Medical hemostatic material capable of rapidly forming film after being sprayed, and application method of medical hemostatic material

A hemostatic material, a technology of spray film formation, applied in the field of medical materials, can solve the problems of difficult operation, difficult to effectively stop bleeding, secondary damage, etc., to achieve good biocompatibility, reduce wound damage, and promote healing effects.

Inactive Publication Date: 2018-07-24
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the problem that the currently widely used rapid adsorption hemostatic materials are difficult to effectively stop bleeding, and there are high requirements when supplemented with compression hemostasis, it is difficult to effectively compress hemostasis, bandage hemostasis is difficult to operate, and it is easy to cause secondary damage. The present invention proposes a rapid The medical hemostasis material and its application method that are sprayed into a film can effectively realize rapid hemostasis, and it is convenient to bandage and has good safety

Method used

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  • Medical hemostatic material capable of rapidly forming film after being sprayed, and application method of medical hemostatic material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The hemostatic material consists of:

[0031] The medical hemostatic material consists of liquid A and liquid B.

[0032] The preparation process of liquid A is: add 10 parts by weight of silica airgel powder, 13 parts by weight of chitosan microspheres, 7 parts by weight of graphene and 13 parts by weight of gelatin particles into 57 parts by weight of natural rubber emulsion, ultrasonically disperse Uniform, prepared A liquid; the average particle size of silica airgel powder is 6μm, and the density is 0.09g / cm 3 , the porosity is 95%; the average particle size of chitosan microspheres is 12μm, and the porosity is 94%; graphene is single-layer graphene, the average particle size is 14μm, and the specific surface area is 2200m 2 / g, the porosity is 95%; the gelatin particles are skin gelatin particles, the average particle size is 32 μm; the solid content of the natural rubber emulsion is 46%, the pH value is 6.5, and the rubber hydrocarbon content in the natural rubb...

Embodiment 2

[0041] The hemostatic material consists of:

[0042] The medical hemostatic material consists of liquid A and liquid B.

[0043] The preparation process of liquid A is: add 8 parts by weight of silica airgel powder, 10 parts by weight of chitosan microspheres, 6 parts by weight of graphene and 11 parts by weight of gelatin particles into 65 parts by weight of natural rubber emulsion, and ultrasonically disperse Uniform, prepared A liquid; the average particle size of silica airgel powder is 4μm, and the density is 0.06g / cm 3 , the porosity is 95%; the average particle size of chitosan microspheres is 5 μm, and the porosity is 92%; graphene is double-layer graphene, the average particle size is 10 μm, and the specific surface area is 2000 m 2 / g, the porosity is 94%; the gelatin particles are bone gelatin particles, the average particle size is 20 μm; the solid content of the natural rubber emulsion is 40%, the pH value is 6, and the rubber hydrocarbon content in the natural r...

Embodiment 3

[0052] The hemostatic material consists of:

[0053] The medical hemostatic material consists of liquid A and liquid B.

[0054] The preparation process of liquid A is: add 12 parts by weight of silica airgel powder, 15 parts by weight of chitosan microspheres, 10 parts by weight of graphene and 14 parts by weight of gelatin particles into 49 parts by weight of natural rubber emulsion, ultrasonically disperse Uniform, prepared A liquid; the average particle size of silica airgel powder is 10 μm, and the density is 0.12g / cm 3 , the porosity is 998%; the average particle size of chitosan microspheres is 20μm, and the porosity is 96%; graphene is few-layer graphene, the average particle size is 20μm, and the specific surface area is 2500m 2 / g, the porosity is 99%; the gelatin particles are tendon gelatin particles, the average particle size is 40 μm; the solid content of natural rubber emulsion is 50%, the pH value is 7, and the content of rubber hydrocarbon in natural rubber i...

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Abstract

The invention provides a medical hemostatic material capable of rapidly forming a film after being sprayed, and an application method of the medical hemostatic material. The medical hemostatic material capable of rapidly forming the film after being sprayed is formed by liquid A and liquid B, wherein the liquid A is prepared by adding silicon dioxide aerogel powder, chitosan microspheres, grapheneand gelatin particles into natural rubber emulsion, and evenly dispersing; the liquid B is prepared by evenly dispersing lactic acid, alginic acid and polyacrylic emulsion; when the medical hemostatic material is in use, the liquid A and the liquid B are simultaneously sprayed out and mixed together, so that a hemostatic film is formed at a wound, and the aim of rapid hemostasis is further achieved. The hemostatic material provided by the invention can rapidly form the hemostatic film with strong adhesive pressure for stopping bleeding, and a material having a function of absorbing blood is adopted, so that the hemostatic film can be closely adhered to the wound, and the aims of rapidly stopping bleeding and reducing wound damage are achieved; the medical hemostatic material is not only excellent in hemostasis, but also can effectively promote the healing of the wound, has good biocompatibility, does not need to be individually wrapped, and is convenient to use, thus being a necessarymaterial for first-aid and household use.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to the preparation and application of a medical hemostatic material, in particular to a medical hemostatic material rapidly sprayed into a film and an application method thereof. Background technique [0002] Bleeding is not only the second leading cause of death in trauma patients, massive bleeding and trauma are the main risk factors for coagulopathy, bleeding also plays an important role in late morbidity and mortality, persistent hypotension, sepsis, massive Erythrocyte and plasma product transfusion can lead to multiple organ failure. Therefore, for surgeons, hemostasis is an important challenge in clinical work. The direct consequence of achieving rapid hemostasis is to improve hemodynamic stability and avoid the potential negative effects of blood transfusion. [0003] At the earliest, bandaging was mainly used for hemostasis, but the hemostatic effect was poor. With the dev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/06A61L24/02A61L24/00
CPCA61L24/104A61L24/001A61L24/0026A61L24/0036A61L24/02A61L24/06A61L24/08A61L2400/04C08L5/08C08L7/00C08L33/02
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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