navigation Jump to search. Feline calicivirus (FCV) is a virus of the family Caliciviridae that causes disease in cats. It is one of the two important viral causes of respiratory infection in cats, the other being feline herpesvirus. FCV can be isolated from about 50% of cats with upper respiratory infections.
Hemorrhagic feline calicivirus, calicivirus vaccine and method for preventing calicivirus infection or disease
The present invention relates to a novel, isolated and purified hemorrhagic feline calicivirus FCV-DD1. The invention further embraces monovalent and multivalent vaccines containing the new FCV-DD1 strain. In addition, the invention encompasses methods of protecting felines against infection or preventing disease caused by feline calicivirus alone or in addition to other pathogens that comprises administering to the felines an immunologically effective amount of the monovalent and multivalent vaccines described herein. Also, the invention concerns methods for diagnosing or detecting the hemorrhagic feline calicivirus in a susceptible host, asymptomatic carrier and the like by detecting the presence of feline calicivirus FCV-DD1 or antibodies raised or produced against feline calicivirus FCV-DD1 antigen.
Owner:ELANCO US INC
Multiplex PCR (polymerase chain reaction) primer group for simultaneously detecting feline panleucopenia virus, feline calicivirus and feline herpes virus type 1
InactiveCN103276106AMicrobiological testing/measurementDNA/RNA fragmentationFeline calicivirus infectionMultiplex
The invention discloses a multiplex PCR (polymerase chain reaction) primer group for simultaneously detecting feline panleucopenia virus, feline calicivirus and feline herpes virus type 1. The primer group comprises three pairs of primers, wherein the sequences of the primers for detecting the feline panleucopenia virus are shown in SEQ ID NO:1 and SEQ ID NO:2, the sequences of the primers for detecting the feline calicivirus are shown in SEQ ID NO:3 and SEQ ID NO:4, and the sequences of the primers for detecting the feline herpes virus type 1 are shown in SEQ ID NO:5 and SEQ ID NO:6. The feline panleucopenia virus, feline calicivirus and feline herpes virus type 1 can be simultaneously detected by using the primer sequences through a multiplex PCR method, the result is positive, while the detection result of other common feline viruses is negative, which shows that the primer group has the advantages of strong specificity, high sensitivity, good repeatability and the like.
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Feline infectious rhinoconjunctivitis and feline panleukopenia combined vaccine and preparation method thereof
ActiveCN108371710AHigh titerImproving immunogenicitySsRNA viruses positive-senseViral antigen ingredientsFeline panleukopeniaFeline calicivirus infection
The invention provides a feline infectious rhinoconjunctivitis and feline panleukopenia combined vaccine and a preparation method thereof. The feline infectious rhinoconjunctivitis and feline panleukopenia combined vaccine is prepared by: using baculovirus / insect cell expression system to produce virus-like particles of feline calicivirus and virus-like particles of feline panleukopenia, and mixing the virus-like particles of the two viruses with preservatives and adjuvants. The combined vaccine herein has the advantages of good safety, high efficiency, good production convenience, low cost and the like, and has good immuno preventive effect for feline infectious rhinoconjunctivitis and feline panleukopenia.
Owner:CHANGCHUN SR BIOLOGICAL TECH
Vaccine against feline calicivirus
InactiveUS20050208073A1SsRNA viruses positive-senseViral antigen ingredientsFeline calicivirus infectionMedicine
Owner:MERIAL INC
Triple vaccine for feline calicivirus infection, feline infectious rhinotracheitis and feline panleukopenia as well as preparation method and application thereof
ActiveCN111632137ASolve the requirements of cultivating large-scale productionGood immune effectPowder deliverySsRNA viruses positive-senseFeline calicivirus infectionFeline panleukopenia
The invention belongs to the technical field of veterinary biological products, and particularly relates to a triple vaccine for feline calicivirus infection, feline infectious rhinotracheitis and feline panleukopenia as well as a preparation method and application thereof. The triple vaccine comprises antigen components and a freeze-drying protective agent, and the antigen components comprise a feline calicivirus BJ strain inactivated antigen, a feline infectious rhinotracheitis virus SH strain inactivated antigen and a feline panleukopenia virus SY strain inactivated antigen. The feline calicivirus antigen, the feline infectious rhinotracheitis virus antigen and the feline panleukopenia virus antigen are prepared by adopting a full-suspension technology, the triple inactivated freeze-dried vaccine for feline calicivirus, feline infectious rhinotracheitis and feline panleukopenia is prepared through the processes of inactivation, concentration, freeze-drying and the like, three diseases are avoided by one injection, the animal immunization frequency is reduced, the animal stress frequency is reduced, and the economic cost of feeders is greatly reduced.
