38 results about "Nanomotor" patented technology

The application relates to a light-degradation-driven high-molecular nanomotor and a preparation method, and aims to solve the environmental pollution and biological safety problems caused by the degradation difficulty or long cycle of the nanomotor power assembly. The nanomotor has an asymmetric nanostructure and is assembled by a light-degradation high-molecular assembly and a biocompatible high-molecular effective load in a nanometer scale. The preparation method comprises the following steps: 1. uniformly mixing a light-degradation high-molecule and a biocompatible high-molecule in an organic solvent to prepare a mixture A; 2. mixing the mixture A and water at a high speed to prepare a mixture B; and 3. removing the organic solvent to prepare the nanomotor. Under light, the light-degradation assembly absorbs light energy to degrade and generate bubbles, which push the nanomotor to move in the solution. The start / stop of the nanomotor is controlled by the on / off of the light source, and the fast / slow movement of the nanomotor is controlled by the strong / weak of the light source. The structure of the light-degradation assembly is gradually degraded and finally completely destructed with the reaction, so that the biological safety and environmental pollution problems of the nanomaterial are relieved.

The invention provides a preparation method of a meso-porous silicon / polydopamine nano motor. The meso-porous silicon / polydopamine nano motor is assembled into a dumbbell structure by meso-porous silicon and meso-porous polydopamine nanospheres. The load is protected by lipid encapsulation. The excellent photo-thermal conversion capability of polydopamine enables the surface of the motor to generate a temperature gradient under the action of near-infrared light, and displacement is generated by using self-thermophoresis force. The double-mesoporous structure endows the motor with the capability of efficiently loading cargoes with different molecular weights, and lipid wraps and protects the load and enhances biological interaction. The nano motor can overcome the problems of insufficient drug targeting and single load, and has important significance for the application of the micro-nano motor in the field of biomedicine.

The application relates to a carrier-free self-driven nanomotor and a preparation method and application thereof, and belongs to the technical field of biological medicines. The nanomotor is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force, or is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force and modified by a polyethylene glycol modifier. The application realizes a synergistic treatment mode of deep tumor penetration and high-efficiency killing by constructing a functional coupling system of "photothermal driving-NO release-motion enhancement-RNS cascade generation".

The application discloses a kind of magnetically sensitive β-CD-OTf@Au@R-Fe3O4 Nanomotor and its preparation method and application, including the following steps: respectively preparing Zn (OTf) 2 solution and supersaturated β-CD solution, based on host-guest interaction, after mixing, β-CD-OTf is obtained;R-Fe3O4 is in situ assembled on Au NPs by electrostatic force, and R-Fe3O4@Au is obtained;Au@R-Fe3O4 is coupled to β-CD-OTf by electrostatic force, and magnetically sensitive β-CD-OTf@Au@R-Fe3O4 Nanomotor is obtained.The preparation method is simple, and the obtained nanomotor can not only significantly improve selective adsorption capacity to cationic dye, but also has high SERS activity, can realize self-cleaning after SERS detection, has excellent self-cleaning performance and recycling performance, and is suitable for being applied in cyclic selective capture and high-sensitivity SERS detection of cationic dye.

The application discloses a method for improving ion tolerance of self-electrophoretic driving micro-nanomotor and application thereof, and belongs to the technical field of micro-nanomotor.The method is characterized in that a metal organic framework (MOF) pore structure material is used to modify the surface of a self-electrophoretic driving micro-nanomotor, so that the ion tolerance of the self-electrophoretic driving micro-nanomotor in a high-salt environment is significantly improved.Compared with a self-electrophoretic driving micro-nanomotor without the surface modification of the MOF pore structure material, the ion tolerance of the self-electrophoretic driving micro-nanomotor with the surface modification of the MOF pore structure material can be improved by 266 times, so that the self-electrophoretic driving micro-nanomotor can keep stable movement under an electrolyte concentration of up to 150 mM.The ion quenching problem of the micro-nanomotor driven by the electrophoresis mechanism in a high-salt solution is solved, and the driving efficiency is improved.

