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73 results about "Methylglyoxal" patented technology
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Methylglyoxal (MGO) is the organic compound with the formula CH₃C(O)CHO. It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. Methylglyoxal is produced industrially by degradation of carbohydrates using overexpressed methylglyoxal synthase.
Use of lotus procyanidin as advanced glycosylation end product formation inhibitor
InactiveCN103070400AHigh inhibition rateEnhanced inhibitory effectMilk preparationFood preparationAdditive ingredientAdduct
The present invention discloses a use of lotus procyanidin as an advanced glycosylation end product formation inhibitor. The drug composition adopting the lotus procyanidin as a main active component comprises the following nature active component extracts, by weight, 70-80% of lotus procyanidin, 10-20% of a synergist such as VE, VC, epigallocatechin gallate (EGCG), cysteine and other ??complexes, and 5-10% of other nature extracts such as a lotus leaf extract, a ginkgo leaf extract and the like. According to the present invention, a high performance liquid chromatography method is adopted to detect a methylglyoxal removing effect of the lotus procyanidin and the main structure unit thereof (catechin), wherein methylglyoxal is an important intermediate substance during an advanced glycosylation end product formation process; a high performance liquid chromatography / multi-stage mass spectrometry method is adopted to identify adducts of four catechin and methylglyoxal and adducts of nine lotus procyanidin and methylglyoxal; and results show that lotus procyanidin provides good inhibition effects for advanced glycosylation end product formation in simulated physiological environments and simulated food systems.
Owner:HUAZHONG AGRI UNIV
Process for preparing 5-methyl pyrazine-2-carboxylic acid
The preparation process of 5-methyl pyrazine-2-carboxylic acid with pyruvic aldehyde and o-diaminobenzene as basic material includes the cyclization in the presence of catalyst, oxidation with inorganic oxidant, acidification with sulfuric acid, decarbolxylation, extraction and separation with butanone, crystallization, drying and crushing. The 5-methyl pyrazine-2-carboxylic acid product has smelting point of 164-172 deg.c. The product is used as the intermediate for the medicine for treating diabetes and hyperlipemia.
Owner:常州市康瑞化工有限公司
Wound Healing Compositions Involving Medicinal Honey, Mineral ions, and Methylglyoxal, and Methods of Use
ActiveUS20160220722A1Decreasing both wound protease activityDecreasing active infectionAntipyreticAnalgesicsWound healingWound dressing
The invention provides compositions based on either medicinal honey containing broad spectrum antibacterial activities of peroxide, polyphenols and methylglyoxal, or an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity, or a mixture of both for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with any one of the above compositions or a wound dressing containing any one of the above compositions.
Owner:SANMELIX LAB INC
Anti-inflammatory proteins and peptides and methods of preparation and use thereof
ActiveUS20150337019A1Good anti-inflammatory effectSenses disorderNervous disorderMedicineRoyal jelly
The present disclose relates to anti-inflammatory proteins / peptides, their uses, methods of preparation and methods of their detection. In particular, the invention relates to major royal jelly proteins modified by methylglyoxal and fragments thereof from a Leptospermum derived honey and royal jelly.
Owner:MANUKAMED HLDG LLP
Process for preparing nano silver zeolite film catalyst for 1,2-propylene glycol gas phase dehydrogenation and oxidation to synthesize pyruvic aldehyde
InactiveCN1586719AImprove conversion rateHigh selectivityMolecular sieve catalystsCarbonyl compound preparation by oxidationElectrolysisGas phase
The present invention belongs to the field of chemical technology, and is especially one kind of nano silver zeolite film catalyst for gas phase dehydrogenation and oxidation of 1, 2-propylene glycol to synthesize pyruvic aldehyde and its preparation process. The catalyst has nanometer electrolytic silver particle carried onto metal net coated with superthin zeolite film, and is prepared through lamination electrolysis process to deposite electrolytic silver onto zeolite film. The catalyst has low temperature catalytic effect superior to traditional electrolytic silver catalyst and features the continuous catalytic dehydrogenation in the conversion rate up to 96.1 % and selectivity up to 75.6 %.
