401 results about "Bile Juice" patented technology

Aerosol formulations suitable for use in pressurised metered dose inhalers comprise a hydrofluoroalkane propellant, an medicament for inhalation and a surfactant which is a a C₈–C₁₆ fatty acid or salt thereof, a bile salt, a phospholipid, or an alkyl saccharide.

Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.

The invention relates to a preparation method and application of a sulfonylurea compound and a composition containing the same component as FXR and / or TGR5 agonist, the FXR and / or TGR5 agonist is a compound shown as a formula (I), or a pharmaceutically acceptable salt, a solvate, a prodrug, an isomer and a stable isotope derivative thereof. The compounds can be used for treatment of FXR and / or TGR5 mediated diseases including primary biliary cirrhosis, nonalcoholic fatty liver, portal hypertension, bile acid diarrhea and cholestasis, type II diabetes and obesity and other field.

The invention provides a duodenal internal covering membrane, which is made of degradable shape memory biocompatible material and relates to degradable medical equipment internally installed in a digestive tract. After the internal covering membrane is implanted into a duodenum, chyme can be split from bile and pancreatic juice, so stomach exudates are prevented from being directly digested, absorbed and metabolized in the duodenum, and the histocompatibility is good; after being implanted into a human body, the duodenal internal covering membrane is steady, is not easy to slide off to be incarcerated and can be gradually degraded in the human body after 2 months to 5 years, so complicated operation and the injury to organs and tissue, which are caused when the duodenal internal covering membrane is removed from the human body in the future, are avoided, a rebound effect achieved after the original barrier is instantaneously and thoroughly dismounted can be slowed down, and the duodenal internal covering membrane can be prepared into medical equipment which is used for curing obesity and diabetes mellitus and does not need to be removed from the human body in the future; and tube-shaped part sinking induced by gastrointestinal motility and jejunum content backflow caused by the decrease of a gap between a tube-shaped part of the internal covering membrane and the inner wall of the duodenum can be avoided. The prepared medical equipment for curing the obesity and the diabetes mellitus can achieve the effects of dropping prevention, removal exemption, rebound inhibition and injury reduction.

The present invention relates to process of extracting cholic acid, deoxycholic acid and bilirubin from bile of pig, ox and sheep. Bile of pig, ox and sheep consists of water in about 97 %, bile acid in about 2.5 % and bilirubin in about 0.4 %; and contains also phospholipid, cholesterol, Na, K, Ca, phosphate, carbonate, small amount of protein, and other components. Fresh bile is treated through cooling, filtering to defat, basic hydrolysis, acidification and organic solvent extracting to obtain bilirubin; the rest solution is further treated through deep saponification, acidification and organic solvent precipitation to obtain the mixture of cholic acid and deoxycholic acid; and the mixture is re-crystallization separated to obtain high purity cholic acid and deoxycholic acid.

A process for separating the chenodeoxycholic acid from pig's gall and purifying it includes such steps as preparing general cholic acid from the mother liquid generated by extracting the cholerythrin from pig's gall, saponifying, regulating pH value to obtain crude chenodeoxycholic acid, decoloring, defatting, preparing the deposit of barium chenodeoxycholate, reacting on potassium carbonate to remove Ba, regulating pH value, and purifying by silicon gel column.

The invention discloses a method to manufacturing high purity chemocholic acid from fowl bile that belongs to refinement chemical and medicine field. It includes the following steps: a. saponification reaction: mixing the fowl bile and sodium hydroxide and reacting for 20-30 hours under the certain temperature; b. neutral reaction: adding dilute hydrochloric acid after saponification reaction and gaining raw cholic acid after filtering; c. column chromatography: adding dilute sodium hydroxide into raw cholic acid and injecting into chromatography column, uniting the eluent; super filtering: taking super filtering by super filtering film; e. gaining chemocholic acid that the purity is over 96% after adding dilute acid, filtering and drying. The invention has simple technology, high purity, low cost and environment protection.

The invention provides a method for separating and purifying chenodeoxycholic acid from duck gall, and concretely comprises to the following steps: dissolving and extracting a duck gall paste crude product, extracting ethyl acetate, and ultrafiltering and removing impurities. The method has the following advantages that 1) the raw material source of chenodeoxycholic acid can be enlarged, the method for separating and purifying chenodeoxycholic acid from the duck gall is provided; and 2) the content of chenodeoxycholic acid extracted from the duck gall by a traditional method is low with about 60%. The HPLC content of chenodeoxycholic acid obtained by using the method of the invention can reach more than 96%, and the extraction efficiency of chenodeoxycholic acid is enhanced.

