236 results about "Bile Juice" patented technology

The invention provides a probiotic enteric dry suspension as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations. The probiotic enteric dry suspension comprises the following components in parts by mass: 1-8 parts of probiotic powder; 25 to 60 parts of a microcapsule cross-linking system; 1-15 parts of a suspending aid; 20 to 70 parts of a filling agent; 0-0.1 part of a coloring agent; and 0-1 part of an aromatic. According to the invention, when the probiotic powder is dispersed in water by utilizing the gelling property of sodium alginate, the probiotic powder is wrapped to form a probiotic-sodium alginate compound, citric acid and calcium carbonate are subjected to an acid-base reaction, and generated carbon dioxide bubbles can prevent the probiotic-sodium alginate compound from agglomerating; meanwhile, the released calcium ions and chitosan interact with the probiotic-sodium alginate compound, a compact probiotic microcapsule structure is rapidly and stably formed in one step, the probiotics in the microcapsule are effectively protected from being damaged by gastric acid and bile, the survival rate of the probiotics is increased, and the enteric effect is achieved.

The invention belongs to but is not limited to the technical field of biomedicine, and discloses application of golden amide alcohol ester to preparation of a medicine for treating cholestasis. The in-vitro cell level verifies that the golden amide alcohol ester has relatively strong activity of activating FXR and CAR. The golden amide alcohol ester can relieve the cholestasis symptom of a cholestasis model mouse. The golden amide alcohol ester can obviously reduce the content of total bile acid and bilirubin in cells, relieve cholestasis and relieve hepatocyte damage. The golden amide alcohol ester can regulate and control the protein level of transporters and metabolic enzymes related to bile acid and bilirubin through double excitation of FXR and CAR, relieve cholestasis and achieve the purposes of benefiting gallbladder and removing jaundice.

The invention discloses a compound xanthogenic bacterium and an application of the compound xanthogenic bacterium. The compound xanthogenic bacterium comprises brevibacillus sp. NCD08, bacillus sp. MCD04 and escherichia coli NCD04, and the compound xanthogenic bacterium is prepared from the following components: bacillus brevis, bacillus sp. MCD04 and escherichia coli NCD04. The in-vitro cultured calculus bovis is obtained by fermenting the oxgall by adopting the compound yellow bacteria, so that a new method is provided for the production of calculus bovis factitius, and the problem of shortage of calculus bovis in the medicine market can be relieved.

The invention discloses a method for extracting bilirubin, cholic acid and chenodeoxycholic acid from chicken bile. The method comprises the steps of pretreatment, chicken bile treatment, hydrolysis reduction, chromatographic separation and the like. The method comprises the following steps: slicing frozen chicken gallbladder, heating, unfreezing and melting to denature protein into solid, then cooling, performing three-phase centrifugal degreasing and deproteinization, and adding three enzymes including biliverdin reductase, coenzyme I and glucose dehydrogenase to reduce free biliverdin and combined biliverdin, so as to obtain the biliverdin-free biliverdin-glucose dehydrogenase-free biliverdin-glucose dehydrogenase-free biliverdin-glucose dehydrogenase. The method comprises the following steps: adding cholic acid and chenodeoxycholic acid into a container, adding gluconic acid hydrolase and bile salt hydrolase to hydrolyze biliverdin and bile acid, adding trypsin to hydrolyze impure protein, performing chromatography by using macroporous silica gel, and separating bilirubin, cholic acid and chenodeoxycholic acid by using different molecular space structures to obtain high-purity bilirubin, cholic acid and chenodeoxycholic acid. The method has the advantages of simple process, few types of used solvents, low toxicity, and facilitation of environmental protection and industrial production.

The invention aims to provide a preparation method of in-vitro cultured bear gall powder, which comprises the following steps: carrying out primary concentration, alcohol precipitation, macroporous adsorption separation, secondary concentration and freeze-drying purification on conversion liquid which is qualified in reaction to obtain the in-vitro cultured bear gall powder. Wherein the conversion liquid is prepared by mixing a chicken bile refined liquid with four-enzyme co-expression bacterial sludge or immobilized cells thereof, then adding NADP coenzyme, a surfactant and cosubstrates sodium pyruvate and dextrose monohydrate in a fixed proportion, and carrying out catalytic reaction at 25-30 DEG C for 2-24 hours; the obtained in-vitro cultured bear gall powder is subjected to whole-cell catalysis under proper conditions through whole cells expressing four enzymes or an immobilized cell form of the whole cells, the in-vitro cultured bear gall powder with stable TUDCA content is obtained, and no intermediate product T-7-KLCA residues exist.

