Photoacoustic signal detection and imaging method based on micro-nano motor

Abstract

The invention relates to the field of micro-nano motor application, and particularly relates to a photoacoustic signal detection and imaging method based on a micro-nano motor, which comprises the following steps: S1, preparing a photoacoustic signal detection and imaging system based on the micro-nano motor for detection and imaging; S2, generating a magnetic field by an electromagnetic coil to drive and guide the micro-nano motor; S3, irradiating the micro-nano motor through a nanosecond pulse near-infrared laser light source, exciting thermoelastic expansion of surrounding liquid based on the plasmon effect of a photothermal conversion metal layer, periodically irradiating the micro-nano motor to generate photothermal conversion, and generating an ultrasonic photoacoustic signal; S4, after detecting the ultrasonic photoacoustic signal by the ultrasonic detector, amplifying and filtering the ultrasonic photoacoustic signal, and transmitting the signal to a started image reconstruction computer for algorithm imaging. The method can achieve the tracking, positioning and imaging of the micro-nano motor in the organism, and breaks through the technical bottleneck that the micro-nanomotor is difficult in tracking and imaging in the organism.

Description

technical field [0001] The invention relates to the application field of micro-nano motors, in particular to a photoacoustic signal detection and imaging method based on micro-nano motors. Background technique [0002] In 2004, the first complete chemically catalyzed micro-nano motor was born—Au / Pt bimetallic nanowires, which consume hydrogen peroxide fuel through Pt catalysis to drive the motor. In the following ten years, people have gained a deeper understanding of the driving methods of micro-nano motors, not only in chemically driven micro-nano motors, but also in external field drives, such as external magnetic fields, electric fields, ultrasonic fields, and light. Lots of new motors. These external field-driven motors are extremely important for the application of micro-nanomotors in vivo, because they do not require chemical fuels like chemically driven micro-nanomotors, so they can be applied to drug delivery, biosensing and micro-repair in vivo. [0003] The magn...

AI Technical Summary

Problems solved by technology

On the whole, the first two micro-nano motors are mainly prepared by means of electrodeposition or micro-nano processing, and the preparation process is relatively complicated. Later, many researchers have developed a new micro-nano motor preparation method based on a method similar to rotational motion. surface action driven

But the resulting motor drive speed is lower

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