64 results about "Nanomotor" patented technology

The invention discloses a nano-motor capable of realizing efficient targeted enrichment in inflammatory disease tissues and preparation and application thereof, the nano-motor is mainly formed by connecting two or more enzymes to nano-particles, at least one enzyme is used for driving the motor in a physiological medium, and at least one enzyme is used for driving the motor in the physiological medium. And at least another enzyme is used for sensing an inflammation focus part and controlling the movement direction of the motor. According to the invention, the synergistic effect of two enzymes is creatively utilized, so that the chemotactic sensitivity of the nano-motor and the targeting efficiency of the nano-motor on a focus part are remarkably improved; under better conditions, compared with a traditional single-enzyme chemotactic motor, the chemotactic ability of the nano motor is improved by more than 10 times, the targeting efficiency is remarkably improved by more than 20 times, and compared with an inert carrier, the targeting efficiency of the nano motor is remarkably improved by more than 200 times. The nano motor has ultrahigh plasticity, the preparation method is simple and efficient, and the nano motor has important significance in application of the micro-nano motor in the field of biological medicine.

The application relates to a light-degradation-driven high-molecular nanomotor and a preparation method, and aims to solve the environmental pollution and biological safety problems caused by the degradation difficulty or long cycle of the nanomotor power assembly. The nanomotor has an asymmetric nanostructure and is assembled by a light-degradation high-molecular assembly and a biocompatible high-molecular effective load in a nanometer scale. The preparation method comprises the following steps: 1. uniformly mixing a light-degradation high-molecule and a biocompatible high-molecule in an organic solvent to prepare a mixture A; 2. mixing the mixture A and water at a high speed to prepare a mixture B; and 3. removing the organic solvent to prepare the nanomotor. Under light, the light-degradation assembly absorbs light energy to degrade and generate bubbles, which push the nanomotor to move in the solution. The start / stop of the nanomotor is controlled by the on / off of the light source, and the fast / slow movement of the nanomotor is controlled by the strong / weak of the light source. The structure of the light-degradation assembly is gradually degraded and finally completely destructed with the reaction, so that the biological safety and environmental pollution problems of the nanomaterial are relieved.

The invention provides a preparation method of a meso-porous silicon / polydopamine nano motor. The meso-porous silicon / polydopamine nano motor is assembled into a dumbbell structure by meso-porous silicon and meso-porous polydopamine nanospheres. The load is protected by lipid encapsulation. The excellent photo-thermal conversion capability of polydopamine enables the surface of the motor to generate a temperature gradient under the action of near-infrared light, and displacement is generated by using self-thermophoresis force. The double-mesoporous structure endows the motor with the capability of efficiently loading cargoes with different molecular weights, and lipid wraps and protects the load and enhances biological interaction. The nano motor can overcome the problems of insufficient drug targeting and single load, and has important significance for the application of the micro-nano motor in the field of biomedicine.

The application relates to a carrier-free self-driven nanomotor and a preparation method and application thereof, and belongs to the technical field of biological medicines. The nanomotor is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force, or is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force and modified by a polyethylene glycol modifier. The application realizes a synergistic treatment mode of deep tumor penetration and high-efficiency killing by constructing a functional coupling system of "photothermal driving-NO release-motion enhancement-RNS cascade generation".

The application discloses a kind of magnetically sensitive β-CD-OTf@Au@R-Fe3O4 Nanomotor and its preparation method and application, including the following steps: respectively preparing Zn (OTf) 2 solution and supersaturated β-CD solution, based on host-guest interaction, after mixing, β-CD-OTf is obtained;R-Fe3O4 is in situ assembled on Au NPs by electrostatic force, and R-Fe3O4@Au is obtained;Au@R-Fe3O4 is coupled to β-CD-OTf by electrostatic force, and magnetically sensitive β-CD-OTf@Au@R-Fe3O4 Nanomotor is obtained.The preparation method is simple, and the obtained nanomotor can not only significantly improve selective adsorption capacity to cationic dye, but also has high SERS activity, can realize self-cleaning after SERS detection, has excellent self-cleaning performance and recycling performance, and is suitable for being applied in cyclic selective capture and high-sensitivity SERS detection of cationic dye.

