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Medicinal composition for treating diabetes mellitus and application thereof

A composition and medicine technology, applied in the field of pharmaceutical compositions for the treatment of diabetes, can solve problems such as inconvenience for patients to take, increase patient suffering, increase production costs, etc., reduce adverse reactions and side effects, relieve gastrointestinal discomfort, and save production. cost effect

Active Publication Date: 2011-01-12
广州市和藤医药研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also some literatures that disclose the method of using guava extract in combination with some chemical drugs, but in order to achieve the same effect as chemical drugs, usually the amount of traditional Chinese medicine extract is relatively large, generally more than 300g / kg, a large Dosage of medication will increase production costs, inconvenient for patients to take, and large doses will bring many side effects, which will bring a great burden to internal organs such as kidneys, liver, etc.
Animal experiments have shown that the intake of large doses of guava extract will bring great side effects to the gastrointestinal tract, such as nausea, vomiting, and significant weight loss, which increase the suffering of patients
However, traditional pure Chinese medicine prescriptions contain several to dozens of Chinese medicines, which have slow onset and difficult quality control.

Method used

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  • Medicinal composition for treating diabetes mellitus and application thereof
  • Medicinal composition for treating diabetes mellitus and application thereof
  • Medicinal composition for treating diabetes mellitus and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 10 times the amount of 50% ethanol solution to the guava, soak at 50° C., reflux for extraction, combine the extracts, concentrate under reduced pressure, dry and pulverize to obtain the extract.

[0038] With 50g of guava extract, add 0.3g of evening primrose oil, 0.02g of chromium picolinate (converted to the weight of chromium), and then add an appropriate amount of excipient microcrystalline cellulose, disintegrant sodium carboxymethyl starch and hydroxyl Promellose, lubricant magnesium stearate, etc., pass through a 100-mesh sieve, mix well, use 75% ethanol to make soft material, granulate with a 12-mesh sieve, dry at 55°C for 3 hours, granulate with a 14-mesh sieve, add micronized silica gel , mixing, and tabletting to obtain the pharmaceutical composition tablet (1000 preparations) of the present invention.

Embodiment 2

[0040] Add 10 times the amount of 50% ethanol solution to the guava, soak at 50° C., reflux for extraction, combine the extracts, concentrate under reduced pressure, dry and pulverize to obtain the extract.

[0041] Add 100g of guava extract to 1g of evening primrose oil, 0.08g of chromium hydrochloride (converted to the weight of chromium), and then add an appropriate amount of excipient microcrystalline cellulose, disintegrant sodium carboxymethyl starch and hypromellose Cellulose, lubricant magnesium stearate, etc., pass through a 100-mesh sieve, mix well, use 75% ethanol to make soft material, granulate with a 12-mesh sieve, dry at 55°C for 3 hours, granulate with a 14-mesh sieve, add micropowder silica gel, mix Uniform, tabletting, obtained pharmaceutical composition tablet (1000 preparations) of the present invention.

Embodiment 3

[0043] Prepare 200g of powdered guava extract (available for purchase), add 0.15g evening primrose oil, 0.2g chromium chloride (calculated as the weight of chromium), mix well, then add appropriate amount of sucrose, starch and dextrin, Sieve with 100 mesh, mix well, use appropriate amount of starch slurry to make soft material, granulate with 12 mesh, dry at 55°C, granulate with 16 mesh, and pack into granules to obtain granules.

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Abstract

The invention relates to a medicinal composition for treating diabetes mellitus and application thereof. The medicinal composition contains 20 to 200 parts of guava by weight, 0.01 to 0.2 part (converted to the weight of chromium) of medicinal compound containing chromium ions by weight, and 0.1 to 2 parts of evening primrose oil weight. The medicinal composition is a compound preparation combined by traditional Chinese herb and west medicine chromium picolinate to ensure that the two medicines can play the effect of synergy, so the medicinal composition not only has the advantages of accurate curative effect and quick response of the west medicine, but also can play the effects of harmonized medicines, compatibility between monarch and ministerial medicines, and abnormal metabolism balancing in human bodies in the traditional Chinese medicinal composition, and has the effect of treating both principal and secondary aspect of diabetes mellitus, hyperlipemia, in particular II-type diabetes mellitus with the hyperlipemia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes and its application. Background technique [0002] With the improvement of people's living standards and changes in dietary life, diabetes, hyperlipidemia, hypertension and other "rich diseases" have become serious chronic non-communicable diseases in the world after tumors and cardiovascular diseases, and their incidence is increasing. Increase year by year, if can not get effective control, its various secondary diseases, complications etc. will seriously endanger the health of human body. For a long time, although traditional Chinese medicine and traditional Chinese medicine have started from the root cause and applied dialectical treatment, there is still a gap in the rapid and accurate reduction of blood sugar and blood lipids. However, Western medicine and Western medicine take insulin supplementation or oral hypoglycemic and lipid-lowering drugs. Blood sugar and blood l...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K36/8968A61P3/10A61P3/06A61K31/555A61K33/24
Inventor 钱陈钦冯丽燕卢平华侯峰戴世华
Owner 广州市和藤医药研究开发有限公司
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