The invention relates to large-section high-performance hot work die steel for die casting and a preparation technology thereof and belongs to the technical field of an alloy steel preparation technology. The steel is characterized in that main alloy elements in alloy chemical components comprise, by weight, 0.35-0.65% of C, 0.30-1.00% of Si, 0.30-1.00% of Mn, 3.50-5.50% of Cr, 2.00-3.00% of Mo, 0.40-0.80% of V, P being less than or equal to 0.02%, S being less than or equal to 0.01%, 1.00-2.00% of Ni, Nb being greater than or equal to 0.15%, and the balance Fe. The preparation process of the hot work die steel comprises the following steps: burdening, smelting, casting and electroslag remelting; heat treatment by high-temperature heat diffusion, hot working by multi-directional forging and controlled cooling after forging; refining and heat treatment of proeutectoid carbide and isothermal annealing treatment; and heat treatment by quenching and tempering, namely austenitizing by heating to 950-1100 DEG C, oil cooling or mist cooling, and tempering at 540-630 DEG C for two to three times. The hot work die steel provided by the invention has advantages of high hardenability, high thermal stability, high toughness and good resistance to thermal fatigue.