50 results about "Macrocyclic ligand" patented technology

A tetradendate amide based macrocyclic ligand and its Fe(III) complex which act as activators of hydrogen peroxide. The synthetic methodology to develop the ligands is new, simple and provides better yield for each step of the ligand synthesis. The Fe(III)-complexes and hydrogen peroxide together are can perform several environmentally benign oxidation reactions. Organic dye bleaching, bleaching of pulp and paper effluent and N-oxide synthesis may be performed using the newly developed catalyst and hydrogen peroxide. Alcohol oxidation and alkene epoxidation may also be performed using the catalysts and hydrogen peroxide.

The present invention discloses metal (III) complex of a biuret-amide based macrocyclic ligand as green catalysts that exhibit both excellent reactivity for the activation of H2O2 and high stability at low pH and high ionic strength. The invention also provides macrocyclic biuret amide based ligand for designing of functional peroxidase mimics. Further, the present invention discloses synthesis of said metal (III) complex of a biuret-amide based macrocyclic ligand.

Liquid cleaning compositions are described herein that include a metal bleach catalyst which is a complex of a transition-metal and a macrocyclic ligand, the ligand having a calculated Octanol / Water Partition Coefficient value of from about −1.50 to about −0.10, a formulation enabling fraction comprising at least one formulation enabling ingredient, the formulation enabling fraction having a Hydrophilic Index of from about 4.0 to about 10.0, and a formulation deactivating fraction comprising at least one formulation deactivating ingredient that has a calculated Octanol / Water Partition Coefficient value of from about −3.5 to about −0.10.

The invention relates to a modified mesoporous silica adsorbent and a preparation method and application thereof. Under the catalysis of potassium carbonate and potassium iodide, aza-macrocyclic ligand is modified onto the surface of chlorine group functional mesoporous silica through nucleophilic substitution, and the adsorbent is prepared; palladium recycling and enrichment under different nitric acid concentrations are achieved through the adsorbent, and the selective recovery performance of palladium in highly-active effluent simulated feed liquid is evaluated. According to the modified mesoporous silica adsorbent, mesoporous nanomaterials are combined with the supermolecule recognition performance of the aza-macrocyclic ligand, the problems that selectivity is poor, operation is complex, the raw material cost is high and the stability is poor in the traditional treatment technology for palladium in highly-active effluent are solved, and the adsorbent has the advantages of being good in selectivity, large in adsorption capacity, high in adsorption speed and easy to recycle for palladium within the wide nitric acid concentration range, and has the great practical significance in the aspects of nuclear fuel reprocessing and hydrometallurgy.

A method for the treatment of a tumor, comprising administering to a subject a therapeutically effective amount of a complex of a heavy element with a polydentate, pyrrole-containing macrocyclic ligand substituted with charged chemical groups, wherein said complex is capable of bringing said heavy element into close proximity to the nuclear DNA of cells in said tumors, and irradiating said tumor with photons above the K or L shell adsorption edge of said heavy element to elicit the emission of densely ionizing Auger electrons at the level of DNA.

The invention relates to a contaminated soil remediation method. The method comprises the following step: treating contaminated soil by using a transition metal tetraacylamino macrocyclic ligand oxidation catalyst and an oxidizing agent in a leaching mode or a non-leaching mode to remove pollutants in the soil. According to the remediation method, the overall use amount of a remediation agent is low, the remediation agent can be degraded or recycled, and secondary pollution caused by introduction of new pollutants into a reaction system is avoided; and pollutants, especially cyanogen, in the soil can be efficiently and greenly removed, the adaptability is high, the application range is wide, operation is easy, no filler or carrier needs to be added, the problems that in the prior art, operation is difficult, the reaction period is long, the treatment cost is high, and the occupied area is large are solved, and industrial application is easy to achieve.

