188results about How to "Effective hemostasis" patented technology

The invention relates to the adhesion of platelet GpIbα to strand β3 of domain A1 of von Willebrand factor (vWF), the strand β3 comprising amino acid residues at amino acid position 560-566 and / or a functional part or equivalent thereof, the platelet GpIbα, the GpIbα region comprising an amino acid sequence corresponding to a beta-switch loop of platelet GpIbα, comprising amino acid residues at amino acid position 227-242 and / or a functional part or equivalent thereof. The invention provides a method of interfering with adhesion of blood platelets to vWF that includes modulating adhesion. The invention further provides proteinaceous compounds, antibodies, medicaments and pharmaceutical compositions to that end. The invention also provides means and methods to increase platelet adhesion by topical application of a compound increasing platelet adhesion.

For defects that existing hemostasis research and products cannot intelligently perform self-propelling or cannot be driven to forward deep in the wound under the action of external field force, the invention provides a preparation method for a janus structure based rapid hemostatic agent having a directional propulsion function. The preparation method includes performing esterification on microporous starch to unidirectionally grow calcium carbonate particles so as to obtain esterified microporous starch / calcium carbonate Janus particles; fixedly assembling thrombin on the surfaces of the esterified microporous starch / calcium carbonate Janus particles to obtain esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin; mixing the esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin and protonated tranexamic acid powder so as to obtain the janus structure based rapid hemostatic agent having a directional propulsion function. Through the formation of the biphasic heterogeneous Janus structure, the unidirectional and intelligent self-propulsion of hemostatic starch can be realized by cooperating with the protonated tranexamic acid, so that rapid three-dimensional hemostasis on deep wounds, penetrating wounds and irregular wounds such as aortic / venous rupture can be realized.

It is disclosed herein that protein C functions as a hemostatic agent. Thus, provided is a method of preventing, treating or ameliorating abnormal bleeding in a subject, comprising administering to the subject a protein C polypeptide or polynucleotide. Abnormal bleeding can result from a bleeding disorder, such as hemophilia or a platelet disorder, or from a bleeding episode, such as from a traumatic injury.

The invention discloses an injectable type self-healing hemostatic material as well as a preparation method and application thereof. The injectable type self-healing hemostatic material is obtained by self-assembling macromolecular microgel particles with surface charges through electrostatic interaction between the particles or the particles and macromolecules. The electrostatic action between the microgel particles or the particles and the macromolecules is physical crosslinking and has reversibility, so the hemostatic material prepared by the method has high injectability, self-healing capability and high mechanical strength, does not need to introduce chemical crosslinking reaction in the injection and solidification process, is different from chemical macromolecules, does not introduce a micromolecular crosslinking agent, has high biocompatibility, can be degraded and absorbed, does not have toxic or side effects, has high safety and makes wide application in the field of biomedicine possible.

Hemostatic devices and methods of making same are disclosed. Disclosed hemostatic devices include biocompatible non-oxidized regenerated cellulose. The disclosed hemostatic devices are effective in providing and maintaining hemostasis in cases of moderate to severe bleeding caused by non-compressional and / or non-tourniquetable injuries, among other things. The disclosed methods enable manufacture of a bioabsorbable, biocompatible, biodegradable carboxylmethyl cellulose having high stability and high adherence.

The invention relates to application of a hemostasis material of sodium alga acid and sodium alga acid added calcium salt or zinc salt composition in wound surface hemostasis. The sodium alga acid composition comprises 50-100 parts by weight of sodium alga acid and 0.5-50 parts by weight of calcium salt. The invention also provides a hemostasis material prepared from the sodium alga acid composition and at least one pharmaceutically acceptable solvent, carrier and / or excipient. The sodium alga acid composition and the hemostasis material in the invention have the characteristics of rapid hemostasis, good biocompatibility, biodegradation absorbability, simpleness in treatment, no need of debridement, low cost and the like, and is suitable for the hemostasis in the wound surface, especially in war wound surface.

