The invention relates to high-performance hot stamping die steel and a manufacturing process thereof. The high-performance hot stamping die steel comprises the following components of, in percentage by mass, 0.66% - 0.80% of C, 0.80% - 1.20% of Si, 0.20% - 0.50% of Mn, 5.00% - 6.50% of Cr, 1.50% - 2.00% of Mo, 0.40% - 0.80% of V, less than 0.015% of P, less than 0.015% of S and the balance Fe. Themanufacturing process of the die steel comprises the following steps of carrying out burdening, smelting, casting, electroslag remelting; carrying out high-temperature diffusion thermal treatment, multi-direction forging and hot machining and cooling control after forging; then carrying out secondary carbide refining thermal treatment and isothermal annealing treatment; and finally carrying out quenching and tempering thermal treatment. The high-performance hot stamping die steel and the manufacturing process thereof has the advantages that the hardenability, the thermal stability, the wear resistance and the thermal fatigue performance of the hot-work die steel are superior to the hardenability, the thermal stability, the wear resistance and the thermal fatigue performance of H13 steel,and the hot-work die steel can be machined into a large-scale hot stamping die with the single-piece weight reaching 5 tons or above, and the usability is good.