The invention discloses a traditional Chinese medicine prescription for treating hyperbilirubinemia caused skin itch and a preparation method thereof. The traditional Chinese medicine prescription disclosed by the invention is prepared from the following raw materials in parts by weight: 10-15 parts of Chinese parsnip root, 15-20 parts of schizonepeta, 12-16 parts of cortex dictamni, 8-12 parts of periostracum cicada, 10-15 parts of Chinese angelica, 4-8 parts of ephedra, 7-11 parts of zornia gibbosa, 3-5 parts of root of common peony, 6-12 parts of pericarpium granati, 10-15 parts of liquorice, 5-10 parts of radix bupleuri, 8-12 parts of oriental wormwood, 9-13 parts of curcuma aromatic, 5-10 parts of campsis grandiflora, 10-15 parts of polygonum cuspidatum, 5-10 parts of rheum officinale, 14-18 parts of rabdosia rubescens, 10-15 parts of schisandra chinensis, 11-17 parts of medlar leaves, 8-12 parts of radix sophorae flavescentis, 5-10 parts of lysimachia christinae Hance, and 10-15 parts of propolis. All drugs are fit for use, therefore, the traditional Chinese medicine prescription disclosed by the invention has the effects of clearing heat, dehumidifying, dispelling the wind, relieving itching, cooling blood, moistening dryness, being antiviral, anti-inflammatory and cholagogue, removing jaundice, protecting liver, reducing bile salt, preventing histamine secretion and irritability and the like; the traditional Chinese medicine prescription has obvious curative effect for treating hyperbilirubinemia caused skin itch; furthermore, the traditional Chinese medicine prescription has the advantages of being rapid in curative effect, short in treatment course, high in curative rate, difficult for recurrence and free from toxic and side effects and adverse reaction.