33 results about "Rabdosia rubescens" patented technology

The invention discloses medical soap for sterilizing, relieving itching and removing acne and a manufacturing method thereof, belonging to the field of articles of everyday use. The medical soap is prepared from ingredient A, ingredient B and ingredient C, wherein the ingredient A is prepared from dandelions, folium isatidis, rabdosia rubescens and glabrous sarcandra herb; the ingredient B is prepared from radix angelicae, rhizoma typhonii, white poria, Chinese angelia root tai, radix pseudostellariae, raw milkvetch root, Chinese honeylocust fruit, red paeony root, prepared kusnezoff monkshood root, radices lithospermi, cortex dictamni, thunberg fritillary bulb, fiveleaf akebia fruit, white muscardine silkworms and solanum lyratum; the ingredient C is prepared from soap base, honey and bovine bone marrow oil. The medical soap disclosed by the invention is used for external washing or smearing after being wet by adding water in the morning and evening every day; after a person with smelly feet washes the feet, the medical soap is smeared in gaps between toes; and the medical soap is not suitable for use when the skin is damaged. The medical soap prepared by the invention is a black brown solid body, and has soap medicine odor; the medical soap can be used for nourishing the skin, is antiallergic, beautifies the features, removes acne, relieves itching, removes freckles, clearing heat and deterring sweat; the medical soap can beautify the features, whiten the skin, and remove the acne and the freckles when used for washing the face, and can deter the sweat, remove the smelly odor and treat dermatophytosis when used for washing the feet; and the medical soap has a control effect on the itching toxin which appears after mosquito bite, and has a moisturizing effect for the person having the dry skin.

The invention discloses an anti-helicobacter pylori pharmaceutical composition containing lactobacillus reuteri as well as a preparation method and application of the anti-helicobacter pylori pharmaceutical composition, and relates to the technical field of medicines. The anti-helicobacter pylori pharmaceutical composition comprises a traditional Chinese medicine composition and a lactobacillus reuteri liquid, the traditional Chinese medicine composition comprises the following components: uncinata spikemoss herb, dianthus chinensis root, airpotato yam rhizome, rabdosia rubescens and rabdosia amethystoides. The mass volume ratio of the traditional Chinese medicine composition to the lactobacillus reuteri liquid is (30-50) g: (7-15) mL. The traditional Chinese medicine composition and the lactobacillus reuteri liquid are combined for use, helicobacter pylori in the oral cavity and digestive tract of the human body is efficiently removed, and other side effects are not generated.

The invention discloses a rabdosia rubescens and roxburgh rose stock solution (puree) and honey beverage and a preparation method thereof, and belongs to the technical field of functional beverages. The beverage is prepared from the following raw materials in parts by weight: 20-50 parts of a rabdosia rubescens extracting solution, 80-150 parts of a roxburgh rose stock solution (primary pulp), 10-30 parts of honey and 50-200 parts of water. The preparation method comprises the following steps: decocting and extracting rabdosia rubescens for a short time, mixing with a roxburgh rose stock solution, adding honey and water, blending, standing, filtering, filling, sterilizing and the like. The beverage gives full play to the synergistic effects of the rabdosia rubescens for clearing away heat and toxic materials, the roxburgh rose for resisting oxidation due to high-dimensional C and the honey for moistening lung to arrest cough, meanwhile, taste coordination is realized through scientific proportioning, the problems of bitterness of the rabdosia rubescens and over-acidity of the roxburgh rose are solved, and the beverage has the advantages of synergistic function, unique taste, simple process, good stability and the like, and is suitable for industrial production.

The present application relates to a kind of traditional Chinese medicine for treating female HPV infection, which is prepared from the following weight ratio of traditional Chinese medicine raw materials: 2-4 parts of catechu, 2-4 parts of half lotus, 2-4 parts of snakeberry, 1-2 parts of longjin, 1-2 parts of gotu kola, 1-2 parts of wintergreen, 1-2 parts of coptis, and 1-2 parts of sophora. The present application can effectively treat female HPV infection.

