10 results about "Research center" patented technology

This invention relates to the field of molecular marker screening technology, specifically to a SNP combination and method for paternity testing in cynomolgus monkeys. The method provided by this invention utilizes 100 selected specific SNP combinations (SNP1~SNP100) combined with low-depth sequencing for paternity testing in cynomolgus monkeys. The cost per sample is only 1 / 5 to 1 / 10 of existing high-depth sequencing and 1 / 2 of SNP chips. For large-scale experimental monkey populations (such as populations of thousands), this can save hundreds of thousands of yuan in testing costs annually, significantly reducing the economic burden of breeding and management of experimental monkeys, demonstrating extremely high economic efficiency. The method provided by this invention is applicable to cynomolgus monkey population pedigree management, kinship tracing, breeding pair optimization, and genetic quality control, and can be widely applied in experimental monkey breeding farms, primate research centers, and biomedical research institutions.

Provided is a wide-range vibration-free high-speed linear reciprocating scanning device capable of solving mechanical vibration problems during transfer of a scanning head. This work was supported by the IITP (Institute of Information & Communications Technology Planning & Evaluation)-ITRC (Information Technology Research Center) grant (RS-2023-00259676) and Commercialization Promotion Agency for R&D Outcomes'grant (RS-2024-00423610) funded by the Korea government (Ministry of Science and ICT).

This invention discloses an automatic medical coding normalization method, system, and storage medium for multimodal medical data, belonging to the field of medical information technology. The method includes: collecting original textual terms and subject structured information of adverse events and / or concomitant medications, and performing text denoising, format standardization, and data deduplication; generating an initial candidate coding set based on a pre-trained medical language model; performing context-aware semantic disambiguation and rearranging of candidate codes in conjunction with subject structured information; retrieving historically confirmed coding cases from other research centers during the coding confirmation stage, outputting consistency prompts based on the differences between the current context and historical contexts, and receiving reconfirmation, coding modification, or review submission operations; and storing the final confirmation results and retrieving them to an electronic data acquisition system. This invention can improve the accuracy, processing efficiency, traceability, and multi-center coding consistency of medical coding.

The invention discloses a research center information evaluation method and system based on multi-source data analysis. The method comprises the following steps: acquiring basic information, dynamic data and unstructured text data of a research center to obtain multi-source data; integrating and comparing the multi-source data by using rule matching, NLP analysis and trend comparison methods so as to identify a conformity standard and an expression trend and obtain a comparison result; automatically adjusting and optimizing the index weight through machine learning on the basis of the initial weight set by an expert in combination with the comparison result, and meanwhile, calculating the grouping success rate and the starting speed by applying a prediction model to obtain a calculation result; further based on the key parameters of the project and a basic database, intelligently drawing a test scheme by using a generative model, generating a grouping plan and cost prediction, matching the generated scheme requirement with a calculation result, and intelligently recommending the most adaptive research center; generating a comprehensive report including root cause speculation, semantic extraction and multi-dimensional analysis according to a calculation result; actual project performance feedback is recorded, model calibration is carried out, and data recollection is guided according to data sensitivity and timeliness. By implementing the method provided by the invention, a more efficient, comprehensive and dynamic solution is realized to improve the success rate and management efficiency of clinical tests.

This invention discloses a method and system for intelligent monitoring of the entire clinical trial cycle based on multidimensional data fusion. To address the problems of high false alarm rates, lack of interpretability, and difficulty in forming a monitoring closed loop under multidimensional evidence fusion conditions, this invention acquires and standardizes multidimensional clinical trial data and its source data, constructs an evidence layer graph and a source layer graph, and establishes cross-layer associations to form a two-layer evidence graph. Based on source features, the source credibility is calculated and assigned to evidence layer nodes and edges. Source credibility gating is introduced into the heterogeneous graph Transformer attention mechanism for risk inference and risk score output. The risk score is calibrated for confidence and grouped by trial stage and research center. Group-based shape-preserving prediction is used, and the group warning threshold is determined based on the target false alarm rate to output warning labels and risk levels. The minimum sufficient evidence chain is extracted from the triggering warning object for interpretation. Under the condition of frozen model weights, feedback is used to update the credibility parameters, calibration parameters, and thresholds to form a closed loop, achieving the technical effects of low false alarms, interpretable risk warning grading, and a closed-loop intelligent monitoring throughout the entire cycle.

