The invention discloses a method for manufacturing an operation auxiliary skeleton model. The method comprises the following steps that (1) according to the CT technology, skeleton three-dimensional reconstruction is carried out; (2), three-dimensional reconstruction data are made into three-dimensional printing data; (3), the skeleton model at the ratio of 1:1 is manufactured according to the 3D printing technology; (4), cleaning and completing are carried out on the printed model. The method for manufacturing the operation auxiliary skeleton model has the advantages that the operation auxiliary skeleton model is made of non-toxic polylactic acid material, and therefore the operation auxiliary skeleton model is environmentally friendly; the operation time is shortened, the bleeding amount of a patient is reduced, and the probability of complications is reduced; the visibility is higher, direct simulation of treatment can be conducted, an operation plan can be discussed, and operation risks are more controllable; more powerful assistance is provided for post-operation analysis and medical appraisal; restoration analysis of the skeleton is achieved by medical colleges, diversified cases are provided, and theories and reality are combined; a great number of potential clients exist in the aspect of the application of the method, and the market application prospect is broad.