The invention discloses a woman hemostatic absorption plug which comprises a plug body. The woman hemostatic absorption plug is characterized in that the plug body consists of a plug core and an outer layer for packaging the plug core, the plug body is formed by rolling an activated carbon fiber felt textile, the outer layer is made of chitin-chitosan non-woven fabrics, and a lead-out line is fixed on the plug body. By using the adsorption and drainage actions of activated carbon fibers as well as the good biocompatibility, the haemostatic action, the antibacterial action, the bacteriostatic action and the healing promoting action of chitin-chitosan fibers, pathogens and bad secretions in a vagina are adsorbed and taken out of bodies, thereby achieving the purposes of disease cure and prevention. The woman hemostatic absorption plug is safe, nontoxic, harmless and non-irritant to human bodies.

The invention discloses a preparation method of a hemostatic sponge, comprising the following steps: (1) dispersing oxidized cellulose powder into water to obtain 0.1-2.0wt% of oxidized cellulose dispersion, and then homogenizing the oxidized cellulose dispersion under high pressure to obtain a nanooxidized cellulose suspension; (2) injecting the nanooxidized cellulose suspension into a mold, performing 1 to 7 times of freeze-thaw cycles to obtain nanocellulose hydrogel, freezing the nanocellulose hydrogel for sizing, and then drying to obtain the hemostatic sponge; wherein one freeze-thaw process is: freezing for 8-16 h at -40 to -18 DEG C, and then unfreezing for 8-16 h at 4-25 DEG C. The invention also provides the hemostatic sponge prepared by the preparation method. The hemostatic sponge has high carboxyl content, high porosity and water absorption capacity, and can quickly absorb excess blood on the wound surface to achieve effective hemostasis.

The invention provides an arteria cruralis compression hemostasis device. After the transfemoral coronary intervention operation is completed, hemostasis is carried out on the puncture point. The arteria cruralis compression hemostasis device comprises an air bag type compressing assembly, a splint, at least one horizontal bandage assembly and an inclined bandage assembly, wherein the air bag type compressing assembly is provided with an inflatable air bag and a compressing block mounted on the bottom end of the inflatable air bag and pressing the puncture point; the splint is arranged on the bottom of the thigh at the puncture side, and is provided with an upper end part crossing the hip joint; two ends of the at least one horizontal bandage assembly are mounted on the left and right side edges of the splint, and the splint is fixed to the bottom of the thigh at the puncture side; the inclined bandage assembly is provided with an inclined bandage extending along the hip joint and fixing the air bag type compressing assembly to the puncture point.

The invention relates to the technical field of medical materials, in particular to a preparation method of blended functional surgical irrigating fluid. The method includes: respectively taking 4% of sterile sodium carboxymethyl cellulose and 1% of sterile sodium alginate, disposing the two into a stirring container with a circulating device, adding purified water for swelling under the sterile condition, heating up, stirring well, obtaining a clear and transparent blended solution of the sodium alginate and the sodium carboxymethyl cellulose, and cooling the solution to normal temperature; and taking 1% of soluble lysozyme powder, adding 9% of sodium chloride solution into the powder and stirring, slowly pouring into the blended solution while stirring, mixing well, and using hydrochloric acid to adjust pH to 4.0-7.5. The preparation method of the blended functional surgical irrigating fluid has the advantages that the irrigating fluid prepared by the method is suitable for errhysis and exudation in surgery and trauma, can effectively stop bleeding and promote tissue healing, has an antibacterial action, and is complete in degradation, capable of being absorbed and utilized by bodies, free of side effect on the bodies, and safe in use.

The invention relates to a foldable portable first-aid external fixation bracket for bone fracture, which comprises an external liner, wherein an air bag is arranged on the external liner; the air bag can be inflated, and a plurality of bulges are formed on the surface of the air bag after the air bag is inflated; multiple sets of foldable connecting rods arrayed in parallel are arranged between the air bag and the external liner; each set of connecting rods comprises a plurality of sleeves; a sleeve core capable of sliding into the sleeves is arranged between each two sleeves; a guide rope which is fixed with the sleeve cores of each set of connecting rods and is used for sliding the sleeve cores is penetrated through the interiors of the sleeve cores and the sleeves of each set of connecting rods; pulling handles are arranged at the two ends of the external liner; lacings are arranged on the two sides of the external liner. The foldable portable first-aid external fixation bracket for bone fracture is foldable and portable, can be contained in a knapsack or haversack, is convenient to carry and is especially fit for field first-aid fixation for outdoor limb fracture.