The invention discloses calculus bovis combining in-vitro cultivation and in-vivo cultivation and a preparation method. The preparation method specifically comprises the following steps: (1) preparing an escherichia coli mixed bacteria solution; (2) preparing composite mucoprotein paste; and (3) carrying out in-vivo cultivation of the calculus bovis. Bacteria are preserved in the composite mucoprotein paste, and the composite mucoprotein paste has viscosity and is used as condensation nuclei for inducing calculus bovis condensation. Compared with the traditional crystal nucleus, the scheme can better protect the activity of the strain, the effect of protecting and slowly releasing the strain is achieved by using an embedding method, and strain inactivation caused by direct contact of the strain with ox bile is avoided. The ox bile simulation liquid with the best escherichia coli amplification effect is used as a bacterial liquid amplification culture medium injected into the ox gall bladder; after the mixed solution is injected, the 10% calcium chloride solution is injected again, so that a sticky bezoar bed is formed; the bilirubin content of the prepared bezoar is greater than or equal to 30%, and the cholic acid content is greater than or Each cattle cattle yellow is greater than 8g of calculus bovis; the success rate of calculus bovis preparation is greater than 90%.

The invention relates to the technical field of health-care food, and discloses a health-care composition containing microbial beneficial bacteria and a preparation method of the health-care composition. Comprising the following components in parts by weight: 30-40 parts of gelatinized starch, 8-15 parts of plant enzyme powder, 2-10 parts of microcapsule compound beneficial bacteria, 3-5 parts of selenium-enriched yeast powder, 0.5-2 parts of an American ginseng extract, 12-20 parts of fructo-oligosaccharide, 1-2.5 parts of curcumin, 7-9 parts of ovalbumin and 5-8 parts of sodium carboxymethyl cellulose. Microcapsule composite beneficial bacteria are prepared by compounding bifidobacterium longum, lactobacillus acidophilus, lactobacillus rhamnosus and lactococcus lactis, bridging with carboxymethylated beta-glucan and a Fe < 3 + >-polyphenol network structure and embedding with a protein-polysaccharide system, and can stably exist in an environment with strong acid and high-concentration bile salt to gastrointestinal tracts; through the synergistic effect of different nutrient substances, the intestinal microbe balance can be improved, and the immunity can be remarkably improved.

The invention relates to the technical field of medical equipment and biomarker detection, and provides an optical fiber biosensing probe for detecting a biomarker in a biliary tract, the optical fiber biosensing probe comprises a computer, a spectrometer and a light source, the computer is electrically connected with the spectrometer, the spectrometer is electrically connected with the light source, the output end of the light source is connected with a probe, and the surface of the probe is of a spiral structure; the probe extends into a biliary tract system, the light source emits light with specific wavelength and intensity, so that the light can reach the probe along the incoming optical fiber, and a biomarker in the biliary tract is specifically combined with the surface of the probe, so that an optical signal is changed and output through the outgoing optical fiber; the spectrograph can be used for carrying out detailed spectral analysis on an optical signal output from the outgoing optical fiber, and the spectral analysis comprises the characteristics of wavelength, intensity, absorption peak and the like, so that in-vivo, rapid, accurate and stable detection on bile protein in the biliary tract is realized; during bile detection, collection, storage and in-vitro detection are not needed, the pollution deterioration possibility is small, and the in-vivo detection result is more real.

The invention relates to the technical field of health wine preparation, and discloses a multi-effect synergistic enhanced bear gall body-building wine compound preparation process which comprises the following steps: taking sorghum, corn and fructus lycii as fermentation base materials, and carrying out double-strain synergistic fermentation by adopting saccharomyces cerevisiae and lactobacillus plantarum; adding fresh ursodesoxycholic acid during fermentation, carrying out in-situ enzymatic debinding conversion by using a compound enzyme system generated by a fermentation system, and converting the bound bile acid into free ursodesoxycholic acid; after fermentation, distilling to obtain raw wine; a molecularly imprinted polymer prepared by taking a wolfberry polyphenol key monomer as a template molecule is adopted to carry out targeted anchoring refining on raw wine, selective capture and enrichment of wolfberry polyphenol are carried out, and finally aging is carried out to obtain a finished product. According to the method disclosed by the invention, upstream double-strain fermentation in-situ enzymatic conversion and downstream molecular imprinting targeted refining are systematically integrated, so that the technical contradictions that the conversion rate of combined bile acid is low and a large amount of polyphenol functional components are synchronously lost during purification and impurity removal in a traditional process are solved.

