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Preparation method for janus structure based rapid hemostatic agent having directional propulsion function

A technology of hemostatic agent and function, which is applied in the field of preparation of rapid hemostatic agent with directional propulsion function, can solve the problems of lack of intelligent self-propelling and unsatisfactory hemostatic effect, and achieve good biodegradability and good biocompatibility , easy processing effect

Active Publication Date: 2020-05-12
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the powder hemostatic materials including the above-mentioned patents do not have the function of intelligent self-propelling or cannot be driven toward the depth of the wound under the action of an external field force. Under the physical impact of blood, it is often difficult for these powder hemostatic materials to reach the bleeding point deep in the wound to exert a rapid coagulation effect after being sprinkled on the wound, so the hemostatic effect is not ideal

Method used

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  • Preparation method for janus structure based rapid hemostatic agent having directional propulsion function
  • Preparation method for janus structure based rapid hemostatic agent having directional propulsion function
  • Preparation method for janus structure based rapid hemostatic agent having directional propulsion function

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Experimental program
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Effect test

Embodiment 1

[0045] A preparation method based on a Janus structure-based rapid hemostatic agent with directional propulsion function, comprising the following steps:

[0046] S1: Add 40g of cornstarch to 200ml of sodium acetate buffer solution with a pH of 4.6 containing α-amylase and glucoamylase for reaction, heat at 40°C and stir at a speed of 250r / m for 10h, filter after the reaction is completed, wash the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 0.6 g of sodium carbonate and 1.2 g of sodium trimetaphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the solution The pH value is 11, after the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase to glucoamylase is 1:4, and the ratio of amylase to cornstarch is 2: 100.

[0047] S2: Stir and...

Embodiment 2

[0051] A preparation method based on a Janus structure-based rapid hemostatic agent with directional propulsion function, comprising the following steps:

[0052] S1: Add 40g of tapioca starch to 200ml of sodium acetate buffer solution containing α-amylase and glucoamylase at a pH of 4.6 to react, heat at 35°C and stir at a speed of 250r / m for 12h, filter after the reaction is completed, wash the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 0.2 g of sodium carbonate and 0.8 g of sodium hexametaphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the solution The pH value is 11, after the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase and glucoamylase is 1:4, and the ratio of amylase and tapioca starch is 2: 100.

[0053] S2: Sti...

Embodiment 3

[0057] A preparation method based on a Janus structure-based rapid hemostatic agent with directional propulsion function, comprising the following steps:

[0058] S1: Add 40g of wheat starch to 200ml of sodium acetate buffer solution with a pH of 4.6 containing α-amylase and glucoamylase for reaction, heat at 55°C and stir at a speed of 250r / m for 6h, filter after the reaction is completed, clean the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 2 g of sodium carbonate and 4 g of sodium tripolyphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the pH value of the solution After the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase to glucoamylase is 1:4, and the ratio of amylase to wheat starch is 2:100.

[0059] S2: Stir and mix 1...

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Abstract

For defects that existing hemostasis research and products cannot intelligently perform self-propelling or cannot be driven to forward deep in the wound under the action of external field force, the invention provides a preparation method for a janus structure based rapid hemostatic agent having a directional propulsion function. The preparation method includes performing esterification on microporous starch to unidirectionally grow calcium carbonate particles so as to obtain esterified microporous starch / calcium carbonate Janus particles; fixedly assembling thrombin on the surfaces of the esterified microporous starch / calcium carbonate Janus particles to obtain esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin; mixing the esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin and protonated tranexamic acid powder so as to obtain the janus structure based rapid hemostatic agent having a directional propulsion function. Through the formation of the biphasic heterogeneous Janus structure, the unidirectional and intelligent self-propulsion of hemostatic starch can be realized by cooperating with the protonated tranexamic acid, so that rapid three-dimensional hemostasis on deep wounds, penetrating wounds and irregular wounds such as aortic / venous rupture can be realized.

Description

technical field [0001] The invention is applied in the technical field of hemostatic materials, and in particular relates to a preparation method of a rapid hemostatic agent with a directional propulsion function based on a janus structure. Background technique [0002] The new powder hemostatic material is a type of product that realizes hemostasis by concentrating blood coagulation factors based on the water absorption mechanism of molecular sieves. Thanks to its excellent liquid-like fluidity, it is suitable for the control of various irregular wound bleeding. Among them, the most representative one is the starch-based powder hemostatic material. Compared with traditional inorganic powder hemostatic materials (zeolite, kaolin and montmorillonite, etc.), starch-based powder has a natural microsphere structure, generally 10-80 μm in diameter, has a larger specific surface area, and can quickly absorb blood Water can effectively concentrate the coagulation components in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/00A61L24/02A61L24/08
CPCA61L24/0015A61L24/0036A61L24/02A61L24/08A61L24/108A61L2300/254A61L2300/418A61L2400/04C08L3/02C08L89/00
Inventor 蓝广芊李庆胡恩岭陆飞谢瑞琪余堃
Owner SOUTHWEST UNIVERSITY
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