113 results about "Malabsorption" patented technology

A liposome-capsule dosage unit system for the delivery of a biologically active material is formed by encapsulating a biologically active materials in liposomes and then placing the liposome encapsulated material into a capsule. The capsule is typically a soft gel capsule or a two piece capsule capable of tolerating a certain amount of water. A less water tolerant capsule can be employed if the liposomes are dehydrated prior to placement within the capsule. Biologically active material include drugs, nutritional supplements, vitamins, minerals, enzymes, hormones, proteins and polypeptides. The system is especially suited for the delivery of materials with poor oral solubility, materials that are not absorbed or are poorly absorbed from the gastrointestinal tract, and materials that have conventionally been given by an invasive route. The system can be administered orally, intra-occularly, intranasally, rectally, or vaginally.

The invention provides compositions and methods for treating pancreatic enzyme insufficiency, such as the pancreatic enzyme insufficiency associated with cystic fibrosis. The invention also provides compositions comprising lipase from Candida cylindracea, alone or in combination with amylase or amyloglucosidase, protease and / or lactase. Furthermore, the invention discloses methods for treating pancreatic enzyme insufficiency comprising administering compositions to patients in need thereof.

The invention provides a total nutrient formula food for patients with gastrointestinal malabsorption to eat, a specific total nutrient formula food or a non-total-nutrient formula food. According to the requirements of general principles of the special medical use formula food, the formula is developed by combining with the constitutive characters of the patients with gastrointestinal malabsorption and synthesizing with the research results of advanced physiology, medicine, nutriology, clinical application and the like in Harvard University at present according to the essence theories (simultaneous recuperation of the liver, the spleen and the kidneys) of supplement in digestion and balanced recuperation in the traditional Chinese medicine. According to the total nutrient formula food, essence of more than ten medicinal and edible traditional Chinese medicine extracts, a plurality of probiotics and prebiotics are taken as main raw materials, and oligopeptide, amino acid, water-soluble dietary fiber, multi-vitamin and composite minerals are taken as auxiliary materials, the total nutrient formula food not only can meet the nutritional requirements of the patients with gastrointestinal malabsorption as a single nutrient source, but also can have the efficacies of invigorating the stomach and helping digestion, warming the middle warmer and rectifying the spleen, tonifying the stomach and promoting fluid, tonifying the spleen and nourishing the stomach, helping digestion and eliminating indigestion, resolving dampness and activating the stomach, and preventing and treating gastrointestinal malabsorption.

The present invention is an improved separating device for providing the malabsorptive component of a minimally invasive weight reduction system. This device may be a sleeve, liner, or tubular sheath that alters absorption of compositions through walls of hollow organs (stomach, intestines). The improvement involves better long-term retention through the ability of the device to engage with the interserosal fibrotic tissue formed in an intussusception. The separating device may be a distal extension of a retaining member that is directly engaged with and retained by intussuscepted tissue. Intussusception shrinks a hollow organ to provide a volume reducing restrictive component of a weight reduction system. Securing the separating device to an intussusception avoids retention problems of reference art devices as interserosal fibrosis helps secure the device. Also provided are an apparatus for retaining the device, a device and method for delivering the separating device, and a method for removing it.

Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and / or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and / or degraded within the GI tract.