Described herein is a general solution to 1,2-cis-amino-
glycoside synthesis through an iron-catalyzed, exclusively 1,2-cis-selective
glycal aminoglycosylation via cooperative atom transfer
catalysis. Further described is a 1,2-cis-selective
glycal aminoacyloxylation method for 2-amino saccharide synthesis. The methods are effective for a wide variety of
glycosyl donors with consistently high
stereoselectivity and excellent functional-group compatibility, which facilitates late-stage amino group incorporation for complex-
carbohydrate and other biologially-related molecule synthesis.