25 results about "Janus particles" patented technology

The invention provides a composite Janus particle. The composite Janus particle disclosed by the invention can be used for treating the dentin hypersensitivity, not only can be accurately oriented on the surface of the dentin, but also has the effects of inducing mineralization and inhibiting bacteria on the two sides respectively, and has great application potential for treating the dentin hypersensitivity and preventing decayed teeth.

This invention discloses a Janus particle crosslinking agent, a two-step preparation method, and its applications, belonging to the field of functional coating technology. The Janus particle crosslinking agent comprises SiO2 particles, one end of which is modified with a hydrophilic isocyanate group, and the other end with a low surface energy material, hydrogen-containing silicone oil. The Janus particle crosslinking agent with the hydrogen-containing silicone oil as the hydrophobic side can achieve directional arrangement, thereby imparting excellent hydrophobic properties to the coating. Utilizing the isocyanate group of the Janus particle crosslinking agent, it can not only exert its crosslinking effect in the coating but also stabilize the toluene / water Pickering emulsion. The two-step preparation method involves using hydrogen-containing silicone oil as a modifier to prepare J(SiO2·PMHS) particles via the Pickering emulsion interface method; then, using isocyanate propyltriethoxysilane as a modifier, a one-pot method is used to prepare the Janus particle crosslinking agent with the isocyanate group as the hydrophilic end and the hydrogen-containing silicone oil as the hydrophobic end. The isocyanate groups in the crosslinking agent are directly modified on one side of the Janus particles, thereby enabling them to play their crosslinking role in the coating and improving the wear resistance of the coating.

The application discloses a method for preparing a high-stability W / O / W type multiple Pickering emulsion based on Janus particles and belongs to the technical field of colloid and interface chemistry. Different chain length alkyl silane is used to modify SiO2 to prepare Janus particles with different hydrophilicity and hydrophobicity, the multiple emulsion is co-stabilized, different types of Janus particles are adsorbed on different oil-water interfaces, the interfacial activity and amphiphilicity of the Janus particles are fully exerted, and the high-stability multiple emulsion is prepared. The multiple emulsion has excellent stability, is stable under conditions of long-term storage, strong acid and strong base and high-concentration electrolyte, and can effectively expand the practical application of the multiple emulsion.

The invention provides a preparation method of snowman-shaped Janus particles, the snowman-shaped Janus particles prepared by the method and application of the snowman-shaped Janus particles. The preparation method comprises the following steps: 1, preparing solid microspheres by using a stepped asymmetric T-shaped tube with a micro-channel; 2, silicon oxide is prepared on the surfaces of the solid microspheres through a polymerization reaction and a sol-gel reaction; wherein the snowman-shaped Janus particles comprise a microsphere part and a convex part in contact with the microsphere part, the microsphere part is a solid microsphere containing a cross-linked polymer, the convex part contains silicon oxide, and the average particle size of the snowman-shaped Janus particles is 0.5-60 [mu] m. The snowman-shaped Janus particle disclosed by the invention is adjustable in particle size, uniform in distribution and high in particle size stability, and has the characteristics of good biocompatibility and excellent stability and mechanical strength.

The present invention relates to Janus particles for detecting a target material and a method for detecting a target material using same and, more specifically, to Janus particles for detecting a target material and a method for detecting a target material using same, wherein the Janus particles vary in orientation depending on whether a mass label is bound thereto, and, by including a first surface and a second surface satisfying formula 1, are simple and economical and have high sensitivity.

The invention relates to a magnetic snowman-shaped Janus particle and a manufacturing method thereof. The magnetic snowman-shaped asymmetric Janus particle comprises a hydrophilic part and an oleophylic part, the hydrophilic part comprises solid or porous polymer microspheres subjected to hydrophilic modification and at least one part of magnetic nanoparticles attached to the surfaces of the polymer microspheres, the oleophylic part comprises silicon oxide subjected to hydrophobic modification, and the size of the Janus particle ranges from 200 nm to 1500 nm. The magnetic snowman-shaped asymmetric Janus particle disclosed by the invention is high in magnetic response speed and excellent in settleability, solvent resistance and mechanical strength.