Owner:FUDAN UNIV
Process for improving product quality and yield of propanediol and glycol
InactiveCN101157598AHigh yieldQuality improvementHydroxy compound separation/purificationPreparation from organic carbonatesChromium trioxideSolvent
A method of preparing pyruvaldehyde by propylene glycol in low temperature liquid phase oxidation highly selectively is characterized in that below 50 to 55 DEG C and in the acidic solvent, taking chromium trioxide as the oxidant and highly selectively oxidizing 1, 2-propylene glycol to pyruvaldehyde. The conversion of the 1, 2-propylene glycol is 100 percent, and the selection of preparing pyruvaldehyde is from 95.6 percent to 99.6 percent.
Owner:北京格瑞华阳科技发展有限公司
Method for improving synthesis process of Acipimox
ActiveCN101899012AOvercome the defect of easy slow oxidationImprove responseOrganic chemistryCatalytic oxidationDecarboxylation
The invention provides a method for improving the synthesis process of Acipimox, which is characterized by carrying out one-pot method on the steps of oxidization, acidification, decarboxylation and oxidization after cyclizing methylglyoxal and o-phenylenediamine which are taken as the original raw materials to directly prepare Acipimox. The method dispenses with intermediate processing, thus greatly simplifying the process steps, and overcomes the defect that the intermediate is easy to oxidize slowly due to multi-step processing, simultaneously utilizes the catalyst for catalytic oxidation in the process of H2O2 oxidation so as to facilitate reaction, improves the reaction yield (66% of overall yield) and is more beneficial to industrial production.
Owner:LUNAN PHARMA GROUP CORPORATION
Method for improving synthesis process of Acipimox
ActiveCN101899012BOvercome the defect of easy slow oxidationImprove responseOrganic chemistryCatalytic oxidationDecarboxylation
The invention provides a method for improving the synthesis process of Acipimox, which is characterized by carrying out one-pot method on the steps of oxidization, acidification, decarboxylation and oxidization after cyclizing methylglyoxal and o-phenylenediamine which are taken as the original raw materials to directly prepare Acipimox. The method dispenses with intermediate processing, thus greatly simplifying the process steps, and overcomes the defect that the intermediate is easy to oxidize slowly due to multi-step processing, simultaneously utilizes the catalyst for catalytic oxidation in the process of H2O2 oxidation so as to facilitate reaction, improves the reaction yield (66% of overall yield) and is more beneficial to industrial production.
Owner:LUNAN PHARMA GROUP CORPORATION
Dual-photon methylglyoxal fluorescent probe and preparation method and application thereof
InactiveCN108409655AWith two-photon propertiesImprove stabilityOrganic chemistryFluorescence/phosphorescenceFluorescent imagingPhysiological function
The invention provides a methylglyoxal (MGO) fluorescent probe with a dual-photon property. The MGO fluorescent probe is sensitive in response, low in detection limit, good in specificity, capable ofachieving deep penetration and avoiding photo-bleaching and photo-poisoning, good in optical stability and specificity response and capable of detecting methylglyoxal in living tissue. The invention also provides a synthesizing method of the probe. The synthesizing method is simple in steps, convenient in purification and high in yield. The probe can be used for evaluating and researching the content of physiological function of methylglyoxal in cells through the fluorescent imaging technology, is especially applicable to the detection of methylglyoxal in the living tissue and has an application value in the researching and acquiring of the physiological function of the methylglyoxal in biological samples.
Owner:UNIV OF JINAN
System and method for synchronous on-line measurement of concentrations of glyoxal and methylglyoxal in atmosphere
PendingCN108931490AEasy to adjustImprove mechanical stabilityColor/spectral properties measurementsSpectroscopyHigh reflectivity
The invention discloses a system and a method for synchronous on-line measurement of concentrations of glyoxal and methylglyoxal in atmosphere. The synchronous on-line measurement of the glyoxal and the methylglyoxal in the atmosphere can be realized based on cavity enhanced absorption spectroscopy technology, a cage structure cavity frame constructed by a cage plate and a fiber rod support is used as a carrier to construct, by two high-reflectivity reflectors, an optical resonant cavity for measurement of characteristic spectral absorption of the glyoxal and the methylglyoxal in the wavelength range of 440-460 nm to quantify the concentrations of the glyoxal and the methylglyoxal in a sampled gas. . The interference of nitrogen dioxide on the glyoxal and the methylglyoxal in a spectrum analysis process is reduced by photolysis of the nitrogen dioxide in the sample gas, the sensitivity and the accuracy of the on-line measurement of the concentrations of the glyoxal and the methylglyoxal can be improved, and the system and the method have the advantages of high temporal-spatial resolution, high sensitivity, high stability, high degree of automation, low detection limit and low cost.