The present application relates to the field of biotechnology, in particular to the application of Radix Rabdosiae Rubescens derived exosomes in the preparation of a drug for promoting wound healing, wherein the prepared Radix Rabdosiae Rubescens derived exosomes are uniform in size, good in appearance, can promote cell proliferation, have good effects of promoting fibroblast migration and reducing scar formation; and a scar-free wound healing hydrogel containing Radix Rabdosiae Rubescens derived exosomes is also provided, wherein the hydrogel can encapsulate rEVs or ORI, can effectively increase the proportion of type III collagen in the new skin tissue, effectively reduce the formation of scars, effectively promote the healing of deep second-degree burn wounds, and effectively inhibit the MMT process of macrophages in the wound healing process, and has a wide application prospect in the field of scar prevention and treatment.

The invention provides a traditional Chinese medicine composition for treating pulmonary nodules and a preparation method thereof. The traditional Chinese medicine composition is prepared by extracting the following traditional Chinese medicine decoction pieces in parts by weight: 25-35 parts of raw coix seeds, 8-12 parts of platycodon grandiflorum, 8-12 parts of curcuma zedoary, 8-12 parts of radix curcumae, 8-12 parts of salvia chinensis, 8-12 parts of astragalus membranaceus, 8-12 parts of radix pseudostellariae, 8-12 parts of akebia fruits, 10-20 parts of oldenlandia diffusa, 10-20 parts of rabdosia rubescens, 3-7 parts of radix ranunculi ternati and 8-12 parts of glossy privet fruits. The traditional Chinese medicine can be used for treating the phlegm stasis and toxin stagnation syndrome type pulmonary nodule, and fully embodies the treatment principle of clearing damp and reducing phlegm, promoting blood circulation to remove blood stasis, promoting qi circulation to relieve pain, tonifying qi and lifting yang, replenishing qi and strengthening spleen, promoting salivation and moistening lung, promoting qi circulation to diuresis, promoting qi circulation to relieve pain, strengthening spleen to promote digestion, clearing away heat and toxic materials, promoting diuresis and eliminating carbuncle, promoting blood circulation to relieve pain, nourishing liver and kidney, and preventing blood-activating drugs from consuming blood and injuring yin; the traditional Chinese medicine is an effective prescription for treating the phlegm stasis and toxin stagnation syndrome type pulmonary nodule.

This invention provides a traditional Chinese medicine composition for reflux esophagitis, relating to the field of traditional Chinese medicine pharmaceutical technology. The composition comprises rose, Lithospermum erythrorhizon, Sargentodoxa cuneata, Rabdosia rubescens, honeysuckle, licorice, Evodia rutaecarpa, pearl, Coix seed, and Salvia miltiorrhiza. This composition is obtained through rational combination based on the principles of traditional Chinese medicine syndrome differentiation and treatment, with synergistic effects among the various herbs. This invention's composition exhibits significant anti-inflammatory effects and demonstrates significant repair and improvement effects on damaged esophageal mucosa. It shows significant efficacy in treating reflux esophagitis, significantly improving the treatment effectiveness and cure rate, significantly alleviating patient discomfort and pain. This invention's composition is a pure traditional Chinese medicine preparation, with no toxic side effects and no drug resistance.

The invention relates to the technical field of tea processing, and discloses a rabdosia rubescens and Pu'er tea mixed processing device and process, the rabdosia rubescens and Pu'er tea mixed processing device comprises a feeding box, the interior of the feeding box is divided into two storage cavities; a mixing bin is arranged at the bottom of the feeding box in a communicating mode, a mixing paddle driven by a motor is arranged in the mixing bin, and a valve is arranged at the bottom of each storage cavity. A conveying mechanism is arranged at the bottom of the mixing bin in a communicating mode, an outlet of the conveying mechanism is formed in an inlet of the tea frying machine, and a receiving mechanism communicating with the interior of the tea frying machine is arranged on the tea frying machine. The device is high in automation degree, the working efficiency can be effectively improved, the labor cost is reduced, meanwhile, precise mixing and efficient stir-frying can be achieved, and the processing quality is guaranteed.