The invention discloses a technetium-99m-labeled graphene oxide nanoparticle and a preparation method thereof. The preparation method comprises the steps as follows: (1) enabling an alkynyl-modified ligand compound and azido-modified graphene oxide to have a Click reaction, and purifying coarse products to obtain a reactant A, wherein the ligand compound is a macrocyclic ligand compound; (2) evenly mixing the reactant A, a hydrochloric acid of stannous chloride and high-technetium acid radial ions in a solvent to obtain mixed liquor, adjusting the pH of the mixed liquor to 6.0-7.5, and performing a reduction coordination reaction to obtain the nanoparticle. The preparation method is high in reaction selectivity, mild in condition, simple to operate and higher in labeling yield. The technetium-99m-labeled graphene oxide nanoparticle is very good in biocompatibility and better in water solubility, can be used for studying the real-time distribution condition of graphene oxide in the cell level and the small animal level and provides more basic information for the application of the graphene oxide to organisms later.

The present invention relates to a process for preparing a macrocyclic ligand and for producing a pharmaceutical liquid formulation comprising a complex of said ligand with a lanthanide or similar compounds. The macrocyclic ligand of the present invention is a derivative of tetraaza macrocycles such as 1,4,7,10-tetraazacyclododecane (cyclen), 1,4,7,10-tetrazacyclotridecan (homocyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam), such as DOTA, TRITA, TETA, DOTMA, TCE-DOTA, DOTA-pNB, D03A, HP-D03A, D03A-butrol, D03MA, ODOTRA, D03A-L2, DOTP, DOTMP, DO2a, THP, THED, DOTAM, DOTTA. The preferred lanthanide and similar compounds are Gadolinium (Gd), Yttrium (Y) and Terbium (Tb). The process of the present invention aims to obtain an accurate balance between the ligand and the lanthanide, and to avoid the presence of free lanthanide in said formulation, by calculating the necessary amount of ligand for a formulation batch, measuring the moisture content of a sample of the material in said batch, calculating the total amount of moisture present of the batch and calculating the total amount of material which is required to prepare the batch size. In this way, the production of a pharmaceutical liquid formulation comprising a complex of a macrocyclic ligand with lanthanide is more accurate, faster and easier. The present invention is thus useful for the production of pharmaceutical liquid formulations comprising a complex of a macrocyclic ligand with a lanthanide, which can be used as contrast agents for magnetic resonance imaging.

The invention discloses a composite material for improving the reaction activity of Fe(III)-tetra-amido macrocyclic ligand (Fe(III)-TAML) and a preparation method and application method thereof, belongs to the field of synthesis of environment functional materials, and solves the issue of significantly reduced reaction activity of the Fe(III)-TAML under neutral or near neutral conditions. A micro Composite material Fe(III)-TAML / DODMA / PFOA, with the Fe(III)-TAML as a base, is synthesized by a self-assembly method assisted by a surface active agent dioctadecyl dimethyl ammonium chloride (DODMA), wherein a dichloromethane / water mixed solvent is used as a medium and perfluorooctanoic acid (PFOA) is used as a dopant. Compared with the free Fe(III)-TAML of the prior art, the reaction activity of the composite material Fe(III)-TAML / DODMA / PFOA synthesized by the self-assembly method assisted by the surface active agent is significantly improved.

The invention provides a method of determining the amount of an analyte having an oxidation potential, for a one electron oxidation process, of about +0.10 to about +1.20 volts at pH 7, relative to the normal hydrogen electrode at 298K, said method comprising measuring the emission intensity or emission lifetime, at two or more wavelengths, from a sample comprising said analyte and two or more different macrocyclic lanthanide (III) complexes, wherein each of said macrocyclic lanthanide (III) complexes comprises a different lanthanide ion but the same macrocyclic ligand, and using a ratio of emission intensities or emission lifetimes measured at two different wavelengths to calculate the amount of analyte in said sample.

The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

The present invention is tetraazacyclo tetradecane derived ligand complexes and their synthesis process in fine chemical technology. Their macrocyclic ligand is 5, 5, 7, 12, 14, 14-hexamethyl-1, 4, 8, 11- tetraazacyclo tetradecane with 1-substituent; the metal ion in the complexes may be Fe, Cu or Mg ion. These complexes have the property of activating hydrogen peroxide and per-acids.

