Method for preparing chenodeoxycholic acid

A technology of chenodeoxycholic acid and hyodeoxycholic acid, which is applied in the field of preparation of chenodeoxycholic acid, can solve the problems of long chenodeoxycholic acid synthesis process cycle, high cost, and limited source of raw materials, and achieve raw material Abundant, low cost, and easy-to-obtain raw materials

Inactive Publication Date: 2006-09-13
CHANGDE YUNGANG BIOTECHNOLOGY CO LTD
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AI Technical Summary

Problems solved by technology

[0003] In order to overcome the shortcomings of the existing chemical synthesis or direct extraction of chenodeoxycholic acid synthesis process, such as long cycle time, high cost, or limited source of raw materials, the present invention

Method used

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Embodiment Construction

[0012] The present invention will be further described below by specific examples.

[0013] (1) Separation of hyodeoxycholic acid. Get the leftovers (paste) that pig bile extracts bilirubin, saponify the leftovers with sodium hydroxide, the weight ratio of feeding intake is: leftovers: water: sodium hydroxide=1: 7: 1.2, press the weight ratio of feeding intake For cutting, add water first, then put sodium hydroxide into the water and stir, put the leftovers into the leftovers after it is completely dissolved, heat and keep boiling for 24 hours, and carry out saponification, during which the evaporated water needs to be continuously replenished. To room temperature, let it stand for 12 hours, draw out the lye in the upper layer, and the lower layer is the precipitate. The sediment produced by saponification is oxidized with hydrogen peroxide, and the weight ratio of the feed is: sediment: water: hydrogen peroxide = 50: 200: 1, and the material is cut according to the weight ra...

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Abstract

The invention relates to a method of distilling the chenodeoxychoilc acid from the offcuts which be gained by distilling the bilirubin from the bile of the pig. With the offcuts of the alkali saponification, the deposit is treated with the oxidation treatment by means of the hydrogen peroxide, the filtrate is treated by the dilute sulfuric acid and decolored by means of the active carbon and solved, crystaled using the ethyl acetate again and again; the coordinate production of the hyodeoxycholic acid is purified, the mother liquor is concentrated to the cream and melted using the alkali and have the salifying treatment with the chloride of barium, so the cholate is formed, the cholate is treated to take off barium when the cholate suspending the aqueous solution containing the sodium carbonate, then it is acidificated with the dilute sulfuric acid and is separated ,deposited and dried to gain the crude chenodeoxycholic acid which is decolored using the active carbon and is melted, rimed and dried using the ethyl acetate. Then the finished production of the chenodeoxycholic acid form.The whole technics has some merits of the abundant material, the amity of the environment, the safety and innocuity, producing many outputs from the single stuff and easy to the mass production. The invention is used for distilling the chenodeoxycholic acid.

Description

technical field [0001] The invention relates to a method for preparing chenodeoxycholic acid, in particular to a method for extracting chenodeoxycholic acid from leftovers of pig bile for extracting bilirubin. Background technique [0002] The role of chenodeoxycholic acid: it has strong anti-inflammatory, cough, phlegm and calculus-dissolving effects. In addition to its medicinal value, it can also be used as a raw material for the production of ursodeoxycholic acid. It is clinically used to treat various gallbladder diseases and digestive tract diseases. At present, to extract chenodeoxycholic acid, one is to extract chenodeoxycholic acid from the bile of cattle and sheep, and then chemically synthesize chenodeoxycholic acid with cholic acid as a raw material; the other is to directly extract chenodeoxycholic acid from poultry bile. Chemically synthesizing chenodeoxycholic acid with cattle and sheep bile as the starting material has a long process cycle and high cost; dir...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 邓家国
Owner CHANGDE YUNGANG BIOTECHNOLOGY CO LTD
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