The invention relates to a hemostasis spraying type adhesive and a preparation method thereof. The method comprises the following steps: preparing an adhesive solution; preparing nanometer grains; preparing an amine chitosan derivative; preparing the final adhesive. The adhesive prepared according to the method has the advantages that the gelation time required by adhesion is short, the mechanical strength is excellent, the bleeding can be quickly stopped and the adhesive also has quick and strong adhering property even under the existence of water.

The invention provides a hybrid fiber sponge with hemostasis and wound repair functions and a preparation method thereof. The hybrid fiber sponge is formed by processing after soaking a freeze-dried sponge in an ethanol solution of 1-ethyl-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, wherein the freeze-dried sponge is formed by freeze-drying hydrogel formed by crosslinking polyphenol modified chitosan and a protein material and has a composite three-dimensional network structure; and in the process that the freeze-dried sponge is soaked in the ethanol solution of 1-ethyl-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, carboxyl and amino in the freeze-dried sponge form amido bonds, and meanwhile, the protein material in the freeze-dried sponge are denatured to form beta folds, so that the hybrid fiber sponge is of a porous structure. The hybrid fiber sponge provided by the invention can take effects of inhibiting bacteria and promoting tissue regeneration while stopping bleeding, and is suitable for various bleeding models such as body surface oppression bleeding and in-vivo non-oppression bleeding.

The invention discloses a composite hemostatic material for external trauma and a preparation method thereof. The hemostatic material comprises a porous material, a metal oxide and a high molecular polysaccharide, and the mass ratio is 1: 0.50-0.01: 5-0.05, and the pore size range of the porous material is 1 nm-100 mu m. The material has porous structure, can quickly adsorb various proteins in blood, so that coagulation factors are enriched in macropores. The chitosan hydrogel provides a positively charged surface, accelerates the enrichment rate of coagulation factors, and further acceleratesthe coagulation reaction. And the material has good biocompatibility, and can be used in animal models of rat femoral artery trauma for effective hemostasis. The hemostatic material can be made intopowder or added into fabric to make tourniquet, hemostatic sponge and other forms, and is suitable for complex wounds. The hemostatic process does not exothermic has higher safety, and the hemostaticmaterial can still retain efficacy after moisture absorption, and is convenient for long-term storage.

The invention relates to the field of animal medicines, and particularly provides a Chinese medicine composition for stopping bleeding of sawing antler, a preparation method and application thereof. The Chinese medicine composition for stopping bleeding of sawing antler is mainly prepared from the following various raw materials in parts by mass: 32 to 37 parts of herba agrimoniae, 17 to 22 partsof rhizoma bletillae, 7 to 12 parts of radix notoginseng, 7 to 12 parts of Chinese arborvitae twig, 7 to 12 parts of pollen typhae, 7 to 12 parts of radix sanguisorbae and 4 to 6 parts of camphol. According to the Chinese medicine composition for stopping bleeding of sawing antler, rich traditional Chinese medicine resources and the characteristics of easiness for availability of the traditional Chinese medicines, low cost, greenness, no residues and the like are utilized, through a traditional theory of traditional Chinese medicine, rules of assistance and guide of monarch and minister medicines, dialectical treatment and mutual generation and restriction are conformed, and the characteristics of variety of the traditional herbal medicine components and complexity of the functions are used, and the compatibility is reasonable, so that the obtained Chinese medicine composition for stopping bleeding of sawing antler has the effects of quickly stopping bleeding and resisting bacteria andeliminating inflammation and also no side effect.

