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3results about How to "Improve constipation" patented technology

Guanylate cyclase-c activator peptide and uses thereof

PendingCN122356212Aactivation activityGood water solubilityCyclasePharmaceutical Substances
This invention discloses a guanylate cyclase-C (GC-C) activating peptide and its applications, belonging to the field of bioactive peptide technology. The amino acid sequence of the GC-C activating peptide is PFPGPIPN. The GC-C activating peptide of this invention can significantly activate GC-C activity, increasing intracellular cGMP levels. Furthermore, the GC-C activating peptide of this invention can alleviate constipation and abdominal pain symptoms in mice, thereby effectively preventing or improving irritable bowel syndrome (IBS). Therefore, the GC-C activating peptide provided by this invention has advantages such as high activity, safety and non-toxicity, and good water solubility. It can be used as a candidate molecule for alternative or adjuvant drugs in the clinical treatment of IBS, and also as a health product or food to improve constipation or abdominal pain.
Owner:NORTHWEST A & F UNIV +1

Highland barley seedling compound powder for lubricating intestines and defecation, preparation method and application thereof

PendingCN122720694AUniform texturefine tissue
This invention relates to a compound powder of highland barley seedlings for promoting bowel movements, its preparation method, and its applications. The raw materials include highland barley seedling powder, fructooligosaccharides, matcha powder, and compound probiotic powder. Excipients are then added to formulate it into solid beverages, compressed candies, jellies, and gummies. Animal experiments have verified that the compound powder of highland barley seedlings of this invention can significantly promote intestinal peristalsis and defecation in mice with constipation, effectively repair the intestinal immune barrier, significantly increase serum gastrin (MTL) levels, and significantly reduce vasoactive peptide (VIP) levels, thereby effectively improving constipation symptoms. The compound powder of highland barley seedlings of this invention is safe, readily available, and has no side effects. The components work synergistically, possessing a unique flavor and taste. It has significant bowel-regulating and laxative effects, and low doses are sufficient to achieve the desired effect, making it of great application value.
Owner:SHANGHAI JIAOTONG UNIV +1

Medical multifunctional inflatable mattress for prone position

ActiveCN224207013UReduce overall body stressRelieve symptoms of chest tightness and breathlessnessChiropractic devicesNursing bedsPhysical medicine and rehabilitationCotton pad
The utility model discloses a medical multifunctional prone position inflatable mattress, which relates to the technical field of medical mattresses and comprises an air cushion bed main body. An air cushion cotton cushion is installed on the upper surface of the air cushion bed body, an air pump is installed on the rear surface of the air cushion bed body, an air bag partition module is installed on the left side of the upper surface of the air pump, a pressure regulator is arranged on the right side of the upper surface of the air pump, and an inflation connector is arranged on the right side surface of the air cushion bed body. Compared with an existing common multifunctional medical prone-position mattress, the medical prone-position multifunctional inflatable mattress has the advantages that the first wedge-shaped air bag and the second wedge-shaped air bag are arranged, so that the medical prone-position multifunctional inflatable mattress is convenient to use; the body position of a patient can be assisted to turn over by 15-30 degrees by independently inflating and pressurizing the wedge-shaped air bag I and the wedge-shaped air bag II, so that the pressure of the whole body of the patient is relieved, the chest distress and suffocation symptoms of the patient are relieved and the constipation incidence rate is reduced on the basis that the traditional position of the patient after the spinal cord and spinal column operation is kept.
Owner:PEKING UNIVERSITY THIRD HOSPITAL (THE THIRD CLINICAL MEDICAL SCHOOL OF PEKING UNIVERSITY)