The application discloses a method for improving ion tolerance of self-electrophoretic driving micro-nanomotor and application thereof, and belongs to the technical field of micro-nanomotor.The method is characterized in that a metal organic framework (MOF) pore structure material is used to modify the surface of a self-electrophoretic driving micro-nanomotor, so that the ion tolerance of the self-electrophoretic driving micro-nanomotor in a high-salt environment is significantly improved.Compared with a self-electrophoretic driving micro-nanomotor without the surface modification of the MOF pore structure material, the ion tolerance of the self-electrophoretic driving micro-nanomotor with the surface modification of the MOF pore structure material can be improved by 266 times, so that the self-electrophoretic driving micro-nanomotor can keep stable movement under an electrolyte concentration of up to 150 mM.The ion quenching problem of the micro-nanomotor driven by the electrophoresis mechanism in a high-salt solution is solved, and the driving efficiency is improved.

The invention discloses a magnetic-sensitive beta-CD-OTf (at) Au (at) R-Fe3O4 nano motor and a preparation method and application thereof, and the preparation method comprises the following steps: respectively preparing a Zn (OTf) 2 solution and a supersaturated beta-CD solution, and based on the host-guest interaction, mixing to obtain beta-CD-OTf; the method comprises the following steps: assembling R-Fe3O4 on Au NPs in situ through static electricity to obtain R-Fe3O4 (at) Au; and the Au (at) R-Fe3O4 is coupled to the beta-CD-OTf through the electrostatic interaction, so that the magnetic sensitive beta-CD-OTf (at) Au (at) R-Fe3O4 nano motor is obtained. The preparation method is simple, and the obtained nano motor not only can significantly improve the selective adsorption capacity of cationic dyes, but also has high SERS activity, can realize self-cleaning after SERS detection, has excellent self-cleaning performance and recycling performance, and is suitable for being applied to cyclic selective capture and high-sensitivity SERS detection of cationic dyes.

This invention provides a bubble-driven micro / nano motor, its fabrication method, and its applications, belonging to the technical field of micro / nano motors. The micro / nano motor comprises a host material and noble metal nanoparticles, wherein the host material constitutes the host of the micro / nano motor; the host of the micro / nano motor has a hollow shape with a single opening and inner and outer surfaces; wherein one of the inner or outer surfaces of the host is modified with the noble metal nanoparticles. Because the micro / nano motor host is hollow with inner and outer surfaces, and one of its surfaces is directionally modified with catalytically functional noble metal nanoparticles, the noble metal nanoparticles can react with substrates in the environment to generate bubbles, thereby achieving controllable movement of the micro / nano motor. This micro / nano motor has a highly flexible structural design, a simple fabrication method, strong operability, and is easy to adjust, showing broad application prospects in environmental remediation and biomedicine.

The invention discloses a magnetic drive porous spiral nano motor for active antigen delivery and a preparation method and application thereof. The magnetic drive porous spiral nano motor comprises a nickel layer, porous spiral silicon and surface antigen ovalbumin OVA, and the nickel layer modifies the surface antigen ovalbumin OVA on the surface of the porous spiral silicon. The preparation method comprises the following steps: S1, adding tetraethyl orthosilicate into a water solution containing sodium hydroxide, perfluorooctanoic acid and hexadecyl trimethyl ammonium bromide by adopting a sol-gel method, mixing, stirring and reacting, and calcining to obtain a spiral siliceous mesoporous material HR; s2, a metal nickel layer is formed on the surface of the spiral siliceous mesoporous material through magnetron sputtering, and the HR-Ni spiral magnetic drive motor is obtained; s3, surface antigen ovalbumin OVA is modified for the HR-Ni spiral magnetic drive motor, and therefore the magnetic drive porous spiral nano motor is obtained. The nano motor has high antigen loading efficiency and high cell uptake efficiency, and can enhance cross delivery of antigens.

The present invention relates to a nucleic acid nanomotor. The present invention further relates to a system comprising a nanomotor and a control unit configured to generate an alternating current for rotating said nanomotor. The present invention also relates to a method of rotating a rotor of a nanomotor with respect to a stator of said nanomotor. Furthermore, the present invention relates to a use of a nanomotor or a system as a turbine, propulsion, fluid mixer, energy storing device, machine applying mechanical force e.g. on a system coupled to said nanomotor, and / or in chemical synthesis.