The invention discloses a collagen aggregate based flocculent antibacterial hemostatic material and a preparation method thereof. The preparation method is characterized by comprising steps as follows: DCMC (dialdehyde carboxymethyl cellulose) and silver nitrate are blended, a mixed solution containing nano-silver is prepared through redox reaction, then certain amount of collagen aggregate and certain amount of polyvinylpyrrolidone are dissolved in the mixed solution sequentially, the mixture is subjected to processes including gradient dilution, dealcoholization, vacuum drying, impregnation, freeze-drying, moderate grinding, sterilization and the like, and the collagen aggregate based flocculent antibacterial hemostatic material is obtained finally. The material adopts the collagen aggregate more similar to a natural tissue collagen structure, and compared with common collagen materials, the prepared flocculent hemostatic material has excellent physical and chemical properties and biological properties such as structural stability, mechanical property, biological degradability, biocompatibility and the like, can promote wound healing and repair, has broad-spectrum antibacterial / antimicrobial activity of the nano-silver, has large contact surface with the wound surface, is high in hydrophilia and stickiness and can be used for hemostasis repair of body surface wound and general civil hemostasis emergency.

The invention discloses a medical hemostasis antibacterial dressing. The medical hemostasis antibacterial dressing is prepared from the raw materials in parts by weight: 60 to 80 parts of polyglutamicacid-Pulullan cross-linked polymer, 25 to 35 parts of collagen, 13 to 17 parts of bamboo vinegar powder, 12 to 18 parts of glycollic acid, 6 to 10 parts of garlic polysaccharide, 5 to 15 parts of hyaluronic acid, and 50 to 60 parts of pure water. The invention also discloses a preparation method of the medical hemostasis antibacterial dressing. The medical hemostasis antibacterial dressing of theinvention has excellent performance for covering wounds, helping the wound healing, efficiently stopping bleeding, preventing the bacterial invasion, promoting the tissue restoration and preventing the adhesion, can rapidly absorb the water in the blood when contacting the wound, can keeping the environment wet, and can effectively seal the bleeding wound.

The invention discloses a pit-hole composite micro-nano-structure polysaccharide microsphere and a preparation method. The preparation method comprises the following steps: (1) preparing a polysaccharide water solution; (2) adding an emulsifying agent into an oil phase so as to prepare the oil phase containing the emulsifying agent, dropwise adding the polysaccharide water solution into the oil phase containing the emulsifying agent, and stirring for emulsification, so as to obtain a uniform emulsion; (3) dissolving a polyvalent metal cross-linking agent into ultrapure water to prepare a cross-linking agent water solution, dropwise adding the cross-linking agent water solution into the uniform emulsion; and (4) adding n-hexane or petroleum ether into liquid obtained in the step (3), standing until the solution is layered, pouring out an upper oil phase layer, remaining a water phase, cleaning the water phase, and carrying out freeze-drying, so as to obtain the pit-hole composite micro-nano-structure polysaccharide microsphere. The surface of the microsphere is provided with nano-scale pits, and nano-scale fine holes are formed in the surfaces of the pits; the microsphere is uniformin particle size distribution, high in porosity and water absorption rate and strong in adsorbability; and the microsphere has good biocompatibility, and hemostasis can be effectively finished within20s-50s.

The invention relates to the adhesion of platelet GpIbα to strand β3 of domain A1 of von Willebrand factor (vWF), the strand β3 comprising amino acid residues at amino acid position 560-566 and / or a functional part or equivalent thereof, the platelet GpIbα, the GpIbα region comprising an amino acid sequence corresponding to a beta-switch loop of platelet GpIbα, comprising amino acid residues at amino acid position 227-242 and / or a functional part or equivalent thereof. The invention provides a method of interfering with adhesion of blood platelets to vWF that includes modulating adhesion. The invention further provides proteinaceous compounds, antibodies, medicaments and pharmaceutical compositions to that end. The invention also provides means and methods to increase platelet adhesion by topical application of a compound increasing platelet adhesion.

