45results about How to "Good biological adaptability" patented technology

A hyaluronic acid compound which is a reaction product between hyaluronic acid and a phosphatidyl ethanolamine. This compound has biocompatibility and bio-safety, and can be formed into a hydrogel or molded form having a certain shape. Making use of these properties, it is used to treat a knee joint, prevent the accretion of a tissue after an operation and keep a skin wet.

An intervertebral implant is shaped in the form of a hollow cylinder and has a cover face, a base face, a hollow cylinder wall with an outer lateral area and an inner lateral area, as well as a hollow cylinder central axis. The implant is formed at least 95 percent by volume of a radiolucent material which has a modulus of elasticity of between 1 and 20 GPa. Postsurgical observation is permitted by means of X-rays, and at the same time the implant has a high degree of biocompatibility.

The invention provides an ecological young shrimp culture method for macrobrachium rosenbergii. The method includes the steps of preparing a young shrimp culture pond, preparing water used for young shrimp culture, obtaining young shrimp larvas, feeding bait, managing water quality, transferring the young shrimps to another pond, desalting for young shrimp emergence and the like. In the bait feeding process, the young shrimps are fed on natural bait unit cell algae, fairy shrimp nauplii and artificial bait egg custard, the natural bait is environmentally friendly and healthy, the articical bait is rich in nourishment, and nutritional ingredients are not prone to running off; when the water quality is managed, nuisanceless water quality ameliorant and microbial preparations are adopted to adjust the water quality. Hormones and poisonous chemicals are not used in the young shrimp culture process, the young shrimps are high in survival rate and grow healthily and strongly, young shrimp emergence is fast, and the ecological young shrimp culture method is low in cost, high in efficiency and capable of effectively increasing economic benefits of an aquaculture farm.

The invention discloses an ultrasonic precision micro-fluidic chip based on a nano motor array and an implementation method thereof. The ultrasonic precision micro-fluidic chip comprises a substrate,a cover plate, a piezoelectric transducer, a film fixed with a nano motor, a liquid inlet and outlet pipe and a liquid medium. The piezoelectric transducer excites and drives the whole micro-fluidic chip to vibrate at ultrasonic frequency, a specific acoustic flow field is generated in the micro-channel, meanwhile, a catalyst component contained in the nano-motor promotes the substrate to be decomposed to generate bubbles, and vibration of the bubbles in the acoustic flow field is used for controlling small particles around the bubbles to move along a specific track. The liquid medium is catalyzed by the nano motor array to be decomposed to generate bubbles, and directional movement of tiny particles is controlled by utilizing local acoustic flow field change caused by bubble vibration. According to the micro-particle motion control mode, bubble vibration in the acoustic flow field is used as a power source, the motion speed of the micro-particles is effectively increased, the micro-particles of various shapes and sizes can be controlled, no special requirement is needed for the material of the controlled micro-particles, and thus the application range is wide.

The invention discloses a coating and modification method for a prussian blue nanometer mesocrystal cytomembrane. The method comprises the steps that biological membrane and prussian blue nanometer mesocrystal are coated with ultrasonic waves at the pH of 7.4-8.0, and then the prussian blue nanometer mesocrystal coated with the biological membrane is obtained through centrifugalization, wherein the ultrasonic power is 150-300 w, and the ultrasonic frequency is 20-40 kHz. In the coating and modification method, the biological membrane and the prussian blue nanometer mesocrystal are coated efficiently by the coating and modification method with ultrasonic waves at the pH. Moreover, according to the method, the hydrophobic treatment or other pretreatments of the prussian blue nanometer mesocrystal are not needed, the operation is simple, the coating effects are good, and after the prussian blue nanometer mesocrystal is coated and modified, the effects of the prussian blue in the body are improved greatly.

Belonging to the technical field of nano materials, the invention relates to a multi-arm magnetic graphene oxide composite microsphere, a preparation method and application thereof. The method includes: subjecting GO@Fe3O4 and 4arm-PEG-NH2 to covalent binding to prepare GO@Fe3O4@4arm-PEG-NH2, then dissolving a certain amount of GO@Fe3O4@4arm-PEG-NH2 in a citrate buffer solution, then adding glutaraldehyde into the solution, and carrying out activating reaction for certain period of time; and washing the obtained product with the citrate buffer solution, and then conducting vacuum drying to obtain the material needed by the invention. The material obtained by the invention has superparamagnetism, the carry capacity of the composite microsphere applied to immobilized cellulase is increased to 575mg / g, and the obtained immobilized enzyme has the advantages of high temperature resistance, strong storage capacity and high reusability.

