46results about How to "Improve side effects" patented technology

The invention relates to an electrode plate complex and a preparation method thereof, an all-solid-state battery and application thereof, and the preparation method of the electrode plate complex comprises the following steps: sequentially preparing an interface layer and a solid electrolyte layer on any surface of a conductive substrate to obtain a transfer printing part, the interface layer comprises a polyanion layer and a polycation layer which are sequentially stacked on the conductive base material; providing an electrode plate, attaching the electrode plate to a transfer printing part, enabling the solid electrolyte layer of the transfer printing part to be in contact with the active material coating of the electrode plate, then applying voltage between the transfer printing part and the electrode plate, and enabling the solid electrolyte layer and the polycation layer in the transfer printing part to be transferred to the surface of the active material coating of the electrode plate, and obtaining the electrode plate complex. By adopting the preparation method disclosed by the invention, the solid electrolyte layer can be completely transferred to the electrode plate, and when the electrode plate complex is applied to the all-solid-state battery, the overall performance and reliability of the all-solid-state battery can be ensured.

The invention discloses a pyrenyl Schiff base fluorescent derivative, a fluorescent probe, a preparation method of the pyrenyl Schiff base fluorescent derivative and application of the pyrenyl Schiff base fluorescent probe in biological imaging, and belongs to the technical field of fluorescent probes. The pyrenyl Schiff base fluorescent probe capable of specifically detecting the zinc ions is prepared through two-step chemical reaction of Suzuki coupling reaction and aldehyde amine condensation reaction, and the pyrenyl Schiff base fluorescent probe has good recoverability and low cytotoxicity, is high in practicability and low in cost, and can be applied to detection of the zinc ions. In addition, the sensor has excellent ion selectivity to zinc ions, extremely high sensitivity, good Stokes displacement and visual sensing performance, and detection of exogenous zinc ions and endogenous zinc ions in cells and tissues is realized through biological imaging. The problems of difficult synthesis process, slow response speed, high detection cost, non-ideal biological imaging effect and the like of the conventional fluorescent derivative are solved.

The invention relates to application of VBIT-4 or pharmaceutically acceptable salt thereof in preparation of drugs for preventing or treating vitiligo and complications thereof. A large number of modern pharmacological scientific researches and in-vivo pharmacodynamic tests prove that VBIT-4 has a treatment effect on a leucoderma mouse model and inhibits synthesis of inflammatory factors and chemotactic factors in a leucoderma mouse skin lesion area. The mechanism of the invention is that VBIT-4 inhibits the expression of inflammatory factors and chemotactic factors in skin tissues so as to treat leucoderma, compared with the existing treatment means, VBIT-4 can promote the compound color of pigments in a skin lesion region on the back of a leucoderma mouse, has no obvious toxicity, and reduces the expression level of inflammatory factors (IL-1beta, IL-6 and IFN-alpha) and chemotactic factors (CXCL9 and CXCL10). In conclusion, the VBIT-4 is clear in action mechanism, remarkable in effect and free of obvious side effects, and has remarkable advantages and progress compared with existing drugs.

The invention discloses an electrolyte, a secondary battery and a power utilization device, and belongs to the technical field of batteries, the electrolyte comprises a lithium salt, the molecular structure of the lithium salt contains C3-C20 alkyl ether, a sulfonic acid amine group and a fluorine element, the lithium salt has a large dipole moment and a high donor number, meanwhile, the lithium salt can be combined with Li < + >, and the lithium salt can be combined with Li < + >. A solvation structure is formed, solvent decomposition is inhibited, and the fast charging performance and the cycle performance of the secondary battery are remarkably improved.

The invention belongs to the technical field of biology, and particularly relates to tilapia skin peptide, a preparation method thereof and application of the tilapia skin peptide in preparation of anti-aging related products. The tilapia skin peptide disclosed by the invention is IL, FGP or LPGL. In the invention, the tilapia skin is subjected to enzymolysis to prepare protein peptide, a peptide fragment with high content and high reliability is selected through mass spectrum identification, and a pure product is prepared by using a solid-phase chemical synthesis method. And by taking GPH as a positive control group, IL, FGP and LPGL are found to have a protection effect on UV-induced cell injury, have good antioxidant activity and an effect of repairing injured cells, and are beneficial to protecting a skin barrier and delaying skin aging.