The invention discloses an application of a pit-hole composite micro-nano-structure polysaccharide micro-sphere to preparation of haemostatic wound dressing. According to GB / T16886.5-2003 in-vitro cytotoxicity judgment standards, acquired pit-hole composite micro-nano-structure polysaccharide micro-sphere extracting solution has 0-grade cytotoxicity under the concentration of 10-40 micrograms / L and shows good biocompatibility, bleeding can be effectively stopped within 20s-50s, good physical and chemical property is achieved, hemolysis ratio is smaller than 5%, national standards are met, themicro-sphere has an instant haemostatic function for a liver injury wound surface (haemostatic time is shorter than 5 seconds), haemostatic materials are completely degraded 72 hours after, and any residue is omitted. The pit-hole composite micro-nano-structure polysaccharide micro-sphere can stop bleeding within 20 seconds when being used for excessive bleeding of a femoral artery, surgical woundsurface recovers normal one week after, and any haemostatic micro-sphere sample residues are omitted.

The invention discloses a preparation method of a polyurethane bandage with the functions of promoting blood circulation and removing blood stasis and the bandage prepared by the method. The preparation method comprises the following steps of preparing a polyurethane prepolymer and chitosan microspheres with the functions of promoting blood circulation and removing blood stasis, then adjusting the temperature of the polyurethane prepolymer to 55 DEG C, coating the polyurethane prepolymer on base cloth by adopting a double-roller coating method under a nitrogen protection environment in which the moisture content of air is lower than 10%, feeding and rolling the base cloth coated with the polyurethane prepolymer, uniformly spraying the chitosan microspheres with the functions of promoting blood circulation and removing blood stasis, finally rolling, shearing and packaging by using an aluminum plastic compound bag. The preparation method is simple in technology and low in cost. The bandage prepared by the method can be used for accelerating the blood circulation of an affected region and has the functions of promoting blood circulation and removing blood stasis.

The invention provides a preparation method of a composite artificial bone material. The preparation method includes steps: (1) dissolving PLGA into an organic solvent, adding nano hydroxyapatite and beta-tricalcium phosphate, and well mixing to obtain 3D printing ink; (2) subjecting the 3D printing ink to low-temperature deposition printing by 3D printing equipment, and performing freeze drying to obtain a porous bone scaffold; (3) performing negative-pressure pouring of modified starch solution into the porous bone scaffold, and carrying out freeze drying to obtain the composite artificial bone material; (4) subjecting the composite artificial bone material to irradiation sterilization to obtain an artificial bone finished product. The composite artificial bone material is prepared from PLGA, nano hydroxyapatite, beta-tricalcium phosphate and modified starch by compounding, and the modified starch is capable of quickly and effectively stopping bleeding in a bone surgery process and also promoting osteoblast maturation and differentiation.

An external-applied Chinese medicine for promoting the healing of wound and decreasing the generation of scar is prepared from bletilla tuber, Chinese angelica root, dalbergia wood and Chinese gall. Its preparing process is also disclosed.

The invention aims to provide fiber suitable for clinical application, in particular to the application of hemostasis, scalding, chronic wound treatment and others. The invention is a hemostatic material, wherein the hemostatic material includes fiber, and the material is possessed of biodegradability; the hemostatic material is characterized in that the fiber includes a polymer expressed by the following structural formula: FORMULA, wherein R is at least one of groups consisting of -NH2, -CH2CH20H, -OCH2CH2CH2OH, -OH, -ONa, -OK, -OCa; m, n and p respectively represent the quantity percent of corresponding repeat unit in the polymer molecule and can meet the following relationship formula: m+n+p=1, p / (m+n+p)=0.05-0.30; the degree of substitution D is defined as m / (m+n+p), the total degree of substitution of fiber is defined as Ds, and the degree of substitution of polymer at the center of the fiber cross section is defined as D0; when the degree of substitution of the edge of the fiber cross section is defined as D, the following relationship formula can be satisfied: Ds=0.09-0.8, Do / D=0-0.7.