This invention provides a bubble-driven micro / nano motor, its fabrication method, and its applications, belonging to the technical field of micro / nano motors. The micro / nano motor comprises a host material and noble metal nanoparticles, wherein the host material constitutes the host of the micro / nano motor; the host of the micro / nano motor has a hollow shape with a single opening and inner and outer surfaces; wherein one of the inner or outer surfaces of the host is modified with the noble metal nanoparticles. Because the micro / nano motor host is hollow with inner and outer surfaces, and one of its surfaces is directionally modified with catalytically functional noble metal nanoparticles, the noble metal nanoparticles can react with substrates in the environment to generate bubbles, thereby achieving controllable movement of the micro / nano motor. This micro / nano motor has a highly flexible structural design, a simple fabrication method, strong operability, and is easy to adjust, showing broad application prospects in environmental remediation and biomedicine.

The invention relates to the technical field of biomedicine, and discloses an application of a light-driven organic semiconductor nano motor in preparation of a product for promoting differentiation of neural stem cells, and the organic semiconductor nano motor is obtained by carrying out surface treatment on poly (3-hexylthiophene) through lauryl sodium sulfate and normal propyl alcohol. In-vivo experiments find that in-situ injection of the P3HT nanomotor in a subventricular region (V-SVZ) of a mouse can maintain stable photoresponse performance under visible light irradiation, and can promote directional differentiation of neural stem cells to a neural pedigree (rather than glial cells). In addition, the organic semiconductor nano motor has good cytocompatibility and systemic biological safety, and has a good application prospect in the field of nerve regeneration medicine.

The invention discloses an immunochromatography test strip based on an asymmetric near-infrared driving nano motor and a preparation method and application thereof.The immunochromatography test strip comprises a bottom plate and a sample pad, filter paper, a nitrocellulose membrane and absorbent paper which are sequentially overlapped and pasted to the bottom plate, and when the immunochromatography test strip is used, a PZSA-Ab buffer solution is dropwise added to the surface of the sample pad; the PZSA (at) Ab buffer solution is prepared from a PS-SiO2 (at) Au nano composite material and an antibody to be marked; the PS-SiO2 (at) Au nano composite material is nanoparticles of an asymmetric snowman-shaped structure, polystyrene nanospheres are arranged at one end of the asymmetric snowman-shaped structure, hemispherical SiO2 nanoparticles are arranged at the other end of the asymmetric snowman-shaped structure, and Au nanoparticles are loaded on the surface of the asymmetric snowman-shaped structure. According to the present invention, the PS-SiO2 (at) Au nano-composite material is adopted as the nano-motor to be combined with the antibody to be labeled, and the near-infrared light is adopted to drive the snowman-shaped nano-motor to directionally move so as to achieve the active capture and enrichment of the tumor marker, such that the detection sensitivity and the detection speed of the immunochromatography test strip can be significantly improved.

The invention provides a cobalt-based nano-motor, a preparation method thereof and application of the cobalt-based nano-motor in preparation of space distribution heterogeneity drugs for radiotherapy injury, and belongs to the technical field of nano-drugs. The cobalt-based nano motor constructed by the invention can amplify the killing effect of ROS on tumor cells under low-dose X-ray irradiation, and obviously enhance the tumor radiotherapy effect. Besides, the cobalt-based nano motor contains ammonium bicarbonate, so that the cobalt-based nano motor can respond to a tumor acidic microenvironment, release carbon dioxide in the tumor acidic microenvironment, push the carbon dioxide to go deep into tumor tissues and accumulate in tumors, consume antioxidant glutathione in tumor cells through a catalytic treatment effect, and amplify ROS damage. According to the invention, the cobalt-based nano-motor is preliminarily proved to realize non-uniform radiodynamic therapy by virtue of the excellent penetrating power of the cobalt-based nano-motor in tumor tissues, and achieve the effect of spatial distribution heterogeneity of radiotherapy injury, so that the immune response is activated, and the effect of improving the tumor radiotherapy curative effect is realized.