The invention belongs to the field of neurobiology and drug research and development, and discloses application of NR3A as a protein target in screening or preparing drugs for preventing and / or treating depression-like behaviors. According to the invention, the expression of NR3A in hippocampus is enhanced by stereotactic injection of adeno-associated virus containing Grin3a gene. A chronic constraint stress (CRS) is adopted to induce a depressive mouse, and a sucrose preference test (SPT), a forced swimming test (FST) and an open field test (OFT) are adopted for identification. The expression of proteins such as NR3A, calpain 2 (Calpain2), neuron nitric oxide synthase (nNOS), 3-nitrotyrosine (3-NT), an NLRP3 inflammation complex and the like is detected by WesternBlot; and performing DHE staining to detect reactive oxygen species (ROS). By enhancing hippocampus NR3A expression, depression-like behaviors induced by CRS can be improved, signal cascade activated by calcium is inhibited, ROS generation and 3-NT expression are reduced, and neuroinflammation driven by NLRP3 inflammasomes is inhibited. The NR3A participates in depression-like behaviors induced by CRS, and the mechanism of the NR3A is related to calcium homeostasis regulation, ROS generation and inflammatory response driven by NLRP3 inflammasomes.

The invention discloses a composite modification film, a lithium metal negative electrode and a preparation method of the lithium metal negative electrode. The composite modified film comprises an organic polymer solid electrolyte, an inorganic solid electrolyte and a film-forming agent, and the mass ratio of the organic polymer solid electrolyte to the inorganic solid electrolyte to the film-forming agent is (10%-35%): (10%-35%): (30%-80%). The composite modified film effectively buffers cyclic stress, prevents early mechanical failure of the protective layer, and realizes mechanical durability of the interface protective layer; the immobilized film-forming agent can be slowly released, so that the continuous and stable repair of SEI is realized, the dynamic repair capability of the whole life cycle is provided, and the efficient cycle life of the battery is greatly prolonged; and the electrolyte does not need to depend on a high-concentration liquid additive, dramatic change of electrolyte components in circulation is avoided, the overall chemical stability of the battery is improved, and the stability of an electrolyte system is guaranteed.

The application provides a sodium ion battery electrolyte and a sodium ion battery, and relates to the technical field of sodium ion batteries.A sodium ion battery electrolyte comprises a sodium salt, an organic solvent and an additive.The additive is selected from one or more of a thioimide functional additive and a film-forming additive.The sodium ion battery electrolyte provided by the application can inhibit the dissolution of SEI films and CEI films, improve the cycle stability of the sodium ion battery under high pressure, and thus improve the energy density and service life of the sodium ion battery.

The application discloses a preparation method of medium and long chain fatty acid triglyceride, and belongs to the technical field of oil deep processing. Firstly, plant oil and medium chain fatty acid triglyceride are used as substrates, a low eutectic solvent is used as a reaction medium, and an ester exchange reaction is carried out under the catalysis of immobilized lipase; after the reaction is completed, centrifugal treatment is carried out, and the low eutectic solvent, the immobilized lipase and the reaction product are recovered respectively; the recovered low eutectic solvent and the immobilized lipase are used for the next batch of reaction, and the recovered upper oil phase is the reaction product. The application uses immobilized lipase to catalyze ester exchange to prepare medium and long chain fatty acid triglyceride in a low eutectic system, the substrate conversion rate and the product generation amount are high, the product separation is easy, further separation and purification are not needed, the low eutectic solvent is green, environment-friendly and reusable, and the method has good ecological, economic benefits and industrialization application prospects.

The application discloses Lactobacillus reuteri and application thereof in preparation of a medicine for treating diffuse large B-cell lymphoma, and relates to the technical field of biological medicine. The application provides application of Lactobacillus reuteri and / or a metabolite thereof in preparation of a medicine for treating diffuse large B-cell lymphoma, wherein the Lactobacillus reuteri is Lactobacillus reuteri (HG001). Limosilactobacillus reuteri The Lactobacillus reuteri is separated from feces of healthy people and used for preparation of the medicine for treating diffuse large B-cell lymphoma, and it is found that the Lactobacillus reuteri is confirmed as a probiotic strain for enhancing the chemotherapy effect of diffuse large B-cell lymphoma and can improve side effects caused by cyclophosphamide treatment of diffuse large B-cell lymphoma; and the Lactobacillus reuteri and the cyclophosphamide have a synergistic effect in treatment of diffuse large B-cell lymphoma.