The present invention relates to a haemostatic bio-material composition and method for achieving hemostasis. The method for providing hemostasis generally comprises: supplying a dry potassium phosphate based hemostat mixture comprising: monobasic potassium phosphate, a metal oxide, and a tertiary calcium phosphate, wherein the weight percent ratio of monobasic potassium phosphate to metal oxide is between about 3:1 and 1:1; mixing the dry potassium phosphate based hemostat mixture with an aqueous solution forming an activated hemostat slurry; applying an hemostasis-promoting amount of the activated potassium phosphate based hemostat slurry to a site of bleeding; wherein the site of bleeding is in, on, or proximate to bone.

The invention relates to a novel high-efficiency composite hemostatic sponge and a preparation method thereof. According to the technical scheme, the preparation method comprises the following steps: dissolving Col in acetic acid solution, adding a proper amount of ORC, magnetically stirring at normal temperature until the powder is uniformly dispersed, and performing freeze drying, thereby obtaining a composite material Col-ORC; soaking the composite material Col-ORC in 15-45% ethanol / MES buffer solution, filtering, and removing the filtrate, thereby obtaining a filtered material; taking the filtered material and ethanol / MES buffer solution according to a material-liquid ratio of 1:(2.5-4.5), soaking for 3-6 hours, slowly adding EDC and NHS, reacting for 4-8 hours, neutralizing excessive EDC and NHS by using 1M disodium hydrogen phosphate, filtering, removing the filtrate, and washing by deionized water, thereby obtaining a cross-linked product. The hemostatic sponge prepared by the invention accelerates hemostatic process, does not have biotoxicity and can promote tissue healing.

The present invention relates to a haemostatic bio-material composition and method for achieving hemostasis. The method for providing hemostasis generally comprises: supplying a dry potassium phosphate based hemostat mixture comprising: monobasic potassium phosphate, a metal oxide, and a tertiary calcium phosphate, wherein the weight percent ratio of monobasic potassium phosphate to metal oxide is between about 3:1 and 1:1; mixing the dry potassium phosphate based hemostat mixture with an aqueous solution forming an activated hemostat slurry; applying an hemostasis-promoting amount of the activated potassium phosphate based hemostat slurry to a site of bleeding; wherein the site of bleeding is in, on, or proximate to bone.

The invention provides a medical hemostatic material capable of rapidly forming a film after being sprayed, and an application method of the medical hemostatic material. The medical hemostatic material capable of rapidly forming the film after being sprayed is formed by liquid A and liquid B, wherein the liquid A is prepared by adding silicon dioxide aerogel powder, chitosan microspheres, grapheneand gelatin particles into natural rubber emulsion, and evenly dispersing; the liquid B is prepared by evenly dispersing lactic acid, alginic acid and polyacrylic emulsion; when the medical hemostatic material is in use, the liquid A and the liquid B are simultaneously sprayed out and mixed together, so that a hemostatic film is formed at a wound, and the aim of rapid hemostasis is further achieved. The hemostatic material provided by the invention can rapidly form the hemostatic film with strong adhesive pressure for stopping bleeding, and a material having a function of absorbing blood is adopted, so that the hemostatic film can be closely adhered to the wound, and the aims of rapidly stopping bleeding and reducing wound damage are achieved; the medical hemostatic material is not only excellent in hemostasis, but also can effectively promote the healing of the wound, has good biocompatibility, does not need to be individually wrapped, and is convenient to use, thus being a necessarymaterial for first-aid and household use.

The invention discloses a fibrous protein compound hemostatic material and a preparation method thereof. The fibrous protein compound hemostatic material is prepared from, by mass, 5-10 parts of carboxymethylcellulose, 2-4 parts of carboxyethyl cellulose, 1-5 parts of chitosan, 3-8 parts of starch, 1-3 parts of sodium trimetaphosphate, 1-4 parts of sodium alga acid, 3-8 parts of gelatin, 8-12 parts of soy isolate protein, 2-5 parts of amino acid and 20-40 parts of water. The amino acid is basic amino acid. The fibrous protein compound hemostatic material can stop bleeding rapidly and effectively, the amount of bleeding is reduced, and the fibrous protein compound hemostatic material is safe to use; the preparation method is simple, and the prepared membrane-shaped compound hemostatic material is convenient to use and store.