51results about How to "Has immunomodulatory function" patented technology

The invention discloses a pet chaw with high protein. The chaw comprises 40 to 60 wt. percent of protein compound which consists of plant protein and animal protein, 15 to 40 wt. percent of faecula, 6 to 12 wt. percent of oil, 1 to 8wt. percent of prandial fibre, 1 to 4wt.percent of quality modifying agent and flavouring agent, 0.1 to 3wt. percent of antioxidant, 0.1 to 3wt. percent of nutrition or health additive, and the rest is water. The weight percentage is counted by the total weight of the pet chaw. Simultaneously, the invention also discloses a preparing method for the pet chaw with high protein and a pet toy or artificial dog bone manufactured by the method.

The invention discloses a pet masticatory containing a nutrition bar and consists of a nutrition bar and a livestock skin which enwinds the nutrition bar. The pet masticatory comprises by weight percentage: 20-80 percent of livestock skin selected from pigskin, cowskin or sheepskin, 10-60 percent of protein nutrition bar which is the mixture of animal protein and vegetable protein, 5-50 percent of starch, 1-10 percent of grease, 1-8 percent of dietary fiber, 1-4 percent of quality modifying agent and flavoring agent, 0.1-5 percent of antioxidant, 0.1-3 percent of nutrient or healthy additive and the rest of water. At the same time, the invention also discloses a preparation method for the product.

Provided is a production method for bacillus natto and cordyceps fungus composite enzyme series of products. The main products comprise bacillus natto and cordyceps fungus composite low molecular weight enzyme beverage, composite enzyme capsules and composite enzyme tablets. The production method comprises a single-microorganism fermentation technology and a mixed-microorganism fermentation technology. The bacillus natto employs bacillus subtilis natto, and the cordyceps fungus employs cordyceps sinensis or cordyceps militaris. The bacillus natto can inhibit pathogenic bacteria. The generated nattokinase can dissolve thrombus, inhibit generation of angiotensin and reduce blood pressure. No acids are generated during fermentation of the bacillus natto, and no sweeteners need to be added into the products, which is beneficial to health. The cordyceps fungus has immune modulating functions, has anti-tumor, bacteriostasis and antiinflammation effects, and has some effects on nervous systems and livers. The effective substances of the products are stable active ingredients generated from the living microorganism, and with low molecular weight, such as peptides with low molecular weight, oligosaccharides, saponins, isoflavone, cordycepin, phosphatidylcholine, trace elements and the like. The products do not need to be stored at low temperature and has a long storage life. The products contain essential amino acids and vitamins of human body, and are nutritive and healthy.

The present invention discloses one kind of recombinant plasmid containing grass carp interferon gene with the nucleotide sequence as shown in SEQ ID No. 1. The present invention also discloses engineering bacterium INVSC1-pYES2-IFN as one kind of Saccharomyces cerevisiae in the preservation number of CGMCC1847. The engineering bacterium is used for aquatic animals to resist viruses. The present invention also discloses the application of protein coded by the recombinant plasmid containing grass carp interferon gene with the nucleotide sequence as shown in SEQ ID No. 1 for aquatic animals to resist viruses.

The invention discloses application of lactobacillus reuteri in replacement of feed antibiotic and belongs to the field of microorganisms and application of the microorganisms. The lactobacillus reuteri is obtained through separation from healthy piglets, and therefore safety is high. The bacterial strain is added into antimicrobial-free feed so as to well prevent the piglets from diarrhea after ablactation, and has a good effect on growth promotion. The bacterial strain can obviously promote repair of intestinal mucous membrane damage caused by ablactation of the piglets, and has an immunity-adjusting function. In this way, the lactobacillus reuteri can be used for resisting diarrhea of the piglets after ablactation and promoting growth as a substitude of antibiotics.

A multi-bacterium composition for regulating immunity by activating, repairing and reconfiguring immune system and preparing immunoregulator, anticancer medicine and health-care food is prepared from two or more lacticacid bacteria through culture. Its preparing process is also disclosed.