Owner:PEKING UNIV
Method for reducing methylglyoxal and formaldehyde in food
InactiveCN113349327AMethylglyoxal reductionReduce formaldehyde contentDough treatmentBakery productsAldehydeMethylglyoxal
The invention discloses a method for reducing the content of methylglyoxal and formaldehyde in food, and belongs to the technical field of hot processing food. The invention provides a method for adding L-cysteine into food as a removing agent for methylglyoxal and formaldehyde, and the purpose of reducing the content of methylglyoxal and formaldehyde in food at the same time is achieved. The method disclosed by the invention is simple and convenient to operate and has a remarkable effect of eliminating the methylglyoxal and the formaldehyde.
Owner:JINAN UNIVERSITY
Chemical synthesis method for 2-formylcyanoacetylhydrazone-quinoxaline-1,4-dioxide
InactiveCN101323599ALow priceMild reaction conditionsAntibacterial agentsOrganic chemistryChemical synthesisQuinoxaline
The invention belongs to the medicine synthesis field, in particular to a method for chemically synthesizing a feed additive 2-carbaldehyde acylhydrazone-quinoxaline-1,4-dioxide (cyadox). The invention comprises the steps that: benzofuroxan used as a raw material and N,N-dimethylformamide used as a reaction medium react with Methylglyoxal 1,1-dimethyl acetal under the function of catalyst pyrrolidine to synthesize an intermediate, quinoxaline-1,4-dioxygen-2-formaldehyde dimethyl acetal; the intermediate is alcoholysized in methanol and concentrated hydrochloric acid and reacts with cyanazine to synthesize the final product 2-carbaldehyde acylhydrazone-quinoxaline-1,4-dioxide (cyadox). The invention has the advantages of moderate reaction conditions, cheap and easily obtained raw material, low-toxicity or non-toxicity of all reagents, relatively high yield of synthesized product, relatively good purity and being applicable to expanded production under industrialization conditions.
Owner:HUAZHONG AGRI UNIV
Artemisia selengensis straw extractive and preparation method and application thereof
The invention relates to an artemisia selengensis straw extractive, a preparation method and a function of inhibiting protein glycosylation. The preparation method of the extractive comprises the following steps of: by taking the artemisia selengensis straw as the raw material, carrying out reflux extraction by using 75% of ethanol with the solid-liquid ratio of 1:15 at 90 DEG C, filtering, carrying out decompression concentration on the filtrate, extracting and decoloring with petroleum ether, further purifying macroporous resin AB-8 column chromatography, eluting the chromatography column by 10% of water, 30-50% of water and 95% of ethanol, collecting 30-50% of eluted component of ethanol for decompression concentration and carrying out vacuum drying to obtain solid powder. The total flavone content of the artemisia selengensis extractive is not less than 80% and the main components comprise rutin and luteolin; the artemisia selengensis straw extractive has the activities of capturing active dicarbonyl compound (methylglyoxal MGO and glyoxal GO) and inhibiting the protein glycosylation (AGEs).
Owner:NANJING NORMAL UNIVERSITY
Method for the detection of prediabetes
InactiveUS20130004972A1Effectively and rapidly and precisely performingAccurate detectionOrganic chemistryDisease diagnosisArgininePrediabetes
Provided is a method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay, with which it is possible to treat many samples as simply and as safely as with blood sugar assay, and to collect a blood sample taken during a primary health screening in one procedure without imposing any time restraints, complications or risks on the subject. The method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay comprises assaying the methylglyoxal-modified arginine derivative in blood using an assay system which employs an antibody that specifically recognizes methylglyoxal-modified arginine derivative.