Owner:郑州爱科生物科技有限公司
Primer group, product and method for detecting feline respiratory tract pathogens as well as application
InactiveCN111455107ADoes not affect analysisHigh sensitivityMicrobiological testing/measurementMicroorganism based processesFeline calicivirus infectionNucleic acid test
The invention provides a primer, product and method for detecting feline respiratory tract pathogens as well as application, and relates to the technical field of nucleic acid tests. In the primer group for detecting the feline respiratory tract pathogens, a primer for detecting feline herpesvirus type 1 (FHV1), a primer for detecting feline calicivirus (FCV), a primer for detecting mycoplasma, aprimer for detecting feline chlamydia and a primer for detecting bordetella bronchiseptica are primers designed through highly conservative regions of each pathogen, have no cross reaction with otherfeline pathogens, and have the characteristics of high specificity and high sensitivity. By use of the primer group, five feline respiratory tract pathogens including the FHV1, the FCV, the mycoplasma, the feline chlamydia and the bordetella bronchiseptica can be identified in the same reaction system, and the detection cost and time are greatly reduced as compared with a traditional method.
Owner:HANGZHOU BIOER TECH CO LTD
Composition, kit and application for detecting feline calicivirus and feline parvovirus
ActiveCN110643745AAvoid false positivesEasy to detectMicrobiological testing/measurementAgainst vector-borne diseasesFeline calicivirus infectionFeline parvovirus
The invention relates to a composition for detecting feline calicivirus and feline parvovirus. The composition comprises primers and probes for detecting the feline calicivirus and the feline parvovirus respectively, wherein the primers include, for example,the sequences shown in SEQ ID NO.1 to SEQ ID NO.4, the probes include, for example,the sequences shown inSEQ ID NO.5 to SEQ ID NO.6; or, the primers include, for example, the sequences shown inSEQ ID NO.7 to SEQ ID NO10, the probes include, for example, the sequences shown inSEQ ID NO.11 to SEQ ID NO12. The invention further relates to a kit and application comprising the composition. The kit performs amplification reaction and product detection in a closed tube state, and false positivity due to contamination of amplification productsis avoided; the probes are higher in hybridization specificity and higher in sensitivity; and no follow-up treatment is after the PCR, operation is simpler and faster, safe and pollution-free effectsare realized, and the detection of both FCV and FPV viruses can be realized at the same time.
Owner:SHANGHAI ANIMAL EPIDEMIC PREVENTION & CONTROL CENT
Feline calicivirus fluorescent quantitative detection card and detection method
PendingCN109991413ASimple and fast operationWide variety of sourcesFluorescence/phosphorescenceDiseaseFeline calicivirus infection
The invention discloses a feline calicivirus fluorescent quantitative detection card and detection method. The fluorescent quantitative detection card is composed of a sample adding groove, a scanningwindow and a handheld device; the sample adding groove covers a sample pad, a bonding pad and part of a reaction membrane; the scanning window covers the reaction membrane; the bonding pad is coatedwith a fluorescent latex microsphere-coupled anti-feline calicivirus monoclonal antibody; the reaction membrane contains a detection line and a quality control line; the detection line is coated withthe anti-feline calicivirus monoclonal antibody; and the quality control line is coated with a goat anti-mouse polyclonal antibody. A quantitative detection result can be provided. In addition, the invention discloses a feline calicivirus disease condition and prognosis judging method based on the quantitative detection result. The method can be used for quantitative detection of feline calicivirus, has the advantages of being high in sensitivity, easy to operate, high in stability and the like, and can realize tracking and monitoring of clinical samples.