The invention discloses an external-use compound formula for assisting skeletal development and cartilage health of teenagers, and belongs to the technical field of external-use health-care preparations. According to the formula, yak bone marrow peptide, glucosamine hydrochloride, chondroitin sulfate and bone collagen peptide serve as core active ingredients, rose hip oil is matched to serve as a transdermal penetration enhancing component, transdermal absorption of the active ingredients is achieved through reasonable matching, osteoblast metabolism of teenagers (6-18 years old) can be promoted in a targeted mode, the bone mineral density can be increased, and the effect of preventing and treating osteoporosis is achieved. Meanwhile, cartilage matrix synthesis is strengthened, cartilage injury is reduced, and the problem that external health care products are deficient in the teenager skeletal cartilage development stage is solved. According to the technical verification of the Zhejiang traditional Chinese medicine university medicine college modern medicine research center, the formula is high in safety and excellent in transdermal efficiency, adapts to teenager skin barrier characteristics, and has remarkable application value in the fields of teenager skeletal development and cartilage health maintenance.

An example method for implementing location based dashboards for clinical trials includes obtaining a target health condition, accessing patient medical claims data and patient prescription claims data stored in one or more databases. For each candidate patient in the set of candidate patients, the method includes removing the candidate patient from the set in response to the candidate patient having demographic data which matches demographic exclusion criteria, the candidate patient having medical history data which matches medical exclusion criteria, or a distance between the candidate patient and a clinical trial study site is greater than a specified distance threshold. The method includes storing a set of eligible candidate patients after selective removal of candidate patients, transmitting a communication to at least one computing device, and displaying the set of eligible candidate patients and the at least one study site on a dashboard map of a user interface.

The invention relates to a process for dehydrating peaches using microwaves, which can be used in food industry enterprises, laboratories and research centers related to dehydration processes.The process, according to the invention, consists in initially selecting peaches suitable for drying, ripe, undamaged, with a humidity of 87-91%, washing and removing the pits therefrom, then slicing them using a slicer into 3 mm thick round slices and arranging a predetermined amount of slices horizontally in a single layer on a flat perforated support in a drying chamber. After that, the slices are dehydrated using microwaves from a magnetron with a total power of 600 W at a regime of 185-245 W, or 800 W at a regime of 210-260 W, or 900 W at a regime of 225-285 W, for 180-225 min until a product humidity of no more than 20% is reached. At the same time, room air with a temperature of 26-30 °C, its relative humidity of 50-65%, normal atmospheric pressure and air flow speed of 1.0-1.8 m / s is used as a thermal agent, intended for removing humidity from the drying chamber.

The invention discloses a clostridium perfringens bacteriophage cp2p, a bacteriophage preparation and application of the clostridium perfringens bacteriophage cp2p, the classification name of the clostridium perfringens bacteriophage cp2p is Clostridium perfringens bacteriophage cp2p, the preservation unit is China Center for Culture Collection, the preservation number is CCTCC NO.M 20242714, and the preservation time is December 4, 2024. Experiments prove that the clostridium perfringens bacteriophage cp2p has the advantages of high titer, good thermal stability, high splitting rate and the like, and can specifically partially or completely inactivate clostridium perfringens; the clostridium perfringens bacteriophage cp2p can stably survive under an acidic environment condition, so that clostridium perfringens colonized in intestinal tracts can be killed; the clostridium perfringens bacteriophage cp2p can be well proliferated in clostridium perfringens host bacteria, so that the clostridium perfringens bacteriophage cp2p can be subjected to large-scale fermentation culture; the clostridium perfringens bacteriophage cp2p can also be used for preparing feed additives and drinking water additives, the morbidity of clostridium perfringens is greatly reduced, and a new prevention and treatment scheme is provided for replacing antibiotics.