The invention provides a method for preparing a double-sided nanometer motor by constructing an eccentric structure based on polyacrylic acid, and belongs to the field of nanometer devices, and the method comprises the following steps: preparing the eccentric structure by adjusting electrostatic adsorption and coordination bonding between spherical nanoparticles and PAA; and based on the eccentric structure, asymmetrically modifying the surface of the spherical nano-particle. The method has the advantages of being simple in preparation process, mild in reaction condition, capable of achieving macro preparation and the like, the industrialization process of the nano motor can be accelerated, the method can be expanded to various nano material systems, and a new thought is provided for preparation of the double-sided nano motor.

The invention relates to the technical field of biomedicine, and discloses an application of a light-driven organic semiconductor nano motor in preparation of a product for promoting differentiation of neural stem cells, and the organic semiconductor nano motor is obtained by carrying out surface treatment on poly (3-hexylthiophene) through lauryl sodium sulfate and normal propyl alcohol. In-vivo experiments find that in-situ injection of the P3HT nanomotor in a subventricular region (V-SVZ) of a mouse can maintain stable photoresponse performance under visible light irradiation, and can promote directional differentiation of neural stem cells to a neural pedigree (rather than glial cells). In addition, the organic semiconductor nano motor has good cytocompatibility and systemic biological safety, and has a good application prospect in the field of nerve regeneration medicine.

The invention discloses an immunochromatography test strip based on an asymmetric near-infrared driving nano motor and a preparation method and application thereof.The immunochromatography test strip comprises a bottom plate and a sample pad, filter paper, a nitrocellulose membrane and absorbent paper which are sequentially overlapped and pasted to the bottom plate, and when the immunochromatography test strip is used, a PZSA-Ab buffer solution is dropwise added to the surface of the sample pad; the PZSA (at) Ab buffer solution is prepared from a PS-SiO2 (at) Au nano composite material and an antibody to be marked; the PS-SiO2 (at) Au nano composite material is nanoparticles of an asymmetric snowman-shaped structure, polystyrene nanospheres are arranged at one end of the asymmetric snowman-shaped structure, hemispherical SiO2 nanoparticles are arranged at the other end of the asymmetric snowman-shaped structure, and Au nanoparticles are loaded on the surface of the asymmetric snowman-shaped structure. According to the present invention, the PS-SiO2 (at) Au nano-composite material is adopted as the nano-motor to be combined with the antibody to be labeled, and the near-infrared light is adopted to drive the snowman-shaped nano-motor to directionally move so as to achieve the active capture and enrichment of the tumor marker, such that the detection sensitivity and the detection speed of the immunochromatography test strip can be significantly improved.

The invention discloses a method for preparing a double-sided structured micro-nano motor based on Pickering emulsion, and belongs to the technical field of nano device preparation, and the method comprises the following steps: preparing a paraffin-nano particle semi-surface structure by using Pickering emulsion; after selective modification is conducted on the surfaces of the exposed nano particles in the paraffin-nano particle semi-face structure, paraffin is removed, and eccentric nano particles are obtained; the invention discloses a micro-nano motor with a double-sided structure prepared on the basis of eccentric nanoparticles. The Pickering emulsion is creatively used for preparing the micro-nano motor of the double-sided structure, the method has the advantages of being simple, efficient, independent of equipment and the like, large-scale preparation of the micro-nano motor can be achieved, and industrial application of the micro-nano motor can be promoted.

The present invention relates to the technical field of oil extraction, and particularly to an oil extraction method using nano-motors, comprising: obtaining geological parameters of a target reservoir area and characteristic parameters of the nano-motors; constructing a reservoir-nano-motor coupling model based on the geological parameters and the characteristic parameters, and determining an initial injection speed and an initial injection pressure of the nano-motors; injecting the nano-motors into the target reservoir area based on the initial injection speed and the initial injection pressure, and detecting initial behavior characteristics of the nano-motors during the initial injection process; determining an injection method for a key injection process based on the initial behavior characteristics of the nano-motors within a preset time period; detecting key behavior characteristics of the nano-motors during the key injection process, and determining whether to adjust the injection method based on the key behavior characteristics. The present invention can improve the injection efficiency and distribution uniformity of the nano-motors.