The present invention relates to the technical field of microorganisms, in particular to a Lactobacillus acidophilus GOLDGUT-LA100 having functions of lipid lowering, blood glucose lowering and weight loss and application thereof. The Lactobacillus acidophilus GOLDGUT-LA100 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28398. The strain has strong acid resistance, can adapt to the digestive tract environment, and has high bile salt hydrolase activity. At the same time, in animal experiments, the strain significantly reduces blood glucose and serum cholesterol levels, reduces liver fat deposition, reduces adipose tissue inflammation, effectively reduces the weight, and has broad application prospects in the development of products for improving obesity, lowering lipid and lowering blood glucose.

The invention discloses a bile conversion product and a preparation method thereof, and belongs to the field of bioengineering technology. The preparation method comprises the following steps: mixing the culture fluid of 7α hydroxysteroid dehydrogenase and 7β hydroxysteroid dehydrogenase secreted and expressed by engineering bacteria with a buffer solution after adsorption, impurity removal, and ultrafiltration concentration, and adding the culture fluid to an ion exchange agar gel column to immobilize the enzyme after adjusting the pH, thereby obtaining an immobilized enzyme column; mixing the avian bile extract with NADP+, adjusting the pH, and then adding the mixture to the immobilized enzyme column for conversion, and obtaining the bile conversion product after the clear liquid is concentrated under reduced pressure and dried under vacuum. The invention uses an ion exchange agar gel column as a carrier for immobilizing hydroxysteroid dehydrogenase, which has good stability, high mechanical strength, and large loading capacity, and the enzyme molecules are not easy to fall off, and can react continuously and the reaction product can be separated from the enzyme in time, thereby reducing the occurrence of reverse reaction, thereby obtaining a bile conversion product with a higher ratio of TUDCA:TCDCA.

The invention belongs to the technical field of disease medicine preparation, and particularly relates to nanocellulose, a preparation method thereof and application of the nanocellulose to reduction of bile acid level. The nano-crystalline cellulose is nano-crystalline cellulose fiber or nano-crystalline cellulose crystal; wherein the nano-crystalline cellulose fibers are in a slender whisker shape, the average length of the nano-crystalline cellulose fibers is 250-400 nm, and the nano-crystalline cellulose fibers are partially gathered and wound; the nanocellulose crystal is in a short rod crystal shape, the surface of the nanocellulose crystal is connected with a sulfuric acid half ester group, and the length of the nanocellulose crystal is 50-200 nm. The nanocellulose provided by the invention can achieve the purpose of treating intrahepatic cholestasis in the gestation period by improving the TBA level and improving the filial generation live birth rate; the traditional Chinese medicine composition has no obvious influence on liver and kidney functions, blood sugar, blood fat and the like, and is high in safety; in addition, the nanocellulose does not have potential target organ poison or accumulative effect, the biological safety performance is improved, and the nanocellulose can be used for a long time and is suitable for special crowds during pregnancy.

The invention discloses application of rhodotorula red in preparation of a product for effectively preventing / treating hypercholesteremia, and belongs to the technical field of dual purposes of medicine and food. The invention relates to an application of rhodotorula benthamiana in preparation of a product for effectively preventing / treating hypercholesteremia. The rhodotorula benthamiana is rhodotorula benthamiana electrostatic spinning microspheres. Compared with a rhodotorula red bile system, the rhodotorula red electrostatic spinning microsphere system has an obviously better intervention effect on hypercholesterolemia. Meanwhile, compared with a rhodotorula rubra bile system, the rhodotorula rubra electrostatic spinning microsphere system can effectively improve the serum and liver inflammatory factor level of a hypercholesteremia mouse and prevent excessive accumulation of liver lipid, especially ceramide lipid, of the hypercholesteremia mouse.

