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Medicine composition for treating intrahepatic cholestasis of pregnancy and preparation method thereof

A technology of cholestasis and composition, which is applied in the field of pharmaceutical composition and preparation for the treatment of intrahepatic cholestasis of pregnancy, can solve the problems of no effective treatment, perinatal harm, etc., achieve postpartum hemorrhage reduction, stable process, and reasonable formula Effect

Inactive Publication Date: 2016-08-17
NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the serious harm of this disease to perinatal infants, this disease has been listed as a high-risk pregnancy to attract people's attention to it. At present, there is no effective drug for the treatment of this disease.

Method used

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  • Medicine composition for treating intrahepatic cholestasis of pregnancy and preparation method thereof
  • Medicine composition for treating intrahepatic cholestasis of pregnancy and preparation method thereof

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preparation example Construction

[0014] A traditional Chinese medicine composition for treating intrahepatic cholestasis during pregnancy, the raw material components of which include 5-20 parts of Eucommia ulmoides, 5-20 parts of Danshen, 5-20 parts of turmeric, and 5 parts of capillary -20 parts, 5-20 parts of rhubarb, 5-20 parts of gardenia, 5-20 parts of Scutellaria baicalensis, 5-20 parts of Tianjihuang, 5-20 parts of cloud poria cocos, 5-20 parts of white fresh skin. The preparation method of this Chinese medicine composition comprises the following steps:

[0015] a) Medicinal solution extraction: mix Eucommia ulmoides, Salvia miltiorrhiza, Curcuma, capillary, Rhizoma rhubarb, Gardenia, Scutellaria baicalensis, Tianjihuang, Yun Fuling, and white fresh skin medicinal materials of the above weight components, add water and boil for three times, and water The volume multiples are respectively 10 times, 8 times, and 8 times the mass of the medicinal materials. The first extraction is 3 hours, the second ex...

Embodiment 1

[0053] A pharmaceutical composition for treating intrahepatic cholestasis of pregnancy, which is composed of the following drugs: 5 parts of Eucommia ulmoides, 5 parts of Salvia miltiorrhiza, 5 parts of curcuma, 7 parts of capillary, 8 parts of rhubarb, 10 parts of gardenia, and 10 parts of skullcap 20 parts of Tianjihuang, 5 parts of Yun Fuling, and 5 parts of Baixianpi.

[0054] A method for preparing a pharmaceutical composition for treating intrahepatic cholestasis of pregnancy, comprising the following steps: mixing the above medicinal materials evenly, placing them in an extraction tank, adding water to boil and extracting three times, and the volume of adding water each time is 10 times the mass of the medicinal materials , 8 times, 8 times, the first extraction is 3 hours, the second extraction is 2 hours, the third extraction is 2 hours, the three extractions are combined, filtered with a sieve, and the filtrate is placed in a vacuum distillation pot and concentrated u...

Embodiment 2

[0057] A pharmaceutical composition for treating intrahepatic cholestasis during pregnancy, which is composed of the following drugs: 15 parts of Eucommia ulmoides, 15 parts of Salvia miltiorrhiza, 15 parts of curcuma, 10 parts of capillary, 9 parts of rhubarb, 10 parts of gardenia, and 10 parts of skullcap 15 parts of Tianjihuang, 10 parts of Yun Fuling, and 15 parts of Baixianpi.

[0058] A method for preparing a pharmaceutical composition for treating intrahepatic cholestasis of pregnancy, comprising the following steps: mixing the above medicinal materials evenly, placing them in an extraction tank, adding water to boil and extracting three times, and the volume of adding water each time is 10 times the mass of the medicinal materials . Appropriate (every kg crude drug is concentrated to 2000m1 medicinal liquid), filter supernatant; Supernatant is equivalent to the 2% flow rate of resin volume per minute on D101 type macroporous adsorption resin column (the mass ratio of r...

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Abstract

The invention discloses a medicine composition for treating intrahepatic cholestasis of pregnancy. The medicine composition is prepared from, by weight, 5-20 parts of eucommia ulmoides, 5-20 parts of Salvia miltiorrhiza, 5-20 parts of radix curcumae, 5-20 parts of herba artemisiae scopariae, 5-20 parts of prepared rhubarb, 5-20 parts of fructus gardeniae, 5-20 parts of radix scutellariae, 5-20 parts of herba hyperici japonici, 5-20 parts of poria and 5-20 parts of cortex dictamni. The invention further discloses a preparation method of the medicine composition for treating intrahepatic cholestasis of pregnancy. The preparation process is simple, operability is high, extraction efficiency is high, the dosage of the final product is small, and quality is controllable; the traditional Chinese medicine composition has effects on tonifying kidney and preventing abortion, removing stasis and promoting cholagogue, and tonifying spleen and resolving dampness, and has a good treatment effect on intrahepatic cholestasis of pregnancy.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition and a preparation method for treating intrahepatic cholestasis during pregnancy. Background technique [0002] Intrahepatic cholestasis of pregnancy (ICP) is a common disease idiopathic to pregnancy, mostly occurs in the second and third trimesters of pregnancy, and is characterized by skin itching and jaundice, with an incidence of about 2% to 4% in China . ICP has no obvious harm to pregnant women and will not leave behind chronic liver lesions. Pruritus and jaundice usually subside on their own within 1 to 2 weeks after delivery. The main hazard of this disease lies in the adverse effects on perinatal infants. Bile acid can stimulate the uterus and decidua to release prostaglandins, trigger uterine contraction prematurely, and cause premature labor. Data show that the incidence of premature birth caused by this d...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/16A61P15/00
CPCA61K36/9066A61K36/076A61K36/185A61K36/282A61K36/46A61K36/537A61K36/539A61K36/708A61K36/744A61K36/75A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 席明名
Owner NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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