The invention provides a cobalt-based nano-motor, a preparation method thereof and application of the cobalt-based nano-motor in preparation of space distribution heterogeneity drugs for radiotherapy injury, and belongs to the technical field of nano-drugs. The cobalt-based nano motor constructed by the invention can amplify the killing effect of ROS on tumor cells under low-dose X-ray irradiation, and obviously enhance the tumor radiotherapy effect. Besides, the cobalt-based nano motor contains ammonium bicarbonate, so that the cobalt-based nano motor can respond to a tumor acidic microenvironment, release carbon dioxide in the tumor acidic microenvironment, push the carbon dioxide to go deep into tumor tissues and accumulate in tumors, consume antioxidant glutathione in tumor cells through a catalytic treatment effect, and amplify ROS damage. According to the invention, the cobalt-based nano-motor is preliminarily proved to realize non-uniform radiodynamic therapy by virtue of the excellent penetrating power of the cobalt-based nano-motor in tumor tissues, and achieve the effect of spatial distribution heterogeneity of radiotherapy injury, so that the immune response is activated, and the effect of improving the tumor radiotherapy curative effect is realized.

The invention provides a bowl-shaped Janus mesoporous silica nano motor and a preparation method and application thereof, and belongs to the technical field of novel biomedical materials and eye disease treatment. The preparation method comprises the following steps: preparing ZIF-8 amp by taking a ZIF-8 nanocube as a seed and taking tetraethoxysilane as a silicon source; the preparation method comprises the following steps: preparing an mSiO2 anisotropic nano hybrid, performing amino functional modification, etching to remove a ZIF-8 core to obtain amino functional bowl-shaped mesoporous silicon dioxide, and passing through B-mSiO2amp; and asymmetrically and covalently grafting catalase on the outer surface of the Janus mesoporous silica nano-motor through amino active sites on the surface of NH2 to obtain the bowl-shaped Janus mesoporous silica nano-motor. The nano-motor prepared by the invention can realize directional autonomous movement in the presence of H2O2 at an infected part, effectively enhances the penetrating ability of a drug across a corneal barrier, goes deep into corneal stroma and a bacterial biofilm, and solves the problem of low delivery efficiency of a traditional drug.

The invention belongs to the field of nano composite materials, and discloses a photoresponsive metal phenolic network composite material and a preparation method and application thereof.The composite material comprises poly (m-phenylenediamine) nanoparticles, the poly (m-phenylenediamine) nanoparticles are of asymmetric structures formed by incompletely wrapping shells outside spheres, and uniform mesopores are distributed in the surfaces of the shells; a metal-phenolic aldehyde network layer is assembled on the surfaces of the poly (m-phenylenediamine) nanoparticles. The composite material prepared by the invention has a unique asymmetric structure and highly ordered mesopores, shows excellent photoelectric properties, stable photon-generated carrier separation efficiency and reversible photoelectric response characteristics, is simple and controllable in preparation process, and has application value in the field of photoresponsive nano motors.

The invention relates to the technical field of oil exploitation, in particular to an oil exploitation method using a nano motor, which comprises the following steps: acquiring geological parameters of a target oil reservoir area and characteristic parameters of the nano motor; based on the geological parameters and the characteristic parameters, an oil reservoir-nano motor coupling model is constructed, and the initial injection speed and initial injection pressure of a nano motor are determined; injecting the nano motor into the target oil reservoir area based on the initial injection speed and the initial injection pressure, and detecting initial behavior characteristics of the nano motor in the initial injection process; determining an injection mode of the key injection process based on the initial behavior characteristics of the nano motor in a preset time period; key behavior characteristics of the nano motor in the key injection process are detected, and whether the injection mode needs to be adjusted or not is judged based on the key behavior characteristics. According to the invention, the injection efficiency and the distribution uniformity of the nano motor can be improved.

The invention belongs to the field of micro-nano motors, and provides a cell membrane camouflage light-driven nano motor and a preparation method and application thereof. The nano-motor Cu < 2-x > Se-PMO is composed of near-infrared light response copper selenide Cu < 2-x > Se nano-particles and periodic mesoporous organosilicon PMO nano-spheres, and the drug-loaded nano-motor and the cell membrane nano-vesicles are mixed and jointly pass through a microporous filter membrane to obtain the cell membrane disguise nano-motor CM (at) Cu < 2-x > Se-PMO. The nano-motor can actively find a target disease site, the cell membrane camouflage light-driven nano-motor can improve the efficiency and targeting property of drug transportation, and the preparation method has the characteristics of high loading rate, high targeting property, low cost and the like.