The invention relates to the technical field of semi-solid batteries, in particular to a negative electrode, a preparation method of the negative electrode and a battery. The negative electrode comprises a current collector, a negative electrode active material layer arranged on the current collector and a polymer layer arranged on the side, away from the current collector, of the negative electrode active material layer, the polymer layer comprises an inorganic compound and a polymer, the chemical formula of the inorganic compound is Ax-ByFz, x is larger than or equal to 1, y is larger than or equal to 1, z is larger than or equal to 3, and x is larger than or equal to 1. A is at least one of magnesium, aluminum and zinc, B is at least one of lithium or sodium, and F is fluorine. According to the invention, the polymer is combined with the inorganic compound with the chemical formula of Ax-ByFz, so that cracks generated by the interfacial film due to the change of the volume of the negative electrode in the use process can be avoided, the service life is prolonged, the cycle performance is improved, and meanwhile, the lithium / sodium ion transfer number is increased, so that the electrochemical performance of the battery is remarkably improved.

The invention relates to a medicinal and edible compound extract for improving myelosuppression of a tumor patient after chemotherapy, and a preparation method and application of the medicinal and edible compound extract. The compound extract is extracted from a composition at least comprising the following raw material medicines in parts by weight: 0.9-10 parts of tricholoma matsutake, 0.9-10 parts of mulberry and 0.5-10 parts of rhizoma polygonati. The raw material medicine composition further comprises the following raw material medicines in parts by weight: 0.7-10 parts of longan, 0.5-10 parts of pericarpium citri reticulatae, 0.5-10 parts of scorched hawthorn fruit, 0.5-10 parts of fructus amomi, 1.1-10 parts of cordyceps sinensis rice flour and 2.5-15 parts of rice peptide. The selected raw material medicines are all medicinal and edible components, do not cause adverse effects on liver and kidney functions and gastrointestinal tracts of eaters, and are high in safety and high in patient acceptance degree. Effect verification results show that the mulberry compound extract has an improvement effect on the side effect of bone marrow suppression of tumor patients, especially in the early stage, no related adverse reaction is found, and a safe and effective treatment choice is provided for bone marrow suppression.

The invention provides a composition for improving sleep and application thereof, and belongs to the technical field of biological medicine. The composition with the sleep improving effect comprises ginsenoside RK1 and gamma-aminobutyric acid, has a good sleep improving effect, can obviously improve the content of gamma-aminobutyric acid and the content of 5-hydroxytryptamine in brain tissues, achieves better sleep improving, relieves insomnia, anxiety and nervous mood, improves the sleep quality, improves the sleep quality and improves the sleep quality. The sleep quality is improved. Meanwhile, the composition has no side effect on a human body, the product safety is high, the preparation method is simple, the quality is controllable, the operation is convenient, the production cost is low, and industrial continuous production can be realized.

The invention relates to the technical field of industrial preparation of hydroxypivalaldehyde, in particular to a hydroxypivalaldehyde preparation device and a preparation method thereof.The hydroxypivalaldehyde preparation device comprises a premixer, a tower reactor and a forced circulation pump, and a first reaction zone and a second reaction zone are arranged in the tower reactor and communicated through a plurality of downcomer distribution pipes; a discharge port at the bottom of the tower reactor is respectively connected with a discharge pipeline and a circulating pipeline I, the forced circulating pump is arranged on the circulating pipeline I, the circulating pipeline I is communicated with the plurality of nozzles, the circulating pipeline I is connected with a circulating pipeline II in parallel, and the circulating pipeline II is communicated with the circulating material inlet. According to the present invention, the mixing efficiency of the raw material and the catalyst can be substantially improved, the layering of the material is effectively avoided, the reaction time is ensured, the reaction circulation amount entering the second reaction zone and the first reaction zone is adjusted, the retention time and the reaction temperature of the circulation liquid in the reactor are controlled, the side reaction is reduced, and the HPA yield is improved.

