The invention discloses a mainstream short-range nitrification and denitrification / anammox system and method, belonging to the technical field of water treatment. Sewage undergoes chemical flocculation and precipitation to capture particulate organic matter, colloidal organic matter and phosphorus; followed by anaerobic hydrolysis and acidification, the organic matter in the wastewater is decomposed into volatile fatty acids and ammonia nitrogen. The next stage is the multi-cycle SBR pool. Through multi-step water inflow and multi-step A / O reaction, denitrification / anaerobic ammonium oxidation is strengthened, nitrite nitrogen is removed in time, and nitrifying bacteria (NOB) substrate deficiency is formed, supplemented by dissolution Oxygen online control and short sludge age eliminate NOB bacteria to achieve stable mainstream short-cut nitrification and denitrification / anammox denitrification. The short-cut nitrification rate of the multi-circulation SBR tank is above 80%, and the removal rates of COD, ammonia nitrogen and TN are 87%, 98% and 88% respectively. The method has the advantages of simple control strategy, strong automation, low energy consumption, less greenhouse gas emissions, good effluent quality, and low sludge output.