15 results about "Cyclen" patented technology

The present application relates to a kind of annelated derivative and its preparation method and use, specifically provide the compound or its pharmaceutically acceptable salt, stereoisomer as selective agonist of cannabinoid receptor CB2, wherein the compound has the structure of formula (I).

The application discloses a ternary supramolecular nanoparticle based on a cyclodextrin-opened cucurbituril double host, which is prepared by adding an organic solvent containing a guest hydrophobic pyridine-pyrrole boron derivative and a hydrophobic adamantyl disulfide modified antitumor drug into an aqueous solution of water-soluble cyclodextrin-opened cucurbituril, and then performing ultrasonic treatment, standing, self-assembly through host-guest interaction between molecules, dialysis in the dark, filtration and drying, so as to obtain the ternary supramolecular nanoparticle. The ternary supramolecular nanoparticle has the advantages of mild preparation conditions, simple operation, uniform size and good stability, and can significantly improve the water solubility of the hydrophobic drugs BP and AD-SS-D. The application realizes a significant synergistic effect of photodynamic therapy and chemotherapy, can effectively induce cancer cell apoptosis and inhibit the migration of the cancer cells, and has low toxicity to normal cells, and provides a safe and efficient novel nanoparticle drug delivery platform for multifunctional synergistic antitumor treatment.

The invention belongs to the field of medicine preparation and purification, and relates to a preparation and purification method of high-purity cycleanine. The method comprises the following steps: (1) adding triethylene tetramine into a reaction kettle, and slowly adding methylbenzene; (2) adding DMF (Dimethyl Formamide) and TETA.2H2O into a reaction kettle, introducing nitrogen into the reaction kettle, and catalyzing by alkali; (3) carrying out acid hydrolysis on a cyclization product, and filtering and centrifuging; (4) carrying out free reaction on organic alkali and / or inorganic alkali; and (5) refining and purifying. The process is suitable for industrial production, low in cost and easy for batch production.

The invention discloses a PDA modified cycleanine coordination compound and a synthesis method and application thereof, the coordination compound has the capability of amplifying Zn (II) signals, that is, in normal tissues, the MRI signals of the compound are weak, and in Zn (II) distribution tissues, the compound can be easily combined with HSA so as to detect and amplify the Zn (II) signals. The coordination compound has high responsiveness and sensitivity to Zn (II) detection, can be used as an MRI probe to detect Zn (II) in living cells, and is suitable for the fields of T2ex imaging and detection of Zn (II) in tumors or pathological tissues and the like.

The present invention discloses a method for the preparation of cyclen (1,4,7,10-tetraazacyclododecane) including one or more of the following steps: • (1) intermediate 1 is reacted with butanedione in the presence of an ether solvent to form intermediate 2, • (2) Intermediate 2 is reacted with glyoxal in the presence of a solvent, a reducing agent and benzotriazole to form intermediate 3.

Provided are an etching composition containing (A) an oxidizing agent; (B) a compound capable of releasing fluoride ions or a salt thereof; (C) at least one amine compound selected from the group consisting of an amine compound (c1) having a specific structure, an amine compound (c2) having a specific structure, an amine compound (c3) having a specific structure, piperazine, 1,5,9-triazacyclododecane, 1,4,7-triazacyclononane, cyclen, cyclam, tetraethylenepentamine, and polyethyleneimine, and derivatives thereof, and (D) a corrosion inhibitor, an etching method, and a method for manufacturing a semiconductor substrate.

The invention discloses a synthesis method and application of a bismuth-based chelate X-ray contrast agent. The method comprises the following steps: in N, N-dimethylacetamide, reacting cycleanine with halogenated carboxylic ester under an alkaline condition to obtain a first intermediate; reacting the first intermediate with 4, 4-dimethyl-3, 5, 8-trioxabicyclo [5.1. 0] octane under an alkaline condition, and acidifying to obtain a second intermediate; the second intermediate and a bismuth agent are subjected to a chelation reaction under the hydrothermal condition and purified, and the bismuth-based chelate contrast agent 10-(1, 3, 4-trihydroxybutyl-2-yl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tricarboxylic acid bismuth (1) is obtained. The high-purity large-scale preparation of the contrast agent can be realized, the synthetic route is simple and controllable, and the product is high in water solubility, low in osmotic pressure, stable in property, high in safety and excellent in X-ray imaging performance.