The present invention provides a positive electrode for a lithium secondary battery and a lithium secondary battery comprising the same. In the positive electrode, a positive electrode additive represented by Chemical Formula 1 is contained in a positive electrode mixture layer, and control is performed on a specific X-ray diffraction (XRD) and / or extended X-ray absorption fine structure (EXAFS) peak such that cobalt remaining in the positive electrode mixture layer after initial charging to SOC 100% has a specific oxidation number, thereby improving a side reaction caused by an irreversible additive, i.e., the positive electrode additive, and reducing the amount of gas such as oxygen generated during charging / discharging. Accordingly, the lithium secondary battery has an excellent effect of improving battery safety and electrical performance.

The invention provides a lithium ion battery electrolyte and a lithium ion battery containing the same. The lithium ion battery electrolyte comprises an electrolyte, a non-aqueous organic solvent and an additive, the additive comprises a film-forming additive and at least one compound A, and the compound A has a structure as shown in any one of formulas I-V. By adding the compound A, a layer of protective film can be formed on the surface of the negative electrode, and meanwhile, water and HF acid in the electrolyte can be removed, so that the stability of the electrolyte is greatly improved, and the safety and high-temperature performance of the lithium ion battery are improved.

The invention belongs to the technical field of batteries, and particularly relates to a lithium ion battery. Compared with the prior art, the rapid charging and high-temperature storage performance of the lithium iron phosphate battery is improved by comprehensively controlling the design of the positive and negative pole pieces and the electrolyte. On one hand, by adjusting the particle size distribution of the lithium iron phosphate material particles, the lithium ion transmission path is more uniform, the lithium ion transmission rate consistency is improved, and the overall fast charging performance of the battery is improved; and on the other hand, the carboxylic ester solvent with lower viscosity is adopted, the viscosity of the electrolyte is obviously reduced, the liquid-phase lithium ion transmission capability is greatly improved, and meanwhile, a positive electrode material is matched, so that the comprehensive fast charging performance of the battery is improved. And finally, by selecting a chain binder and compounding a proper amount of unsaturated carbonic ester, the protection of the negative electrode active material is realized, and the side reaction of the electrolyte and the negative electrode side is obviously reduced.

The invention discloses a method for preparing phenylacetaldehyde, which comprises the following steps: preparing liquid A: dissolving cinnamaldehyde and methanol in a light solvent to obtain liquid A, wherein the light solvent is insoluble in water, and the density and boiling point of the light solvent are both lower than those of water; preparing liquid B: preparing liquid B by mixing a water-soluble strong base and hydrogen peroxide with water; first reaction: slowly adding liquid A to the upper layer of liquid B at 0-5°C; adding hydrogen peroxide to liquid B to adjust so that the mass concentration of hydrogen peroxide in liquid B is maintained at 20%-40%; removing volatiles: retaining liquid A after the reaction is completed, evaporating liquid A at 40-60°C to obtain liquid C; filtering liquid C at 0-5°C to obtain solid D; second reaction: mixing solid D with a formic acid aqueous solution and heating under reflux to react, to obtain a reaction liquid containing phenylacetaldehyde. The method for preparing phenylacetaldehyde provided by the invention has the effect of reducing the mutual consumption of methanol and hydrogen peroxide and facilitating the control of the reaction rate.

The invention discloses a polygonatum polysaccharide hydrogel preparation of dihydromyricetin. In the preparation process of the polygonatum polysaccharide hydrogel preparation of dihydromyricetin, polygonatum polysaccharide is used as an adhesive, food-grade low-molecular organic acid is used as a pH regulator and a preservative, and a food-grade calcium chloride ion cross-linking agent is used as a gel structure control agent. The polygonatum sibiricum polysaccharide hydrogel of dihydromyricetin prepared by the invention is a good sustained-release preparation, has better hydrophilic effect, gastrointestinal stability effect, permeability effect and sustained-release effect on dihydromyricetin, and enhances the bioavailability of dihydromyricetin. Meanwhile, the natural bioactive substance, namely, the dihydroxyenzyme, has the characteristics of low side effect and easiness in obtaining, so that the implementation of the invention is of great significance to the development of chronic disease targeted drugs and the prevention and treatment of chronic diseases in the future by the dihydroxyenzyme.