The invention discloses a drug-resistance bacteria resisting compound nano preparation. The compound nano preparation is prepared by compounding a cationic anti-microbial peptide and an anionic lipidosome through an electrostatic interaction, wherein the sequence of the cationic anti-microbial peptide is one of RIVVIRVA, KIWVIRWR, RIWVIRWR, RIWVIWRR or RRWVIWRR; and an antibiotic drug is wrapped in the anionic lipidosome. According to the compound nano preparation, the anti-microbial peptide and the lipidosome drug jointly act on drug-resistance bacteria based on interference of the cationic anti-microbial peptide to a cell efflux mechanism, so that the original antibiotics resisting bacteria can exert the bactericidal effect, and the anti-microbial peptide and the antibiotics realize synergistic interaction to achieve the bactericidal effect; and therefore, the lowest inhibitory concentration of the anti-microbial peptide and the antibiotics in the compound nano preparation is greatlyreduced, and the anti-microbial activity of the compound nano preparation is effectively improved.

The invention relates to the technical field of tissue engineering, and in particular relates to a composite stent material. A preparation method of the composite stent material comprises the steps that a chitosan solution is mixed with an I-type collagen solution; pH is kept acidic; a chitosan / I-type collagen compound is obtained, mixed with a cross-linking agent, and subjected to freeze drying; a multi-hole stent is obtained, and soaked in a serum-free medium; the serum-free medium is removed; a dental pulp stem cell suspension liquid is added; standing is performed; a complete medium is added for cell culture; and the composite stent material is obtained. The research of composite stent material shows that a dental pulp stem cell has better osteogenic differentiation capacity than a bone marrow stem cell; and the dental pulp stem cell can be tightly combined with the stent material, grows well in the stent material well, and can be applied to treatment on a bone defect better.

The present invention discloses anti-aging yoghurt containing modified starch and a preparation method thereof. The anti-aging yoghurt containing the modified starch comprises the following raw materials in parts by weight: 40-100 parts of bovine colostrum, 10-30 parts of fish collagen peptide powder, 1-5 parts of a thickener, 2-6 parts of concentrated fruit juice, 0.5-1.5 parts of tea polyphenol nanoparticles, 0.1-1 part of a sweetener and 0.1-1 part of probiotics. The thickener is composed of sodium alginate and modified starch according to a mass ratio of 1:(4-6). The anti-aging yoghurt containing the modified starch is rich in nutrients, delicate in mouthfeel, smooth and refreshing, has effects of regulating balance of human body intestinal micro-ecology, improving intestinal functions, lowering blood lipids and lowering blood pressure, enhancing human body immunity and delaying aging, and is simple and easy to implement in the preparation method, strong in operability, low in cost and suitable for factory production applications.

The invention belongs to the technical field of body immunity, and discloses a detection model for a mouse intestinal mucosa epithelial barrier function and an intestinal mucosa immune tolerance cell. The model is characterized in that one part of Gal-1 deficient mice is subjected to Gal-1 intraperitoneal injection, and each mouse is injected with 0.25mg each time per day, and injection is carried out for 7 days; small intestines are respectively taken from the Gal-1 deficient mice, B6 mice and mice injected with Gal-1. The method comprises the following steps: obtaining the Gal-1 deficient mice, wherein the Gal-1 deficient mice are subjected to the Gal-1 intraperitoneal injection; respectively taking the intestines from the Gal-1 deficient mice, the B6 mice and the mice injected with Gal-1, and installing in a Ussing chamber system; measuring an epithelial barrier function; taking the small intestines to separate LPMC (Lamina Propria Mononuclear Cells), and detecting immune tolerance cells. The Gal-1 has an immunoregulation function, the intestinal mucosa is an important organ for forming oral tolerance, and the IEC (Intestinal Epithelial cCells) has an immune tolerance function.