The invention relates to the technical field of health-care tea, and particularly discloses mesembryanthemum crystallinum health-care tea and a preparation method thereof.The mesembryanthemum crystallinum health-care tea is prepared from, by weight, 0.28%-0.32% of rabdosia rubescens, 0.15%-0.22% of folium mori, 0.015%-0.025% of pericarpium citri reticulatae, 0.28%-0.31% of persimmon leaves, 0.16%-0.22% of schisandra chinensis, 0.03%-0.05% of green tea, 0.19%-0.21% of gynostemma pentaphyllum and the balance deionized water; the mesembryanthemum crystallinum health-care tea prepared by the invention has the functions of purging fire, relieving restlessness, easing pain, soothing the nerves, resisting cancer, dispelling wind and heat, clearing liver, improving vision, benefiting joints, inducing diuresis, reducing blood pressure, blood sugar and fat, improving immunity, diminishing inflammation, resisting virus, resisting radiation and regulating intestinal tracts, and also has the functions of resisting tumor, resisting fatigue, inhibiting nervous excitation, keeping mental stability, improving stress response, improving immunity and the like. The effects of delaying senescence, beautifying, losing weight, protecting liver, strengthening brain and heart, regulating gastric secretion, astringing lung, relieving cough and relieving asthma are achieved.

The invention provides application of dracocephalum moldavica total flavonoids in preparation of a medicine for preventing and / or treating heart failure with preserved ejection fraction, and belongs to the technical field of biological medicine. After a heart failure model mouse with reserved ejection fraction is constructed and dracocephalum moldavica general flavone is administrated, research finds that compared with an HFpEF model group mouse, the myocardial cell damage degree of the dracocephalum moldavica general flavone group mouse is obviously reduced, the myocardial hypertrophy is obviously reduced, and the myocardial hypertrophy is obviously reduced. The total flavonoids of dracocephalum moldavica can significantly reduce pathological cardiac hypertrophy and myocardial fibrosis of HFpEF model mice, improve cardiac diastolic function, and reduce the degree of liver cell injury and lipid metabolism imbalance, thereby preventing and / or treating heart failure with ejection fraction retention.

The invention discloses a traditional Chinese medicine formula for adjuvant therapy of esophageal cancer and radiation esophagitis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine formula comprises the following raw materials: sculellaria barbata, hedyotis diffusa, nightshade, reed root, salvia chinensis, concha arcae, radix glehniae, radix actinidiae chinensis, cynanchum paniculatum, lotus leaf, blackberry lily, subprostrate sophora, rabdosia rubescens, scaphium scaphigerum, amomum cardamomum, fructus forsythiae, selfheal and garden balsam. , radix clematidis, radix scrophulariae, salvia miltiorrhiza and oyster. The formula has the effects of clearing away heat and toxic materials, diminishing swelling and removing stasis, nourishing yin and moistening dryness, and activating meridians to stop pain, can effectively relieve choking of esophageal cancer patients and red, swollen and painful throat of radiation esophagitis patients in the radiotherapy period, and improves the life quality and treatment effect of the patients.

The invention relates to the field of traditional Chinese medicine preparations and the technical field of medicine analysis, in particular to a traditional Chinese medicine composition for treating liver cancer and intestinal cancer and a preparation method and a detection method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 200 to 300 parts of herba taraxaci, 200 to 300 parts of herba rabdosiae, 250 to 350 parts of ganoderma lucidum spore powder, 50 to 150 parts of solanum lyratum, 250 to 350 parts of centipede, 200 to 300 parts of radix scutellariae, 250 to 350 parts of oldenlandia diffusa, 250 to 350 parts of herba andrographitis, 400 to 500 parts of phellinus igniarius, 250 to 350 parts of radix tetrastigme, 50 to 200 parts of Chinese mahonia and 100 to 250 parts of agkistrodon halys. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, removing blood stasis and phlegm, eliminating sores and removing stasis and is used for treating liver cancer and intestinal cancer.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a rabdosia rubescens-based novel antibacterial and anti-inflammatory external preparation and a preparation method thereof, the rabdosia rubescens-based novel antibacterial and anti-inflammatory external preparation is prepared from the following raw materials in parts by weight: 100-200g of rabdosia rubescens, 50-100g of honeysuckle, 50-100g of fructus forsythiae, 30-80g of radix sophorae flavescentis, 30-80g of fructus cnidii and 10-30g of borneol, and the weight ratio of rabdosia rubescens to honeysuckle and fructus forsythiae is 1: (0.8-1.2). According to the novel anti-bacterial and anti-inflammatory external preparation based on the rabdosia rubescens and the preparation method, the preparation takes the rabdosia rubescens as a main material and is compatible with the traditional Chinese medicine components such as the honeysuckle, the fructus forsythiae, the radix sophorae flavescentis, the fructus cnidii and the borneol, and effective components are fully extracted by a method of combining ethanol reflux extraction and water decoction extraction; the traditional Chinese medicine composition can be prepared into various dosage forms such as lotion, gel, ointment and the like.