Owner:江苏雷森生物科技有限公司
Hemorrhagic feline calicivirus, calicivirus vaccine and method for preventing calicivirus infection or disease
The present invention relates to a novel, isolated and purified hemorrhagic feline calicivirus FCV-DD1. The invention further embraces monovalent and multivalent vaccines containing the new FCV-DD1 strain. In addition, the invention encompasses methods of protecting felines against infection or preventing disease caused by feline calicivirus alone or in addition to other pathogens that comprises administering to the felines an immunologically effective amount of the monovalent and multivalent vaccines described herein. Also, the invention concerns methods for diagnosing or detecting the hemorrhagic feline calicivirus in a susceptible host, asymptomatic carrier and the like by detecting the presence of feline calicivirus FCV-DD1 or antibodies raised or produced against feline calicivirus FCV-DD1 antigen.
Owner:ELANCO US INC
ELISA kit for detecting IgG antibody of feline calicivirus and detecting method thereof
InactiveCN106053801AOperation time is shortThe detection conclusion is clear and clearBiological material analysisFeline calicivirus infectionElisa kit
The invention relates to a kit for detecting feline calicivirus and a detecting method thereof, in particular to an ELISA kit for detecting an IgG antibody of feline calicivirus and a detecting method thereof. The ELISA kit and the detecting method solve the problem that current feline calicivirus diagnosis and detection results are not ideal. The kit comprises an ELISA microwell plate, RaMIgG-HRP and substrate developing liquid. The method comprises the steps that firstly, serum is diluted and added into the ELISA microwell plate to be incubated; secondly, the RaMIgG-HRP is added for incubation; thirdly, the substrate developing liquid is added, and reaction is carried out in a shading mode at the room temperature; fourthly, a stop solution is added to terminate the reaction, an ELIASA is used for detecting 450 nm light absorption value, the 450 nm light absorption value and a Cut Off value of the ELISA kit are compared, and then a detection result is obtained. The ELISA kit detection result is high in repeatability and stability, and the speed is high.
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Improved inactivated FCV vaccines
InactiveCN1933852ASsRNA viruses positive-senseViral antigen ingredientsImmunogenicityFeline calicivirus
Owner:MERIAL LTD
Feline calicivirus VP1-VP2 recombinant protein as well as preparation method and application thereof
PendingCN112321722AHigh sensitivityLow cross-reactivitySsRNA viruses positive-senseBacteriaAnimal virusFeline calicivirus infection
The invention discloses a feline calicivirus VP1-VP2 recombinant protein, and belongs to the field of animal virus antibody detection. The recombinant protein comprises an amino acid sequence shown inSEQ ID NO.1 or an amino acid sequence shown in SEQ ID NO.1. The invention further discloses a gene of the recombinant protein, a vector containing the gene, a host cell containing the gene, a preparation method of the recombinant protein and application of the recombinant protein in detection of a feline calicivirus antibody. When the recombinant protein is used for detecting the feline calicivirus, the recombinant protein is convenient, quick and high in sensitivity, has no cross reaction with other pathogens, is high in specificity, and has huge clinical significance and wide application prospect.
Owner:杭州亿米诺生物科技有限公司
Kit for simultaneously detecting multiple cat pathogens as well as detection method and application of kit
ActiveCN113957172AReduce usageStrong specificityMicrobiological testing/measurementAgainst vector-borne diseasesFeline calicivirus infectionGondii toxoplasma
The invention discloses a kit for simultaneously detecting multiple cat pathogens as well as a detection method and application of the kit. A specific primer group and a probe group are obtained through design, so that rapid and accurate detection and identification on feline plague viruses, feline calicivirus, feline infectious peritonitis viruses, feline toxoplasma gondii, feline herpes viruses, feline chlamydia and feline mycoplasma in one reaction are realized at the same time. The detection kit obtained on the basis of the design is high in specificity and sensitivity, the feline pathogens with the concentration of 1.7 * 10 <2> copies / mL can be effectively detected, repeated detection is not needed, the actual application accuracy is high, and the detection kit can be widely applied to epidemic situation monitoring, prevention and control of feline virus infection.