The invention provides a method for extracting polyphenols from honey made by stingless bees. The method comprises the following steps: (1) dissolving honey made by stingless bees by adopting acetic acid water solution, carrying out stirring and ultrasonic treatment, and carrying out filtering, thus separating out water solution of the honey made by the stingless bees; (2) pouring macroporous resin into the water solution of the honey made by stingless bees, and carrying out stirring for adsorbing for 0.5-2 h; (3) packing the macroporous resin after adsorption into a column, carrying out leaching by adopting acetic acid water solution and pure water, and finally, carrying out elution by adopting alcohol solution; and (4) carrying out reduced pressure vacuum concentration on the eluate till solid matter is formed, re-dissolving the solid matter in pure water, and carrying out extraction by adopting ethyl acetate. According to the technical scheme, the active ingredients of the honey made by the stingless bees are extracted and enriched through XAD-2 column chromatography, the ingredient analysis and application research for the extract of the honey made by the stingless bees are carried out, the result shows that the extract of the honey made by the stingless bees contains rich active ingredients such as flavone and polyphenols, and has the obvious oxidation and inflammation resisting activity, and thus the extract has a wide application value for the development and application of medicines, foods and health products for preventing and treating inflammatory diseases.

The invention relates to the field of foods and discloses a composition with an immunoregulation function. The composition with the immunoregulation function is prepared from the raw materials of ginseng and cordycepsmilitaris liquid shaking-flask seed, wherein the mass-to-volume ratio (g / ml) of the ginseng to the cordycepsmilitaris liquid shaking-flask seed is (100-120):(100-180); health food with an immunoregulation function can be prepared from the composition with the immunoregulation function. The composition with the immunoregulation function is obtained by biologically transforming the ginseng with cordycepsmilitaris through bidirectional solid fermentation and can remarkably improve cellular immunity, humoral immunity and NK cell viability so as to improve the immunoregulation function. The health food with the immunoregulation function, which is prepared from the composition provided by the invention has the advantages of simple production technology, stable product quality, clear functional factors, excellent health-care efficacy, small dosage, safety in use, no toxic side effect and the like and is suitable for crowds with low immunity to eat.

The invention discloses mesenchymal stem cells and exosomes of the mesenchymal stem cell and application of the mesenchymal stem cells in treating anal fistula, and further discloses a method for treating anal fistula by using an autologous-fat-derived mesenchymal stem cell mixed preparation. The stem cell preparation includes autologous-adipose-derived mesenchymal stem cells (ADSCs) and exosomes(EXO-ADSCs) of the ADSCs, autologous platelet-rich plasma (PRP) and synthetic bacteriostatic peptides (AMP). The stem cells have immunoregulatory functions, the exosomes create a micro-environment which is conducive to recovery, meanwhile, the stem cells are stimulated to release various growth factors, and wound healing is promoted. PROP gel provides support and nutrients and works synergistically with stem cells, the survival rate after stem cell transplantation is improved, and the stem cells can better play a role. The synthetic peptides are single in components and controllable and reducethe incidence of infection. The combined use greatly improves the cure rate of anal fistula.

Disclosed is a pine pollen tablet which comprises the following raw materials (by weight portion), pine pollen 85-99 parts, white sugar 1-15 parts, preferably pine pollen 97 parts, white sugar 3 parts.

The invention discloses a young fowl feed additive which is prepared from the following components in parts by weight: a traditional Chinese medicine extract: 1-2 parts of astragalus polysaccharide, 1.5-3 parts of glycyrrhiza polysaccharide, 0.5-1 part of ganoderan, and 0.5-2 parts of pachymaran; traditional Chinese medicine superfine powder: 70-75 parts of sophora japonica, 10-15 parts of pericarpium citri reticulatae and 0.05 -0.1 part of musk, and 0.5-1 part of crude fiber enzyme; beneficial bacteria: 0.5-1 part of bacillus subtilis and 0.5-1 part of saccharomycetes; an auxiliary: 4-8 parts of water-soluble starch and 1-2 parts of rice stone. The raw materials are mixed uniformly, and then added into young fowl feed in the form of particles. The young fowl feed additive disclosed by the invention can improve the immunity and the body digestion and absorption capacity of a fowl, is conductive to increase of the weight of the fowl, reduces the feeding cost and improves the economic benefits.