The invention relates to the technical field of biological medicines and vaccines, in particular to a manganese nano adjuvant as well as a preparation method and application thereof. The manganese nano adjuvant comprises manganous-manganic oxide nano particles and template molecules wrapping the manganous-manganic oxide nano particles, the molar ratio of the template molecules to manganese is 1: (10-1000), and the template molecules comprise template protein and fragments or polypeptides thereof. The manganese nano adjuvant provided by the invention can effectively carry an immune antigen, and can obtain a more excellent immunotherapy effect when the antigen carrying amount is relatively small and the injection usage amount is relatively low; the immune antigen can be effectively delivered to lymph node tissues, cell internalization of the immune antigen is greatly enhanced, and immune cells are activated very efficiently.

The present invention relates to immunoglobulin for intravenous injection of dog, and its preparation process and preparations. Through low temperature ethanol process or rivanol combined low temperature ethanol process, blood plasma or serum from health dog is separated to prepare immunoglobulin with pH 3.0-5.4 and purity over 95 % for intravenous injection of dog. The said immunoglobulin is further compounded into immunoglobulin injection with protein content of 1-15 % and containing one or two kinds of protecting agents of 5-15 % maltose, 5-10 % glucose and 3-10 % glucose salt solution.

The present invention discloses a mold for manufacturing an aneurysm model and a method for using the mold to establish an animal aneurysm model. The mold is in the shape of a ring, a polygon, an oval or a letter n, a letter Omega, a letter U and a gap with an opening. The opening width of the mold is 0.3 to 1 cm, the height of the mold is 1 to 1.5 cm, and the opening width of the mold is 10% to 90% of the length of the widest part of the mold. A modeling method is that the artery of an animal is exposed, the artery is separated, the mold is placed at the lower part or one side of the artery such that a part of artery close to the mold is bent to the other side, finally MMP-2 and MMP-9 expression amounts in the animal increase or the wall thickness of a blood vessel opposite to the part of the animal blood vessel close to the mold is thinned, and a model is formed. According to the mold and the method, the animal aneurysm model can be simply and repeatedly made, the pathogenesis process of a human body aneurysm is realistically simulated, and the research of the aneurysm pathogenesis and treatment drugs is facilitated.

The invention discloses a technetium-99m-labeled graphene oxide nanoparticle and a preparation method thereof. The preparation method comprises the steps as follows: (1) enabling an alkynyl-modified ligand compound and azido-modified graphene oxide to have a Click reaction, and purifying coarse products to obtain a reactant A, wherein the ligand compound is a macrocyclic ligand compound; (2) evenly mixing the reactant A, a hydrochloric acid of stannous chloride and high-technetium acid radial ions in a solvent to obtain mixed liquor, adjusting the pH of the mixed liquor to 6.0-7.5, and performing a reduction coordination reaction to obtain the nanoparticle. The preparation method is high in reaction selectivity, mild in condition, simple to operate and higher in labeling yield. The technetium-99m-labeled graphene oxide nanoparticle is very good in biocompatibility and better in water solubility, can be used for studying the real-time distribution condition of graphene oxide in the cell level and the small animal level and provides more basic information for the application of the graphene oxide to organisms later.

The invention discloses an in-vivo MEMS micro-vibration energy collection based cardiac pacemaker energy system. The cardiac pacemaker energy system comprises an MEMS human body micro-vibration energy collection module used for collecting micro-vibration energy and converting the vibrational energy into electric energy to be stored, an MEMS power supply magnetic shielding packaging part, an information collection module used for collecting an electrocardiosignal of a human heart to generate a pace-making operation instruction, and a pulse electric control module used for generating a pulse voltage to perform pace-making stimulation on the human heart. According to the cardiac pacemaker provided by the embodiment of the invention, the cardiac pacemaker can collect the vibrational energy generated by the micro-vibration of the human body and can convert the vibrational energy into electric energy, so that the service life of the cardiac pacemaker is prolonged, the use cost is lowered, the adaptation of the cardiac pacemaker is improved, and reliability of the cardiac pacemaker can be well guaranteed.

The invention discloses a compound oil paint flocculating agent where bacterial cellulose shell-core structures are added. The following steps including the first step of strain separation and purification, the second step of strain screening, the third step of strain fermentation and cultivation and the fourth step of compound magnetic microsphere preparation are included. The preparation process is simple, the compound oil paint flocculating agent can be suitable for industrialized large-scale production, can be repeatedly used and can reduce cost, the problems that the flocculating efficiency is poor and sediment sinks in circulating water are effectively solved, and the long-term effective safe operation of the circulating water is ensured.