The invention provides a bowl-shaped Janus mesoporous silica nano motor and a preparation method and application thereof, and belongs to the technical field of novel biomedical materials and eye disease treatment. The preparation method comprises the following steps: preparing ZIF-8 amp by taking a ZIF-8 nanocube as a seed and taking tetraethoxysilane as a silicon source; the preparation method comprises the following steps: preparing an mSiO2 anisotropic nano hybrid, performing amino functional modification, etching to remove a ZIF-8 core to obtain amino functional bowl-shaped mesoporous silicon dioxide, and passing through B-mSiO2amp; and asymmetrically and covalently grafting catalase on the outer surface of the Janus mesoporous silica nano-motor through amino active sites on the surface of NH2 to obtain the bowl-shaped Janus mesoporous silica nano-motor. The nano-motor prepared by the invention can realize directional autonomous movement in the presence of H2O2 at an infected part, effectively enhances the penetrating ability of a drug across a corneal barrier, goes deep into corneal stroma and a bacterial biofilm, and solves the problem of low delivery efficiency of a traditional drug.

The invention belongs to the field of nano composite materials, and discloses a photoresponsive metal phenolic network composite material and a preparation method and application thereof.The composite material comprises poly (m-phenylenediamine) nanoparticles, the poly (m-phenylenediamine) nanoparticles are of asymmetric structures formed by incompletely wrapping shells outside spheres, and uniform mesopores are distributed in the surfaces of the shells; a metal-phenolic aldehyde network layer is assembled on the surfaces of the poly (m-phenylenediamine) nanoparticles. The composite material prepared by the invention has a unique asymmetric structure and highly ordered mesopores, shows excellent photoelectric properties, stable photon-generated carrier separation efficiency and reversible photoelectric response characteristics, is simple and controllable in preparation process, and has application value in the field of photoresponsive nano motors.

The invention belongs to the field of micro-nano motors, and provides a cell membrane camouflage light-driven nano motor and a preparation method and application thereof. The nano-motor Cu < 2-x > Se-PMO is composed of near-infrared light response copper selenide Cu < 2-x > Se nano-particles and periodic mesoporous organosilicon PMO nano-spheres, and the drug-loaded nano-motor and the cell membrane nano-vesicles are mixed and jointly pass through a microporous filter membrane to obtain the cell membrane disguise nano-motor CM (at) Cu < 2-x > Se-PMO. The nano-motor can actively find a target disease site, the cell membrane camouflage light-driven nano-motor can improve the efficiency and targeting property of drug transportation, and the preparation method has the characteristics of high loading rate, high targeting property, low cost and the like.

The application provides a method for preparing a double-faced Janus nanomotor based on polyacrylic acid (PAA) constructed eccentric structure, and belongs to the field of nanodevices.The method comprises the following steps: preparing an eccentric structure by adjusting electrostatic adsorption and coordination bonding between spherical nanoparticles and PAA; and based on the eccentric structure, performing asymmetric modification on the surface of the spherical nanoparticles.The method has the advantages of simple preparation process, mild reaction condition and ability to realize macro-preparation, and helps to accelerate the industrialization process of the nanomotor, and the method can be expanded to various nanomaterial systems, thereby providing a new idea for the preparation of the double-faced Janus nanomotor.

The application provides a photothermal driving bowl-shaped polydopamine nanomotor and a preparation method thereof, and belongs to the technical field of micro-nano devices, wherein the photothermal driving bowl-shaped polydopamine nanomotor comprises a hollow bowl-shaped structure constructed by polydopamine, and the hollow bowl-shaped structure is obtained by removing polyacrylic acid nanoparticles after polydopamine is polymerized on one side of the polyacrylic acid nanoparticles to form a single-sided asymmetric structure. The photothermal driving bowl-shaped polydopamine nanomotor provided by the application has strong driving capacity, fast movement speed, and an easy-to-functionalize surface, and the preparation method is simple and can be used for macro preparation, so that the photothermal driving bowl-shaped polydopamine nanomotor has a wide application prospect in the fields of environmental governance, micro-nano processing and biological medicine.