The invention discloses a preparation for preventing and controlling bee fungal diseases. The preparation consists of 0.1 to 2 percent of (E)-N-(6,6-dimethyl heptanoic-2-olefin-4-alkynyl)-N-methyl-1-naphthalene methylamine hydrochloride, 0.1 to 4 percent of beneficial microorganism and 94 to 99.8 percent of soluble starch or saccharides. The beneficial microorganism comprises one or random combination of bacillus subtilis, bacillus licheniformis, bee bifidobacterium, bifidobacterium asteroids, minimum bifidobacterium, bifidobacterium coryneforme, lactobacillus jensenii, lactobacillus amylovorus, lactobacillus plantarum, tiny lactobacillus and lactobacillus bifermentans; and a gram of the beneficial microorganism comprises 10<9> to 5*10<9> viable bacteria. The preparation for preventing and controlling bee fungal diseases is applied to prevention and control of bee or silkworm fungal diseases.

The invention provides a composition with a function of enhancing phagocytic activity of macrophages, application thereof, and an immune medicine, and relates to the technical field of medicines. The composition with the function of enhancing the phagocytic activity of the macrophages, provided by the invention, comprises fucoidan and elderberry, and the inventor finds that the fucoidan and the elderberry both have an immunoregulation function and can enhance the phagocytic activity of the macrophages and inhibit lipopolysaccharide from inducing the macrophages to secrete nitric oxide, the effect of enhancing the phagocytic activity of the macrophages by jointly using the fucoidan and the elderberry is obviously better than that of a single component, the fucoidan and the elderberry have a synergistic effect, and the fucoidan and the elderberry are safe and reliable and can be used for preparing the medicine for enhancing the phagocytic activity of the macrophages.

The invention discloses modified milk powder. The modified milk powder is characterized by comprising the following components: 60-80 parts of milk powder, 3-7 parts of lutein ester, 15-25 parts of colostrum powder, 2-4 parts of whey protein powder, 0.3-0.8 of part glucan, 0.1-0.3 part of beta-carotene, and 2-6 parts of composite fruit and vegetable powder, wherein the milk powder is cow milk powder, goat milk powder or mixed powder of cow milk powder and goat milk powder, the milk powder contains 25% of whole milk powder and 75% of skimmed milk powder, the colostrum powder is bovine colostrumpowder, sheep colostrum powder or mixed powder of bovine colostrum powder and sheep colostrum powder, the composite fruit and vegetable powder is prepared from 1-3 parts of blueberry juice powder and1-3 parts of lycium ruthenicum. By adopting the technical scheme of the invention, the additive and the milk powder are physically mixed, so that the nutritional ingredients and activity of compositions are ensured as much as possible, existing equipment is used for production, and the increase of the production cost is avoided.

The invention discloses a medicinal bath composition capable of dispelling fatigue and improving sleep. The medicinal bath composition is prepared from the following raw materials in parts by weight:25-35 parts of panax notoginseng, 10-20 parts of sappan wood, 10-20 parts of rhizoma curcumae longae, 10-20 parts of Glechoma longituba, 10-20 parts of Chinese penthorum herbs, 10-20 parts of raw radix aconiti feri, 50-60 parts of pregelatinized starch and 20-30 parts of beta-cyclodextrin. According to the medicinal bath composition, development and safety are instructed by dint of theories of traditional Chinese medicine, the medicinal bath composition is free of toxic or side effects on human bodies, and fatigue can be relieved through conditioning five internal organs of bodies. The medicinal bath composition is simple in material drawing, convenient in production, low in price, convenient in use and free of restraints, and the actions of dispelling fatigue and improving sleep are remarkable.