The invention provides an animal feed additive with anti-inflammatory and anti-oxidation functions, namely a traditional Chinese medicine type feed additive with anti-biological efficacy, and a preparation method of the animal feed additive comprises the following steps: mixing a dried olive pomace powder sample with a subcritical extraction agent, and carrying out subcritical extraction to obtain an extraction system; removing the subcritical extraction agent of the extraction system to obtain a pomace powder system without pomace oil; mixing the pomace powder system with ethanol, extracting, and carrying out reduced pressure distillation on the obtained extracting solution to obtain an extract; and mixing the extract system with petroleum ether, standing for layering, taking a petroleum ether phase, and filtering the obtained petroleum ether phase. The extracted maslinic acid and oleanolic acid have anti-inflammatory and anti-oxidation effects, animal experiments prove that the maslinic acid and oleanolic acid can enhance intestinal health in a short time, after the polypeptide is added, side effects caused by long-term use of the maslinic acid and oleanolic acid are improved, and the maslinic acid and oleanolic acid can be popularized and used as novel animal feed additives.

The invention discloses an insomnia massage device in the technical field of massage equipment, and the insomnia massage device comprises a head fixing belt which is used for fixing the head; the hot compress belt is fixed on the inner side of the head fixing belt and is used for performing hot compress on the head; the massage module is fixed on the inner side of the hot compress belt, is used for massaging the head and corresponds to acupuncture points of the head; the vibration module is fixed on the inner side of the hot compress belt and is used for carrying out vibration massage on the head; the control module is arranged on the head fixing band and is used for controlling the massage device; the traditional Chinese medicine and western medicine are combined, and a comprehensive insomnia treatment solution is provided by combining the double advantages of traditional Chinese medicine meridian science and western medicine physiology. A customized massage program is provided, and the treatment effect is improved. Through intelligent equipment control, the operation process is simplified. Non-drug treatment is adopted, so that side effects possibly caused by drugs are avoided. The sleep quality can be improved after long-term use.

The invention belongs to the technical field of phase change materials, and particularly relates to a composite phase change material and a preparation method and application thereof. A one-step in-situ polymerization method is adopted, a silicon dioxide inorganic shell layer is used for coating an organic phase-change material to prepare the composite phase-change material, and lithium alkylide is used for modifying a surface group. When being placed in an electrolyte of a battery, the composite material can reduce temperature rise and improve the high-temperature performance of the battery; the result shows that the thermal conductivity of the composite phase change material in the battery is superior to that outside the battery. Therefore, the self-discharge rate of the battery can be reduced, the calendar life is prolonged, the side reaction of the electrolyte can be reduced, and the cycle performance is improved. Meanwhile, the method can also be used in combination with a liquid or air cooling system.

The invention discloses an application of a thienopyrimidine compound as a beta2 adrenergic receptor (beta2AR) allosteric modulator, and belongs to the field of medicinal chemistry. The thienopyrimidine compound disclosed by the invention is shown as a formula 1, and the structure of the compound comprises a thieno [3, 2-d] pyrimidine ring skeleton. Through deep research on the invention, the inventor finds that the thienopyrimidine compound can be used as a negative allosteric modulator or allosteric antagonist of beta2AR. According to the invention, a GloSensor cAMP content accumulation experiment is adopted to test the functional activity and allosteric regulation mechanism of the compound on beta2AR. Research results show that most of the thienopyrimidine compounds have an allosteric regulation function on beta2AR, namely, the activity of isoproterenol (ISO) serving as an endogenous ligand of beta2AR can be subjected to negative allosteric regulation. Wherein the allosteric regulation function of 6q on beta2AR is 2.7 times that of a positive drug Cmpd-15. Discovery of the thienopyrimidine beta2AR allosteric antagonist provides a new chemical entity for research and development of new drugs targeting beta2AR.

The present invention discloses a divalent inorganic metal ion / photosensitizer protein nanoparticle and its preparation and application. The present invention adopts a new technical idea to effectively solve the problem that the high-valent inorganic oxides usually delivered need to be reduced to a divalent state in cells to exert the immunotherapy effect. The nanoparticles are successfully prepared at room temperature in a certain pH aqueous solution. The divalent inorganic metal ions encapsulated therein form a complex with the photosensitizer, which has the advantages of stable valence and small size, can penetrate deep into the tumor tissue through the blood vessel wall, and release the divalent inorganic metal ions after rapid dissociation in the slightly acidic environment of the lysosome, and exert a phototherapy effect, which can destroy the lysosomal membrane, break through the lysosomal barrier and directly release Mn 2+ It is transported to the cytoplasm and induces the release of double-stranded DNA after illumination, producing cGAMP in situ in the cytoplasm, activating the STING signaling pathway, increasing the immune response rate, and enhancing the efficacy of tumor immunotherapy. Experimental verification has shown that it can completely inhibit tumor growth in a mouse in situ breast cancer model.