Owner:广州蔚捷生物医药科技有限公司
Vaccine against feline calicivirus
InactiveUS7850978B2SsRNA viruses positive-senseViral antigen ingredientsFeline calicivirus infectionImmunogenicity
Owner:MERIAL INC
Inactivated FCV vaccines
InactiveUS20060160101A1Good effectImprove stabilitySsRNA viruses positive-sensePeptide/protein ingredientsFeline calicivirus infectionFamily Felidae
Owner:MERIAL LTD
Feline calicivirus monoclonal antibody and application thereof
ActiveCN110272488AHigh reactivityOvercome broad-spectrum poorMicroorganism based processesImmunoglobulins against virusesFeline calicivirus infectionToxin
The invention provides a variable region sequence of a monoclonal antibody specifically bound to a Feline calicivirus, an antibody specifically bound to a Feline calicivirus and a hybridoma cell secreting the antibody. The variable region sequence can be specially bound to the Feline caliciviruses, and can be combined with various Feline caliciviruses. A dual-antibody sandwich detection reagent kit prepared by the antibody can be used for detecting varied FCV toxin strains clinically, the problems that through detection in the prior art, the broad spectrum of the FCV toxin strains is poor, and the sensitivity is low, are solved, the phenomena of being undetected and false-negative are avoided, particularly the accuracy of detecting the targets of varied types of asymptomatic animals is higher, and the variable region sequence has the advantages of being quick, simple and accurate.
Owner:LUOYANG PULIKE WANTAI BIOTECH +1
Feline calicivirus vaccine
ActiveUS20200338186A1SsRNA viruses negative-senseSsRNA viruses positive-senseFeline calicivirus infectionMultivalent Vaccine
Owner:INTERVET INC
Nucleic acid combination product, detection kit and micro-fluidic chip
PendingCN113061665ABioreactor/fermenter combinationsBiological substance pretreatmentsFeline parvovirusFeline immunodeficiency virus
The invention relates to a nucleic acid combination product, a detection kit and a micro-fluidic chip. The nucleic acid combination product comprises at least two of the following detection primer pairs: a feline parvovirus primer pair, a feline coronavirus primer pair, a feline herpesvirus type I primer pair, a feline calicivirus primer pair, a feline leukemia virus primer pair, a feline immunodeficiency virus primer pair, a feline astrovirus primer pair, a feline rotavirus primer pair, a cat vaccinia virus primer pair and a cat reovirus primer pair. The nucleic acid combination product can be used for detecting at least two feline pathogenic viruses in the sample to be detected at one time, and is good in specificity and relatively high in detection sensitivity.
Owner:深圳市刚竹医疗科技有限公司
PCR (Polymerase Chain Reaction) detection kit for cat and/or dog pathogens, detection method and application
PendingCN114277189AShorten detection timeSave human resourcesMicrobiological testing/measurementAgainst vector-borne diseasesFeline parvovirusLeucosis
The invention relates to the technical field of molecular biomedicine, in particular to a PCR (Polymerase Chain Reaction) detection kit for cat and / or dog pathogens, a detection method and application. The kit is used for detecting canine distemper virus, canine influenza A virus, canine parainfluenza virus, canine parvovirus, canine coronavirus, canine rotavirus, canine babesia, canine ascaris, canine Ehrlichia, canine brucella, rabies virus, borrelia burgdorferi, reference gene ACTB, feline herpes virus, feline calicivirus and feline parvovirus. The kit comprises primers and probes of feline coronavirus, feline immunodeficiency virus, feline leukemia virus, feline mycoplasma, feline mycoplasma, feline chlamydia, giardia, toxoplasma, bartonella and reference gene GAPDH, collected DNA and RNA are added into the kit, a real-time fluorescence PCR instrument is adopted for PCR reaction, FAM, HEX, ROX and CY5 fluorescence signals are collected in each cycle, analysis of related pathogens is carried out, and the kit can be used for detecting the feline and the canine. Compared with a traditional detection method, the method has the advantages of higher specificity and higher sensitivity.
Owner:北京迈基诺基因科技股份有限公司
Hybrid core feline vaccines
ActiveUS20170165356A1Reduce severityReduction in signSsRNA viruses positive-senseViral antigen ingredientsDiseaseFeline calicivirus infection
The present invention relates to a hybrid vaccine for protecting a feline against diseases associated with respiratory diseases. The vaccine commonly includes a feline antigen. Methods for protecting felines against diseases associated with feline gastrointestinal and respiratory diseases, including but not limited to feline calicivirus, feline rhinotracheitis and feline panleukopenia, and methods of producing the feline vaccine are also provided.