To provide cellular uptake.SOLUTION: The invention provides a bile acid or a pharmaceutically acceptable salt thereof for use in a method for treating the human or animal body, the method comprises administering to the human or animal body a therapeutic compound, where: a. the bile acid is chenodeoxycholic acid or deoxycholic acid; b. optionally, the bile acid is employed in conjunction with EDTA; c. in the method, the bile acid or salt thereof and EDTA are used to enable or enhance intracellular uptake of the therapeutic compound.SELECTED DRAWING: None

The invention discloses a chicken bile extract taurochenodeoxycholic acid composition and application thereof in preparing an anti-stress drug for improving the laying period of rutin chickens, belonging to the technical field of animal feed additives. The chicken bile extract taurochenodeoxycholic acid composition consists of the following components by weight: 60-65 parts of a bile acid mixture and 35-40 parts of a composite additive; a preparation method of the bile acid mixture consists of the following steps: adsorbing bile acid, adsorbing curcumin, preparing a coating solution, and coating; a preparation method of the composite additive consists of the following steps: adsorbing a water-soluble additive, adsorbing soy protein, adsorbing a fat-soluble additive, preparing a coating solution, and coating; the chicken bile extract taurochenodeoxycholic acid composition can improve the anti-stress ability and feed intake of rutin chickens during the laying period, has strong storage stability, and is easy to be evenly mixed with feed.

The liver-protecting health-care tea comprises 20 parts of Pu'er tea, 10 parts of centella asiatica leaves, 10 parts of nutgall, 20 parts of dried longan, 10 parts of chrysanthemum, 10 parts of penthorum chinense pursh, 10 parts of dendrobe and 10 parts of Chinese dates. The tea is prepared into tea bags, and each bag is 30g. The traditional Chinese medicine composition is simple in process and low in cost, has a remarkable treatment effect on acute and chronic hepatitis, cholestatic hepatitis, alcoholic hepatitis, fatty liver and the like, and also has the effects of clearing fat, losing weight, inducing diuresis, promoting alcohol metabolism, protecting liver after drinking and the like; the liver health tea bag provided by the invention is rich in nutritional ingredients, very convenient to drink for a long time, high in appearance grade, convenient to use, strong, mellow, sweet and fragrant in taste and worthy of being well developed and utilized, and the products are placed in the tea bag in proportion.

The invention provides rhizoma alismatis purified polysaccharide as well as a preparation method, an identification method and application thereof, the rhizoma alismatis purified polysaccharide is a functional component with a novel structure in a traditional Chinese medicine rhizoma alismatis water extract obtained by further extraction and purification, the administration efficiency is effectively improved, and the pharmacodynamic substances are clarified; in-vivo and in-vitro experiments show that the polysaccharide can improve the antioxidant capacity of the liver and relieve inflammatory response; synthesis and metabolism of liver bile acid can be adjusted, cholestasis of the liver is relieved, and bile acid circulation is promoted so as to relieve acute liver injury caused by acetaminophen; the effect of promoting the recovery of liver injury patients is obvious; and the compound also can be used as prebiotics to improve the homeostasis of intestinal microorganisms and promote the synthesis of short-chain fatty acids so as to have beneficial effects on the liver.

This invention relates to a traditional Chinese medicine combination for treating intrahepatic cholestasis, which is made from the following raw materials in parts by weight: Artemisia capillaris and Glycyrrhiza uralensis 5:1 and 3:1. This invention also provides the preparation of the above-mentioned medicine and its use in treating intrahepatic cholestasis. Its advantages are: the traditional Chinese medicine composition of this invention (Artemisia capillaris and Glycyrrhiza uralensis decoction) has a significant ameliorative effect on intrahepatic cholestasis (non-obstructive type) induced by a 1% CA-containing diet in mice. Artemisia capillaris and Glycyrrhiza uralensis decoction can alleviate weight loss in mice and improve liver necrosis; significantly reduce serum ALT and ALP levels in mice; reduce the content of total bile acids in the liver and decrease the proportion of toxic bile acid taurine deoxycholic acid (TDCA) in the bile acid pool; upregulate liver BSEP protein expression to promote bile acid efflux; and downregulate liver NLRP3 protein expression to alleviate liver necrosis.

The invention provides a liver protection composition as well as a preparation method, functional food and application thereof, and relates to the technical field of food processing. The liver protection composition comprises the following raw materials: dandelion concentrated solution, red ginseng extract and hovenia dulcis thunb. The liver-protecting composition prepared by the invention is remarkable in liver-protecting effect and high in comprehensiveness, can realize the liver-protecting effect from multiple aspects of oxidation resistance, inflammation resistance, biliary secretion promotion and the like, is high in bioavailability, completely selects natural plants as raw materials, and does not contain artificial additives, preservatives or sweeteners.

