5 results about "Nanomotor" patented technology

The application relates to a light-degradation-driven high-molecular nanomotor and a preparation method, and aims to solve the environmental pollution and biological safety problems caused by the degradation difficulty or long cycle of the nanomotor power assembly. The nanomotor has an asymmetric nanostructure and is assembled by a light-degradation high-molecular assembly and a biocompatible high-molecular effective load in a nanometer scale. The preparation method comprises the following steps: 1. uniformly mixing a light-degradation high-molecule and a biocompatible high-molecule in an organic solvent to prepare a mixture A; 2. mixing the mixture A and water at a high speed to prepare a mixture B; and 3. removing the organic solvent to prepare the nanomotor. Under light, the light-degradation assembly absorbs light energy to degrade and generate bubbles, which push the nanomotor to move in the solution. The start / stop of the nanomotor is controlled by the on / off of the light source, and the fast / slow movement of the nanomotor is controlled by the strong / weak of the light source. The structure of the light-degradation assembly is gradually degraded and finally completely destructed with the reaction, so that the biological safety and environmental pollution problems of the nanomaterial are relieved.

This invention provides a magnetically and thermally controlled dynamically powered nanomotor neural graft and its preparation method. The neural graft consists of a biodegradable polymer fiber conduit, an internally filled thermosensitive hydrogel, and a nanomotor loaded on the hydrogel. The surface of the nanomotor is loaded with energy molecules such as succinic acid. The nanomotor is prepared using a highly magnetically responsive material and achieves directional guidance under an applied magnetic field. Heat generated under an alternating magnetic field triggers a gel-sol transition in the thermosensitive hydrogel. Energy molecules are continuously released to increase local ATP levels, maintain cellular homeostasis, and support axonal regeneration and synaptic remodeling. This invention combines the advantages of magnetically driven directional navigation and thermosensitive controlled release, overcoming the shortcomings of traditional methods such as insufficient directionality and energy depletion. The graft exhibits good biocompatibility and is biodegradable, can regulate the immune microenvironment of damaged nerves, avoid oxidative stress, and efficiently promote the regeneration and functional recovery of long-segment damaged peripheral nerves.

The present application relates to the technical field of biological medicine, and particularly relates to a nano motor, a preparation method thereof and application of the nano motor in preparation of an anti-tumor drug. The nano motor provided by the present application takes manganese dioxide nanoparticles as a carrier, internally loads an inhibitor YC-1 of HIF-1 alpha, then is asymmetrically modified by polydopamine, and finally connects an aptamer AS1411 on the surface. The nano motor integrates multiple functions such as targeting, tumor microenvironment responsive movement and drug release, metabolic intervention and immune activation, and proves the strong potential of a new paradigm combining 'targeting lipid droplet metabolism to enhance oxidative therapy' and 'activating the cGAS-STING pathway'. The new paradigm provides a new idea and a feasible technical solution for overcoming multiple barriers of tumor cells such as hypoxia, antioxidant resistance and immunosuppression, and lays a solid foundation for developing the next generation of tumor synergistic treatment strategies.

The present application relates to a self-driven nanometer micromotor for water lock solution of tight gas reservoir and a method for water lock solution of tight gas reservoir, the self-driven nanometer micromotor for water lock solution of tight gas reservoir is a double-section cone structure coated with a core-shell, which is composed of, from inside to outside, a motion control section: a CaCO3 thin layer at the tip of the cone cannot react with water, controlling the generated bubbles to push the motor to directional advance; an Al4C3 reaction section: the atomic ratio of aluminum and carbon is 4:3, the crystal form is face-centered cubic structure, and the cone is the rear section of the motor, with a diameter of 450-2000 nm; a delay coating layer: a polypyrrole (PPY) copolymer film or a polyaniline (PANI) copolymer film, the copolymer film is a porous hydrophobic polymer macromolecular outer layer, coated outside the conical CaCO3-Al4C3 core structure, prolonging the contact time of the nanometer micromotor with water and promoting the motor to push deeper. The present application not only can go deep into the fissure to solve water lock, but also can significantly improve the gas production and recovery efficiency.

The present invention provides an enzyme-powered nanomotor, comprising a particle with a surface, an enzyme, and a heterologous molecule; characterized in that the enzyme and the heterologous molecule are discontinuously attached over the whole surface of the particle. The invention also provides the nanomotor for use in therapy, diagnosis and prognosis, in particular, for the treatment of cancer. Additionally, the invention provides the use of the nanomotor for detecting an analyte in an isolated sample.