The invention relates to a rechargeable lithium battery. A rechargeable lithium battery includes a positive electrode, a negative electrode, a separator, and a non-aqueous electrolyte. The positive electrode includes a first positive electrode active material including a lithium nickel-based composite oxide and in the form of a secondary particle in which a plurality of primary particles are aggregated. The positive electrode includes a second positive electrode active material that includes a lithium nickel-based composite oxide and is in the form of a single particle. The non-aqueous electrolyte comprises an organic solvent, a lithium salt and an additive, and the additive comprises a bicyclic sulfate compound.

This invention relates to a modified MDI with low temperature resistance and narrow molecular weight distribution and its preparation method. By modifying MDI with carbodiimide and urea-ketimide under high pressure, the content of high molecular weight MDI polymer in the product can be significantly reduced. This not only solves the problem of turbidity in some formulations during downstream applications, but also gives the product excellent low temperature resistance.

The present invention relates to a double-layer soluble microneedle patch for local fat reduction, and a preparation method and application thereof, wherein the microneedles are loaded with anti-inflammatory and fat-reducing drugs. The present invention simultaneously loads the fat-reducing drug and nanoparticles capable of sustained-release anti-inflammatory drugs into the same microneedle, and relieves the adverse reactions of the drugs while administering the drugs. The sustained-release anti-inflammatory drug dosage form is loaded into the microneedles, so that the fat-reducing drug is first released in large quantities, destroying fat cells and causing an inflammatory reaction, and the anti-inflammatory drug is then slowly released at the location where the inflammation occurs, so that the concentration of the anti-inflammatory drug is maintained at the treatment threshold, thereby achieving a more optimized balance between the treatment effect and the side effects, and increasing the efficacy and patient compliance.

The invention belongs to the technical field of lithium ion batteries, and particularly relates to a natural graphite tailing-based composite material as well as a preparation method and application thereof. According to the preparation method, the natural graphite tailings are wrapped by liquid polyacrylonitrile, then amorphous carbon layers are formed on the pores and the surface of the natural graphite tailings through sintering, the structural defects of the natural graphite tailings are repaired through the amorphous carbon layers, an isotropic structure is constructed, rapid diffusion of Li < + > is promoted, and anisotropy of a Li < + > diffusion path is weakened; and meanwhile, the side reaction of the electrode and the electrolyte is optimized, a uniform, complete and compact SEI film is formed on the surface of the electrode during charging and discharging, and the generation of lithium metal dendrites is inhibited, so that the electrochemical performance of the lithium ion battery is improved.

The invention provides an application of vorinostat in preparation of a skin external preparation for treating psoriasis, the external vorinostat can inhibit proliferation of keratinocytes, promote differentiation of keratinocytes, inhibit inflammation of keratinocytes and effectively improve skin lesion symptoms of psoriasis, and no obvious side effect is found in the treatment process of the external vorinostat. The safety is high, and long-term use is facilitated. The external medicine for psoriasis provided by the invention is stable in curative effect, small in side effect, good in patient tolerance and relatively short in treatment cycle, and can better meet the treatment requirements of psoriasis patients.

The invention belongs to the technical field of medicines, and particularly relates to application of XBD-173 or pharmaceutically acceptable salts thereof in preparation of medicines for treating and / or preventing pigment decoloring diseases caused by pigment synthesis disorders, in particular to application in preparation of medicines for treating and / or preventing vitiligo, vitiligo, pityriasis albicans and albinism. Experiments prove that XBD-173 can significantly increase melanin synthesis and promote color recovery of pigments in a skin lesion area on the back of a leucoderma mouse, and meanwhile, the XBD-173 has no obvious toxicity. In conclusion, the XBD-173 is clear in action mechanism, remarkable in effect and free of remarkable side effects, and has remarkable advantages and progress compared with an existing medicine.