This invention discloses a photosynthetic nanomotor powered by a biomolecular motor and its preparation method, belonging to the field of colloidal motors. This invention aims to address the current limitations of research on the rotational dynamics of FoF1-ATP synthase molecular machines, which is limited to the motion of single and isolated objects. The photosynthetic nanomotor is prepared based on supramolecular self-assembly technology through the reconstruction of thylakoid vesicles and lecithin vesicles. The photophosphorylation system on the thylakoid membrane surface is reconstructed on the photosynthetic nanomotor. Utilizing the preserved biomolecular motor FoF1-ATPase as the power engine, under external visible light irradiation, protons generated by the photosystem accumulate in the photosynthetic liposome motor, driving the FoF1-ATPase to synthesize the energy currency ATP. Through metabolic reactions, light energy is converted into chemical energy ATP, ultimately generating self-propulsion. Due to its unique energy currency regeneration capability, the photosynthetic liposome motor has broad application prospects in the biomedical field.

This invention belongs to the field of water treatment technology, and relates to a bifunctional nanomotor, its preparation method, and its application. The invention utilizes layered bimetallic hydroxides as a carrier and precursor template to synthesize manganese oxide nanoparticles between the layers of the layered bimetallic hydroxides, resulting in a bifunctional nanomotor exhibiting a typical sheet-like structure with uniformly distributed nanoparticles within the sheets. In water treatment, the bifunctional nanomotor is placed in a solution containing PPCPs, and persulfate is added followed by stirring; or the bifunctional nanomotor is placed in a solution containing NPs, and hydrogen peroxide is added followed by reaction, both of which effectively remove NPs. The bifunctional nanomotor proposed in this invention exhibits strong catalytic ability, abundant active sites, and good recyclability. It can activate persulfate oxidation to remove various toxic and harmful recalcitrant organic micropollutants, including PPCPs, and simultaneously activate hydrogen peroxide to generate micro-nano bubbles to remove NPs from water, demonstrating broad market application prospects.

The application discloses a kind of multistage propulsion motor with sensing function and preparation method thereof, it is related to the preparation technical field of micro-nanomotor.The method comprises the following steps: substitution reaction is carried out to KH and 3-hydroxybenzyl alcohol, then polypropylene glycol is added, and lactic acid is added to prepare polymer PLA-NB-PPG;Dissolved in DCM, add peroxide, AgNO3, photoinitiator and spirooxazine, electrospinning is carried out, and nanofiber membrane is prepared;Ultraviolet irradiation treatment is carried out, alcohol dispersion is used, then solvent is volatilized under reduced pressure, and multistage propulsion motor with sensing function is prepared.The motor of the application has the characteristics of self-provided double power and sensing, can double sensing of enhanced raman signal and fluorescence while moving, that is, multistage propulsion and multiple sensing can be realized.The application solves the problem that existing motor type biosensor has insufficient power, sensing and movement action is split.

This invention provides a magnetically and thermally controlled dynamically powered nanomotor neural graft and its preparation method. The neural graft consists of a biodegradable polymer fiber conduit, an internally filled thermosensitive hydrogel, and a nanomotor loaded on the hydrogel. The surface of the nanomotor is loaded with energy molecules such as succinic acid. The nanomotor is prepared using a highly magnetically responsive material and achieves directional guidance under an applied magnetic field. Heat generated under an alternating magnetic field triggers a gel-sol transition in the thermosensitive hydrogel. Energy molecules are continuously released to increase local ATP levels, maintain cellular homeostasis, and support axonal regeneration and synaptic remodeling. This invention combines the advantages of magnetically driven directional navigation and thermosensitive controlled release, overcoming the shortcomings of traditional methods such as insufficient directionality and energy depletion. The graft exhibits good biocompatibility and is biodegradable, can regulate the immune microenvironment of damaged nerves, avoid oxidative stress, and efficiently promote the regeneration and functional recovery of long-segment damaged peripheral nerves.