The application provides a traditional Chinese medicine composition and a preparation method thereof, which is used for treating the symptom of water and rice not entering of upper gastrointestinal cancer, and is mainly made of eaglewood, borax, green malachite, white vine, belamcanda, ginseng, mint, wintergreen, mountain bittercress, Sichuan fritillary and borneol, and is characterized by that: white vine, belamcanda, ginseng, mint, wintergreen, mountain bittercress and Sichuan fritillary medicinal materials are extracted to obtain an extract; the extract is filtered and concentrated after being combined to obtain a clear paste; the eaglewood and the borax and the green malachite are crushed into fine powder; the fine powder, the borneol and the clear paste are uniformly mixed to obtain a medicinal paste. The traditional Chinese medicine composition has the effect of treating the symptom of water and rice not entering of esophageal cancer, is green, low in cost, low in side effect and the like, fills the blank of water and rice not entering of advanced esophageal cancer at home and abroad at present, combines the traditional Chinese medicine concept and the modern pharmaceutical technology, can become a new type of medicine for treating the symptom of water and rice not entering caused by digestive system cancer, has wide market prospect and application value.

The invention relates to an improved compound cocklebur fruit traditional Chinese medicine composition for treating allergic rhinitis, which is prepared from cocklebur fruit, folium mori, rhizoma phragmitis, platycodon grandiflorum, liquorice, rhizoma atractylodis, rhizoma zingiberis, radix sophorae flavescentis, rabdosia rubescens and cortex mori radicis according to a specific weight part ratio. The improved compound traditional Chinese medicine composition with a new prescription can effectively inhibit the key biological sites of the occurrence and development of rhinitis and improve the symptoms of rhinitis, and compared with the original compound fructus xanthii prescription, the improved compound traditional Chinese medicine composition has higher treatment efficiency and wider applicability to most people.

The invention relates to the technical field of detection, in particular to a content determination and identification method for Shenxianling granules, which comprises the following steps: determining the content of oridonin in the Shenxianling granules by adopting a high performance liquid chromatography (HPLC), and respectively identifying six components, namely hairyvein agrimony, dark plum, liquorice, gynostemma pentaphyllum, ginseng and lucid ganoderma by adopting a thin layer chromatography (TLC). The TLC identification method of each component comprises a unique preparation method of a test solution, a control medicinal material solution and a negative control solution, and specific setting of a sample application amount, a developing solvent and an inspection condition; according to the invention, a full-chain quality control system of the Shenxianling granules is constructed through the technical combination of accurate quantification of characteristic components, exclusive qualitative determination of multiple medicines and efficient removal of impurities. According to the HPLC method, the oridonin is accurately quantified, and the problem that original standard indexes are one-sided is solved; the TLC identification system ensures rapid true and false identification of the six traditional Chinese medicines through double optimization of extraction conditions and an expansion system.

The invention discloses lung heat clearing granules and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The lung heat clearing granule is prepared from the following components in parts by weight: 30 to 50 parts of traditional Chinese medicine preparation, 10 to 15 parts of hesperidin, 5 to 10 parts of flos farfarae polysaccharide, 2 to 6 parts of oridonin, 1 to 3 parts of breviscapine, 1 to 3 parts of maltodextrin and 100 to 200 parts of water, the traditional Chinese medicine preparation comprises the following components in parts by weight: 10-15 parts of Chinese dates, 10-15 parts of scutellaria baicalensis, 5-10 parts of platycodon grandiflorum, 5-10 parts of poria cocos, 5-10 parts of exocarpium citri rubrum, 5-10 parts of thunberg fritillary bulb, 5-10 parts of white mulberry root-bark, 3-8 parts of angelica sinensis, 3-8 parts of asparagus fern, 3-8 parts of gardenia, 3-8 parts of scalded bitter apricot kernels, 3-8 parts of radix ophiopogonis, 3-8 parts of ginger, 2-6 parts of liquorice and 1-4 parts of schisandra chinensis. The prepared lung-heat-clearing granules are free of toxic and side effects, good in medicine effect, simple in preparation process and suitable for large-scale popularization.