Owner:FUKUOKA UNIV
Combined pharmaceutical composition
The present invention relates to a physicochemically stable pharmaceutical composition, in a unit dose characterized in that it comprises effective amounts of the active ingredients thiamine (Vitamin B1), pyridoxine (Vitamin B6), a flavonoid such as quercetin and a polyphenol such as curcumin, or their pharmaceutically acceptable salts in combination with pharmaceutically acceptable excipients, for the prevention of the formation and / or trapping of advanced glycation end products (glyoxal, methylglyoxal, N-carboxymethyl-lysine, N-carboxyethyl-lysine, pyrraline, pentosidine, lysine dimer, etc.), which can be used in the treatment and / or prevention of complications of diabetes mellitus (diabetic neuropathy, nephropathy and retinopathy).The pharmaceutical composition of the invention is presented orally, preferably in capsule, pill or sachet for oral administration.
Owner:GIDD COMMERCIAL USA INC +1
Wound Healing Composition Involving Mineral Ions and Methylglyoxal, and Methods of Use
InactiveUS20170360982A1Reduced activityReduce infectionAntipyreticAnalgesicsWound healingWound dressing
The invention provides compositions based on an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with the above compositions or a wound dressing containing the above compositions.
Owner:PELOGENIX LLC
Pictet-Spengler enzyme and encoding gene and application thereof
The invention discloses a Pictet-Spengler enzyme and an encoding gene and application thereof. The encoding gene nfcbB of the Pictet-Spengler enzyme is as shown in the nucleotide sequence of SEQ ID NO. 1, and NfcbB of the Pictet-Spengler enzyme is as shown in the nucleotide sequence of SEQ ID NO. 2. beta-carboline framework 1-acyl-3-carboxyl-beta-carboline can be produced by constructing recombinant escherichia coli BL21 (DE3) containing the nfcbB gene, and purified NfcbB can catalyze L-tryptophan and pyroracemic aldehyde to react to produce the beta-carboline framework 1-acyl-3-carboxyl-beta-carboline. The discovery and functional identification of the NfcbB have practical guiding significance for the large-scale production of alkaloids, and the NfcbB is applicable to the fields of biology, medicine, fine chemical industry and the like.
Owner:ANHUI MEDICAL UNIV
Wound healing compositions involving medicinal honey, mineral ions and methylglyoxal, and methods of use
InactiveUS20170216369A1Modulate biochemical mechanismsReduced activityAntipyreticAnalgesicsWound healingWound dressing
The invention provides compositions based on either medicinal honey containing broad spectrum antibacterial activities of peroxide, polyphenols and methylglyoxal, or an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity, or a mixture of both for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with any one of the above compositions or a wound dressing containing any one of the above compositions.
Owner:SABACINSKI KENNETH A +1
Use of lotus procyanidin as advanced glycosylation end product formation inhibitor
InactiveCN103070400BEnhanced inhibitory effectImprove side effectsMilk preparationFood preparationAdditive ingredientAdduct
Owner:HUAZHONG AGRI UNIV
Functional beverage
The invention provides a functional beverage. The functional beverage is prepared from the following raw materials in parts by weight: 100 parts of water, 5-10 parts of sucrose, 0.1-0.5 part of citric acid, 0.017-0.102 part of taurine, 0.007-0.068 part of potassium sorbate, 0.007-0.034 part of lysine, 0.007-0.034 part of inositol, 0.007-0.034 part of caffeine, 0.003-0.007 part of nicotinamide and 0.04-0.1 part of rutin. The functional beverage has the advantages that compared with the beverage without the rutin, the content of methylglyoxal and 3-deoxyglucosone in the beverage containing the rutin can be remarkably reduced. The intake of substances harmful to human bodies, including the methylglyoxal and the 3-deoxyglucosone, is reduced to a certain extent, so that the safety of the functional beverage food is improved. The technical scheme and equipment, provided by the invention, are simple, and the functional beverage is easy to produce and convenient to popularize.