Owner:ELANCO US INC
Nucleoside compound, pharmaceutically acceptable salt, composition and application thereof
ActiveCN112939981AExcellent anti-feline calicivirus effectOrganic chemistryAntiviralsFeline calicivirus infectionDisease
The invention relates to a nucleoside compound, a pharmaceutically acceptable salt, a composition and an application thereof. The nucleoside compound has a structure shown as a formula (I) shown in the description. The nucleoside compound has a better anti-feline calicivirus effect, and therefore, the nucleoside compound disclosed by the invention has the potential of preparing the medicine for treating or preventing the diseases (such as cat stomatitis) caused by the feline calicivirus.
Owner:嘉兴金派特生物科技有限公司
Multiplex PCR (polymerase chain reaction) primer group for simultaneously detecting feline panleucopenia virus, feline calicivirus and feline herpes virus type 1
InactiveCN103276106BMicrobiological testing/measurementDNA/RNA fragmentationFeline herpesvirus type 1Feline calicivirus infection
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Joint detection kit for feline herpes and feline calicivirus
ActiveCN114839378ACollection is cumbersomeFew samplesBiological testingImmunoassaysFeline calicivirus infectionNitrocellulose
The invention relates to the technical field of biological detection, in particular to a feline herpes and feline calicivirus combined detection kit which comprises a detection card, a sample diluent and a sterile cotton swab, a test strip, a test strip nitrocellulose membrane, a water absorption pad, a gold-labeled antibody reaction pad and a sample pad are arranged in the detection card, a feline herpesvirus monoclonal antibody-colloidal gold compound coating and a feline calicivirus monoclonal antibody-colloidal gold compound coating are arranged on the gold-labeled antibody reaction pad, and the feline calicivirus monoclonal antibody-colloidal gold compound coating is positioned above the feline herpesvirus monoclonal antibody-colloidal gold compound coating; and an isolation pad is arranged between the feline calicivirus monoclonal antibody-colloidal gold compound coating and the feline herpes virus monoclonal antibody-colloidal gold compound coating. The kit is simple to operate and short in detection time, the detection efficiency is greatly improved, in addition, expensive instruments and equipment are not needed for detection, and the detection cost is reduced.
Owner:山东康华生物医疗科技股份有限公司
Method for rapidly detecting feline calicivirus as well as primer and kit for detection
ActiveCN112921123AHigh sensitivityImprove throughputMicrobiological testing/measurementMicroorganism based processesFeline calicivirus infectionFeline parvovirus
The invention discloses a method for rapidly detecting feline calicivirus as well as a primer and a kit for detection, and relates to a method for detecting the feline calicivirus as well as a primer and a kit for detection. According to the invention, an upstream primer ERA-F, a downstream primer ERA-R and a probe Probe are protected. The kit comprises the primer, the probe, a positive control sample, an isothermal nucleic acid amplification kit and a test strip. The detection method comprises the following steps: 1, preparing a detection solution; and 2, detecting a reaction product in the step 1 by using a test strip to obtain a detection result. According to the invention, the feline calicivirus is rapidly detected through an RT-ERA technology by adopting a primer and probe combination mode. The primer and probe combination disclosed by the invention is designed aiming at a feline calicivirus ORF1 conserved region, has the advantages of high sensitivity, strong specificity, good repeatability and the like, and has no cross reaction with feline herpes virus, feline parvovirus and feline infectious peritonitis virus.
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Inhibition of Feline Calicivirus
We conducted feline calicivirus (FCV) inhibition experiment with two anti-viral aminohydrolases, asparaginase and glutaminase. We found that in the presence of 8 units and 4 units / ml of asparaginase, about 90% of FCV replication was inhibited. In contrast, glutaminase showed no significant inhibition effect on the virus replication. We have also shown that asparaginase did not inhibit the replication of adenovirus suggesting that the inhibition was specific. Our results implicated that asparaginase could be used as a candidate for anti-FCV drug development.