The invention relates to a preparation method and application of a tetra-amido macrocyclic ligand and a metal chelate thereof. The preparation method comprises the following steps: (1) mixing a compound shown as formula (I) with organic alkali to obtain a mixed solution A; mixing the compound shown as formula (II) with a carboxyl activating agent to obtain a mixed solution B; and (2) mixing the mixed solution A with the mixed solution B obtained in the step (1), and then mixing the mixing product with a strong acid solution to obtain the tetra-amido macrocyclic ligand shown as formula (III). Compared with a synthesis method in the prior art, the synthesis method provided by the invention is greener, lower in toxicity, simpler in synthesis route, easy to control synthesis conditions, higherin synthesis efficiency and lower in cost, and can easily achieve industrial production and improve economic benefits. The tetra-amido macrocyclic ligand can be further chelated with a transition metal to obtain an oxidation catalyst, which can be used for treating industrial wastewater of papermaking, printing and dyeing, pharmacy, organic chemical engineering and the like and remediating polluted soil.

The present invention provides a bleach activator which is at least one macrocyclic manganese complex selected from the group consisting of [MnIII(rac-14-decane)X2]Y, [MnIII(mes-14-decane)X2]Y.H2O and [MnIII(mes-14-decane)X2]Y represented by Formulas 1-3, as well as a preparation method thereof. Also, the invention provides a bleaching composition and bleaching detergent composition comprising the bleach activator. The bleach activator comprising the manganese complex is used in a granulated form. wherein X is at least one selected from chlorine (—Cl) and acetate (—OOCCH3), and Y is an anion selected from Cl−, Br−, F−, NO3−, ClO4−, OH−, NCS−, N3−, and PF6−.

Compositions and methods of bleaching are described herein, wherein the compositions include a metal bleach catalyst which is a complex of a transition-metal and a macrocyclic ligand, wherein the metal bleach catalyst is present in the composition in an amount ranging from about 0.0001% to about 10%, based on total weight of the composition, and a bleaching primer, wherein the composition has a molar ratio of bleaching primer to metal bleach catalyst of from about 1:20 to about 100:1.

A process for preparing a tetra-substituted aminobiphenol macrocyclic ligand having the structure (I), comprising the step of treating a precursor compound having the structure (II) with a compound having the structure R6-L where L represents a leaving group (hereinafter compound (III)) in the presence of a base.

The invention discloses a sulfur-sulfur bond containing dipolymacrocyclic nickel (II) complex and an in-situ synthesis method thereof. The nickel complex has a chemical formula [Ni(H4L1)(H2O)2]*2Cl, in the formula, H4L1 is a macrocyclic ligand formed by two 3,3'-di(5-sulfydryl-1,2,4-triazole) through sulfur-sulfur bonds. The in-situ synthesis method of the nickel (II) complex comprises the following steps: (1) weighing 0.04-0.05g of 3,3'-di(5-sulfydryl-1,2,4-triazole) and 0.04-0.05g of hexahydrate nickel dichloride NiCl2*6H2O, adding 3-5mL of methanol and 5-7mL of 1,4-dioxane, and stirring toenable the mixed liquid to react for 6-7 hours at the room temperature; (2) filtering the mixed liquid, putting filtrate into a flask, and naturally volatizing the filtrate at the room temperature, thereby obtaining a single crystal grade purple flaky crystal. The nickel (II) complex has potential application values in antibacterial, anti-tumor and medicine targeted release carriers, and the like,and the method has great application prospects in in-situ synthesis of sulfur-sulfur bond containing macrocyclic metallic complexes.

A ligand of Formula (A):or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i):wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and / or the chelate in biological imaging and / or photoluminescence imaging.

Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.

