Method for carrying out deep brain nucleation positioning by utilizing quantitative magnetic susceptibility graph

A quantitative magnetic susceptibility and depth technology, applied in image analysis, image enhancement, image data processing, etc., can solve the problems of blurring the anatomical structure of the nucleus, affecting the accuracy of the nucleus boundary, and the outline of the nucleus is not clear enough, so as to facilitate the promotion. Effect

Active Publication Date: 2020-05-08
EAST CHINA NORMAL UNIV
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Problems solved by technology

However, the contours of the nuclei in the current T2-weighted images are not clear enough, and T2*-weighted images, FLAIR and SWI sequences are sensitive to local fields, and the magnetic susceptibility artifacts caused by iron deposition in the nuclei will blur the anatomical structure of the nuclei, thereby affecting the nuclei. Accuracy of clique boundaries

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  • Method for carrying out deep brain nucleation positioning by utilizing quantitative magnetic susceptibility graph
  • Method for carrying out deep brain nucleation positioning by utilizing quantitative magnetic susceptibility graph
  • Method for carrying out deep brain nucleation positioning by utilizing quantitative magnetic susceptibility graph

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Embodiment

[0045] This example is an example of the head data of the subject. The data was collected in a general electric 3.0T magnetic resonance imaging system and obtained by bipolar gradient multi-echo sequence acquisition. Scanning parameters: TR = 28ms, TE1 = 4.2ms, ΔTE = 3.96 ms, the number of echoes is 6, the bandwidth is 278Hz / px, the flip angle is 12 degrees, and the voxel size is 0.9*0.9*0.9mm 3 , the matrix size is 256*256*160, the field of view size is 240*240mm 2 , with an acceleration factor of 2.

[0046] Image reconstruction includes the following steps:

[0047] Step 1: export the mode diagram and phase diagram of the 6 echoes from the magnetic resonance imaging system to the PC;

[0048] Step 2: Take the root mean square of the 6 echo patterns to obtain the mean pattern, and use the BET algorithm to generate the head mask with the skull removed; multiply the mask with the pattern and the phase map respectively to obtain The mask and phase map without the skull; inve...

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Abstract

The invention discloses a method for carrying out deep brain nucleation positioning by using a quantitative magnetic susceptibility map, which uses a high-resolution QSM technology to obtain a quantitative magnetic susceptibility map of a head, can display a clear deep brain nuclei contour exceeding that of a traditional MRI method, and especially can distinguish thalamus bottom nuclei from blackmatter. A traditional CT image and a traditional T1 image can conduct spatial positioning on skull and grey matter, a quantitative magnetic susceptibility image, the CT image and the high-resolution T1 image are used in a combined mode, and deep brain nuclei can be accurately positioned. The method has the characteristics that the advantages of the QSM technology and the CT technology are integrated, and the accuracy of nucleus positioning is improved through clear brain deep nucleus imaging; the method does not depend on a specific machine type, is suitable for various commercial magnetic resonance devices, and is convenient to popularize.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a method for locating deep brain nuclei by using a quantitative magnetic susceptibility map. Background technique [0002] Deep brain stimulation (DBS) achieves the purpose of long-term and chronic electrical discharge stimulation of specific nuclei by implanting electrodes near the deep nuclei of the brain. DBS requires doctors to use medical imaging technology to accurately locate the deep nuclei of the brain before surgery, and plan the target location coordinates for electrode implantation. The error between the position of DBS electrode implantation and the target position is generally required to be no more than 1 mm. The subthalamic nucleus is one of the main targets of DBS, and electrodes are placed at the junction of the subthalamic nucleus and the substantia nigra. The subthalamic nucleus and the substantia nigra are very close in space, and it is v...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/33G06T5/50
CPCG06T7/33G06T5/50G06T2207/10088G06T2207/30016
Inventor 童睿李建奇吴曦陈录广赵玮玮马超
Owner EAST CHINA NORMAL UNIV
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