The invention provides a preparation method of a vegetable freshness-keeping agent. The preparation method of the vegetable freshness-keeping agent comprises the following steps: a, performing processing treatment on a chitosan solution, mixing the processed chitosan solution with sodium alginate, astaxanthin and sodium citrate, and carrying out stirring while heating so as to obtain a material one; b, mixing a radix isatidis extract and a pomegranate peel extract with soybean protein, and carrying out heating and stirring so as to obtain a material two; c, performing pretreatment on fresh ginger, adding an organic solvent, carrying out heating, carrying out filtration, and carrying out steaming until the mixture is dried so as to obtain an extract; and d, uniformly mixing the material oneand the material two with the extract, adding a beeswax-oil mixture, and carrying out heated dispersing treatment so as to obtain the vegetable freshness-keeping agent. The vegetable freshness-keeping agent prepared by the preparation method has the characteristics of good stability, simple manufacture process, non-pollution to the environment, and long preservation time.

Blood plasma or blood serum from health dog is separated in low temperature ethanol process or rivanol process to prepare dog blood albumin with pH value of 6.4-7.4 and purity not lower than 95 % and capable of being used for dog's intravenous injection. The dog blood albumin may be added with proper amount of stabilizer to prepare intravenous albumin injection with albumin content of 1-25 % or albumin injection with albumin content of 1-25 % and glucose in 3-10 % or glucose brine in 3-5 %.

A cell composition includes neural stem cells and neural stem cells derived from mesenchymal stem cells, and at least one selected from the group consisting of immature neural stem cells and mesenchymal stem cells. The number of the neural stem cells is at least 70% of the number of the cells included in the cell composition, and the total number of the cells of the immature neural stem cells and the mesenchymal stem cells is at most 30% of the number of the cells included in the cell composition. The cell composition has a very low probability of being developed into a cancer cell and thus can be used as a cell therapeutic.

The present invention provides a substrate for ligand support in which a copolymer represented by the following formula (1) is bonded to at least a surface of a water-insoluble carrier: [in the formula (1), n and m represent a positive integer, and a value of m / (n + m) is greater than or equal to 0.1 and less than or equal to 0.45, R 1 represents H or CH 3 , R 2 represents an organic group including an electrophilic functional group, and R 3 represents

The invention discloses a cell electrofusion chip which is formed by bonding a silicon wafer and a glass sheet, wherein microelectrode units are arranged on the silicon wafer, a plurality of microelectrodes are arranged on the microelectrode units, and the microelectrode units are provided with signal leading-out wires; the microelectrodes are arranged on one side or two sides of each microelectrode unit in a jagged shape, the microelectrodes arranged on the adjacent microelectrode units are opposite in a staggered way, and a continuous microchannel is formed among the microelectrode units; the cell electrofusion chip not only can observe and record the cell fusion process more easily during the fusion process, but also can improve the anti-chemical corrosion ability, the high-temperature and high-pressure resistant ability and the biocompatibility of the cell electrofusion chip; meanwhile, the invention also discloses a manufacturing method of the cell electrofusion chip.

The invention belongs to the technical field of anti-cancer nano materials, and provides a manganese titanate nano material. The manganese titanate nano material has mimic enzyme activity and can killcancer cells on the basis of the mimic enzyme activity and cascade reaction of various mimic enzyme activities, thereby overcoming the defects of insufficient anti-cancer ability, difficulty in killing cancer cells and the like of the traditional chemodynamic therapy (CDT).

A non-traumatic glass ion-cement liquid for repairing decayed tooth is prepared from distilled water, acrylic acid, unsaturated carboxylic acid, 4-methylpropenoyloxyethyl trimellitate anhydride, isooctyl acrylate, isopropanol, and initiator through dissolving, introducing N2, removing air from reactor, heating, reaction, evaporating isopropanol, and vacuum concentrating.

The present invention relates to immunoglobulin for intravenous injection of dog, and its preparation process and preparations. Through low temperature ethanol process or rivanol combined low temperature ethanol process, blood plasma or serum from health dog is separated to prepare immunoglobulin with pH 3.0-5.4 and purity over 95 % for intravenous injection of dog. The said immunoglobulin is further compounded into immunoglobulin injection with protein content of 1-15 % and containing one or two kinds of protecting agents of 5-15 % maltose, 5-10 % glucose and 3-10 % glucose salt solution.