This invention relates to the use of a recombinant protein ANG in the preparation of medicaments for treating cholestatic liver disease. Specifically, this invention provides the use of the angiopoietin ANG gene, or its protein, or its promoter, for the preparation of medicaments, compositions, or formulations for the prevention, improvement, and / or treatment of cholestatic liver disease. It is particularly effective in treating primary biliary cholangitis and primary sclerosing cholangitis.

The invention discloses a probiotic with the characteristic of high yield of bile salt hydrolase and application of the probiotic in a preparation for preventing or improving cholestatic jaundice, and is characterized in that the probiotic is at least one of a bifidobacterium longum subsp. Infantis QS033 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35879 and a lactobacillus delbrueckii subsp. Lactis QS021 strain with the preservation number of CGMCC No.35880; according to the present invention, the Chukrasone A has the application of the Chukrasone A in the preparation of the product for preventing, relieving or regulating the cholestatic jaundice, and has the advantages of effective degradation of sodium glycocholate, sodium glycodeoxycholate, sodium glycochenodeoxycholate and sodium glycoursodeoxycholate, effective regulation of bile acid metabolism disorder in the cholestatic jaundice, and improvement of the cholestatic jaundice.

The invention provides a high-fidelity calculus bovis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the technical scheme provided by the invention, the high-fidelity calculus bovis is accurately prepared by taking the mean value of the contents of various components of the natural calculus bovis as a reference and accurately measuring the contents of various components in the raw materials, fully utilizing the original components of the ox bile or ox gall powder, not adding other non-calculus bovis components and combining the existence forms of the components. The problems that existing artificial calculus bovis is greatly different from natural calculus bovis in efficacy, and toxic and side effects are relatively high are solved. The shape, the forming process and the components of the product are highly similar to those of natural calculus bovis; the medicine effect of the calculus bovis is improved, and the production cost is reduced.

The invention relates to the technical field of biological pharmacy, in particular to a method for extracting bile acid from pig bile, which comprises the following steps: (1) taking the pig bile, adjusting the pH value of the pig bile to be alkaline, heating the pig bile to 80-90 DEG C, stirring at constant temperature for 25-35 minutes, then cooling to room temperature, and adjusting the pH value of the system to be neutral to obtain pretreated pig bile; (2) filtering the pretreated pig bile in the step (1) by using a hyperbranched polymer film, concentrating filtrate under reduced pressure, adding an ethanol solution, heating to reflux, stirring for 25-35 minutes, and then filtering to obtain a crude bile acid product; and (3) adding a hydrochloric acid solution into the crude bile acid product in the step (2), adjusting the pH value to 2-3, centrifuging, filtering, washing and drying the obtained solid, adding ethyl acetate, heating to reflux until the solid is dissolved, cooling to room temperature, stirring for 2-4 hours, recrystallizing, separating and drying to obtain the bile acid. The extraction method is simple, and the extraction purity is high.

The utility model discloses an online beagle bile collecting device, which relates to the technical field of collecting devices and comprises a base plate and a liquid pumping component. A cage is fixed to the upper end of the base plate, an opening is formed in the middle of the cage, a fixing ring is fixed into the opening, and a connecting assembly is installed at the upper end of the cage. The liquid pumping assembly comprises wrapping cloth, a flow guide hose, a one-way valve, a gall bladder cannula, a hook-and-loop fastener and a hook-and-loop fastener, the wrapping cloth is arranged in the cage, the lower end of the connecting assembly is connected with the wrapping cloth, a fixing hole is formed in the middle of the wrapping cloth, and the flow guide hose is fixed in the fixing hole. A one-way valve is installed on the circumferential face of the flow guide hose, a gall bladder cannula is fixed to the lower end of the flow guide hose, and two corresponding hook-and-loop fasteners are fixed to the lower end of the left side of the wrapping cloth. According to the utility model, falling can be avoided, and meanwhile, long-time nursing can be avoided.