The invention discloses an integrated bile and pancreatic juice drainage pipe which comprises a water sac type bile outer drainage pipe and a pancreatic juice inner drainage pipe. The water sac type bile outer drainage pipe comprises a drainage pipe section I, a drainage pipe section II and a drainage pipe section III which are communicated in sequence. The outer wall of the drainage pipe section II is sleeved with a balloon thin film. The pancreatic juice inner drainage pipe comprises a drainage pipe body, a pipe cap and a drainage pipe tail portion. The end, far away from the drainage pipe section II, of the drainage pipe section III is matched with the drainage pipe tail portion. The integrated bile and pancreatic juice drainage pipe has strong tension force, can have the function of avoiding disengagement of the water sac type bile outer drainage pipe, is suitable for bile ducts of various diameters, has no damage to bile duct mucosa, duodenal papillae and upper gastrointestinal tract mucosa, and cannot cause obstruction of biliary tracts while avoiding displacement of the water sac type bile outer drainage pipe. The pancreatic juice inner drainage pipe is connected with the water sac type bile outer drainage pipe through a line, and the function of avoiding displacement or disengagement of the pancreatic juice inner drainage pipe is achieved.

The invention relates to preparation methods of sulphonylaminocarbonyl derivatives and compositions containing the same component and a use of the sulphonylaminocarbonyl derivatives as FXR and/or TGR5 agonists; the agonists are the sulphonylaminocarbonyl derivatives represented by the formula I, or pharmaceutically acceptable salts, prodrugs, solvates, hydrates, polymorphs, isomers, and stable isotope derivatives thereof. The compounds can be used for treatment of diseases and symptoms mediated by FXR and/or TGR5 and other therapeutic fields, wherein the diseases and symptoms include primary biliary cirrhosis, nonalcoholic fatty liver, portal hypertension, bile acid diarrhea and cholestasis, type II diabetes and obesity.

The invention relates to Chinese medicinal herb pills for treating cholecystitis and gallstone. The Chinese medicinal herb pills are prepared from 22 gouts of Chinese medicinal herbs, namely coptis root, baikal skullcap root, phellodendron, corydalis tuber, curcuma, costus root, loosestrife herb, Japanese climbing fern spore, dark plum, white peony root, fine-leaf schizonepeta herb, green tangerine peel, immature bitter orange, turmeric, polygonum cuspidatum, Szechwan chinaberry fruit, gentian, bupleurum, oriental wormwood, chicken's gizzard-membrane, compound of glauber-salt and liquorice and slaked lime. The pills can lighten the pathological change of cholecystitis, promote gallbladder contraction and promote gallstone excretion and biliary excretion; by the pills, biliary excretion components are radically changed, the metabolism requirement of the human body is met, calculi are gradually disintegrated and deposited, the micro environment in the gall bladder is recovered when the calculi are discharged, and the aim of thoroughly discharging the calculi is fulfilled. The Chinese medicinal herb pills have the advantages of quick response, short treatment course, high healing rate, low recurrence rate, treatment for both symptoms and root causes, no toxic or side effects and the like.

The invention discloses a bile and pancreatic juice drainage tube which comprises a loop type bile external drainage tube and a pancreatic juice internal drainage tube. The loop type bile external drainage tube comprises a straight tube, an elastic loop pipe I and an elastic loop pipe II which are connected in sequence, wherein the elastic loop pipe I and the elastic loop pipe II are in the shapes of Archimedean curves one the whole. The pancreatic juice internal drainage tube comprises a drainage tube body and a tube cap located at the upper end of the drainage tube body, and a line II is arranged on the drainage tube body and penetrates through the side wall of the straight tube and extends in a tube cavity of the straight tube. The bile and pancreatic juice drainage tube reduces the probability of slipping of the loop type bile external drainage tube, does not stimulate bile duct mucosae, duodenal papilla, gastrointestinal mucosae and throat mucosae, and has an effect of preventing the pancreatic juice internal drainage tube from dislocating or escaping.

An embodiment of the invention belongs to the technical field of healthcare products and discloses a composition for dispelling effects of alcohol and protecting the liver and a preparation method of the composition. The composition for dispelling the effects of alcohol and protecting the liver is prepared from, by weight, 50-150 parts of rhizoma curcumae longae, 50-150 parts of fructus phyllanthi, 50-150 parts of medicine terminalia fruits and 50-150 parts of olives, wherein the rhizoma curcumae longae has an anti-inflammatory function, a liver protection function and a cholagogue effect; the fructus phyllanthi and the medicine terminalia fruits have liver protection effects and are capable of realizing reduction of liver injuries and realizing an anti-liver fibrosis function; polyphenols in the olives have functions of blood purifying, liver soothing, stomach harmonizing and qi regulating and are capable of effectively alleviating symptoms such as headache, dizziness, stomachache, nausea, poor mental state and the like caused by alcohol consumption. Choleresis increasing and gallbladder contract promoting functions of the rhizoma curcumae longae and lipid metabolism promotion and gastrointestinal peristalsis promotion functions of the olives promote liver protection functions of the fructus phyllanthi and the medicine terminalia fruits, and remarkable healthcare effects of dispelling the effects of alcohol and protecting the liver are achieved owing to synergistic interaction of the four ingredients. The preparation method of the composition is suitable for industrial popularization and application.