The application provides an anti-esophageal cancer drug derived from fresh Rabdosia rubescens and a preparation method thereof, and relates to the technical field of traditional Chinese medicine fresh medicine pharmacy. The application takes fresh Rabdosia rubescens as a base medicinal material, improves and optimizes an extraction process, obtains an extract containing oridonin (Ori) and rosmarinic acid (RA), and studies the anti-esophageal cancer effect of the extract from fresh Rabdosia rubescens. The experimental results show that the treatment effect of Ori combined with RA on esophageal cancer model mice is remarkable, and the effect is better than that of single administration of Ori or RA, which indicates that oridonin combined with rosmarinic acid can significantly improve the anti-esophageal cancer effect. The application provides a new drug and treatment idea for the treatment of esophageal cancer.

The invention discloses a Chinese herbal medicine composition for cattle and sheep and a processing and preparing method, and belongs to the technical field of cattle and sheep breeding. The invention provides a traditional Chinese medicine formula, which is prepared from the following components in parts by weight: 20 to 30 parts of fructus crataegi, 20 to 30 parts of radix astragali seu hedysari, 30 to 40 parts of flos lonicerae, 40 to 50 parts of flos chrysanthemi, 30 to 40 parts of radix rehmanniae praeparata, 20 to 30 parts of herba rabdosiae, 35 to 45 parts of pericarpium citri reticulatae, 30 to 40 parts of lycium ruthenicum, 20 to 30 parts of gallnut and 30 to 40 parts of activated carbon. All the raw materials of the Chinese herbal medicine formula product are traditional Chinese medicines, are safe and reliable and have no toxic or side effect; the product provided by the invention has the effects of improving cattle and sheep breeding health care and breeding benefits; the conception rate and postpartum recovery of cattle and sheep in the estrus period are improved; the feeding time and calving interval of cattle and sheep are shortened; the number of somatic cells in fresh milk is reduced; and the production process is simple, is economical and practical, and has a good popularization and application prospect.

The invention relates to the technical field of medicinal chemistry, and particularly discloses a preparation method of a traditional Chinese medicine extract and application of the traditional Chinese medicine extract in preparation of a medicine with an anti-colorectal cancer effect. The preparation method of the traditional Chinese medicine extract comprises the following steps: crushing traditional Chinese medicine raw materials, extracting with a solvent, separating an extracting solution after the extraction is finished, and concentrating and drying the extracting solution to obtain the traditional Chinese medicine solvent extract; and taking the traditional Chinese medicine solvent extract to obtain the traditional Chinese medicine extract. The traditional Chinese medicine raw materials comprise oldenlandia diffusa, astragalus membranaceus and rabdosia rubescens. Researches show that the traditional Chinese medicine extract prepared by the method disclosed by the invention has the effect of resisting colon cancer; therefore, the compound has important application value when being used as an active ingredient for preparing the medicine with the colon cancer resisting effect.

The invention relates to a shower gel containing natural plant components and a preparation method thereof, and belongs to the technical field of daily chemicals, the shower gel comprises an oil-control whitening composition, a humectant, an anionic surfactant, a nonionic surfactant, a zwitterionic surfactant, an emulsifier, a thickener, a pearling agent, a chelating agent, a preservative and a solvent. According to the oil-controlling and whitening composition disclosed by the invention, the isodon lanceolata extract, the epilobium fischeri extract and the hydrolyzed pea protein are selected in the oil-controlling and whitening composition, so that the prepared shower gel finished product effectively has a remarkable oil-controlling effect by improving oil secretion and combining pore shrinking and water replenishing, and the oil outlet state of the skin is improved; the potassium methoxysalicylate, the melissa officinalis extract and the ascorbic acid polypeptide are compounded, so that cuticle can be softened to promote skin renewal, melanin generation can be reduced from the source, newly-synthesized pigmentation is inhibited, and the prepared shower gel finished product can synergistically act on different links to comprehensively and effectively whiten the skin.

The present application mainly relates to a kind of traditional Chinese medicine composition for treating phlegm and qi mutual knotting type esophageal cancer and recurrence and preparation method and application thereof, belong to the field of biological medicine technology.The traditional Chinese medicine composition includes 3-90 parts of Huangqi, 1-60 parts of Donglingcao, 1-30 parts of Dangshen, 1-30 parts of Shengbaishu, 1-30 parts of Fuling, 1-30 parts of Chenpi, 1-30 parts of Chaihu, 1-30 parts of Weilingxian and 1-30 parts of Zhigancao.The above-mentioned raw materials are extracted by water to obtain the traditional Chinese medicine composition of the present application.The traditional Chinese medicine composition can correct the phlegm and qi mutual knotting symptoms of phlegm and qi mutual knotting type esophageal cancer patients, effectively inhibit the growth and recurrence of tumor, and has good safety.

