Ultrasonic precision micro-fluidic chip based on nano motor array and implementation method thereof

A technology for microfluidic chips and implementation methods, applied in fluid controllers, chemical instruments and methods, laboratory appliances, etc., capable of solving the problems of weak sample processing capabilities, complex microfluidic chip structures, and single functions of microparticles of various sizes and other issues, to achieve good biological adaptability, high energy conversion efficiency, and low process difficulty

Active Publication Date: 2020-10-16
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention aims to provide an ultrasonic precision microfluidic chip based on a nanomotor array and its implementation method, which solves the problems of complex structure, single function, low throughput, Weak processing ability for samples containing microparticles of various sizes

Method used

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  • Ultrasonic precision micro-fluidic chip based on nano motor array and implementation method thereof
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  • Ultrasonic precision micro-fluidic chip based on nano motor array and implementation method thereof

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specific Embodiment approach

[0036] An acoustically controlled microfluidic chip comprising an immobilized nanomotor array, the specific implementation of which is as follows:

[0037] As shown in Figure 1(a) and Figure 1(b), the present invention discloses an ultrasonic precision microfluidic chip based on a nanomotor array, including a substrate 1, a nanomotor layer 2, a piezoelectric transducer 3, a cover Plate 4, liquid outlet pipe 5, liquid inlet pipe 6. Substrate 1 is made of quartz glass, with a size of 25×15×0.5mm; cover plate 4 is made of PDMS, with a size of 18×15×2mm; here piezoelectric transducer 3 is made of piezoelectric ceramic sheet (3), made of PZT-8, with a size of 15×5×0.5 mm; the substrate material of the immobilized nanomotor layer 2 is polycarbonate film. During installation, the piezoelectric ceramic sheet 3 is pasted on the upper edge of the quartz substrate 1, and at the same time connected to the electrode and grounded; the nanomotor solidified layer 2 is pasted on the top of th...

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Abstract

The invention discloses an ultrasonic precision micro-fluidic chip based on a nano motor array and an implementation method thereof. The ultrasonic precision micro-fluidic chip comprises a substrate,a cover plate, a piezoelectric transducer, a film fixed with a nano motor, a liquid inlet and outlet pipe and a liquid medium. The piezoelectric transducer excites and drives the whole micro-fluidic chip to vibrate at ultrasonic frequency, a specific acoustic flow field is generated in the micro-channel, meanwhile, a catalyst component contained in the nano-motor promotes the substrate to be decomposed to generate bubbles, and vibration of the bubbles in the acoustic flow field is used for controlling small particles around the bubbles to move along a specific track. The liquid medium is catalyzed by the nano motor array to be decomposed to generate bubbles, and directional movement of tiny particles is controlled by utilizing local acoustic flow field change caused by bubble vibration. According to the micro-particle motion control mode, bubble vibration in the acoustic flow field is used as a power source, the motion speed of the micro-particles is effectively increased, the micro-particles of various shapes and sizes can be controlled, no special requirement is needed for the material of the controlled micro-particles, and thus the application range is wide.

Description

technical field [0001] The invention relates to a micro-nano-mechanical power device, in particular to an ultrasonic precision microfluidic chip based on a nano-motor array and an implementation method thereof. Background technique [0002] Microfluidic technology is a system that controls the flow of a small volume of fluid in a small channel or component. It can save the amount of samples and reagents, reduce the reaction time, reduce the volume of the instrument, and improve the automation of the experiment. It is widely used in experiments. It is widely used in nucleic acid detection, immunoassay, cell analysis and other fields. Among them, the method of combining acoustic waves with microfluidics provides an effective solution for the motion control and experimental analysis of micro-nano objects. Acoustic manipulation technology can be used to achieve precise manipulation of micro-nano-sized objects and their surrounding fluids. This feature also makes this technology...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/50273B01L2200/10B01L2300/0861B01L2300/0887B01L2300/12B01L2400/0436B01L2400/046
Inventor 芦小龙魏莹沈晖赵康东王志文
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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