The invention discloses a high performance liquid chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR) combined interface device, and belongs to the field of environmental studies. The device is composed of seven components: an optical table, a zinc selenide (ZnSe) crystal, a round drive rotary table, a heating casing pipe, an atomizer, a cleaning device and a drying device. A target pollutant enters a heating casing pipe and atomizer integrated device after being separated by a chromatography column, is heated and atomized, and then is evenly sprayed on the surface of the ZnSe crystal, and the ZnSe crystal is rotated to the optical table from the round drive rotary table. Infrared light enters the ZnSe crystal at a certain angle through the optical table, is reflected, then enters an FTIR detector and is subjected to atlas analysis. The ZnSe crystal having testing completed is transferred to the cleaning device and the drying device successively, is washed and dried respectively and then is re-used. The round rotary table carries the crystal and a sample for reciprocating detection by means of rotation, and sample batch processing and on-line detection are realized.