The invention discloses application of a watery part of Japanese peristrophe herb in treating hepatitis, namely the watery part of the Japanese peristrophe herb is used for treating the hepatitis. Thewatery part of the Japanese peristrophe herb has the advantage that: the watery part of the Japanese peristrophe herb can prevent and treat various kinds of hepatitis (viral hepatitis, infection withnon hepatitis virus, alcoholic liver damage, drug and chemical poison induced hepatitis lesion and the like), has the effects of adjusting immunity, inhibiting hepatitis virus, and protecting and improving liver function, has obvious pharmacodynamic effects of preventing and treating the hepatitis and obvious treatment effect, and has low toxicity, safety and reliability, and low cost.

The invention relates to a CpG ODN with an immunoregulation function and application of CpG ODN. The CpG ODN has good immunostimulation activity, can stimulate B cell proliferation, and meanwhile generates specific cytokines. The CpG ODN can be used as a vaccine adjuvant, can be used alone, can be combined with other adjuvants to play a synergistic role, and can also be applied to the preparation of drugs for preventing or treating tumors, infections and allergies.

The invention discloses digestive yogurt containing modified starch and a preparation method thereof. The yogurt is prepared from the following raw materials in parts by weight: 80-120 parts of bovinecolostrum, 1-5 parts of the modified starch, 2-6 parts of fruit juice concentrate, 0.1-1 part of a sweetening agent, 0.1-1 part of probiotics and 0.5-1.5 parts of prebiotics, wherein the modified starch is composed of corn modified starch, cassava modified starch and potato modified starch according to a mass ratio of 1 to (3 to 5) to 2. The digestive yogurt containing the modified starch disclosed by the invention is rich in nutrition, and delicate and smooth in mouthfeel, has the functions of regulating the balance of human intestinal microecology, improving intestinal function, aiding digestion, reducing lipids and blood pressure, enhancing human immunity, and resisting aging, and is suitable for children, the aged and diabetics to eat; meanwhile, the preparation method of the yogurt is simple and practicable, strong in operability, low in cost, and is suitable for industrialized production and application.

The invention provides a preparation method and application of an immunomodulatory peptide. The immunomodulatory peptide is a synthetic protein which is formed by a dust mite peptide segment which cannot combine immunoglobulin E to cause an allergic reaction and a fungal immunomodulatory protein. A research result shows that: compared with a control group, a culture medium contains the dust mite peptide segment which cannot cause the allergic reaction and is cultured together with the fungal immunomodulatory protein, so that not only the CD4+CD25+Foxp3+ modulatory T-cells of an allergy patient are increased remarkably, but also the function of inhibiting an immunoreaction is increased. Because the culture medium contains the dust mite peptide segment which cannot cause the allergic reaction and is cultured together with the fungal immunomodulatory protein, the CD4+CD25+Foxp3+ modulatory T-cells of an allergy patient can secrete interleukin-10 and the percentage of beta-type transforming growth factors is increased remarkably. Therefore, the immunomodulatory peptide has the effect of increasing and secreting the modulatory T-cells and can regulate the immunologic function of the allergy patient so as to treat allergy.

The invention provides a method for producing inulin, cordyceps sinensis and natto enzyme powder through fermentation in a solid-liquid combination mode, which comprises the following steps: weighing soybeans, soaking the soybeans in water for 12-24 hours, and cooking the soybeans at the temperature of 100 DEG C or above for 0.5-1 hour to form cooked soybeans; when the cooked soybeans obtained in the step (1) are cooled to 45 DEG C or below, bacillus natto is uniformly scattered on the surfaces of the cooked soybeans, solid fermentation is carried out, the temperature is kept at 37-45 DEG C, fermentation is carried out for 8-12 hours, and fermented natto is formed; drying the natto obtained in the step (2), and then crushing to form a natto powder semi-finished product; the solid-liquid fermentation mode is combined, the natto adopts the solid fermentation mode, the nutritional ingredients of the natto can be well preserved, the cordyceps sinensis and the inulin adopt the liquid fermentation mode, and the operation is simple and convenient while the nutritional ingredients of the cordyceps sinensis and the inulin are preserved.