The invention relates to the technical field of medicines, in particular to a nitric oxide-driven nano motor composition as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving cyclodextrin and Boc protected arginine in DMF, and adding EDC and DMAP; carrying out water bath reaction under a nitrogen condition; dialyzing, freeze-drying and separating to obtain a white product CD-Arg; the preparation method comprises the following steps: dissolving rapamycin and thioketal in anhydrous DMF, and adding EDC and DMAP; carrying out water bath reaction under a nitrogen condition; dialyzing, freeze-drying and separating to obtain a yellow product RAPA-TK; the preparation method comprises the following steps: dissolving CD-Arg and RAPA-TK in DMF, and then adding EDC and DMAP; carrying out water bath reaction under a nitrogen condition; dialyzing the product, and freeze-drying and separating to obtain the nano-motor composition. The nano motor provided by the invention has special chemical bonds sensitive and responsive to an inflammatory microenvironment, and is easy to break in the inflammatory environment, so that targeted drug release can be realized.

The application provides a light-driven composite nanomotor based on oxygen-containing hole oxidized cuprous oxide and preparation and application of the light-driven composite nanomotor. 2+1 The rGO / CuO composite nanomotor is prepared by taking CuO material as a matrix and rGO as an outer wall material and by using an electrochemical deposition method as a preparation means. 2+1 The rGO / CuO composite nanomotor can realize high-efficiency movement in a low-concentration biocompatible fuel under visible light irradiation and can realize highly controllable targeted movement in a high-concentration cell isotonic environment under ultraviolet light irradiation. 2+1 The rGO / CuO composite nanomotor can load anticancer drugs in a short time. 2+1 The rGO / CuO composite nanomotor can effectively load drugs, can be applied to targeted drug delivery by using effective light driving, can be applied to environmental remediation, has a large application range, and meanwhile, the preparation method of the composite nanomotor is green, simple and easy to implement, and can realize batch preparation.

The invention discloses a magnetic response nano-motor for microwave hyperthermia and a preparation method and application of the magnetic response nano-motor. The magnetic response nano motor is formed by compounding boron nitride and a zeolite imidazole skeleton (ZIF-67), is of a regular dodecahedron structure, has the particle size of 700-900 nm, and has magnetic responsiveness and microwave absorption heating performance. When in use, the nano motor is injected into a human body and then is guided to be enriched in a tumor area through an external magnetic field, and electromagnetic energy is converted into heat energy under microwave irradiation, so that local thermal killing of tumors is realized. The nano motor is simple in preparation process, shows good magnetic response performance and microwave thermal therapy effect, and is suitable for tumor drug delivery and / or tumor cell thermal killing.

The invention belongs to the technical field of nano motors, and particularly relates to an MXene (at) Au photo-thermal nano motor and a preparation method and application thereof. The MXene (at) Au composite nano motor provided by the invention comprises a modified single-layer MXene nanosheet and an active component loaded on the surface of the modified single-layer MXene nanosheet, the active component is a gold nano-cluster coated with bovine serum albumin; the modified single-layer MXene nanosheet is obtained by modifying with a cationic surface active agent; the loading is realized through an electrostatic adsorption effect. The MXene (at) Au nano motor provided by the invention generates an asymmetric thermal gradient under illumination to drive the nano motor to realize self-propelling movement in a solution, so that the diffusion efficiency and the A beta targeted enrichment capacity in a complex biological medium can be remarkably enhanced, and further efficient recognition and photo-thermal degradation of A beta protein aggregates are realized.

The invention discloses a preparation method of a Pt-Fe3O4 nano-motor accelerated degradation agent capable of dynamically and automatically searching a target. The preparation method is specifically implemented according to the following steps: step 1, modifying Fe3O4 particles; step 2, constructing a Janus structure, and preparing a nano motor; and step 3, preparing the accelerated degradation agent. The invention further discloses a Pt-Fe3O4 nano motor speed-increasing degradation agent capable of dynamically and automatically searching a target, and the problems of mass transfer limitation, ineffective consumption of free radicals and target deficiency in PAM gel degradation in the prior art are solved.

The present application relates to the technical field of biological medicine, and particularly relates to a nano motor, a preparation method thereof and application of the nano motor in preparation of an anti-tumor drug. The nano motor provided by the present application takes manganese dioxide nanoparticles as a carrier, internally loads an inhibitor YC-1 of HIF-1 alpha, then is asymmetrically modified by polydopamine, and finally connects an aptamer AS1411 on the surface. The nano motor integrates multiple functions such as targeting, tumor microenvironment responsive movement and drug release, metabolic intervention and immune activation, and proves the strong potential of a new paradigm combining 'targeting lipid droplet metabolism to enhance oxidative therapy' and 'activating the cGAS-STING pathway'. The new paradigm provides a new idea and a feasible technical solution for overcoming multiple barriers of tumor cells such as hypoxia, antioxidant resistance and immunosuppression, and lays a solid foundation for developing the next generation of tumor synergistic treatment strategies.