The application provides a method for preparing a double-faced Janus nanomotor based on polyacrylic acid (PAA) constructed eccentric structure, and belongs to the field of nanodevices.The method comprises the following steps: preparing an eccentric structure by adjusting electrostatic adsorption and coordination bonding between spherical nanoparticles and PAA; and based on the eccentric structure, performing asymmetric modification on the surface of the spherical nanoparticles.The method has the advantages of simple preparation process, mild reaction condition and ability to realize macro-preparation, and helps to accelerate the industrialization process of the nanomotor, and the method can be expanded to various nanomaterial systems, thereby providing a new idea for the preparation of the double-faced Janus nanomotor.

The present invention belongs to the technical field of functional nanomaterials, and specifically relates to a method for preparing a mesoporous silica-platinum Janus nanomotor. The preparation method uses tetraethyl orthosilicate and bis-[γ-(triethoxysilyl)propyl]-tetrasulfide as silicon sources and hexadecyltrimethylammonium bromide as a pore-forming agent to synthesize mesoporous silica nanospheres. 3-aminopropyltrimethoxysilane is used to modify the amino groups, polyethyleneimine is coupled to the mesoporous silica nanospheres by glutaraldehyde, and then chloroplatinic acid is adsorbed onto the mesoporous silica nanospheres by electrostatic adsorption. Hydrazine hydrate is used as a reducing agent to reduce the chloroplatinic acid, and finally a mesoporous silica-platinum Janus nanomotor is formed; the nanomotor is anisotropic particles composed of mesoporous silica spheres and metallic platinum. The preparation method of the mesoporous silica-platinum Janus nanomotor provided by the present invention has the advantages of simple operation, no need for special equipment, and batch preparation.

The application provides a photothermal driving bowl-shaped polydopamine nanomotor and a preparation method thereof, and belongs to the technical field of micro-nano devices, wherein the photothermal driving bowl-shaped polydopamine nanomotor comprises a hollow bowl-shaped structure constructed by polydopamine, and the hollow bowl-shaped structure is obtained by removing polyacrylic acid nanoparticles after polydopamine is polymerized on one side of the polyacrylic acid nanoparticles to form a single-sided asymmetric structure. The photothermal driving bowl-shaped polydopamine nanomotor provided by the application has strong driving capacity, fast movement speed, and an easy-to-functionalize surface, and the preparation method is simple and can be used for macro preparation, so that the photothermal driving bowl-shaped polydopamine nanomotor has a wide application prospect in the fields of environmental governance, micro-nano processing and biological medicine.

The present invention discloses a self-driven Au-Zn nanomotor, its preparation method and application. The self-driven Au-Zn nanomotor is tubular, with a length of 3 to 7 μm, an outer diameter of 320 to 500 nm, an inner diameter of 150 to 260 nm, an atomic percentage of Au of 85 to 95%, and an atomic percentage of Zn of 5 to 15%. No bubbles are generated during the propulsion of the motor, which can avoid the influence of bubbles on the movement of the self-driven Au-Zn nanomotor. The interaction mode between the self-driven Au-Zn nanomotor and the passive particles switches between attraction and repulsion, which can provide new ideas for the organizational behavior of active materials in biological evolution, the formation of condensates and cell component clusters. In addition, the self-driven Au-Zn nanomotor can also be used for biomolecule detection and biological information collection.

The patent of the invention discloses a preparation method of an NIR II driven Janus-Au-SiO2 nano motor, and aims to be used for deeply penetrating a biological membrane and eradicating the biological membrane, and the key point of the technical scheme is that a Janus-Au-SiO2 nano composite material is constructed by combining an electrostatic assembly method with a seed growth method. The preparation method comprises the following steps: spreading a single layer of aminated silicon dioxide spheres (DPSN-NH2) on a hydrophilic silicon wafer, carrying out gold nanoparticle sputtering on particles on the silicon wafer under a vacuum condition, and carrying out ultrasonic stripping to obtain the Janus-Au-SiO2 nano motor through a seed growth method. The method is simple in process and safe to operate, the synthesized Janus-Au-SiO2 nano motor has an asymmetric structure, an ultraviolet absorption peak has broadband absorption under NIR II (1000-1700nm), the Janus-Au-SiO2 nano motor can be driven by laser to generate rapid movement, multiple functions of deep penetration of a biological membrane, photo-thermal sterilization and the like are realized, and a new strategy is provided for deep eradication and killing of the biological membrane.