The present invention relates to the technical field of fowl bile processing, and in particular to a method for detecting the bile acid content in fowl bile based on turbidity, which comprises the following steps: adjusting a solution containing bound bile acid to alkaline to obtain a suspension; and then measuring the OD value of the suspension. 600 This solution can solve the technical problems of long time and high cost in detecting bile acid content in poultry bile. When the purchased poultry bile raw materials arrive at the inspection site, this method can be used to conduct a preliminary test on the bile acid content in the poultry bile, and complete the on-site inspection work. Unqualified products with too low bile acid content can be returned on the spot, which greatly saves time and cost. This solution can be applied to practical operations such as the quality inspection of poultry bile, the research and development and production of poultry bile powder and artificial bear bile powder.

The application relates to the embedding technical field, and particularly discloses a double emulsion gel bead embedding beta-carotene and probiotics and a preparation method thereof. The double emulsion gel bead comprises a composite layer, an oil phase and an inner water phase from outside to inside. The composite layer comprises an outer water phase and calcium alginate which are fused with each other. The outer water phase comprises a product after carrageenan and sodium caseinate are subjected to a Maillard reaction. The oil phase comprises beta-carotene, vegetable oil and a food emulsifier. The inner water phase comprises probiotics. In the gel bead, the beta-carotene and the probiotics are simultaneously embedded in the double emulsion gel bead, the calcium alginate hydrogel shell starts to decompose when entering the intestinal tract, then the double-layer emulsion is slowly decomposed after being subjected to chemical digestion of pancreatic juice, bile and small intestinal juice and mechanical digestion of the small intestine in the small intestine, and the beta-carotene and the probiotics are gradually released, the beta-carotene is converted into vitamin A in the intestinal tract and is absorbed, and the probiotics are delivered to the colon to play a probiotic effect.

The present application provides a compound of formula (I), or an optical isomer thereof, a pharmaceutically acceptable salt, a solvated form, or a prodrug. The compound may modulate NTCP function for the prevention and / or treatment of HBV / HDV and hepatitis virus-related diseases, bile acid-related cholestasis disorders, metabolic disorders, and / or liver diseases. Additionally, the present application relates to a pharmaceutical composition comprising such a compound and a method for modulating NTCP.

The utility model relates to the technical field of cholic acid purification, in particular to a cholic acid purification device which comprises a bottom plate, a centrifugal device fixedly connected to the top of the bottom plate through a second fixing rod, a first filtering box body fixedly connected to the top of the bottom plate through a first fixing rod, and a second filtering box body fixedly connected to the first filtering box body through a fifth fixing rod. The second filtering box body is fixedly connected with a distillation box body through a fourth fixing rod, the distillation box body is fixedly connected with a condensation recovery box body through a condensation pipe, a stirring barrel is fixedly installed at the top of the first filtering box body, a bile feeding port and an ethanol feeding port are formed in the top of the stirring barrel, and a first telescopic rod stretches out and draws back to drive a first long strip to move. Filtering of the bile and ethanol mixed solution is accelerated, the ethanol and cholic acid mixed solution generated by the first filtering box body, the second filtering box body and the condensation recycling box body is centrifugally layered, the centrifugally layered liquid flows into the drying box to dry the ethanol solution, and finally cholic acid is obtained.

The bear bile sterilization and disinfection device comprises a bottom plate and a sterilization box fixedly installed on the upper surface of the bottom plate, the top of the inner wall of the sterilization box is fixedly connected with an electric heating plate and a sterilization pot respectively, and a cover plate is hinged to the rear side of the upper surface of the sterilization box. A servo motor is fixedly mounted in the center of the upper surface of the cover plate, and an output shaft of the servo motor penetrates and extends into the sterilization pot and is provided with a stirring assembly. According to the device disclosed by the utility model, the servo motor, the stirring assembly, the ultraviolet lamp and the quartz glass protective cover are arranged, so that bear bile can be synchronously treated in two modes of ultraviolet sterilization and high-temperature heating sterilization, the bear bile is more thoroughly sterilized and disinfected, and the servo motor can run to drive the stirring shaft and the stirring blades to stir the bear bile; and moreover, the bear bile is heated more uniformly and quickly through stirring, so that the sterilization and disinfection speed of the whole device on the bear bile is improved, and the working efficiency is relatively high.

The present invention relates to a molecular association of a bile acid or a bile salt and a composition containing the same, and more specifically, to a skin-permeable formulation of deoxycholic acid, a lipolytic pharmacological agent, which has been developed as an external preparation rather than a conventional injection, and which dramatically improves patient compliance.