Owner:HE RUNTAO
Feline calicivirus vaccine
PendingCN114591405ASsRNA viruses positive-senseViral antigen ingredientsFeline calicivirus infectionTGE VACCINE
The invention relates to a feline calicivirus vaccine. The present invention relates to novel feline capsid proteins, live attenuated feline caliciviruses comprising the capsid proteins, live recombinant vector viruses and live attenuated hybrid feline caliciviruses comprising the capsid proteins, vaccines comprising such live attenuated feline caliciviruses, live recombinant vector viruses and live attenuated hybrid feline caliciviruses, and methods for preparing such viruses.
Owner:INTERVET INT BV
Feline calicivirus reverse genetic platform and construction method thereof
PendingCN113493804ASsRNA viruses positive-senseVirus peptidesFeline calicivirus infectionGenome structure
The invention provides a feline calicivirus reverse genetic platform and a construction method thereof. A feline calicivirus DL19 strain genome is divided into two segments to be connected to a modified pBluescript II SK (+) vector, a feline calicivirus DL19 strain full-length infectious clone plasmid capable of serving as the reverse genetic platform is constructed, and a foundation is laid for subsequent virus rescue and genome structure research.
Owner:INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
Tandem expression of universal epitopes of feline calicivirus gi and gii strains and establishment of an indirect ELISA method
ActiveCN113801243BImmunogenicHigh sensitivitySsRNA viruses positive-senseAntibody mimetics/scaffoldsFeline calicivirus infectionCellular antigens
The present invention provides a tandem expression of common antigenic epitopes of feline calicivirus GI and GII strain groups and the establishment of an indirect ELISA method. Using a prokaryotic expression vector, multiple B cell antigens of feline calicivirus VP1 protein were expressed in tandem. The expressed recombinant protein was purified and used as a coating antigen for the detection of feline calicivirus antibodies. A parallel comparison with the method of encapsulating whole virus showed that the value of detecting negative and positive sera was highly consistent. The antigen processing of the invention is convenient, the test time is shortened, and the operation steps are simpler. The invention establishes an indirect ELISA method for detecting the antibody level of feline calicivirus in cat serum, has the characteristics of good repeatability and high specificity, and can be used for feline calicivirus serological investigation. Therefore, the feline calicivirus indirect ELISA detection kit based on the tandem expression of the VP1 protein B cell antigen provided by the present invention is very suitable for the detection of large clinical samples, and is suitable for large-scale promotion.
Owner:SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
Feline infectious rhinoconjunctivitis and feline panleukopenia dual vaccine and preparation method thereof
ActiveCN108371710BHigh titerImproving immunogenicitySsRNA viruses positive-senseViral antigen ingredientsFeline panleukopeniaFeline calicivirus infection
Owner:CHANGCHUN SR BIOLOGICAL TECH
Feline calicivirus antibody sequence, tetrapeptide chain molecule and immunoglobulin molecule
ActiveCN111848788AHomogenizationBiological material analysisImmunoglobulins against virusesFeline calicivirus infectionPhage antibodies
The invention belongs to the technical field of virus antibodies, and discloses a feline calicivirus antibody sequence, a tetrapeptide chain molecule, an immunoglobulin molecule and applications thereof, and the sequences are as follows: the amino acid sequence of a heavy chain variable region SEQ ID NO: 1 and a nucleotide sequence SEQ ID NO: 3; the amino acid sequence of a light chain variable region is SEQ ID NO: 2, and the nucleotide sequence of the light chain variable region is SEQ ID NO: 4. The screening method of the virus antibody sequence comprises the following steps: preparing a bacteriophage antibody; screening the phage antibody library; identifying an anti-feline calicivirus feline phage single-chain antibody by virtue of a Page ELISA method; sending the scFv bacterial liquidwith the positive Page ELISA identification result to a sequencing company for sequencing to obtain sequences of variable regions of the heavy chain and the light chain. The invention provides support for constructing a cat-derived anti-feline calicivirus genetic engineering antibody with high affinity and low immunogenicity, and has important significance for promoting the development of cat-derived antibody drugs.
Owner:青岛博隆基因工程有限公司
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