The invention discloses a method for carrying out colored hair dyeing based on enzymatic oxidation of tyrosine derivatives. The method comprises the following steps: (1) washing human hair with water; (2) dissolving the tyrosine derivatives in PBS (Phosphate Buffer Solution) to obtain tyrosine derivative-PBS solution; (3) dissolving polyphenol oxidase in the PBS to obtain polyphenol oxidase-PBS solution; (4) soaking the hair washed with water in the solution obtained in the step (2), adding the polyphenol oxidase-PBS solution obtained in the step (3) under the shaking or stirring condition , and performing a reaction; and (5) washing with water, absorbing moisture on the surface of the hair, and carrying out drying and color fixing. The method disclosed by the invention is simple and convenient to operate, green, friendly, safe, non-toxic, mild in reaction and stable. The method is carried out under the chemical enzymatic reaction, alkali and additional additives are not used, a dye cannot permeate into the hair cortex, and the method is a green dyeing technology which does not damage the hair.

The invention discloses a preparation process of a titanium-zirconium alloy applied to a tooth root implant. The preparation process comprises the following steps that high-purity raw materials in batches under different heating powers are smelted by using a vacuum suspension smelting furnace under the protection of argon; and after vacuum pumping, refining, water cooling and turning ingot castingare performed, a final titanium-zirconium alloy ingot is obtained. The titanium-zirconium alloy prepared by the preparation process has the advantages of good uniformity, high purity, refined grain,excellent mechanical property and the like, and is preferably selected for the tooth root implant, and the preparation process is simple in technological process and suitable for industrial production.

The invention relates to a preparation method of an intelligent supramolecular aquagel for detecting formaldehyde in interior decoration and wastewater, which comprises the following steps: (1) weighing alpha-cyclodextrin powder, and adding ultrapure water to prepare an alpha-cyclodextrin water solution; (2) adding a Tyloxapol liquid, and adding ultrapure water to prepare a Tyloxapol water solution; and (3) taking the alpha-cyclodextrin water solution and Tyloxapol water solution, adding ultrapure water until the alpha-cyclodextrin concentration in the gel is 90-130 mg.mL<-1> and the Tyloxapol concentration is 15-50 mg.mL<-1>, carrying out ultrasonic dispersion, and standing. The preparation method is simple, and the used raw materials have favorable biocompatibility and are friendly to application environments. The intelligent supramolecular aquagel has the advantages of low cost and no toxic byproducts.

The invention discloses a closure device, which comprises a skeleton supporting body and a sealing membrane which covers the surface of the skeleton supporting body. The sealing membrane integrally forms a sealed bag. The sealing membrane is made of a nylon fabric, a polyester fabric, PTFE (polytetrafluoroethylene), an autologous or heterologous pericardium, an autologous or heterologous artery organic membrane, an autologous or heterologous vein organic membrane or the like. When the closure device is clinically used, the sealing membrane isolates the skeleton supporting body from a human body. Only the sealing membrane is in contact with blood and tissues and metallic materials do not enter the blood and the risk of complications is reduced. Since the sealing membrane is made of the nylon fabric, the polyester fabric, the PTFE (polytetrafluoroethylene), the autologous or heterologous pericardium, the autologous or heterologous artery organic membrane, the autologous or heterologous vein organic membrane or the like, the biocompatibility is good, the human body repulsion is small and the physiological harmfulness is small; and since the sealing membrane is integrally sealed, the situation that thrombus is caused because the blood seeps into the sealing membrane is avoided and the safety in clinical use is improved.

The invention relates to a titanium alloy for a dental implant, and belongs to the technical field of machining of titanium alloys. The titanium alloy for the dental implant is prepared from niobium and zirconium. The titanium alloy is high in biocompatibility and is extremely high in corrosion resistance, and is also excellent in mechanical performance; and moreover, the problems that an existingtitanium alloy for the dental implant is low in cellular adaptability and harm to a human body possibly occurs are solved.

The invention provides self-growing artificial skin with an antibacterial effect for burns and a preparation method of the self-growing artificial skin. The preparation method comprises the following steps: step S1, preparing a bacterial cellulose membrane and drying the bacterial cellulose membrane; s2, preparing an iodophor solution of which the iodine content is 0.5-12wt%; and S3, putting the dried bacterial cellulose membrane into the iodophor solution in the step S2, and soaking for 12-48 hours to obtain the self-growing artificial skin with the antibacterial effect for burn. The bacterial cellulose membrane with the antibacterial effect, which is obtained by the technical scheme of the invention, still has a very high killing rate on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, bacillus subtilis, candida albicans and the like after 30 days, and can be used as artificial skin for treating burns. The artificial skin has excellent biocompatibility, biocompatibility and biological adaptability, has very good antibacterial performance, can provide a humid and low-oxygen environment for new skin growth, and has the effect of promoting wound healing.