The application discloses a preparation method of double-load food-grade Janus particles, and comprises the following steps: S1, dissolving zein, shellac, curcumin and resveratrol in ethanol, and performing ultrasonic dispersion to obtain a mixed alcohol solution of zein, shellac, curcumin and resveratrol; adding Tween 80 into deionized water, and performing ultrasonic dispersion to obtain a Tween 80 aqueous solution; S2, taking the mixed alcohol solution as an inner phase, taking the Tween 80 aqueous solution as an outer phase, and passing through a coaxial flow focusing type chip to obtain a dispersion liquid of the double-load food-grade Janus particles in the Tween 80 aqueous solution; and S3, placing the dispersion liquid into a dialysis bag to dialyze for a certain time, and performing freeze-drying to obtain the Janus particles. The preparation method has low cost, good particle loading effect and easy scale production. The application further provides the double-load food-grade Janus particles and application of the double-load food-grade Janus particles in loading and delivering curcumin and resveratrol. The Janus particles have the beneficial effect of high loading rate.

The present application relates to the technical field of functional coating materials, and particularly relates to a Pickering emulsion containing Janus particles and a preparation method and application thereof, the preparation method comprising the following steps: hydrophilic particles are subjected to a silanization reaction to obtain hydrophobic modified particles; a film-forming polymer is mixed with a solvent as an oil phase; the hydrophobic modified particles, the oil phase and an ionized water solution of a bonding compound are mixed, and after ultrasonic emulsification, a Pickering emulsion is obtained. In the present application, the hydrophobic modified particles are used as Pickering stabilizers, the ionized water solution of the bonding compound with both reactivity and bonding function is used as an aqueous phase, and the solvent containing a low-surface-energy film-forming polymer is used as an oil phase. In the process of high-shear emulsification, the hydrophobic modified particles migrate to the oil-water interface, the strong alkaline environment provided by the ionized water solution of the bonding compound hydrolyzes the hydrophobic layer on the side of the hydrophobic modified particles in contact with the aqueous phase, and the surface of the particles is in situ changed from isotropic hydrophobicity to hydrophilic / hydrophobic amphiphilic Janus structure.

The present invention relates to the technical field of colloid and interface chemistry, and disclosed are a method for preparing a high-stability W / O / W-type multiple Pickering emulsion on the basis of Janus particles, and a use. The present invention uses alkylsilanes of different chain lengths to modify SiO2, thereby preparing Janus particles having distinct hydrophilic and hydrophobic properties, which jointly stabilize a multiple emulsion; and different types of Janus particles are adsorbed on different oil-water interfaces, fully exerting the interfacial activity and amphiphilicity of the Janus particles, thereby preparing a high-stability multiple emulsion. The multiple emulsion of the present invention has excellent stability, and remains stable under conditions such as long-term storage, strong acids and bases, and high-concentration electrolytes, thereby effectively expanding the practical application of the multiple emulsion.

The invention discloses a method for asymmetrically assembling Janus microspheres in micro-droplets and application, and the method for assembling the Janus microspheres comprises the following steps: S1, preparing hydrophobic micron particles; s2, preparing hydrophilic nanoparticles; s3, performing asymmetric assembly in the micro-droplets to prepare Janus particles; and S3-2, preparation of the Janus microspheres. The microspheres prepared by the method are characterized in that hydrophilic nano-particles are distributed on one side of hydrophobic micro-particles, and the particle diameter is 0.1-10 microns; the self-propelled Janus microspheres are prepared by loading a MnO2 catalyst in situ on nano-particles which are asymmetrically distributed on the MnO2 catalyst. The Janus microsphere can be decomposed on one side of the microsphere in an H2O2 solution to generate oxygen, and the movement of the microsphere is promoted. The diffusion effect of the microspheres in a solution can be enhanced, and the catalytic and pollutant capturing and removing efficiency in the solution can be enhanced.

The application provides a Janus particle based on GMA monomer emulsion polymerization and a preparation method and application thereof, and belongs to the technical field of functional materials; the application first synthesizes functional composite particles with fine controllable morphology and structure based on GMA monomer in one step, and then prepares amphiphilic PFC-PGMA-NH2 Janus particles based on the functional composite particles; the particles prepared by the method have a topological structure that can be accurately controlled, and the method has the advantages of simple process, low cost and environmental friendliness; the PFC-PGMA-NH2 Janus particles are expected to be used for protein immobilization and interfacial biological catalysis, and have good practicability.

The invention discloses a Janus magnetic particle preparation and separation device which mainly comprises an upper chip integration, a lower chip integration and an adjustable three-dimensional magnetic field generation structure. The upper chip integration comprises a cover plate, a runner layer and a transparent substrate; a hollow groove is formed in the center of the transparent substrate, and the runner layer is located above the hollow groove; the cover plate is provided with a hollow groove and a hollowed-out groove, the flow channel layer and the transparent substrate are sequentially embedded in the cover plate, the flow channel layer and the cover plate are located on the same horizontal line, and the upper chip integration and the lower chip integration are connected in a sealed mode. The adjustable three-dimensional magnetic field generating device mainly comprises a cylindrical coil base frame, a coil assembly and a sliding block. According to the device, the problem that all modules cannot be flexibly disassembled, assembled and combined is solved, and an upper runner layer and a lower runner layer are freely replaced, so that Janus particles contain stable double-phase components; the cylindrical base frame and the sliding block can move freely, each coil can be independently disassembled, assembled and driven, the magnetic field intensity, the range and the direction are changed, and the particle sorting problem in each range can be highly solved.

