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An artificial bear bile and artificial technology, applied in the field of bear bile, can solve the problems of unreachable bear bile powder, low content of tauroursodeoxycholic acid, difference in content ratio and the like
Active Publication Date: 2012-12-26
HANGZHOU BAOJI BIO TECH
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The disadvantage is that the content of tauroursodeoxycholic acid is extremely low, which is far below the standard of 30% or more stipulated in the current 2010 version of bear bile powder, and it also contains excessive lithocholic acid and other harmful substances with cytotoxicity. Bear bile powder is similar, but the content ratio is significantly different from natural bear bile
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Embodiment 1
[0072] Artificial bear bile formula:
[0073]
[0074] Wherein amino acid refers to aspartic acid, threonine, serine, glutamic acid, alanine, proline, leucine, lysine, arginine equal ratio mixture.
[0075] Trace elements refer to the mixture of edible and pharmaceutical grade salt compounds of 8 kinds of metals including potassium, magnesium, manganese, zinc, copper, iron, chromium and calcium.
[0076] The mixed bile is a mixture of chicken bile, duck bile, ox bile and dog bile, and their mass ratio is 6:1:0.5:1.
[0077] Preparation of chicken bile: Broken chicken gall, filtered separately with filter cloth, collected bile, refrigerated to remove grease, separated and precipitated protein, polysaccharide, fat and other impurity components by changing the pH value, heated denatured physical method to centrifuge to remove impurities, and the centrifuged liquid was vacuum Concentrate into a thick paste for later use.
[0078] The preparation method of duck bile, ox bile a...
Embodiment 2
[0081] What this embodiment is different from embodiment 1 is that mixed courage is different, and all the other are identical with embodiment 1.
[0082] The mixed gallin used in this embodiment is:
[0083] The mixture of chicken bile, duck bile, ox bile and dog bile, the mass ratio of their bile is 6:1:0.5:1.
Embodiment 3
[0085] What this embodiment is different from embodiment 1 is that mixed courage is different, and all the other are identical with embodiment 1.
[0086] The mixed gallin used in this embodiment is:
[0087] A mixture of chicken bile, goose bile, ox bile, sheep bile, rabbit bile and dog bile, the mass ratio of their bile is 6:3:0.5:0.5:1:2.
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Abstract
The invention provides an artificial bear bile. The formula of the artificial bear bile comprises the following ingredients by mass percent: 35-48 of tauroursodeoxycholic acid, 50-63 of mixed choline, 1-3 of amino acid and 0.5-1 of trace element, wherein the mixed choline is an avian bile or a mixture of a plurality of avian biles and one or a mixture of a plurality of ox bile, sheep bile, rabbit bile and dog bile. The whole pharmacological tests prove that the artificial bear bile powder has the pharmacological functions which are similar to natural bear bile in the aspects of analgesia, sedation, convulsion prevention, inflammatory prevention, liver and gallbladder protection and the like, and can be used for completely substituting for the natural bear bile, the industrial production can be realized; and moreover, the price of the artificial bear bile is lower than that of the natural (drainage) bear bile, so the artificial bear bile is easily accepted. In addition, the molecular pharmacology also proves that the artificial bear bile has the functions of inhibiting MGc80-3 cancer cell growth and proliferation.
Description
technical field [0001] The invention relates to the technical field of bear bile, in particular to an artificial bear bile. Background technique [0002] Bear bile, bezoar and musk are called the three treasures of traditional Chinese medicine. Bear bile is the dried gallbladder of bears (Selensrctos thibetsuns cuvier) or brown bears (vrsus actos L.), first recorded in "Tang Materia Medica". Antibacterial and anti-inflammatory, gallbladder and stone removal, crown expansion and lipid-lowering effects, etc., used for convulsions, convulsions, red eyes, sore throat, gallstones, cardiovascular diseases, viral infections and other diseases. Bear bile is a traditional Chinese medicine used in Chinese medicine clinics in my country. It has a wide range of uses and remarkable curative effect. The traditional method is to capture bile by caesarean section in winter, and one bear has one gallbladder, which has led to the depletion of wild bear resources. In order to protect bears,...
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