146results about How to "Synthetic is simple" patented technology

Oligonucleotide and nucleotide amine analogs and methods of preparing and using these compounds are provided by the present invention.

Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R/IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases. This invention also discloses an isolated compound having an IL-1R antagonist activity, said compound being selected from the group consisting of: a peptide comprising the amino acid sequence RYTPELX, wherein R, Y, T, P, E, L, refer to their corresponding amino acids, and X is selected from no amino acid and alanine (A); and a derivative of (a) wherein the derivative incorporates one, two or three amino acid modification selected from an amino acid addition, deletion or substitution in the RYTPEL portion of the peptide, and wherein said derivative maintains its antagonist IL-1R activity.

PCT No. PCT/US98/23482 Sec. 371 Date Feb. 7, 2000 Sec. 102(e) Date Feb. 7, 2000 PCT Filed Nov. 4, 1998 PCT Pub. No. WO99/26616 PCT Pub. Date Jun. 3, 1999The present invention provides compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of diseases whose treatment benefits from the inhibition of phosphodiesterase (PDE-IV) or Tumor Necrosis Factor (TNF) including asthma, allergic diseases, rheumatoid arthritis, osteoarthritis, septic shock. The compounds provided by this invention have formula (I) wherein R1, R2, R3, R4 are as defined herein.

The synthesis of Pt and PtRu and other Pt based nano-particles that catalyze the electrochemical oxidation of methanol, carbon monoxide and hydrogen, as well as oxygen reduction, is described. The Pt based catalysts are synthesized in solution forming particles of 0.8 to 10 nm size (forming a “colloidal” solution) and are subsequently applied to a desired substrate as e.g., carbon black, graphite, metals. The application of the nano-sized catalyst particles on the substrates involves electroless deposition at open-circuit, such as immersing the substrate into the colloidal solution or spraying the catalyst particles on the substrate. The Pt, PtRu and other Pt based catalyst can also be directly deposited on the substrate involving the simultaneous reduction and deposition of the Pt based catalysts onto the substrate surface and into its porous structure. The presently described synthesis and deposition of the resulting Pt based nano-particles on and into a variety of high surface area and preferably electronically conductive substrates results in electrodes of high surface areas, relates directly to the preparation and use of high surface area electrodes, (anodes and cathodes) which could be used in e.g., direct methanol, hydrogen and hydrogen containing carbon monoxide fuel cells.

The present invention relates to a synthetic method of graphitic carbon nitride material. The method involves a homogenous mixing of carbon nitride precursor and ammonium salt, and calcining the mixture to obtain a porous graphitic carbon nitride material. Wherein, the ammonium salt is any one or a combination of at least two which could release gaseous NH₃ during thermolysis. The present invention uses thermolabile ammonium salt as a pore former; the thermolysis of ammonium salt could release soft gas bubbles during the calcination; the later burst of bubbles leads to the formation of nanoporous structure. The proposed method is template-free and environmentally-friendly, and the resultant material exhibits high photocatalytic activity in the field of gas and water decontamination.

A method for catalytic polymerization of alpha-olefin monomers using an ultra-high activity non-metallocene pre-catalyst featuring an amine bis(phenolate) ligand-metal chelate, having general formulas of [{(O)1R1R2R3R4(C6)1(CH2)1(RnY-T)N(CH2)2(C6)2R5R6R7R8(O)2}MX1X2] and [{(O)1R1R2R3R4(C6)1(CH2)1(RnY-T)N(CH2)2(C6)2R5R6R7R8(O)2}MX3], where, M, O, and N, are metal, oxygen, and, nitrogen; X1, X2, and X3, are ligands bonded to M; R1 through R8 are radicals; (RnY-T) is an optional non-donor or donor group bonded to N. The relatively stable and simply synthesized pre-catalyst is activated by a co-catalyst under mild reaction conditions, producing exceptionally reactive polymerization of a wide variety of alpha-olefin monomers, and forming a variety of poly(alpha-olefin) products, having high molecular weight and low molecular weight distribution (PDIs close to 1). Living polymerization is performed at or above room temperature, along with achieving block co-polymerization of alpha-olefin monomers at room temperature, and producing polymers and oligomers having a wide range of molecular weights. The catalyst formed during reaction remains "alive' for as long as 31 hours, for producing a polymer with a molecular weight as high as 450,000 grams/mole.

This invention relates to a method of preparing multicomponent bismuth molybdate catalysts composed of four metal components and a method of preparing 1,3-butadiene using the catalyst, and particularly, to multicomponent bismuth molybdate catalysts composed of a divalent cationic metal, a trivalent cationic metal, bismuth and molybdenum, a preparation method thereof, and a method of preparing 1,3-butadiene from a C4 mixture including n-butene and n-butane using oxidative dehydrogenation. According to this invention, it is possible to prepare catalysts having high activity for the preparation process of 1,3-butadiene only using four metal components as shown through systematic investigation of types and ratios of metal components, unlike conventional multicomponent metal oxide catalysts having a complicated composition of metal components.

A fluorescence molecular probe having a hydrophilic polypeptide backbone conjugated with a hydrophobic alkyl chain and a function group with aggregation induced emission is disclosed. The hydrophilic peptide sequence renders DNA binding capacity and the hydrophobic alkyl chain provides capacity for embedding within cell membrane. The aggregation induced emission renders real time tracking for live cell function studies. The synthesis of the probe is simple and easy for purification.