The invention provides a micro-nano motor based on liquid metal and a preparation method and application thereof, and belongs to the technical field of micro-nano motor devices. Liquid metal nanoparticles are asymmetrically anchored in an empty shell to form an asymmetric core-shell structure serving as a basic framework of the micro-nano motor, then metal and / or metal oxide with catalase-like activity grow on the surfaces of the liquid metal nanoparticles in situ, and the micro-nano motor based on the liquid metal is prepared. The basic framework has wide material compatibility, can adapt to all inorganic materials with response to hydrogen peroxide, and effectively overcomes the problems of process sensitivity, material singleness, limited function application and the like in the preparation process of the existing biological response self-driven micro-nano motor; according to the technical breakthrough, the universality of the micro-nano motor preparation method is remarkably improved, and a solid foundation is laid for wide expansion of application scenes of the micro-nano motor preparation method.

The present invention relates to a biocompatible polydopamine nanomotor capable of infiltrating a bladder wall in a biological environment and remaining inside a bladder for a long time.

The invention discloses a space-limited double-foot DNA nano-motor with enhanced dynamics and a preparation method and application thereof. The preparation method comprises the following steps: annealing a specific DNA single chain to form a Cy5-substrate probe, a Cy3-substrate probe, a double-foot walker 1 and a double-foot walker 2; and respectively assembling the two substrate probes and the gold nanoparticles through a freezing method to obtain the DNA nano motor 1 and the DNA nano motor 2. The nano motor, a corresponding biped walker and a fuel chain form a detection system which is used for detecting messenger RNA (Ribonucleic Acid). The space confinement effect of the gold nanoparticles and the proximity effect of the biped walker are utilized, entropy-driven catalytic reaction kinetics is remarkably accelerated, ultra-high-sensitivity detection of survivin mRNA and TK1 mRNA is achieved, and the detection limits reach 501 aM and 314 aM respectively. And rapid and high-contrast in-situ imaging can be carried out on double mRNA in living cells.

The application discloses a bispecific aptamer triggered 3D-DNA nanomotor sensor and application thereof in lysozyme detection, and belongs to the technical field of lysozyme detection. A novel DNA-walker-based biosensor is developed, the high synergy of DNA-walking and DNA-rolling improves the walking speed and persistence of the walking chain, and finally promotes the rapid accumulation of signals. The method can be applied to lysozyme detection, and can effectively improve the stability of the sensor without relying on the specific enzyme cutting action of traditional proteases, thereby avoiding the influence of environmental factor fluctuation on the performance of the sensor. The method can realize high-sensitivity detection of lysozyme, and the detection limit can reach 0.01 pg / mL.

The present application relates to a self-driven nanometer micromotor for water lock solution of tight gas reservoir and a method for water lock solution of tight gas reservoir, the self-driven nanometer micromotor for water lock solution of tight gas reservoir is a double-section cone structure coated with a core-shell, which is composed of, from inside to outside, a motion control section: a CaCO3 thin layer at the tip of the cone cannot react with water, controlling the generated bubbles to push the motor to directional advance; an Al4C3 reaction section: the atomic ratio of aluminum and carbon is 4:3, the crystal form is face-centered cubic structure, and the cone is the rear section of the motor, with a diameter of 450-2000 nm; a delay coating layer: a polypyrrole (PPY) copolymer film or a polyaniline (PANI) copolymer film, the copolymer film is a porous hydrophobic polymer macromolecular outer layer, coated outside the conical CaCO3-Al4C3 core structure, prolonging the contact time of the nanometer micromotor with water and promoting the motor to push deeper. The present application not only can go deep into the fissure to solve water lock, but also can significantly improve the gas production and recovery efficiency.