Application of p-hydroxybenzene ethanone and its derivant in preparation of agentia treating gallstone disease

Abstract

The invention discloses an application of hydroxyacetophenone and its derivatives in preparing drugs for curing cholelithiasis, which can enhance the excretion of bile and lower down the content of cholesterin and bilirubin in the bile, thus realizing the dual effects of bile expelling and lithiasis resolving. Therefore, the invention can be applied to treat lithiasis.

Description

technical field [0001] The invention relates to the application of p-hydroxyacetophenone and its derivatives in the pharmaceutical field, in particular to the application of p-hydroxyacetophenone and its derivatives in the preparation of medicaments for treating cholelithiasis. Background technique [0002] Cholelithiasis is a common disease that affects human health. The incidence in most western countries is similar, and the incidence in adults is about 10-20%. It is about 10% in our country. Female patients are about twice as common as male patients. The onset characteristics of this disease are not only age, gender, occupation, obesity and regional differences, but also environmental and genetic differences. Acquired factors, such as drugs, endotoxins, infections (including parasitic infections), hormones, biliary obstruction, liver transplantation, etc. will increase the incidence of cholelithiasis. [0003] Gallstones can be divided into cholesterol stones, pigment ...

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Problems solved by technology

[0006] However, these stone-dissolving drugs often have some side effects that often make it difficult for patients to persist in taking them for a long time, especially gastrointestinal reactions, such as diarrhea, and abnormal liver function after long-term use. have teratogenic effects and are therefore subject to great restrictions

[0007] Traditional Chinese medicine has played a very prominent role in the treatment of cholelithiasis. The compound mainly composed of Desmodium sativa has achieved certain effects, but we have not obtained obvious curative effect in the cholelithiasis-dissolving test with the components separated and extracted from Desmodium.

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