Owner:TIANJIN UNIV OF SCI & TECH
Synthesis process of 2-methyl-5-pyrazinecarboxylic acid
The invention provides a method for preparing 2-methyl-5-pyrazinecarboxylic acid. The method provided by the invention is characterized in that potassium permanganate which is more harmful to the environment is not used, a target compound 2-methyl-5-pyrazinecarboxylic acid can be prepared from cheap and easily available methylglyoxal and 2-amino malonamide taken as raw materials through four stepsof cyclization, hydrolysis, chlorination and reduction, the yield of the reaction route is high, the amount of byproducts is small, and products are purer.
Owner:东营曜康医药科技有限公司
Antimicrobial compositions
This invention provides antimicrobial compositions containing methylglyoxal and material with methylglyoxal contained (such as manuka honey). The antimicrobial activity of methylglyoxal, or material with a methylglyoxal presence, is maintained and / or enhanced by mixing methylglyoxal or material with a methylglyoxal presence with cyclodextrin. Methods of preparing such compositions, including powder composition, and methods of using such compositions are also provided.
Owner:MANUKA HEALTH NEW ZEALAND
Method for prediabetes screening
InactiveCN102792162AImprove the immunityEasy to detectOrganic chemistryDisease diagnosisArgininePrediabetes
Provided is a method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay, with which it is possible to treat many samples as simply and as safely as with blood sugar assay, and to collect a blood sample taken during a primary health screening in one procedure without imposing any time restraints, complications or risks on the subject. The method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay comprises assaying the methylglyoxal-modified arginine derivative in blood using an assay system which employs an antibody that specifically recognizes methylglyoxal-modified arginine derivative.
Owner:FUKUOKA UNIV
Method for generating acetylacetone through extracellular enzyme reaction
ActiveCN112011578AAddressing Toxicity Inhibition IssuesMicroorganism based processesOxidoreductasesLyaseMethyl palmoxirate
The invention discloses a method for generating acetylacetone through an extracellular enzyme reaction, and belongs to the technical field of bioengineering. The method comprises the following steps:1) connecting an acetylacetone lyase mutant gene Dke1<K15Q> to an expression vector to obtain a recombinant vector; 2) transforming the recombinant vector obtained in the step 1) into host bacteria toobtain recombinant bacteria, and performing fermentation culture on the recombinant bacteria to obtain a culture solution; 3) treating the culture solution obtained in the step 2) to obtain an enzymesolution; and 4) mixing the enzyme solution obtained in the step 3) with reaction substrates, and then carrying out a reaction to prepare acetylacetone. According to the method provided by the invention, methylglyoxal and ammonium acetate can be converted into acetylacetone by utilizing the enzyme reaction in vitro, the yield reaches 388.9 mg / L, and a new thought is provided for solving the problem of toxicity inhibition of acetylacetone on cells in a whole-cell synthesis system.
Owner:QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
Gene AKR18A1 relevant to detoxification of fusarium toxin and toxic aldehydes and applications of gene AKR18A1
ActiveCN109251933AHigh expressionImprove solubilityAccessory food factorsOxidoreductasesFusarium toxinsAmino acid
The invention discloses a gene AKR18A1 relevant to detoxification of fusarium toxin and toxic aldehyde compounds and applications of the gene AKR18A1. The gene AKR18A1 has the sequence as shown in SEQID NO.1, amino acid coded by the gene AKR18A1 comprises a conservative feature structure element of aldo-keto reductase, and the sequence of the amino acid is as shown in SEQ ID NO.2. Purified protein is obtained through prokaryotic expression of the gene AKR18A1, and the in-vitro experiment proves that the purified protein can oxidize deoxynivalenol, so that 3-keto-deoxynivalenol is formed; andmeanwhile, the protein can act on zearalenone and derivatives of zearalenone, including alpha-zearalenol and beta-zearalenol, and also can effectively degrade the toxic aldehyde compounds, namely, glyoxal and methylglyoxal.