Cyclen based compounds of general formula (I) are disclosed. X is nitrogen and Y, Z are —CH—, or X, Z are —CH— and Y is nitrogen, or X, Y are —CH— and Z is nitrogen. R1 is independently selected from H; COOH; benzyloxycarbonyl; fluorenylmethyloxycarbonyl; tert-butoxycarbonyl; methylcarbonyl; trifluoromethylcarbonyl; benzyl; triphenylmethyl; tosyl; mesyl; benzyloxymethyl; phenylsulfonyl; ethoxycarbonyl; 2,2,2-trichloroethyloxycarbonyl; methoxycarbonyl; methoxymethyloxycarbonyl; R2 is selected from H; methylcarbonyl; tert-butyldimethylsilyl; (C1-C4)alkyl; R3 is independently selected from H; (C1-C6)alkyl.

The application discloses a PDA modified wheel ring temugin coordination compound and a synthesis method and application thereof. The coordination compound has the ability of amplifying Zn(II) signals, that is, in normal tissues, the MRI signal of the compound itself is weak, and in tissues with Zn(II) distribution, the compound can be easily combined with HSA, so that the signal of Zn(II) can be detected and amplified. The coordination compound has high responsiveness and sensitivity for Zn(II) detection, can be used as an MRI probe for the detection of Zn(II) in living cells, and is suitable for the T 2ex imaging and detection fields.

The invention discloses an ilaprazole sodium freeze-dried preparation as well as a preparation method and application thereof. The invention provides an ilaprazole sodium freeze-dried preparation which comprises the following components: ilaprazole sodium, an excipient, cycleanine tetraacetic acid and a pH (Potential of Hydrogen) regulator, and does not contain ethylenediamine tetraacetic acid. The ilaprazole sodium freeze-dried preparation is good in stability, lower in impurity content, good in solubility, safer, simple to prepare and suitable for industrial production.

The present invention relates to granules comprising 1,4,7,10-tetraazacyclododecane (cyclen). Cyclen granules prepared according to the novel granulation process exhibit advantageous properties for transportation.

The invention provides a molecular perovskite energetic material NP-1 and a preparation method thereof. The molecular formula of the molecular perovskite energetic material NP-1 is (C14H32N4) [NH4 (ClO4) 3]. The invention also relates to a preparation method of the molecular perovskite energetic material NP-1. The preparation method comprises the following steps: step 1, dissolving cycleanine in deionized water to form a solution A; step 2, adding perchloric acid into the solution A to form a solution B; step 3, slowly heating the solution B, and keeping the temperature; step 4, pouring the solution B into a beaker, cooling, precipitating and filtering to obtain a precipitate; and step 5, freezing the precipitate, and freeze-drying to obtain white NP-1 powder. The raw materials 1, 4, 7, 10-tetraazacyclododecane and dilute perchloric acid are adopted as the raw materials, the interaction between the two is milder and more stable, and the molecular perovskite energetic material NP-1 with the advantages of high yield, high density, low sensitivity and the like is prepared.

The invention relates to a preparation method of DOTA-PNP, and belongs to the technical field of material synthesis. Cheap cycleanine is used as a starting raw material and reacts with tert-butyl bromoacetate to generate a tri-substituted product, the tri-substituted product is further substituted with ethyl bromoacetate to obtain a tetra-substituted product, ethyl ester is further hydrolyzed to obtain substituted carboxylic acid, the substituted carboxylic acid and p-nitrophenol are condensed, and finally tert-butyl is removed to obtain a target product.

The invention discloses a preparation method of cycleanine. The preparation method specifically comprises the following steps: step 1, in the presence of an ether solvent, reacting an intermediate 1 with butanedione to prepare an intermediate 2; step 2, reacting the intermediate 2 with glyoxal in the presence of a solvent, a reducing agent and benzotriazole to prepare an intermediate 3; step 3, reacting the intermediate 3 with hydrochloric acid in the presence of a solvent to prepare an intermediate 4; step 4, reacting the intermediate 4 with alkali in the presence of a solvent to prepare an intermediate 5; and step 5, dewatering the intermediate 5 in a solvent to prepare cycleanine. The preparation method disclosed by the invention is simple to operate, high in productivity, simple in equipment, good in safety, low in cost and suitable for industrial production.