The invention discloses a treatment method of methylene blue dye waste water. The treatment method comprises the following steps: firstly, an aza-macrocyclic ligand, potassium iodide and potassium carbonate are dissolved in an organic solvent, mesoporous silica with a functional chlorine group is added under the protection of nitrogen, the mixture is subjected to a reflux reaction for 20-40 h while being constantly stirred and is cooled to the room temperature after the reaction ends, a product is obtained after filtration, washed with ethanol and water 2-5 times alternately and dried under a vacuum condition at the temperature of 60-80 DEG C for 12-16 h, and a modified silica adsorbent is obtained; then the modified silica adsorbent is added to the methylene blue dye waste water, the pH of the dye waste water is adjusted to range from 5 to 10, the mixture is stirred at the speed of 3,000-5,000 r / m for 24-28 h, left to stand still and filtered to remove the adsorbent adsorbing methylene blue dye, and the methylene blue dye in the waste water is removed. The method is simple, convenient and quick to operate, the treatment cost is low, the adopted adsorbent can adsorb a large amount of dye, and the methylene blue dye in the methylene blue dye waste water can be effectively removed.

Compositions and methods of bleaching are described herein, wherein the compositions include a metal bleach catalyst which is a complex of a transition-metal and a macrocyclic ligand, wherein the metal bleach catalyst is present in the composition in an amount ranging from about 0.0001% to about 10%, based on total weight of the composition, and a bleaching primer, wherein the composition has a molar ratio of bleaching primer to metal bleach catalyst of from about 1:20 to about 100:1.

The invention discloses a tetrameric macrocyclic trinuclear iron complex containing sulfur-sulfur bonds and an in-situ synthesis method thereof. A chemical formula of the iron complex is [Fe3(L1) 5H2O], wherein H8L1 is a macrocyclic ligand formed by four 3,3'-di(5-mercapto-1,2,4-triazole) through sulfur-sulfur bonds. The in-situ synthesis method of the iron complex comprises the following steps: (1) weighing 0.04-0.05 g of 3,3'-di(5-mercapto-1,2,4-triazole) and 0.08-0.09 g of ferric nitrate nonahydrate Fe(NO3)3 9H2O, mixing them in a 8-9 mL dimethylformamide and enabling the mixed solution tobe subjected to stirring reacction at room temperature for 6-7 hours; (2) filtering the mixed solution, placing the filtrate in a beaker, and executing natural volatilization at room temperature to obtain single-crystal-grade black flaky crystals. The iron complex has a potential application value on the aspects of bacterium and tumor resistance, targeted release as a carrier and the like, and themethod has the wide application prospect on the aspect of in-situ synthesis of macrocyclic metal complexes containing sulfur-sulfur bonds.

The invention relates to a modified mesoporous silica adsorbent and a preparation method and application thereof. Under the catalysis of potassium carbonate and potassium iodide, aza-macrocyclic ligand is modified onto the surface of chlorine group functional mesoporous silica through nucleophilic substitution, and the adsorbent is prepared; palladium recycling and enrichment under different nitric acid concentrations are achieved through the adsorbent, and the selective recovery performance of palladium in highly-active effluent simulated feed liquid is evaluated. According to the modified mesoporous silica adsorbent, mesoporous nanomaterials are combined with the supermolecule recognition performance of the aza-macrocyclic ligand, the problems that selectivity is poor, operation is complex, the raw material cost is high and the stability is poor in the traditional treatment technology for palladium in highly-active effluent are solved, and the adsorbent has the advantages of being good in selectivity, large in adsorption capacity, high in adsorption speed and easy to recycle for palladium within the wide nitric acid concentration range, and has the great practical significance in the aspects of nuclear fuel reprocessing and hydrometallurgy.

Disclosed are fine-particulate powders containing particles with at least 80% by weight of a manganese complex with nitrogen-containing ligands, wherein one or more of the ligands are macrocyclic ligands, wherein at least 70% by weight of the particles have particle sizes in the range from 1 μm to 50 μm, at most 15% by weight of the particles have particle sizes >50 μm and at most 15% by weight of the particles have particle sizes <1 μm, wherein the percentages refer to the total amount of the particles.These powders can be used as bleaching catalysts in washing and cleaning agents and display an improved activity and at the same time these are toxicologically non-hazardous during manufacturing and use.