The invention discloses a jujube-propolis lozenge which comprises components in the following parts by weight: 2 to 4 parts of jujube and 1 part of propolis. As both the jujube and the propolis have multiple effects on health care, the finished product of the jujube-propolis lozenge can be obtained by the following steps: blending the propolis and the ground jujube by a proper proportion, granulating, drying, tabletting and finally packaging. The finished product not only has good flavor, but also has the effects of medical health care. The invention has the advantages that the jujube-propolis lozenge is convenient for storing and carrying, all you need to do for administration is to directly put one jujube-propolis lozenge in the mouth and suck or chew for absorption, therefore, the jujube-propolis lozenge is convenient for taking. The jujube-propolis lozenge has good social and economical values and is easy to be promoted and applied.

The present invention discloses immune regulator prepared with waste material of Mailuoning injection process and its application in producing medicine. The dregs after ethyl acetate extraction is water extracted, and the extractive is concentrated or dried and mixed with supplementary material to prepare the immune regulator. The immune regulator may be used in preparing medicine for preventing and treating immunological diseases. Utilizing the waste to prepare the immune regulator has high economic value and excellent environment protecting effect.

The invention provides a preparation method of a traditional Chinese medicinal preparation for treating chicken diarrhea. The preparation method comprises the following steps: firstly, taking radix aucklandiae, myristica fragrans, radix angelicae, mangnolia officinalis, perilla leaf, pogostemon cablin, pinellia and poria cocos, mixing, crushing, adding water, heating, extracting, concentrating an extract, and adsorbing a concentrate by using macroporous adsorbent resin to obtain a permeate; secondly, taking argentina anserina, crushing, percolating by using an aqueous ethanol solution, extracting a percolate by using diethyl ether, and concentrating an extraction solution under reduced pressure to obtain an extract; thirdly, mixing the permeate with the extract, adding into an aqueous beta-cyclodextrin solution, stirring at the constant temperature of 50-60 DEG C, refrigerating in a refrigerator with the temperature of 4 DEG C, performing spray drying, and granulating; finally, mixing obtained granules with soybean lecithin, a diluent, a binder and a wetting agent, and granulating to obtain the traditional Chinese medicinal preparation. The traditional Chinese medicinal preparation has broad-spectrum effects of resisting viruses, bacteria, fungi, spirochetes and the like, has a body immunity-adjusting function, and can improve the pathogen resistance of a chicken while the chicken diarrhea is effectively treated.

The invention provides a composition with the function of enhancing the phagocytic activity of macrophages and its application and immune medicine, and relates to the technical field of medicine. The composition with the function of enhancing the phagocytic activity of macrophages provided by the present invention includes fucoidan and elderberry. The inventor's experimental research found that both fucoidan and elderberry have immunoregulatory functions, which can enhance the phagocytic activity and phagocytic effect of macrophages. Inhibiting lipopolysaccharide-induced macrophage secretion of nitric oxide, the co-use of fucoidan and elderberry has a significantly better effect on enhancing the phagocytic activity of macrophages than a single component. There is a synergistic effect between fucoidan and elderberry. It is safe and reliable, and can be used to prepare a drug for enhancing the phagocytic activity of macrophages.

The invention discloses heat-inactivated clostridium butyricum for preventing or treating asthma and a preparation method of the heat-inactivated clostridium butyricum, and belongs to the technical field of medicines. The thermal inactivation clostridium butyricum is obtained by performing thermal inactivation on clostridium butyricum powder at high temperature of 110 kpa and 121 DEG C and high pressure for 20 minutes. The heat-inactivated clostridium butyricum can well inhibit airway inflammation and airway mucus secretion in an asthma mouse model experiment, has an immune regulation function, can effectively prevent and treat asthma, can also be used for prevention or treatment of other allergic diseases, and has a good application prospect.