A cosmetic composition, comprising Janus particles, wherein the Janus particles are constituted by concave fragments of hollow spherical particles with internal surface energy a and external surface energy B, an aqueous phase and an organic phase, and wherein the Janus particles are comprised between 0.01% by weight and 99.99% by weight and the sum of aqueous phase and organic phase is between 0.01% by weight and 99.99% by weight.

The present invention discloses a high-efficiency temperature-control and anti-cracking protective coating for concrete structures. This high-efficiency temperature-control and anti-cracking protective coating is prepared by mixing a resin containing a Janus special filler and a curing agent strong material. The present invention introduces Janus particles with large and small composite surface amphiphilic partitions as particulate fillers. During the coating drying and curing process, the composite Janus filler particles undergo a particle enrichment self-assembly process under relevant effects to form a regular microstructure with a cluster shape, and the microstructures also produce particle interactions, so that the surface of the cured coating presents a regular micro-nanostructure distribution. Compared with the irregular uniform distribution of traditional isotropic particle fillers, the regular microstructure formed by the composite Janus particle filler during the drying and curing process significantly improves the reflection, scattering and heat radiation capabilities of the coating surface to sunlight, and significantly enhances the thermal insulation and temperature control capabilities. Compared with conventional surface microstructure treatment processes, the present invention utilizes compounded Janus particle fillers to self-assemble and spontaneously form a regular microstructure. The process is relatively simple, not limited to specific professional equipment, and can be produced and applied on a large scale. It is of great significance for temperature control, protection, energy conservation and environmental protection of concrete structures in exposed environments under various conditions.

A 3-D printer apparatus has a tank that includes a bottom wall and a printing area that is located above and spaced apart from the bottom wall. At least a portion of the tank is filled with a polymerizable resin used to print an object within the printing area. The bottom wall is transparent and defines an upper surface. A layer of Janus particles overlays the upper surface of the bottom wall. Each of the Janus particles has a hydrophobic side and a hydrophilic side, with the hydrophilic side directly overlaying the upper surface of the bottom wall. The layer of Janus particles defines a barrier that prevents small bits of cured polymerizable resin within the tank from becoming attached to the upper surface of the bottom wall during the printing process.

The application provides a soap-free high-efficiency fluorine-containing easy-to-remove finishing agent prepared by Janus Pickering method, a preparation method and application on fabrics, and the finishing agent comprises the following components in percentage by mass: effective substance 25% and water. The effective substance is obtained by emulsion polymerization reaction of perfluorohexyl ethyl methacrylate, methacryloyloxyethyl trimethyl ammonium chloride, methoxy polyethylene glycol methacrylate, octadecyl methacrylate and hydroxyethyl methacrylate. The stabilizer used is fluorinated Janus particles obtained by asymmetric modification of SiO2 particles. The application of the application eliminates the use of small molecule emulsifiers, has better three-proofing effect and easy-to-remove effect, and has better washing resistance compared with the prior art. The application belongs to an environmentally-friendly finishing agent, has no biological toxicity and non-degradability, has simple process, mild conditions, and green and efficient production process.

The invention relates to a preparation method of snowman-shaped 3-APF (at) mSiO2Janus particles and application of the snowman-shaped 3-APF (at) mSiO2 Janus particles. According to the method, tetraethyl silicate is adopted as an oil drop template and a precursor of SiO2 at the same time, and Janus particles with rich mesopores and two end compositions of 3-APF and SiO2 are obtained under the combined action of positive and negative charges and interfacial tension; the particles serve as a carrier of a color developing agent and a compatibilizer of linseed oil and WPU, and the intelligent anti-corrosion coating with corrosion self-reporting and damage self-repairing functions is obtained. The method breaks through the limitation that an existing emulsion template technology can only be used for preparing single-component Janus particles, avoids a later complex template removal step, and has the advantages of being simple in step, suitable for large-scale preparation of the Janus particles and the like.

Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

The invention provides hollow amphiphilic Janus particles as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) taking a linear polystyrene seed emulsion as a dispersion phase; taking a first surfactant as a water phase, taking a divinyl benzene monomer and a first initiator as an oil phase, emulsifying the water phase and the oil phase, adding the dispersed phase, and polymerizing to obtain PS / PDVB nanosphere emulsion; (2) removing oxygen to obtain a seed emulsion, dropwise adding the pre-emulsion, and reacting to obtain Janus particles; the pre-emulsion contains a second surfactant, a second initiator and a silane coupling agent; (3) dispersing in a first organic solvent, and carrying out solid-liquid separation to obtain SiO2 (at) PDVB particles; and (4) dispersing in a second organic solvent, adding a silane modifier containing an epoxy group, and reacting to obtain the hollow amphiphilic Janus particles. The hollow amphiphilic Janus particles prepared through seed emulsion reaction are high in controllability and can be prepared on a large scale.

A method for using tadpole-shaped Janus single-chain particles for material surface modification comprises: using N,N-dimethylformamide, methanol or chloroform as a solvent to configure the tadpole-shaped Janus single-chain particles into a Janus particle modification liquid; applying the Janus particle modification liquid to the surface of a metal, oxide or plastic material by immersion or spraying, so as to modify the tadpole-shaped Janus single-chain particles on the surface of the material to be modified. The tadpole-shaped Janus single-chain particles of the present invention have uniform size and clear structure, contain non-covalently cross-linked heads and linear chain tails, and can be used for surface modification of materials by simple immersion or spraying, and the molecular weight length of the brush layer can be adjusted over a wide range. The Janus particles of the present invention have strong surface binding force, excellent bonding stability, and present a configuration in which the non-covalently cross-linked heads are located on the surface of the modified layer, while the functional linear chain tails are located outside the coating, thereby achieving efficient functionalization of the material surface.

The invention discloses an amphiphilic Janus particle and a preparation method of a durable hydrophobic coating. The Janus particle is prepared from a high-surface-energy light-cured resin prepolymer and a low-surface-energy light-cured prepolymer and has two surface areas, and the two sides of the Janus particle show polar and non-polar properties respectively; the surface energy of the high-surface-energy light-cured resin prepolymer is higher than 20mN / m; the surface energy of the low-surface-energy light-cured resin prepolymer is lower than 20 mN / m. The preparation method comprises the following steps: uniformly dispersing Janus particles, film-forming resin and an organic solvent to prepare a Janus particle dispersion liquid, spraying the dispersion liquid on a base material to prepare a coating, and then drying and curing to prepare the durable hydrophobic coating. By regulating and controlling the two ends of the Janus particles, the problem that durability is insufficient when a hydrophobic coating is prepared through a spraying method can be solved, the service life of the hydrophobic coating is prolonged, and the method has wide application prospects.

The invention discloses Janus particles and a preparation method thereof, a Pickering emulsion prepared from the Janus particles and a method and application of the Pickering emulsion, and belongs to the technical field of medicines. The preparation method of the Janus particles comprises the following steps: dissolving a hydrophobic polymer and a hydrophilic polymer in a solvent to prepare a mixed solution; adding water and a surfactant, uniformly mixing, and emulsifying to form a primary emulsion; carrying out rotary evaporation on the primary emulsion, and removing the solvent to obtain a concentrate; and washing and drying to obtain the Janus particles. The invention further discloses the Janus particles prepared by adopting the method, a method for preparing the radix saposhnikoviae Pickering emulsion by adopting the particles, and application of the radix saposhnikoviae Pickering emulsion in preparation of medicines for relieving and treating arthritis. The method for preparing the amphiphilic Janus particles is a simple and convenient method capable of expanding production. The Pickering emulsion prepared by adopting the compound shows high stability, slow release characteristic and shear thinning behavior, and is suitable for emulsifiable paste or emulsion dosage forms.

The invention provides snowman-shaped Janus particles as well as a preparation method and application thereof. The snowman-shaped Janus particle is provided with a microsphere part and a protruding part located on the surface of the microsphere part, the microsphere part is a solid microsphere containing a cross-linked polymer, the protruding part contains silicon oxide, and the average particle size of the snowman-shaped Janus particle is 0.5-80 micrometers. The snowman-shaped Janus particle disclosed by the invention is adjustable in particle size, uniform in distribution and high in particle size stability, and has the characteristics of good biocompatibility and excellent stability and mechanical strength. The snowman-shaped Janus particles with different particle sizes can meet different drug loading and adsorption requirements.

The invention relates to a composite snowman-shaped Janus particle as well as a preparation method and application thereof. The composite snowman-shaped Janus particle has an organic polymer part and a silicon-containing material part, the organic polymer part is a solid sphere containing a linear polymer and a cross-linked polymer, the silicon-containing material part contains silicon oxide, and the size of the composite snowman-shaped Janus particle is 0.5-60 [mu] m.