The invention discloses an orally-administered traditional Chinese medicine composition. The composition is prepared from traditional Chinese medicine raw materials such as desmodium, rhubarb, Herba Artemisiae Capillaris, achyranthes, Alisma orientale, tuckahoe, an animal gall product and so on, has functions of clearing heat and promoting diuresis, soothing liver and benefiting gall, regulating qi and dredging stranguria, promoting urination, promoting the secretion of bile, resisting inflammation, killing pain, relieving fever, resisting bacteria and so on, is used for treating diseases such as cholelithiasis and urinary calculus or hepatobiliary lithiasis caused by damp-heat of liver and gallbladder as well as symptoms such as right epigastric pain, upper abdomen fullness and distention, nausea, anorexia to greasiness, jaundice, yellow and greasy fur or osphyalgia, hematuria and so on, and has definite treatment effect and no apparent adverse reaction. The invention also relates to a preparation method, an administration method and a quality checking method for the orally-administered traditional Chinese medicine composition.

The invention belongs to the field of molecular immunology, and in particular relates to an exosome secreted and released from the epidermal cells of a chicken liver, gall bladder and bile duct, and a preparation method of the exosome. The exosome contains hepatogenic proteins, such as C-reactive protein, aspartate aminotransferase, and vitronectin, epithelium-derived mucin and proteins related to an immune reaction, such as immunoglobulin, and can be taken as a biological indicator for studying liver diseases and as an adjuvant for immune reaction for immune-regulation, and can also be takenas a carrier for treating the diseases of livers, gall bladders and intestines.

The invention relates to a method for preparing enzyme-natured bezoar. In the method, colon bacillus is natured in vitro; colon bacillus beta-GA enzyme is extracted and implanted to the gall of animals, such as cattle, sheep, pig, etc; the effective ingredients of gall bezoar are catalyzed and totally precipitated, then the bezoar is prepared. Namely: the colon bacillus is natured in 3.6-4.0% of albumen brothculture at 35-38 DEG C of constant temperature for 24 hours and centrifugally precipitated, then colon bacillus precipitation is gained; then 10-15g of the colon bacillus precipitation is added into 400mlpH6.8 of trihydroxymethyl aminomethane-hydrochloric acid buffer solution, vibrated in an ultrasonic groove for 15-20 minutes and centrifuged, then the colon bacillus beta-GA enzyme solution is gained; 28-32ml of the solution is added into 3,000ml of the gall of the animals, such as cattle, sheep, pig, etc, and 20-30g of borax is added, enzymatic reaction is carried out on the mixture at 35-38 DEG C of constant temperature for 24 hours, the bezoar of the invention is gained. The invention is characterized in that the raw materials are abundant, the technique is simple, the equipment is less, the investment is less, the cost is low, the benefit is high; the therapeutic effect of the enzyme-natured bezoar is the same as or better than that of the natural bezoar; and the enzyme-natured bezoar can be prepared industrially.

The invention provides various novel compositions of berberine in combination with pharmacologically active EPA and DHA, and related methods of their use in treating various diseases or disorders. The pharmaceutical compositions of the invention are useful in treating and/or preventing various diseases or disorders, including metabolic diseases or disorders such as dyslipidemia, hyperglycemia, hypertriglyceridemia, hyperlipidemia, diabetic dyslipidemia, diabetic hyperlipidemia, dyslipidemia in statin-intolerance patients, diabetes, diabetic complications, hypercholesterolemia, or obesity. Additionally, the pharmaceutical compositions of the invention are useful in treating and/or preventing atherosclerosis, heart diseases, neurodegenerative diseases, inflammation, cancers, as well as various liver diseases or disorders, such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. Furthermore, the pharmaceutical compositions of the invention are useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

The invention relates to a method for preparing pig-bile-combination-type total bile acid. The method comprises the steps of extracting by utilizing ethanol, separating and purifying and drying. Proved by medicinal effectiveness tests for treating colonitis, the pig-bile-combination-type total bile acid prepared by utilizing the method provided by the invention has an inhibitory action on the increase of myeloperoxidase activity and tumor necrosis factor alpha content of model mice and has the advantages of inhibiting the secretion of proinflammatory cytokine, regulating the immune response, effectively blocking the damage of the immunoreactivity to an organism and achieving the purpose of treating colonic inflammation. The pig-bile-combination-type total bile acid prepared by utilizing the method provided by the invention can be adopted as a raw material to be made into various commonly-used preparation types such as tablets, capsules, powders, pills, granules, enemas and the like.