7 results about "Cyclen" patented technology

The present application relates to a kind of annelated derivative and its preparation method and use, specifically provide the compound or its pharmaceutically acceptable salt, stereoisomer as selective agonist of cannabinoid receptor CB2, wherein the compound has the structure of formula (I).

The present invention discloses a method for the preparation of cyclen (1,4,7,10-tetraazacyclododecane) including one or more of the following steps: • (1) intermediate 1 is reacted with butanedione in the presence of an ether solvent to form intermediate 2, • (2) Intermediate 2 is reacted with glyoxal in the presence of a solvent, a reducing agent and benzotriazole to form intermediate 3.

Provided are an etching composition containing (A) an oxidizing agent; (B) a compound capable of releasing fluoride ions or a salt thereof; (C) at least one amine compound selected from the group consisting of an amine compound (c1) having a specific structure, an amine compound (c2) having a specific structure, an amine compound (c3) having a specific structure, piperazine, 1,5,9-triazacyclododecane, 1,4,7-triazacyclononane, cyclen, cyclam, tetraethylenepentamine, and polyethyleneimine, and derivatives thereof, and (D) a corrosion inhibitor, an etching method, and a method for manufacturing a semiconductor substrate.

The invention discloses a synthesis method and application of a bismuth-based chelate X-ray contrast agent. The method comprises the following steps: in N, N-dimethylacetamide, reacting cycleanine with halogenated carboxylic ester under an alkaline condition to obtain a first intermediate; reacting the first intermediate with 4, 4-dimethyl-3, 5, 8-trioxabicyclo [5.1. 0] octane under an alkaline condition, and acidifying to obtain a second intermediate; the second intermediate and a bismuth agent are subjected to a chelation reaction under the hydrothermal condition and purified, and the bismuth-based chelate contrast agent 10-(1, 3, 4-trihydroxybutyl-2-yl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tricarboxylic acid bismuth (1) is obtained. The high-purity large-scale preparation of the contrast agent can be realized, the synthetic route is simple and controllable, and the product is high in water solubility, low in osmotic pressure, stable in property, high in safety and excellent in X-ray imaging performance.

The invention discloses an ilaprazole sodium freeze-dried preparation as well as a preparation method and application thereof. The invention provides an ilaprazole sodium freeze-dried preparation which comprises the following components: ilaprazole sodium, an excipient, cycleanine tetraacetic acid and a pH (Potential of Hydrogen) regulator, and does not contain ethylenediamine tetraacetic acid. The ilaprazole sodium freeze-dried preparation is good in stability, lower in impurity content, good in solubility, safer, simple to prepare and suitable for industrial production.

The present invention relates to granules comprising 1,4,7,10-tetraazacyclododecane (cyclen). Cyclen granules prepared according to the novel granulation process exhibit advantageous properties for transportation.

The invention discloses a preparation method of cycleanine. The preparation method specifically comprises the following steps: step 1, in the presence of an ether solvent, reacting an intermediate 1 with butanedione to prepare an intermediate 2; step 2, reacting the intermediate 2 with glyoxal in the presence of a solvent, a reducing agent and benzotriazole to prepare an intermediate 3; step 3, reacting the intermediate 3 with hydrochloric acid in the presence of a solvent to prepare an intermediate 4; step 4, reacting the intermediate 4 with alkali in the presence of a solvent to prepare an intermediate 5; and step 5, dewatering the intermediate 5 in a solvent to prepare cycleanine. The preparation method disclosed by the invention is simple to operate, high in productivity, simple in equipment, good in safety, low in cost and suitable for industrial production.