This invention discloses a photosynthetic nanomotor powered by a biomolecular motor and its preparation method, belonging to the field of colloidal motors. This invention aims to address the current limitations of research on the rotational dynamics of FoF1-ATP synthase molecular machines, which is limited to the motion of single and isolated objects. The photosynthetic nanomotor is prepared based on supramolecular self-assembly technology through the reconstruction of thylakoid vesicles and lecithin vesicles. The photophosphorylation system on the thylakoid membrane surface is reconstructed on the photosynthetic nanomotor. Utilizing the preserved biomolecular motor FoF1-ATPase as the power engine, under external visible light irradiation, protons generated by the photosystem accumulate in the photosynthetic liposome motor, driving the FoF1-ATPase to synthesize the energy currency ATP. Through metabolic reactions, light energy is converted into chemical energy ATP, ultimately generating self-propulsion. Due to its unique energy currency regeneration capability, the photosynthetic liposome motor has broad application prospects in the biomedical field.

The present invention relates to a tubular micromotor of MOF annealing material and a preparation method thereof, the preparation method comprising: preparing ZIF-67; taking a porous polycarbonate template A1 and a porous polycarbonate template A2, cleaning and drying them respectively, and then using a thermal evaporation instrument to evaporate a layer of metal on one side of the porous polycarbonate template A1 as a substrate; dissolving ZIF-67 in deionized water to obtain a ZIF-67 dispersion, passing the ZIF-67 dispersion through the stacked porous polycarbonate template A2 and the porous polycarbonate template A1 in sequence, taking out the porous polycarbonate template A1 as a tubular micro-nano motor precursor; using dichloromethane to post-treat the tubular micro-nano motor precursor so that the porous polycarbonate template is dissolved, and then centrifuging and washing to obtain a tubular micromotor of MOF annealing material. Compared with the prior art, the preparation method of the present invention is simple, and the obtained micro-nano motor not only has strong magnetism, but also has good adsorption capacity based on the inherent porous structure and porosity.

The present invention belongs to the technical field of preparing functional materials for ion recognition, adsorption, and separation, and discloses a method for preparing a functionalized light-driven nanomotor adsorbent and its adsorption application. The present invention uses a solvent method to load gold nanoparticles (Au NPs) inside HNTs to produce a good photothermal effect. The surface is then covered with a layer of polydopamine (PDA) and dithiothreitol succinate (DMSA), thereby improving the adsorption performance of the adsorbent. Experiments have shown that Au@DHNTs-DMSA has good photothermal conversion efficiency, biocompatibility, and biosafety, and an in vitro blood lead removal rate of up to 91.25%, making it effective in treating lead poisoning.

This invention belongs to the field of water treatment technology, and relates to a bifunctional nanomotor, its preparation method, and its application. The invention utilizes layered bimetallic hydroxides as a carrier and precursor template to synthesize manganese oxide nanoparticles between the layers of the layered bimetallic hydroxides, resulting in a bifunctional nanomotor exhibiting a typical sheet-like structure with uniformly distributed nanoparticles within the sheets. In water treatment, the bifunctional nanomotor is placed in a solution containing PPCPs, and persulfate is added followed by stirring; or the bifunctional nanomotor is placed in a solution containing NPs, and hydrogen peroxide is added followed by reaction, both of which effectively remove NPs. The bifunctional nanomotor proposed in this invention exhibits strong catalytic ability, abundant active sites, and good recyclability. It can activate persulfate oxidation to remove various toxic and harmful recalcitrant organic micropollutants, including PPCPs, and simultaneously activate hydrogen peroxide to generate micro-nano bubbles to remove NPs from water, demonstrating broad market application prospects.

The application discloses a kind of multistage propulsion motor with sensing function and preparation method thereof, it is related to the preparation technical field of micro-nanomotor.The method comprises the following steps: substitution reaction is carried out to KH and 3-hydroxybenzyl alcohol, then polypropylene glycol is added, and lactic acid is added to prepare polymer PLA-NB-PPG;Dissolved in DCM, add peroxide, AgNO3, photoinitiator and spirooxazine, electrospinning is carried out, and nanofiber membrane is prepared;Ultraviolet irradiation treatment is carried out, alcohol dispersion is used, then solvent is volatilized under reduced pressure, and multistage propulsion motor with sensing function is prepared.The motor of the application has the characteristics of self-provided double power and sensing, can double sensing of enhanced raman signal and fluorescence while moving, that is, multistage propulsion and multiple sensing can be realized.The application solves the problem that existing motor type biosensor has insufficient power, sensing and movement action is split.