The invention discloses a preparation process of a sour tea seasoning, which comprises the following steps: step (1), preparing a sour tea base material by an ancient method; the process comprises the steps of fresh leaf withering, infrared fixation, three-dimensional fermentation tank fermentation and geothermal drying, wherein the three-dimensional fermentation tank fermentation is double-bacterium synergistic staged fermentation; step (2), seasoning processing; the method comprises the following steps: enzymatic hydrolysis and fresh extraction, composite blending and granulation molding, and the enzymatic hydrolysis and fresh extraction process comprises the following steps: crushing fermented sour tea, adding neutral protease for enzymatic hydrolysis, and increasing the content of umami peptide to 12mg / g or above; the compounded materials comprise sour tea powder, konjac glucomannan, resistant dextrin, Yunnan wild mushroom powder and low-sodium salt; granulating and forming to enable the particle size of the seasoning to be 0.5-1mm; and (3) packaging and sterilization, nitrogen-filled packaging and irradiation sterilization. The sour tea fermentation product is converted into the seasoning product with high delicate flavor and rich probiotics, and the problems that the traditional sour tea application scene is single, the industrial production of the seasoning lacks cultural characteristics and the like are solved.

The invention provides a medicament for treating skin diseases and a preparation method thereof. The medicament comprises rabdosia rubescens powder, salicylic acid, benzoic acid, procaine, lidocaine and borneol. Preparing powder by combining talcum powder; preparing an ointment by combining with medical albolene; preparing a tincture by combining alcohol and water; the raw materials are low in obtaining cost, skin diseases can be rapidly and effectively treated in a short time, the special effect is achieved especially for fungal diseases, and various preparations can prevent and treat local body surface inflammation, redness, swelling, pain, severe itching and other symptoms caused by local body surface inflammation, redness and swelling of a patient in multiple aspects; the medicament has a remarkable curative effect on acne, psoriasis, eczema, fungal skin infection and mild skin inflammation.

The invention relates to a crushing device for rabdosia rubescens production. The crushing device comprises a shell; the conveying channel is arranged on the top of the supporting frame. The clamping and conveying mechanism is arranged on the conveying channel and comprises a reciprocating motion mechanism and a clamping plate; the cutting mechanism is arranged on the conveying channel and located on the right side of the clamping and conveying mechanism, and the cutting mechanism comprises a lifting mechanism and a cutter arranged at the top of the lifting mechanism; the crushing mechanism is arranged below the conveying channel and comprises a material distributing cylinder, a shredding cylinder and a granulating cylinder; the grinding mechanism is arranged at the bottom of the supporting frame, the grinding mechanism comprises a cover body and a grinding core rotationally arranged in the cover body, and the inner circumferential surface of the cover body and the outer circumferential surface of the grinding core are arranged at an interval to form a circular-truncated-cone-shaped grinding gap; the grinding mechanism comprises a material conveying opening communicated with a material falling opening of the grain cutting cylinder, and a material discharging opening is communicated with the grinding gap; a cooling coil is arranged in the cover body and comprises a cooling water inlet and a cooling water outlet, so that the influence on the medicinal property of the rabdosia rubescens caused by heat generated by grinding friction is avoided.

The invention discloses R8 polypeptide modified rabdosia rubescens-derived nano-vesicles as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The technical problem to be solved is to provide R8 polypeptide modified rabdosia rubescens-derived nano-vesicles to overcome the problems of poor targeting property, large toxic and side effects, poor in-vivo application effect of traditional Chinese medicine active ingredients and the like of existing liver cancer treatment drugs. According to the technical scheme, the method is characterized by comprising the following steps: mixing rabdosia rubescens and a buffer solution, homogenizing, filtering, adding a protease inhibitor, carrying out differential centrifugation to obtain supernate, carrying out ultracentrifugation on the supernate, and collecting precipitates to obtain a rabdosia rubescens-sourced nano-vesicle crude extract; re-suspending and filtering the crude extract of the rabdosia rubescens-derived nano-vesicles, carrying out ultracentrifugation on the filtrate again, collecting the precipitate, and re-suspending to obtain the rabdosia rubescens-derived nano-vesicles; mixing the rabdosia rubescens source nano-vesicles with the R8 polypeptide-polyethylene glycol conjugate, co-incubating, and centrifuging to obtain R8 polypeptide modified rabdosia rubescens source nano-vesicles.