The present invention provides for Troika acids attached to a macroporous resin and Methods of preparing the same, including direct attachment of a Troika acid, and attachment of a Troika acid precursor followed by generation of the Troika acid in situ. Methods of functionalizing a resin to facilitate attachment are also described. Multiple Troika acids, comprising a pair of Troika acids joined together are described. Synthetic routes to both microporous and macroporous resins modified by introduction of a suitable Troika-type acid have been designed and validated. In a preferred embodiment, a macroporous Troika resin removes Cu²⁺ and Ni²⁺ from aqueous solution with high affinity, and is selective against Mg²⁺ or Ca²⁺. The materials of the present invention have advantages for metal removal from power plant waste water.

A method for preparing a hierarchically porous doped carbon material includes the steps of heating a mixture including an etching agent precursor and a pore-generating agent. The pore-generating agent is embedded in a matrix including a carbon source and a dopant source for simultaneously carbonizing the carbon source. The method further includes doping with the dopant and etching the pore-generating agent for obtaining the hierarchically porous doped carbon material.The hierarchically porous doped carbon material can form an electrode, and an energy storage device such as a supercapacitor can include such an electrode. The hierarchically porous doped carbon material can also help form an energy storage and conversion device such as a metal-air battery or a regenerative fuel cell.

The invention discloses a method for the synthesis of monodispersed luminescent quantum dots of transition metal dichalcogenides (TMDC), single- or few-layered, using a single-step electrochemical exfoliation that involves dilute ionic liquid and water. The method disclosed helps to obtain nanoclusters of TMDC of desired size including small sizes ranging up to 6 nm, by varying the concentration of the electrolyte and the applied DC voltage. The invention further discloses a method by which mono- or few-layered luminescent transition metal dichalcogenides can be directly deposited onto conducting substrates in a uniform manner. The monodispersed single- or few-layered luminescent TMDC and electro-deposited substrates exhibit improved electronic conductivity and new active sites, making them suitable as high-performance electrocatalysts in hydrogen evolution reactions in solar water-splitting applications and also as electrodes for solar cell applications.

The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the present invention can provide advantageous solubility properties in aqueous environments. Such cross-linkers may be used to form conjugates for use in a variety of assay formats.

The present invention relates to polymers and to the use thereof in the form of active electrode material or in an electrode slurry as electrical charge storage means, the electrical charge storage means especially being secondary batteries. These secondary batteries are especially notable for high cell voltages, and simple and scalable processing and production methods (for example by means of screen printing).

The present invention relates to polymers and to the use thereof in the form of active electrode material or in an electrode slurry as electrical charge storage means, the electrical charge storage means especially being secondary batteries. The secondary batteries are especially notable for high cell voltages, a small drop in capacity even on undergoing several charging and discharging cycles, and simple and scalable processing and production methods (for example by means of screen printing).

The present invention discloses a material used for rapid separation of oil and water and preparation method and application thereof, the mesh material is placed into monomer solution, reacting with the presence of initiator to prepare material used for rapid separation of oil and water. The monomer is divinylbenzene or 2-(dimethylamino) ethyl methacrylate, and the mesh material is stainless steel mesh. The present invention modifies the functional small molecules and polymers to the surface of the materials, thereby preparing multifunctional composite materials, effectively separating oil-water emulsion, so as to achieve the purpose of oil-water separation.

Specific detection of proteolytic enzymes is achieved by extinguishing dye fluorescence by the amino acid tryptophan. Ttyptophan is disposed on one side of the cutting site of a proteolytic enzyme while an amino acid marked with a dye is arranged on the other side. Extinction of fluorescence occurs prior to enzyme cutting. Spatial separation of the tryptophan and the dye takes place after cutting, whereby fluorescence extinction does not occur. The dye can then fluoresce and a signal increase occurs thereby indicating that cutting has been carried out and the presence of the enzyme.

A process is disclosed for forming a nanosize ceramic powder. A precursor ceramic material is formed of a fugitive constituent and a non-soluble constituent in a single phase. The precursor is contacted with a selective solvent (water, acid, etc.) to form a solution of the fugitive constituent in the solvent and a residue of the non-soluble constituent. The precursor is sufficiently reactive with the solvent to form the solution of the fugitive constituent in the solvent and form the nondissolved residue of the non-soluble constituent. The precursor material and the non-soluble residue are sufficiently insoluble in the solvent such that there is insufficient precursor material and non-soluble residue in solution to deposit and precipitate upon the residue of the non-soluble-constituent. The fugitive constituent is sufficiently soluble in the solvent such that the precursor reacts with the solvent to form the solution of the fugitive constituent without precipitation and deposition of fugitive constituent upon the residue of the non-soluble constituent in the form of nanosize particles. After the fugitive constituent is dissolved the selective solvent containing the fugitive constituent is removed from the residue. The residue remains in the form of a nanosize powder of the non-soluble constituent.

The present invention provides a bisamide-containing novel liquid chromatographic media and method of synthesizing the same. A novel polar bisamide functional group, which can form hydrogen bonds or ion pairs with residual silanols on the surface of silica gel, is used as the bonded phase on the surface of silica gel to better shield the activity of silanols and to eliminate the influence of residual silanol groups. Compared with conventional C18 columns, these novel bonded phases have different selectivity; they can work not only in 0 to 100% water but also in 0 to 100% organic mobile phase. In particular, they exhibit good peak shapes and resolutions for polar and basic compounds and have good stability within a very wide pH range. These properties make the new stationary phases a useful complement to conventional C18 columns for a variety of HPLC applications.