Owner:HUAZHONG AGRI UNIV
Process for preparing 5-methyl pyrazine-2-carboxylic acid
The preparation process of 5-methyl pyrazine-2-carboxylic acid with pyruvic aldehyde and o-diaminobenzene as basic material includes the cyclization in the presence of catalyst, oxidation with inorganic oxidant, acidification with sulfuric acid, decarbolxylation, extraction and separation with butanone, crystallization, drying and crushing. The 5-methyl pyrazine-2-carboxylic acid product has smelting point of 164-172 deg.c. The product is used as the intermediate for the medicine for treating diabetes and hyperlipemia.
Owner:常州市康瑞化工有限公司
Synthesis method of stable isotope labeled quinoxaline-2-carboxylic acid
InactiveCN110642797AExperimental steps are few and simpleOrganic chemistry methodsQuinoxalineStable Isotope Labeling
The invention discloses a synthesis method of stable isotope labeled quinoxaline-2-carboxylic acid. The method comprises the following steps: S1: carrying out a condensation reaction on a methylglyoxal water solution and stable isotope labeled aniline to obtain stable isotope labeled 2-methylquinoxaline; S2, oxidizing the stable isotope labeled 2-methylquinoxaline by using selenium dioxide to formstable isotope labeled 2-formaldehyde quinoxaline; and S3, finally, enabling the stable isotope labeled 2-formaldehyde quinoxaline to react with an oxidizing agent, so as to obtain the stable isotopelabeled quinoxaline-2-carboxylic acid. According to the synthesis method of the stable isotope labeled quinoxaline-2-carboxylic acid, the purity of the prepared quinoxaline-2-carboxylic acid is 98% or above, and the isotope abundance is 99% or above; the reaction route is novel in design, mild in experimental conditions and high in yield; and the stable isotope labeled quinoxaline-2-carboxylic acid can be used as an internal standard substance for detecting quinoxaline veterinary drug residues, so that detection cost is greatly reduced.
Owner:PLANTS & ANIMALS & FOOD TESTING QUARANTINE TECH CENT SHANGHAI ENTRY EXIT INSPECTION & QUARANTINE BUREAU +1
Preparation method of pyrazine carboxylic acid
The invention provides a preparation method of pyrazine carboxylic acid. The method includes the steps of: performing an addition reaction to an initial raw material, acrylic acid, with bromine in dichloromethane; performing a substitution reaction to the addition product with ammonia water in anhydrous ethanol; performing a reaction to the substitution product with methylglyoxal in anhydrous ethanol; and performing DDQ dehydrogenation in dichloromethane to obtain the pyrazine carboxylic acid. In the invention, by changing the synthetic route, an oxidization reaction is avoided smartly, so that risk of explosion is avoided and generation of waste gas and waste water is reduced, thereby preparing the target product under mild conditions. The route also avoids a problem of selectivity, so that yield is increased in another way.
Owner:天津市亨必达化学合成物有限公司
Preparation method of cyclen
InactiveCN110698419AImprove stabilityGood reaction selectivityOrganic chemistryBiochemical engineeringAcid hydrolysis
The invention provides a preparation method of cyclen. The method comprises the following step: taking triethylenetetramine (TETA) as a raw material to carry out refining, then carrying out a reactionon the refined triethylenetetramine with methylglyoxal to obtain an intermediate 2, carrying out cyclization on the intermediate 2 with glyoxal, carrying out reducing with sodium borohydride to obtain a cyclized intermediate 3, finally carrying out ring opening through acid hydrolysis, and then adjusting the pH value by using an alkali solution to free out the cyclen.
Owner:CHEN STONE GUANGZHOU CO LTD
Biomarkers of methylglyoxal and related methods thereof
InactiveUS20190137505A1Lowering hepatic gluconeogenesisAvoid complicationsOrganic active ingredientsPeptide/protein ingredientsPlasminFibrinolysis
The present invention relates to methods and biomarkers for detection, characterization and treatment of conditions associated with methylglyoxal (MG) in biological samples. In particular, the present invention provides compositions and methods for determining diabetic complication onset in a patient through detecting a o-phenylenediamine derivatized MG (2MQ) product as indicative of the presence of MG, impaired fibrinolysis in a patient through detecting a MG modified plasminogen (Pg) product as indicative of impaired fibrinolysis, and the efficacy of metformin (MF) treatment in a patient through detecting IMZ as indicative of a MF / MG product.
Owner:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA
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