A method for preparing an anti-tumor traditional Chinese medicine compound formulation containing isoquercitrin. The specific preparation steps of the anti-tumor traditional Chinese medicine compound formulation containing isoquercitrin are as follows: 8-10 g of Taxus chinensis, 6-12 g of Paris polyphylla, 15-17 g of Solanum nigrum, 3-7 g of Taraxacum officinale, 5-10 g of Angelica sinensis, 12-14 g of Poria cocos, 13-15g of Astragalus membranaceus, 8-10g of Panax ginseng,13-15g of Ganoderma lucidum, 8-10g of Scutellaria barbata, 13-15g of Sophora flavescens, 14-16g of Rabdosia rubescens, 8-12g of Panax notoginseng, 15-17g of Scleromitrion diffusum, 16-17g of Lithospermum erythrorhizon, 8-12g of Morus alba, and 13-14g of Sophora japonica. The raw material formula of the present application incorporates Morus alba and Sophora japonica, and the Morus alba and Sophora japonica are rich in isoquercitrin and have antioxidant, anti-inflammatory and potential antitumor effects, thus significantly enhancing the efficacy of the traditional Chinese medicine compound formulation. Moreover, the preparation process of the formulation is simple. After the preparation of the formulation is completed, the concentration of the isoquercitrin content can be quantitatively determined by using high-performance liquid chromatography technology, and an acute toxicity test and a long-term toxicity test are performed to ensure the safety of the formulation.

The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine external application package composition and application for reducing complications after transradial coronary intervention. The composition of the present invention is composed of Lobelia chinensis, honeysuckle, earthworm, Rubescens rubescens, Scrophularia ningpoensis, Chinese angelica, Trillium gracile, Citrus aurantium, and liquorice. The above-mentioned medicines are used together to achieve the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, and promoting qi and relieving pain. The composition is closely related to the TCM pathogenesis of complications such as arterial occlusion and hand ischemia after transradial coronary intervention, which are caused by toxic invasion of collaterals and blood stasis. The composition can effectively reduce the incidence of arterial occlusion after transradial coronary intervention, alleviate the degree of palm swelling and hand ischemia symptoms after surgery, and reduce the degree of pain in the patient's postoperative wound site.

The application discloses a Chinese medicine compound effective active ingredient preparation for resisting colorectal cancer and a preparation method thereof. The preparation is prepared from the following Chinese medicine raw materials in equal weight parts: Smilax riparia, Rabdosia rubescens, Oldenlandia diffusa and Centella asiatica. The active ingredient extraction method comprises the following steps: (1) immersing the Chinese medicine raw materials in 90% ethanol for extraction; (2) adding chitosan into the extraction liquid, stirring, standing for precipitation, solid-liquid separation, and obtaining a filtrate; (3) adjusting the pH value, standing for precipitation, solid-liquid separation, and obtaining a filtrate; (4) eluting the obtained filtrate on a macroporous adsorption resin D4020; and (5) performing vacuum concentration and drying on the obtained eluate, and then crushing the eluate into fine powder, thereby obtaining the preparation. Compared with the existing compound Smilax three herb soup, the preparation has an inhibition rate on colon cancer HCT116 and DIFI cells which is increased by more than 2 times, and is more than 90%.

The invention provides a special forest medicinal plant large-scale breeding method, and belongs to the technical field of medicinal plant cultivation. The breeding method provided by the invention comprises the following steps: (1) pretreating rabdosia rubescens seeds; (2) sowing the pretreated seeds in a compound substrate for germination and cultivation; (3) transplanting the germinated seedlings into a seedling culture substrate containing a functional microbial agent, and culturing on the bionic seedbed to obtain seedlings; and (4) hardening the seedlings, and transplanting the seedlings to a field. By means of the method, the germination rate and the survival rate of the rabdosia rubescens seeds are remarkably increased, the seedling raising period is remarkably shortened, and the method is suitable for industrialized large-scale seedling raising.